HRP20200386T1 - Derivati biarila kao agonisti gpr120 - Google Patents

Derivati biarila kao agonisti gpr120 Download PDF

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HRP20200386T1
HRP20200386T1 HRP20200386TT HRP20200386T HRP20200386T1 HR P20200386 T1 HRP20200386 T1 HR P20200386T1 HR P20200386T T HRP20200386T T HR P20200386TT HR P20200386 T HRP20200386 T HR P20200386T HR P20200386 T1 HRP20200386 T1 HR P20200386T1
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Croatia
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difluoro
phenoxy
pyridin
acid
butyric acid
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HRP20200386TT
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Young Kwan Kim
Sang Yun Park
Hyun Woo Joo
Eun Sil Choi
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Lg Chem, Ltd.
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Publication of HRP20200386T1 publication Critical patent/HRP20200386T1/hr

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Claims (5)

1. Biarilni derivat ili njegova farmaceutski prihvatljiva sol ili E- ili Z-izomer, ili R- ili S-izomer, odabran između sljedećih spojeva: 4-[4-[6-(ciklobutoksil)-2-piridil]-2-(trifluorometil)fenoksi]maslačna kiselina; 4-[[5-(2-ciklobutilsulfanil-3-piridil)-2-piridil]oksi]pentanoična kiselina; 4-[2,6-difluoro-4-[6-(N-metilanilino)-2-piridil]fenoksi]maslačna kiselina; 4-{2,6-difluoro-4-[6-(2-metil-propenil)-piridin-2-il]-fenoksi}-maslačna kiselina; 4-(4-{2-[3-(tert-butil-dimetil-silaniloksi)-ciklopentiloksi]-piridin-3-il}-2,6-difluorofenoksi)-maslačna kiselina; 4-[4-(6-fenoksi-2-piridil)fenoksi]maslačna kiselina; 4-[2,6-difluoro-4-(6-izopropilsulfanil-2-piridil)fenoksi]maslačna kiselina; 4-[2,6-difluoro-4-(6-fenoksi-2-piridil)fenoksi]maslačna kiselina; 4-[2-chloro-4-(6-izopropilsulfanil-2-piridil)fenoksi]maslačna kiselina; 4-[2-fluoro-4-(6-izopropilsulfanil-2-piridil)fenoksi]maslačna kiselina; 4-[4-(6-ciklopentilsulfanil-2-piridil)-2,6-difluoro-fenoksi]maslačna kiselina; 4-[4-(2-ciklobutilsulfanil-piridin-3-il)-2-metoksi-fenoksi]-maslačna kiselina; 4-[2,6-difluoro-4-(2-izopropilsulfanil-4-piridil)fenoksi]maslačna kiselina; 4-[4-[6-(ciklopentoksi)-2-piridil]-2,6-difluoro-fenoksi]maslačna kiselina; 4-[4-(2-ciklobutilsulfanil-piridin-3-il)-2,6-dimetil-fenoksi]-maslačna kiselina; 4-[4-[3-(ciklopentoksi)fenil]-2,6-difluoro-fenoksi]maslačna kiselina; 4-[2,6-difluoro-4-(6-pirolidin-1-il-2-piridil)fenoksi]maslačna kiselina; 4-[4-(2-sec-butilsulfanil-piridin-3-il)-2,6-difluoro-fenoksi]-maslačna kiselina 