HRP20221099T1 - Automatski injektor sa sustavom zadržavanja uloška - Google Patents

Automatski injektor sa sustavom zadržavanja uloška Download PDF

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Publication number
HRP20221099T1
HRP20221099T1 HRP20221099TT HRP20221099T HRP20221099T1 HR P20221099 T1 HRP20221099 T1 HR P20221099T1 HR P20221099T T HRP20221099T T HR P20221099TT HR P20221099 T HRP20221099 T HR P20221099T HR P20221099 T1 HRP20221099 T1 HR P20221099T1
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Croatia
Prior art keywords
cartridge
ejector
automatic injector
injector according
receiving
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HRP20221099TT
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English (en)
Inventor
Paul Erik Fabricius
Flemming Madsen
Jan Olesen
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Ascendis Pharma A/S
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Publication of HRP20221099T1 publication Critical patent/HRP20221099T1/hr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2066—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2026—Semi-automatic, e.g. user activated piston is assisted by additional source of energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2403—Ampoule inserted into the ampoule holder
    • A61M2005/2411—Ampoule inserted into the ampoule holder from the front
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2433—Ampoule fixed to ampoule holder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2481—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for biasing the ampoule out of the ampoule holder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2485—Ampoule holder connected to rest of syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
    • A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (19)

