HRP20212016T1 - Sinergistički pripravak kao promotor autofagije - Google Patents
Sinergistički pripravak kao promotor autofagije Download PDFInfo
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- HRP20212016T1 HRP20212016T1 HRP20212016TT HRP20212016T HRP20212016T1 HR P20212016 T1 HRP20212016 T1 HR P20212016T1 HR P20212016T T HRP20212016T T HR P20212016TT HR P20212016 T HRP20212016 T HR P20212016T HR P20212016 T1 HRP20212016 T1 HR P20212016T1
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- Croatia
- Prior art keywords
- formulation
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- extract
- synergistic
- plant
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- 239000000203 mixture Substances 0.000 title claims 24
- 230000002195 synergetic effect Effects 0.000 title claims 12
- 230000004900 autophagic degradation Effects 0.000 title claims 4
- 238000009472 formulation Methods 0.000 claims 16
- 238000002360 preparation method Methods 0.000 claims 12
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical group N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 6
- 241000196324 Embryophyta Species 0.000 claims 6
- 241000816457 Galeopsis Species 0.000 claims 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- 229940063673 spermidine Drugs 0.000 claims 4
- 239000011616 biotin Chemical group 0.000 claims 3
- 229960002685 biotin Drugs 0.000 claims 3
- 235000020958 biotin Nutrition 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- 239000012049 topical pharmaceutical composition Substances 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 238000000227 grinding Methods 0.000 claims 2
- ATHGHQPFGPMSJY-UHFFFAOYSA-N spermidine Chemical compound NCCCCNCCCN ATHGHQPFGPMSJY-UHFFFAOYSA-N 0.000 claims 2
- 201000004384 Alopecia Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 241000021559 Dicerandra Species 0.000 claims 1
- 241001096606 Galeopsis segetum Species 0.000 claims 1
- 241001508646 Galeopsis tetrahit Species 0.000 claims 1
- 229920002774 Maltodextrin Polymers 0.000 claims 1
- 239000005913 Maltodextrin Substances 0.000 claims 1
- 235000010654 Melissa officinalis Nutrition 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 1
- 206010068168 androgenetic alopecia Diseases 0.000 claims 1
- 201000002996 androgenic alopecia Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- -1 conditioner Substances 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 238000010828 elution Methods 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 239000006260 foam Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 230000003779 hair growth Effects 0.000 claims 1
- 239000000865 liniment Substances 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 229940035034 maltodextrin Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 230000003658 preventing hair loss Effects 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 239000002453 shampoo Substances 0.000 claims 1
- 239000000741 silica gel Substances 0.000 claims 1
- 229910002027 silica gel Inorganic materials 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/132—Amines having two or more amino groups, e.g. spermidine, putrescine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Mycology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Claims (19)
1. Sinergistički pripravak koji sadrži ekstrakt biljke iz roda Galeopsis i spoj koji potiče autofagiju odabran između R-N1-spermidina ili njegove soli, gdje je R vodik ili metil, biotin i njihovih mješavina.
2. Sinergistički pripravak prema zahtjevu 1, naznačen time što je ekstrakt biljke roda Galeopsis odabran između vrsta Galeopsis segetum i Galeopsis tetrahit i njihovih mješavina.
3. Sinergistički pripravak prema zahtjevu 2, naznačen time što je ekstrakt biljke iz roda Galeopsis suhi ekstrakt koji se može dobiti postupkom koji sadrži sljedeće korake:
- mljevenje najmanje jednog dijela biljke iz roda Galeopsis;
- ekstrahiranje s otapalom, poželjno fiziološki prihvatljivim otapalom;
- filtriranje ekstrakta;
- pročišćavanje filtriranog ekstrakta, poželjno eluiranjem u koloni s otapalom;
- sušenje pročišćenog ekstrakta;
- mljevenje osušenog pročišćenog ekstrakta; i
- izborno dodavanje ekscipijenata.
4. Sinergistički pripravak prema zahtjevu 3, naznačen time što ekscipijenti sadrže maltodekstrin i/ili koloidni bezvodni silika-gel.
5. Sinergistički pripravak prema bilo kojem od zahtjeva 1-4, naznačen time što je spermidin prisutan u pripravku u obliku trihidroklorida.
