HRP20211353T1 - Postupci za ekspanziju ili depleciju regulacijskih t-stanica - Google Patents

Postupci za ekspanziju ili depleciju regulacijskih t-stanica Download PDF

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HRP20211353T1
HRP20211353T1 HRP20211353TT HRP20211353T HRP20211353T1 HR P20211353 T1 HRP20211353 T1 HR P20211353T1 HR P20211353T T HRP20211353T T HR P20211353TT HR P20211353 T HRP20211353 T HR P20211353T HR P20211353 T1 HRP20211353 T1 HR P20211353T1
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Croatia
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cancer
antibody
antigen
preparation
binding fragment
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HRP20211353TT
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Denise L. Faustman
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The General Hospital Corporation
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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Claims (10)

1. Izolirano humanizirano, humano ili himerično protutijelo ili njegov fragment koji veže antigen, koji se selektivno veže na epitop iz TNFR2 unutar aminokiselina 130-149 iz SEQ ID NO: 1, navedeno protutijelo ili njegov fragment koji veže antigen koji ima antagonistički učinak na TNFR2 nakon vezanja.
2. Protutijelo ili njegov fragment koji veže antigen u skladu s patentnim zahtjevom 1, naznačeno time da navedeno protutijelo ili njegov fragment koji veže antigen: a) veže se na epitop koji sadrži aminokiseline 135-147 iz SEQ ID NO: 1; b) veže se na epitop koji sadrži aminokiseline 135-142 iz SEQ ID NO: 1; c) odabrano je iz skupine koju čine monoklonsko protutijelo ili njegov fragment koji veže antigen, poliklonsko protutijelo ili njegov fragment koji veže antigen, Fab, bispecifično protutijelo ili njegov fragment koji veže antigen, njegovo monovalentno protutijelo ili njegov fragment koji veže antigen, jednolančana Fv-molekula, bispecifična jednolančana Fv ((scFv’)2), protutijelo domene, diatijelo, triatijelo, srodno tijelo, protutijelo domene, SMIP, nanotijelo, Fv-fragment, Fab-fragment, molekula F(ab’)2 i tandemski fragment scFv (taFv); ili d) pokazuje ravnotežnu konstantu disocijacije („KD”) manju od oko 50 nM, manju od oko 10 nM ili manju od oko 1 nM.
3. Protutijelo ili njegov fragment koji veže antigen u skladu s patentnim zahtjevom 1 ili 2, naznačeno time da je namijenjeno uporabi u liječenju proliferativnog poremećaja ili zarazne bolesti kod pacijenta.
4. Protutijelo ili njegov fragment koji veže antigen u skladu s patentnim zahtjevom 1 ili 2, naznačeno time da je namijenjeno uporabi prema patentnom zahtjevu 3, gdje: a) je spomenuti proliferativni poremećaj rak odabran iz skupine koju čine akutna limfoblastna leukemija, akutna mijeloična leukemija, adrenokortikalni karcinom, limfom povezan s AIDS-om, maligni tumori povezani s AIDS-om, karcinom mjehura, rak kostiju / zloćudni vlaknasti histiocitom, gliom moždanog debla, gliom optičkog puta i gliom hipotalamusa, rak dojke, bronhijalni adenomi / karcinoidi, kronična limfocitna leukemija, kronična mijelogena leukemija, kronični mijeloproliferativni poremećaji, sarkom čistih stanica omotača tetiva, rak debelog crijeva, kolorektalni karcinom, kožni T-stanični limfom, rak endometrija, epitelni karcinom, rak jednjaka, tumori iz obitelji Ewingovog sarkoma, ekstrakranijalni tumor zametnih stanica, ekstragonadalni tumor zametnih stanica, rak ekstrahepatičnog žučnog kanala, rak oka, intraokularni melanom, retinoblastom, rak žučnog mjehura, rak želuca, leukemija dlakavih stanica, rak glave i vrata, hepatocelularni karcinom (jetre), Hodgkinov