1. Automatski injektor (4) za davanje injekcije lijeka iz uloška (700) koji sadrži lijek, te automatski injektor sadrži: kućište (6); i prihvat za uložak (300) s odjeljkom za prihvat uloška (302) konfiguriran da prihvaća sklop uloška (600) s najmanje jednim elementom za zadržavanje uloška (808) kada je umetnut kroz otvor za prihvat uloška (301) duž uzdužne osi; i izbacivač (200) konfiguriran da nosi sklop uloška (600) tako što je ovješen da se kreće duž uzdužnog smjera i opterećen je oprugom u smjeru suprotnom od smjera prihvata; pri čemu odjeljak za prihvat uloška (302) ima prvi odjeljak (310), na prvoj udaljenosti od otvora za prihvat uloška (301), s prvim elementima za vođenje (312) koji se protežu prema unutra i koji se protežu preko prvih kutova elementa za vođenje (314) i koji su razmaknuti tako da tvore prolaz (316) pod kutovima prolaza (318) između unutarnjih prvih elemenata za vođenje (312); pri čemu unutarnji prvi elementi za vođenje (312) tvore prvi provrt (320) koji prihvaća sklop uloška (600) kada je umetnut kroz otvor za prihvat uloška (301); pri čemu jedan ili više prvih elemenata za vođenje (312) ima/imaju stranu koja je okrenuta suprotno od otvora za prihvat uloška (301) i tvori konkavan oblik s nagnutim dijelom (334), pod kutovima nagiba (336), koji vodi prema dijelu za zadržavanje (328) na ili oko donjeg dijela konkavnog oblika; pri čemu odjeljak za prihvat uloška (302) ima drugi dio (330) prstenastog oblika, na drugoj udaljenosti od otvora za prihvat uloška (301), te s drugim elementima za vođenje (322) s prvim stranama (324) koje su nakošene oko radijalne osi prema uzdužnoj osi i kutno postavljene da se protežu najmanje djelomično preko kutova prolaza (318) i prvih kutova elementa za vođenje (314); pri čemu drugi element za vođenje (322) ima druge strane (326) koje su nakošene oko radijalne osi prema uzdužnoj osi i postavljene su naizmjenično s prvim stranama (324); pri čemu su prve strane (324) i druge strane (326) nakošene prema većoj udaljenosti od otvora za prihvat uloška (301) u smjeru rotacije koji je ili u smjeru kazaljke na satu ili u suprotnom smjeru od kazaljke na satu; pri čemu su prve strane (324) i druge strane (326) odvojene prvim podiznim dijelovima (340); pri čemu su prvi podizni dijelovi (340) postavljeni pod kutom na ili unutar prvih kutova elementa za vođenje (314).
2. Automatski injektor prema zahtjevu 1, naznačen time što prvi elementi za vođenje (312) imaju prvu vodeću površinu koja je okrenuta prema otvoru za prihvat uloška (301) i tvori konveksni šiljati oblik s vrhom usmjerenim prema otvoru za prihvat uloška (301).
3. Automatski injektor prema zahtjevu 1 ili 2, naznačen time što prvi dio (310) i drugi dio (330) jedan u odnosu na drugi održavaju fiksni kutni položaj.
4. Automatski injektor prema bilo kojem od zahtjeva 1-3, naznačen time što su prvi dio (310) i drugi dio (330) integralno oblikovani s prihvatom za uložak (300) tako da tvore jedan komad.
5. Automatski injektor prema zahtjevu 3 i 4, naznačen time što su jedan ili više prvih podiznih dijelova (340) kutno raspoređeni pod kutovima nagiba (336); i pri čemu su jedan ili više prvih podiznih dijelova (340) raspoređeni pod kutom između kuta zadržavanja (332) i središta kutova prolaza (318) u smjeru rotacije koji je ili u smjeru kazaljke na satu ili u suprotnom smjeru od kazaljke na satu.
6. Automatski injektor prema zahtjevu 4, naznačen time što su jedna ili više od prvih strana (324) i drugih strana (326) podijeljene u dijelove (344;346) odvojene drugim podiznim dijelom (342).
7. Automatski injektor prema zahtjevu 5, naznačen time što prvi element za vođenje ima stranu za izbacivanje (338) koja je nagnuta prema otvoru za prihvat uloška (301) pod kutovima iznad kuta zadržavanja (332) u smjeru rotacije koji je ili u smjeru kazaljke na satu ili u smjeru suprotnom od kazaljke na satu.
8. Automatski injektor u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što su drugi elementi za vođenje (322) konfigurirani kao prvi skup stepenica s gazištima koja su nagnuta oko radijalne osi i drugi skup stepenica s gazištima koja su nagnuta oko radijalne osi; pri čemu su gazišta prvih i drugih stepenica nagnuta prema većoj udaljenosti od otvora za prihvat uloška (301) za smjer rotacije u smjeru kazaljke na satu ili suprotno smjeru rotacije kazaljke na satu; pri čemu pri čemu su gazišta prvog skupa stepenica postavljena proksimalnije otvoru za prihvat uloška (301) od gazišta drugog skupa stepenica; i pri čemu je prvi skup stepenica naizmjenično raspoređen s drugim nizom stepenica; s podiznim dijelovima između stepenica, tvoreći prstenasti element sastavljen od drugog dijela (330).
9. Automatski injektor prema zahtjevu 3, naznačen time što su prvi elementi za vođenje (312) i drugi elementi za vođenje (322) konfigurirani i kutno poravnati tako da: - nakon umetanja, element za zadržavanje uloška prolazi prolazom (316) u uzdužnom smjeru, dolazi na prvi dio (344) prve strane (324), rotacijom prati prvu stranu (324) van preko drugog podiznog dijela (342) na drugi dio (346), te - nakon popuštanja sile umetanja: element za zadržavanje uloška (808) putuje do dijela za zadržavanje (328) preko kosog dijela (334).
10. Automatski injektor prema zahtjevima 5 i 6 i 7, naznačen time što su prvi elementi za vođenje (312) i drugi elementi za vođenje (322) konfigurirani i kutno poravnati tako da: - nakon otpuštanja, dio za zadržavanje uloška (808) napušta dio za zadržavanje (328) i dolazi na prvi dio (344) druge strane (326), rotacijom prati drugu stranu (326) izvan preko drugog podiznog dijela (342) do drugog dijela (346); nakon popuštanja sile: dio za zadržavanje uloška (808) putuje do strane za izbacivanje (338), odakle se kroz prolaz element za zadržavanje uloška (808) vodi prema otvoru za prihvat uloška.
11. Automatski injektor prema bilo kojem od prethodnih zahtjeva, naznačen time što izbacivač (200) sadrži bravu izbacivača (212) koja je radi pomoću jedne ili više rotacija, translacijskog pomicanja i aksijalnog pomicanja tako da se pomakne u položaj u kojem je kretanje izbacivača (200) ograničeno u smjeru umetanja.
12. Automatski injektor prema bilo kojem od prethodnih zahtjeva, naznačen time što je izduženi izbacivač (200) konfiguriran s: potpornom stranom izbacivača (204) za podupiranje uloška ili sklopa uloška (600), uzdužnim prorezom za izbacivanje (228) koji se proteže prema potpornoj strani izbacivača (204) od dijela ležišta izbacivača (206); i bravom izbacivača (212) podržanom radi okretanja najmanje jednog djelića okretaja i održavanu u (fiksnom) uzdužnom položaju u odnosu na kućište (6); pri čemu brava izbacivača (212) ima potporni dio za bravu izbacivača (234) koji je konfiguriran za poravnavanje i klizanje duž uzdužnog proreza za izbacivanje (228) pod prvim kutom i radi poravnavanja s dijelom ležišta izbacivača (206) pod drugim kutom.
13. Automatski injektor prema bilo kojem od prethodnih zahtjeva, naznačen time što izbacivač (200) sadrži polugu izbacivača (202) konfiguriranu s jednim ili više izreza izbacivača (228) tako da tvore jedan ili više zupčanika za izbacivanje (226) između izreza izbacivača (228); i pri čemu je brava izbacivača (212) konfigurirana s jednim ili više zupčanika brave za izbacivanje (232) između jednog ili više odgovarajućih izreza brave za izbacivanje (230).
14. Automatski injektor prema zahtjevu 13, naznačen time što jedan ili više izreza (230;228) i zupčanika (232; 226) imaju uglavnom pravokutni oblik.
15. Automatski injektor prema bilo kojem od prethodnih zahtjeva, naznačen time što sadrži polugu klipa (400) koja djeluje pomicanjem duž uzdužne osi kako bi izvršila silu pritiska na uložak koji je smješten u sklopu uloška.
16. Automatski injektor prema zahtjevu 15, naznačen time što je poluga klipa (400) smještena u izbacivaču (200) tako da se može uzdužno pomicati.
17. Automatski injektor prema zahtjevu 15 ili 16, naznačen time što brava izbacivača (212) sadrži klin za vođenje brave izbacivača (216) konfiguriran za zahvaćanje sa stazom poluge klipa (432) postavljenom u poluzi klipa (400), tako da uzdužno pomicanje poluge klipa (400), najmanje preko unaprijed određenog raspona, uzrokuje okretanje brave izbacivača (212) oko uzdužne osi (L)
18. Automatski injektor prema zahtjevu 17, naznačen time što staza poluge klipa (432) sadrži najmanje jedan dio staze (428) koji vodi klin za vođenje brave izbacivača (216) od prvog kuta do drugog kuta tako da okrene bravu izbacivača (212) iz prvog kutnog položaja u drugi kutni položaj.
19. Automatski injektor prema bilo kojem od prethodnih zahtjeva naznačen time što sadrži operativni modul konfiguriran za: - uključivanje poluge klipa (400) da se pomiče duž uzdužne osi kako bi se izvršila sila pritiska na uložak smještenu u sklopu uloška; i - aktiviranje brave izbacivača (212) pomoću jedne ili više rotacija, translacijskim pomicanjem i aksijalnim pomicanjem da se pomakne u položaj u kojem je kretanje izbacivača (200) ograničeno u smjeru umetanja.
HRP20221099TT 2015-12-30 2016-12-29 Automatski injektor sa sustavom zadržavanja uloška HRP20221099T1 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP15203137 2015-12-30
EP15203132 2015-12-30
EP16822214.9A EP3397324B1 (en) 2015-12-30 2016-12-29 Auto injector with cartridge retention system
PCT/EP2016/082856 WO2017114907A1 (en) 2015-12-30 2016-12-29 Auto injector with cartridge retention system