6. Lokalna formulacija koja sadrži sinergistički pripravak prema bilo kojem od zahtjeva 1-5 i najmanje jedan ekscipijent prikladan za topikalnu primjenu.
7. Formulacija za lokalnu primjenu prema zahtjevu 6, naznačena time što je količina ekstrakta biljke iz roda Galeopsis u rasponu od 0.0003% do 0.01% težinski u odnosu na ukupnu težinu pripravka.
8. Formulacija za lokalnu primjenu prema zahtjevu 6 ili zahtjevu 7, naznačena time što je količina biotina u rasponu od 0.0006% do 0.075% težinski u odnosu na ukupnu težinu pripravka.
9. Formulacija za lokalnu primjenu prema bilo kojem od zahtjeva 6-8, naznačena time što pripravak sadrži R-N1-spermidin ili njegovu sol, gdje je R metil ili vodik, u rasponu od 0.0005-0.1% težinski u odnosu na ukupnu težinu pripravka.
10. Formulacija za lokalnu primjenu prema bilo kojem od zahtjeva 6-9, naznačena time što je formulacija u obliku odabranom iz skupine koju čine šampon, gel, regenerator, losion, balzam, emulzija, pjena, šminka i krema.
11. Oralna formulacija koja sadrži sinergistički pripravak prema bilo kojem od zahtjeva 1-5 i najmanje jedan ekscipijent prikladan za oralnu primjenu.
12. Oralna formulacija prema zahtjevu 11, naznačena time što je količina suhog ekstrakta biljke iz roda Galeopsis u oralnoj formulaciji u rasponu od 0.1 mg do 20 mg po jednoj dozi.
13. Oralna formulacija prema zahtjevu 11 ili 12, naznačena time što je količina biotina u oralnoj formulaciji u rasponu od 0.03 mg do 0.08 mg po jednoj dozi.
14. Oralna formulacija prema zahtjevu 11 ili 12, naznačena time što pripravak sadrži R-N1-spermidin ili njegovu sol, gdje je R metil ili vodik, u rasponu od 0.3 mg do 0.8 mg po jednoj dozi.
15. Oralna formulacija prema bilo kojem od zahtjeva 11-14, naznačena time što je formulacija čvrsta formulacija odabrana iz skupine koju čine tableta, kapsula, prašci, granule i pilula.
16. Kozmetička uporaba sinergističkog pripravka prema bilo kojem od zahtjeva 1-5 ili topikalne formulacije prema bilo kojem od zahtjeva 6-10 ili oralne formulacije prema bilo kojem od zahtjeva 11-15 za poticanje rasta kose i/ili sprječavanje gubitka kose.
17. Sinergistički pripravak prema bilo kojem od zahtjeva 1-5 ili topikalna formulacija prema bilo kojem od zahtjeva 6-10 ili oralna formulacija prema bilo kojem od zahtjeva 11-15 za uporabu u liječenju alopecije androgenetike ili defluvije.
18. Sinergistički pripravak prema bilo kojem od zahtjeva 1-5 za uporabu kao promotor autofagije u liječenju bolesti modulirane autofagijom.