4-[4-[3-(ciklopentoksi)fenil]-2,3-difluoro-fenoksi]maslačna kiselina; 4-[2,6-difluoro-4-[6-(1-piperidil)-2-piridil]fenoksi]maslačna kiselina; 4-[4-(6-anilino-2-piridil)-2,6-difluoro-fenoksi]maslačna kiselina; 4-[4-[6-(ciklopentilamino)-2-piridil]-2,6-difluoro-fenoksi]maslačna kiselina; 4-[4-[6-(ciklopropilmetilsulfanil)-2-piridil]-2,6-difluoro-fenoksi]maslačna kiselina; 4-[4-(6-ciklobutilsulfanil-2-piridil)-2,6-difluoro-fenoksi]maslačna kiselina; 4-[2,6-difluoro-4-(6-propilsulfanil-2-piridil)fenoksi]maslačna kiselina; 4-[2,6-difluoro-4-(6-izopropoksi-2-piridil)fenoksi]maslačna kiselina; 4-[2,6-difluoro-4-(6-propoksi-2-piridil)fenoksi]maslačna kiselina; 4-[4-[6-(ciklopropilmetoksi)-2-piridil]-2,6-difluoro-fenoksi]maslačna kiselina; 4-[4-[6-(ciklobutoksil)-2-piridil]-2,6-difluoro-fenoksi]maslačna kiselina; 4-[4-[6-(ciklobutoksil)-2-piridil]-2-metil-fenoksi]maslačna kiselina; 4-[4-(2-ciklobutilsulfanil-3-piridil)-2,6-difluoro-fenoksi]pentanoična kiselina; 4-[4-[6-(ciklobutoksil)-2-piridil]-2,6-difluoro-fenoksi]pentanoična kiselina; 4-{2,6-difluoro-4-[2-(3-metil-butilsulfanil)-piridin-3-il]-fenoksi}-maslačna kiselina 4-{2,6-difluoro-4-[2-(2-fluoro-etoksi)-piridin-3-il]-fenoksi}-maslačna kiselina; 2-[1-[[4-(2-ciklobutilsulfanil-3-piridil)-2,6-difluoro-fenoksi]metil] ciklopropil]octena kiselina; 2-[1-[[4-[3-(ciklobutoksil)fenil]-2,6-difluoro-fenoksi]metil]ciklopropil] octena kiselina; 4-[[6-[3-(ciklobutoksil)fenil]-3-piridil]oksi]maslačna kiselina; 4-[[6-[3-(ciklopentoksi)fenil]-3-piridil]oksi]maslačna kiselina; 4-(2’-fenoksi-bifenil-4-iloksi)-maslačna kiselina; 4-[4-(2-izopropilsulfanil-piridin-3-il)-fenoksi]-maslačna kiselina; 4-(3,5-difluoro-2’-fenoksi-bifenil-4-iloksi)-maslačna kiselina; 4-[4-(2-ciklopentilsulfanil-piridin-3-il)-fenoksi]-maslačna kiselina; 4-[2,6-difluoro-4-(2-izopropilsulfanil-piridin-3-il)-fenoksi]-maslačna kiselina; 4-[2,6-difluoro-4-(2-fenoksi-piridin-3-il)-fenoksi]-maslačna kiselina; 4-[2,6-difluoro-4-(2-izopropoksi-piridin-3-il)-fenoksi]-maslačna kiselina; 4-[4-(2-ciklopentiloksi-piridin-3-il)-2,6-difluoro-fenoksi]-maslačna kiselina; 4-[4-(2-ciklopentilsulfanil-piridin-3-il)-2,6-difluoro-fenoksi]-maslačna kiselina; 4-[4-(2-ciklopropilmetoksi-piridin-3-il)-2,6-difluoro-fenoksi]-maslačna kiselina; 4-[4-(2-ciklopropilmetilsulfanil-piridin-3-il)-2,6-difluoro-fenoksi]-maslačna kiselina; 4-[4-(2-ciklobutilsulfanil-piridin-3-il)-fenoksi]-maslačna kiselina; 4-[4-(2-ciklopropilmetilsulfanil-piridin-3-il)-fenoksi]-maslačna kiselina; 4-[4-(2-ciklobutilsulfanil-piridin-3-il)-2,6-difluoro-fenoksi]-maslačna