Publications (1)

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HRP20221099T1 true HRP20221099T1 (hr) 2022-11-25

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US (4) US11524115B2 (hr)
EP (3) EP3397319A1 (hr)
JP (2) JP6832368B2 (hr)
AU (2) AU2016383022B2 (hr)
CA (2) CA3009735C (hr)
DK (1) DK3397324T3 (hr)
ES (1) ES2924040T3 (hr)
HR (1) HRP20221099T1 (hr)
HU (1) HUE059907T2 (hr)
LT (1) LT3397324T (hr)
NZ (2) NZ742521A (hr)
PL (1) PL3397324T3 (hr)
PT (1) PT3397324T (hr)
RS (1) RS63450B1 (hr)
SI (1) SI3397324T1 (hr)
WO (2) WO2017114907A1 (hr)

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AU2016383022B2 (en) 2015-12-30 2021-04-01 Ascendis Pharma A/S Auto injector with cartridge retention system
WO2017114909A1 (en) 2015-12-30 2017-07-06 Ascendis Pharma A/S Front loaded auto injector for administering a medicament
EP3397322A1 (en) 2015-12-30 2018-11-07 Ascendis Pharma A/S Auto injector with detection of used cartridge and associated method
CA3006626C (en) 2015-12-30 2023-10-03 Ascendis Pharma A/S Auto injector with adaptable air-shot mechanism
CA3006638C (en) 2015-12-30 2024-03-05 Ascendis Pharma A/S Auto injector with charger safety
CN115591054A (zh) 2017-05-23 2023-01-13 阿森迪斯药物股份有限公司（Dk） 自动注射器、系统和用于控制自动注射器的方法
US10473370B2 (en) * 2017-12-12 2019-11-12 GM Global Technology Operations LLC Ejector-receiver refrigeration circuit with valve
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