19. Sinergistički pripravak za uporabu prema zahtjevu 18 naznačen time što su bolesti modulirane autofagijom odabrane iz skupine koju čine neurodegeneracija, rak, Crohnova bolest i kožne bolesti.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102017000089680A IT201700089680A1 (it) | 2017-08-03 | 2017-08-03 | Composizione sinergica come promoter di autofagia/a synergistic composition as a promoter of autophagy |
| PCT/EP2018/071005 WO2019025548A1 (en) | 2017-08-03 | 2018-08-02 | SYNERGIC COMPOSITION AS A PROMOTER OF AUTOPHAGIA |
| EP18758821.5A EP3661534B1 (en) | 2017-08-03 | 2018-08-02 | A synergistic composition as a promoter of autophagy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20212016T1 true HRP20212016T1 (hr) | 2022-04-01 |
Family
ID=60451125
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20212016TT HRP20212016T1 (hr) | 2017-08-03 | 2018-08-02 | Sinergistički pripravak kao promotor autofagije |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US11273193B2 (hr) |
| EP (1) | EP3661534B1 (hr) |
| JP (1) | JP7307715B2 (hr) |
| CN (1) | CN111447937B (hr) |
| AU (1) | AU2018309342A1 (hr) |
| BR (1) | BR112020002216B1 (hr) |
| CA (1) | CA3071317A1 (hr) |
| CY (1) | CY1124899T1 (hr) |
| DK (1) | DK3661534T3 (hr) |
| EA (1) | EA202090437A1 (hr) |
| ES (1) | ES2902036T3 (hr) |
| HR (1) | HRP20212016T1 (hr) |
| HU (1) | HUE057354T2 (hr) |
| IL (1) | IL272371B (hr) |
| IT (1) | IT201700089680A1 (hr) |
| LT (1) | LT3661534T (hr) |
| MA (1) | MA49755B1 (hr) |
| MD (1) | MD3661534T2 (hr) |
| MX (1) | MX2020001317A (hr) |
| PL (1) | PL3661534T3 (hr) |
| PT (1) | PT3661534T (hr) |
| RS (1) | RS62766B1 (hr) |
| SA (1) | SA520411228B1 (hr) |
| SG (1) | SG11202000953VA (hr) |
| SI (1) | SI3661534T1 (hr) |
| WO (1) | WO2019025548A1 (hr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT201700003045A1 (it) * | 2017-01-12 | 2018-07-12 | Giuliani Spa | Estratto vegetale per prevenire e trattare la caduta dei capelli |
| DE102022004360A1 (de) | 2022-11-11 | 2024-05-16 | Epigenics GmbH | Mikronährstoff-enthaltendes Produkt zur Nahrungsergänzung |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2751878B1 (fr) * | 1996-07-30 | 1998-09-04 | Oreal | Utilisation dans une composition d'un extrait d'au moins une labiee |
| TWI282275B (en) * | 2000-08-17 | 2007-06-11 | Control Ox Oy | Plant-derived and synthetic phenolic compounds and plant extracts, effective in the treatment and prevention of chlamydial infections |
| ITMI20020189A1 (it) * | 2002-02-01 | 2003-08-01 | Giuliani Spa | Composizione per uso farmaceutico o dietetico per contrastare la caduta dei capelli |
| ITMI20050498A1 (it) * | 2005-03-24 | 2006-09-25 | Giuliani Spa | Composizione a base di estratti vegetali di ajuga reptans per prevenire la caduta dei capelli stimolare la crescita dei capelli regolare la produzione di sebo |
| FR2916977A1 (fr) * | 2007-06-06 | 2008-12-12 | Engelhard Lyon Sa | STIMULATION DE LA SYNTHESE DES RECPTEURS MCR1, MCR2 ET µ OPIOIDE. |
| ITMI20110644A1 (it) * | 2011-04-14 | 2012-10-15 | Giuliani Spa | Sistema per il rilascio prolungato di agenti cosmetici |
| UA116091C2 (uk) * | 2011-09-13 | 2018-02-12 | Монсанто Текнолоджи Ллс | Способи та композиції для боротьби з бур'янами |
| TW201340874A (zh) * | 2012-03-13 | 2013-10-16 | Marrone Bio Innovations Inc | 殺蟲性黃桿菌屬品種與生物活性組成物、代謝物及使用 |