kiselina; 4-[4-(2-propilsulfanil-piridin-3-il)-fenoksi]-maslačna kiselina; 4-(3,5-difluoro-2’-izopropoksi-bifenil-4-iloksi)-maslačna kiselina; 4-(2’-ciklobutoksil-3,5-difluoro-bifenil-4-iloksi)-maslačna kiselina; 4-(2’-ciklopropilmetoksi-3,5-difluoro-bifenil-4-iloksi)-maslačna kiselina; 4-(2’-ciklopentiloksi-3,5-difluoro-bifenil-4-iloksi)-maslačna kiselina; 4-(2’-ciklopentiloksi-bifenil-4-iloksi)-maslačna kiselina; 4-(2’-izopropoksi-bifenil-4-iloksi)-maslačna kiselina; 4-(2’-ciklopropilmetoksi-bifenil-4-iloksi)-maslačna kiselina; 4-[4-(2-ciklobutilsulfanil-piridin-3-il)-2,6-difluoro-fenoksi]-2-metil-maslačna kiselina; 2-[4-(2-ciklobutilsulfanil-piridin-3-il)-2,6-difluoro-fenoksimetil]-ciklopropanecarboksilic kiselina; 4-[4-(2-ciklobutilsulfanil-piridin-3-il)-2,5-difluoro-fenoksi]-maslačna kiselina; 4-[4-(6-ciklobutilsulfanil-piridin-2-il)-2,5-difluoro-fenoksi]-maslačna kiselina; 4-[4-(2-tert-butilsulfanil-piridin-3-il)-2,6-difluoro-fenoksi]-maslačna kiselina; 6-[2,6-difluoro-4-(2-propilsulfanil-3-piridil)fenoksi]heksanoična kiselina; 4-[2,6-difluoro-4-(6-izobutil-piridin-2-il)-fenoksi]-maslačna kiselina; 4-[4-(2-ciklobutilsulfanil-piridin-3-il)-3,5-difluoro-fenoksi]-maslačna kiselina; 4-{2,6-difluoro-4-[2-(tetrahidro-piran-4-iloksi)-piridin-3-il]-fenoksi}-maslačna kiselina; 4-{2,6-difluoro-4-[2-(tetrahidro-furan-3-iloksi)-piridin-3-il]-fenoksi}-maslačna kiselina; 4-[4-(2-ciklobutoksil-piridin-3-il)-2,6-difluoro-fenoksi]-maslačna kiselina; 4-{2,6-difluoro-4-[2-(2-metoksi-etoksi)-piridin-3-il]-fenoksi}-maslačna kiselina; 4-[2,6-difluoro-4-(2-pirolidin-1-il-3-piridil)fenoksi]butanoična kiselina; 4-[4-[2-(ciklopentilamino)-3-piridil]-2,6-difluoro-fenoksi]butanoična kiselina; 4-[4-[2-(ciklopropilmetilamino)-3-piridil]-2,6-difluoro-fenoksi]butanoična kiselina; 4-[4-[6-(ciklopropilmetilamino)-2-piridil]-2,6-difluoro-fenoksi]butanoična kiselina; 4-[2,6-difluoro-4-[2-(izopropilamino)-3-piridil]fenoksi]butanoična kiselina; 4-[4-[2-(ciklopropilamino)-3-piridil]-2,6-difluoro-fenoksi]butanoična kiselina; 4-[2,6-difluoro-4-[6-(izopropilamino)-2-piridil]fenoksi]butanoična kiselina; 4-[4-[2-(ciklopentilamino)fenil]-2,6-difluoro-fenoksi]butanoična kiselina; 4-[4-[3-(ciklopentilamino)fenil]-2,6-difluoro-fenoksi]butanoična kiselina; 4-[2,6-difluoro-4-[2-(propilamino)fenil]fenoksi]butanoična kiselina; 4-[4-[2-(ciklopropilmetilamino)fenil]-2,6-difluoro-fenoksi]butanoična kiselina; 4-[2,6-difluoro-4-[2-(izopropilamino)fenil]fenoksi]butanoična kiselina; 4-[4-[2-(ciklopentilamino)fenil]fenoksi]butanoična