limfom, rak hipofaringeusa, Kaposijev sarkom, rak bubrega, rak grkljana, rak hipofize, multipli mijelom / rak neoplazma stanica, pleuropulmonalni blastom, rak kože, rak pluća malih stanica, rak tankog crijeva, sarkom mekih tkiva, karcinom skvamoznih stanica vrata, rak testisa, rak štitnjače, rak uretre, sarkom maternice i rak rodnice, ili je solidni tumor mozga, pluća, dojke, limfoida, gastrointestinalnog trakta, genitourinarnog trakta, ždrijela, prostate ili jajnika; ili b) spomenuta zarazna bolest odabrana je iz skupine koju čine bakterijska infekcija, virusna infekcija, gljivična infekcija i parazitska infekcija.
5. Postupak za proizvodnju pripravka obogaćenog limfocitima, naznačen time da obuhvaća in vitro kontaktiranje populacije ljudskih stanica koja sadrži navedene limfocite dobivene iz uzorka ljudske krvi ili koštane srži od pacijenta s protutijelom ili njegovim fragmentom koji veže antigen, u skladu s patentnim zahtjevom 1 ili 2, čime se proizvodi navedeni pripravak obogaćen limfocitima, pri čemu navedene Treg stanice čine manje od 10 % stanica u navedenom pripravku.
6. Postupak prema patentnom zahtjevu 5, naznačen time da: a) spomenuti postupak nadalje uključuje izolaciju navedenih ljudskih stanica iz uzorka ljudske krvi ili uzorka ljudske koštane srži prije navedenog kontakta; ili b) navedene Treg stanice čine manje od 5 % stanica u navedenom pripravku.
7. Pripravak proizveden postupkom prema patentnim zahtjevima 5 ili 6, naznačen time da je navedeni pripravak obogaćen limfocitima i da Treg stanice u navedenom pripravku čine manje od 10 % stanica u navedenom pripravku.
8. Pripravak prema patentnom zahtjevu 7, naznačen time da navedene Treg stanice čine manje od 5 % stanica u navedenom pripravku.
9. Pripravak prema patentnom zahtjevu 7 ili 8, naznačen time da je namijenjen uporabi u liječenju proliferativnog poremećaja ili zarazne bolesti kod pacijenata.
10. Pripravak za uporabu prema patentnom zahtjevu 9, naznačen time da: a) je spomenuti proliferativni poremećaj rak odabran iz skupine koju čine akutna limfoblastna leukemija, akutna mijeloična leukemija, adrenokortikalni karcinom, limfom povezan s AIDS-om, maligni tumori povezani s AIDS-om, karcinom mjehura, rak kostiju / zloćudni vlaknasti histiocitom, gliom moždanog debla, gliom optičkog puta i gliom hipotalamusa, rak dojke, bronhijalni adenomi / karcinoidi, kronična limfocitna leukemija, kronična mijelogena leukemija, kronični mijeloproliferativni poremećaji, sarkom čistih stanica omotača tetiva, rak debelog crijeva, kolorektalni karcinom, kožni T-stanični limfom, rak endometrija, epitelni karcinom, rak jednjaka, tumori iz obitelji Ewingovog sarkoma, ekstrakranijalni tumor zametnih stanica, ekstragonadalni tumor zametnih stanica, rak ekstrahepatičnog žučnog kanala, rak oka, intraokularni melanom, retinoblastom, rak žučnog mjehura, rak želuca, leukemija dlakavih stanica, rak glave i vrata, hepatocelularni karcinom (jetre), Hodgkinov limfom, rak hipofaringeusa, Kaposijev sarkom, rak bubrega, rak grkljana, rak hipofize, multipli mijelom / rak neoplazma stanica, pleuropulmonalni blastom, rak kože, rak pluća malih stanica, rak tankog crijeva, sarkom mekih tkiva, karcinom skvamoznih stanica vrata, rak testisa, rak štitnjače, rak uretre, sarkom maternice i rak rodnice, ili je solidni tumor mozga, pluća, dojke, limfoida, gastrointestinalnog trakta, genitourinarnog trakta, ždrijela, prostate ili jajnika; ili b) spomenuta zarazna bolest odabrana je iz skupine koju čine bakterijska infekcija, virusna infekcija, gljivična infekcija i parazitska infekcija.
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