| ITMI20121323A1 (it) * | 2012-07-27 | 2014-01-28 | Giuliani Spa | Composizione farmaceutica o cosmeticaper il trattamento dell' alopecia |
| WO2014167514A1 (en) * | 2013-04-09 | 2014-10-16 | Tuttle Chris | Formulations and methods for control of weedy species |
| ITMI20130554A1 (it) * | 2013-04-09 | 2014-10-10 | Giuliani Spa | Composizione farmaceutica o cosmetica atta a preservare le cellule staminali epiteliali |
| ITMI20131792A1 (it) * | 2013-10-28 | 2015-04-29 | Giuliani Spa | Uso di un estratto vegetale per la prevenzione e trattamento della caduta dei capelli |
-
2017
- 2017-08-03 IT IT102017000089680A patent/IT201700089680A1/it unknown
-
2018
- 2018-08-02 SI SI201830520T patent/SI3661534T1/sl unknown
- 2018-08-02 MD MDE20200611T patent/MD3661534T2/ro unknown
- 2018-08-02 EP EP18758821.5A patent/EP3661534B1/en active Active
- 2018-08-02 MA MA49755A patent/MA49755B1/fr unknown
- 2018-08-02 US US16/636,291 patent/US11273193B2/en active Active
- 2018-08-02 MX MX2020001317A patent/MX2020001317A/es unknown
- 2018-08-02 HU HUE18758821A patent/HUE057354T2/hu unknown
- 2018-08-02 CN CN201880056903.8A patent/CN111447937B/zh active Active
- 2018-08-02 ES ES18758821T patent/ES2902036T3/es active Active
- 2018-08-02 HR HRP20212016TT patent/HRP20212016T1/hr unknown
- 2018-08-02 WO PCT/EP2018/071005 patent/WO2019025548A1/en active Application Filing
- 2018-08-02 DK DK18758821.5T patent/DK3661534T3/da active
- 2018-08-02 EA EA202090437A patent/EA202090437A1/ru unknown
- 2018-08-02 JP JP2020504725A patent/JP7307715B2/ja active Active
- 2018-08-02 PT PT187588215T patent/PT3661534T/pt unknown
- 2018-08-02 AU AU2018309342A patent/AU2018309342A1/en active Pending
- 2018-08-02 RS RS20211520A patent/RS62766B1/sr unknown
- 2018-08-02 SG SG11202000953VA patent/SG11202000953VA/en unknown
- 2018-08-02 PL PL18758821T patent/PL3661534T3/pl unknown
- 2018-08-02 CA CA3071317A patent/CA3071317A1/en active Pending
- 2018-08-02 LT LTEPPCT/EP2018/071005T patent/LT3661534T/lt unknown
- 2018-08-02 BR BR112020002216-0A patent/BR112020002216B1/pt active IP Right Grant
-
2020
- 2020-01-30 IL IL272371A patent/IL272371B/en unknown
- 2020-02-03 SA SA520411228A patent/SA520411228B1/ar unknown
-
2022
- 2022-01-07 CY CY20221100021T patent/CY1124899T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019025548A1 (en) | 2019-02-07 |
| IT201700089680A1 (it) | 2019-02-03 |
| EP3661534A1 (en) | 2020-06-10 |
| BR112020002216B1 (pt) | 2023-03-21 |
| SI3661534T1 (sl) | 2022-04-29 |
| CY1124899T1 (el) | 2023-01-05 |
| EA202090437A1 (ru) | 2020-06-08 |
| BR112020002216A2 (pt) | 2020-07-28 |
| LT3661534T (lt) | 2022-01-10 |
| SG11202000953VA (en) | 2020-02-27 |
| MD3661534T2 (ro) | 2022-03-31 |
| IL272371A (en) | 2020-03-31 |
| DK3661534T3 (da) | 2021-12-20 |
| CA3071317A1 (en) | 2019-02-07 |
| PT3661534T (pt) | 2021-12-30 |
| MA49755A (fr) | 2020-06-10 |
| EP3661534B1 (en) | 2021-10-20 |
| PL3661534T3 (pl) | 2022-02-21 |
| JP2020529404A (ja) | 2020-10-08 |
| IL272371B (en) | 2022-04-01 |
| US20210177925A1 (en) | 2021-06-17 |
| MA49755B1 (fr) | 2021-12-31 |
| HUE057354T2 (hu) | 2022-05-28 |
| CN111447937A (zh) | 2020-07-24 |
| US11273193B2 (en) | 2022-03-15 |
| RS62766B1 (sr) | 2022-01-31 |
| CN111447937B (zh) | 2022-05-24 |
| MX2020001317A (es) | 2020-03-20 |
| ES2902036T3 (es) | 2022-03-24 |
| SA520411228B1 (ar) | 2023-02-23 |
| AU2018309342A1 (en) | 2020-03-19 |
| JP7307715B2 (ja) | 2023-07-12 |
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