kiselina; 4-[4-[2-(ciklopropilmetilamino)fenil]fenoksi]butanoična kiselina; 4-[4-[2-(propilamino)fenil]fenoksi]butanoična kiselina; 4-[4-[2-(izopropilamino)fenil]fenoksi]butanoična kiselina; 4-[4-[2-(ciklobutilamino)fenil]fenoksi]butanoična kiselina; 4-[4-[2-(ciklobutilamino)fenil]-2,6-difluoro-fenoksi]butanoična kiselina; 4-[4-[3-(ciklopropilmetilamino)fenil]-2,6-difluoro-fenoksi]butanoična kiselina; 4-[2,6-difluoro-4-[3-(izopropilamino)fenil]fenoksi]butanoična kiselina; 4-[2,6-difluoro-4-(3-pirolidin-1-ilfenil)fenoksi]butanoična kiselina; 4-[4-[3-(ciklobutilamino)fenil]-2,6-difluoro-fenoksi]butanoična kiselina; 4-[2,6-difluoro-4-[3-(propilamino)fenil]fenoksi]butanoična kiselina; 4-[4-[5-chloro-2-(ciklopentilamino)fenil]-2,6-difluoro-fenoksi]butanoična kiselina; 4-[4-[2-(ciklopentilamino)-5-fluoro-fenil]-2,6-difluoro-fenoksi]butanoična kiselina; 4-[4-(3-ciklopentilfenil)-2,6-difluoro-fenoksi]butanoična kiselina; 4-[4-[3-(ciklopentilmetil)fenil]-2,6-difluoro-fenoksi]butanoična kiselina; 4-[4-[2-(ciklopentilmetil)fenil]-2,6-difluoro-fenoksi]butanoična kiselina; 4-[4-[6-(ciklopentilmetil)-2-piridil]-2,6-difluoro-fenoksi]butanoična kiselina; 4-[4-[2-(ciklobutilmetil)fenil]-2,6-difluoro-fenoksi]butanoična kiselina; 4-[4-[3-(ciklobutilmetil)fenil]-2,6-difluoro-fenoksi]butanoična kiselina; 4-[4-[6-(ciklobutilmetil)-2-piridil]-2,6-difluoro-fenoksi]butanoična kiselina; 4-[4-(2-ciklopentilfenil)-2,6-difluoro-fenoksi]butanoična kiselina; 4-[4-(6-ciklopentil-2-piridil)-2,6-difluoro-fenoksi]butanoična kiselina; 4-[2,6-difluoro-4-(2-izobutil-3-piridil)fenoksi]butanoična kiselina; 4-[4-(2-ciklopentil-3-piridil)-2,6-difluoro-fenoksi]butanoična kiselina; 4-[4-[2-(ciklopentilmetil)-3-piridil]-2,6-difluoro-fenoksi]butanoična kiselina; 4-[2,6-difluoro-4-(2-pirol-1-il-3-piridil)fenoksi]butanoična kiselina; 4-[2,6-difluoro-4-[2-(4-metilpirazol-1-il)-3-piridil]fenoksi]butanoična kiselina; 4-[2,6-difluoro-4-(2-morfolino-3-piridil)fenoksi]butanoična kiselina; 4-[2,6-difluoro-4-[2-(tetrahidropiran-4-ilmetilamino)-3-piridil]fenoksi] butanoična kiselina; 4-[2,6-difluoro-4-[2-(1-piperidil)-3-piridil]fenoksi]butanoična kiselina; (4S)-4-[4-(2-ciklobutilsulfanil-3-piridil)-2,6-difluoro-fenoksi]pentanoična kiselina; (4R)-4-[4-(2-ciklobutilsulfanil-3-piridil)-2,6-difluoro-fenoksi]pentanoična kiselina; (4R)-4-[4-[3-(ciklobutoksil)fenil]-2,6-difluoro-fenoksi]pentanoična kiselina; (4R)-4-[4-(2-ciklopentilsulfanil-3-piridil)-2,6-difluoro-fenoksi]pentanoična kiselina; (4R)-4-[2,6-difluoro-4-(3-fenoksifenil)fenoksi]pentanoična kiselina; 4-(3’-ciklobutoksil-bifenil-4-ilsulfanil)-maslačna kiselina; 4-(3’-izopropoksi-bifenil-4-ilsulfanil)-maslačna kiselina; [1-(3,5-difluoro-3’-izopropoksi-bifenil-4-ilsulfanilmetil)-ciklopropil]-octena kiselina; 4-(3’-ciklopentiloksi-3,5-difluoro-bifenil-4-ilsulfanil)-maslačna kiselina; 4-[4-(2-ciklopentiloksi-piridin-3-il)-fenilsulfanil]-maslačna kiselina; 4-[4-(2-ciklopropilmetoksi-piridin-3-il)-fenilsulfanil]-maslačna kiselina; 4-(3’-fenoksi-bifenil-4-ilsulfanil)-maslačna kiselina; 4-(3’-ciklopentiloksi-bifenil-4-ilsulfanil)-maslačna kiselina; 4-(3’-propoksi-bifenil-4-ilsulfanil)-maslačna kiselina; 4-[4-(6-ciklobutoksil-piridin-2-il)-fenilsulfanil]-maslačna kiselina; 4-[4-(6-ciklopentiloksi-piridin-2-il)-fenilsulfanil]-maslačna kiselina; 4-[4-(6-izopropoksi-piridin-2-il)-fenilsulfanil]-maslačna kiselina; 4-[4-(2-izopropoksi-piridin-3-il)-fenilsulfanil]-maslačna kiselina; 4-[4-(6-propoksi-piridin-2-il)-fenilsulfanil]-maslačna kiselina; 4-[4-(6-ciklopentilsulfanil-piridin-2-il)-fenilsulfanil]-maslačna kiselina; 4-(3’-ciklobutoksil-3,5-difluoro-bifenil-4-ilsulfanil)-maslačna kiselina; 4-(3,5-difluoro-3’-izopropoksi-bifenil-4-ilsulfanil)-maslačna kiselina; 4-[2,6-difluoro-4-(6-propoksi-piridin-2-il)-fenilsulfanil]-maslačna kiselina; 4-[2,6-difluoro-4-(6-izopropoksi-piridin-2-il)-fenilsulfanil]-maslačna kiselina; 4-[2,6-difluoro-4-(2-izopropoksi-piridin-3-il)-fenilsulfanil]-maslačna kiselina; 4-[2,6-difluoro-4-(2-propoksi-piridin-3-il)-fenilsulfanil]-maslačna kiselina; 4-[2,6-difluoro-4-(6-izopropilsulfanil-piridin-2-il)-fenilsulfanil]-maslačna kiselina; 4-[2,6-difluoro-4-(6-propilsulfanil-piridin-2-il)-fenilsulfanil]-maslačna kiselina; 4-[4-(2-ciklobutilsulfanil-piridin-3-il)-2,6-difluoro-fenilsulfanil]-maslačna kiselina; 4-[4-(2-ciklobutoksil-piridin-3-il)-fenilsulfanil]-maslačna kiselina; 4-[4-(2-ciklobutoksil-piridin-3-il)-2,6-difluoro-fenilsulfanil]-maslačna kiselina; 4-[4-(2-ciklopentiloksi-piridin-3-il)-2,6-difluoro-fenilsulfanil]-maslačna kiselina; 4-[2,6-difluoro-4-(2-izopropilsulfanil-piridin-3-il)-fenilsulfanil]-maslačna kiselina; 4-[4-(2-ciklopentilsulfanil-piridin-3-il)-2,6-difluoro-fenilsulfanil]-maslačna kiselina; 4-[4-(2-izopropilsulfanil-piridin-3-il)-fenilsulfanil]-maslačna kiselina; 4-[4-(2-ciklopentilsulfanil-piridin-3-il)-fenilsulfanil]-maslačna kiselina; 4-[2-fluoro-4-(6-izopropoksi-piridin-2-il)-fenilsulfanil]-maslačna kiselina; 4-[4-(2-ciklopentiloksi-piridin-3-il)-2-fluoro-fenilsulfanil]-maslačna kiselina; 4-[4-(2-ciklobutilsulfanil-piridin-3-il)-2-fluoro-fenilsulfanil]-maslačna kiselina; 4-[4-(2-ciklobutilsulfanil-piridin-3-il)-fenilsulfanil]-maslačna kiselina; 4-[4-(6-ciklobutoksil-piridin-2-il)-2,6-difluoro-fenilsulfanil]-maslačna kiselina; 4-[4-(6-ciklopentiloksi-piridin-2-il)-2,6-difluoro-fenilsulfanil]-maslačna kiselina; 4-[4-(6-ciklobutilsulfanil-piridin-2-il)-fenilsulfanil]-maslačna kiselina; 4-[4-(6-ciklopropilmetoksi-piridin-2-il)-2,6-difluoro-fenilsulfanil]-maslačna kiselina; 4-[4-(6-ciklobutilsulfanil-piridin-2-il)-2,6-difluoro-fenilsulfanil]-maslačna kiselina; 4-[4-(6-ciklopentilsulfanil-piridin-2-il)-2,6-difluoro-fenilsulfanil]-maslačna kiselina; 4-(2’-ciklopentilamino-3-fluoro-bifenil-4-ilsulfanil)-maslačna kiselina; 4-(2’-ciklopentilamino-3,5-difluoro-bifenil-4-ilsulfanil)-maslačna kiselina; 4-[2’-(ciklopropilmetil-amino)-3,5-difluoro-bifenil-4-ilsulfanil]-maslačna kiselina; 4-[2-fluoro-4-(2-izopropilsulfanil-piridin-3-il)-fenilsulfanil]-maslačna kiselina; 4-[4-(2-ciklopentilsulfanil-piridin-3-il)-2-fluoro-fenilsulfanil]-maslačna kiselina; 4-(3,5-difluoro-2’-izopropilamino-bifenil-4-ilsulfanil)-maslačna kiselina; 4-(3,5-difluoro-2’-propilamino-bifenil-4-ilsulfanil)-maslačna kiselina; 4-[4-(2-ciklopropilmetoksi-piridin-3-il)-2,6-difluoro-fenilsulfanil]-maslačna kiselina; 4-[2,6-difluoro-4-(2-propilsulfanil-piridin-3-il)-fenilsulfanil]-maslačna kiselina; 4-[4-(6-ciklobutilsulfanil-piridin-2-il)-2-fluoro-fenilsulfanil]-maslačna kiselina; 4-[4-(2-ciklopentilamino-piridin-3-il)-2-fluoro-fenilsulfanil]-maslačna kiselina; 4-[2-fluoro-4-(2-izopropoksi-piridin-3-il)-fenilsulfanil]-maslačna kiselina; 4-[4-(2-ciklobutoksil-piridin-3-il)-2-fluoro-fenilsulfanil]-maslačna kiselina; 4-[2-fluoro-4-(2-pirolidin-1-il-piridin-3-il)-fenilsulfanil]-maslačna kiselina; 4-[2-fluoro-4-(2-izopropilamino-piridin-3-il)-fenilsulfanil]-maslačna kiselina; 4-(2’-ciklopentilamino-3,5’-difluoro-bifenil-4-ilsulfanil)-maslačna kiselina; 4-(2’-ciklopentilamino-5’-fluoro-bifenil-4-ilsulfanil)-maslačna kiselina; 4-(2’-ciklopentiloksi-5’-metil-bifenil-4-ilsulfanil)-maslačna kiselina; 4-(2’-ciklopentiloksi-4’-metoksi-bifenil-4-ilsulfanil)-maslačna kiselina; 4-(2’-ciklopentiloksi-5’-fluoro-bifenil-4-ilsulfanil)-maslačna kiselina; 4-(2’-ciklopentiloksi-3,5’-difluoro-bifenil-4-ilsulfanil)-maslačna kiselina; 4-[4-(2-ciklopentiloksi-5-metil-piridin-3-il)-fenilsulfanil]-maslačna kiselina; 4-(2’-ciklopentiloksi-3,5,5’-trifluoro-bifenil-4-ilsulfanil)-maslačna kiselina; 4-(2’-ciklopentiloksi-3-fluoro-4’-metoksi-bifenil-4-ilsulfanil)-maslačna kiselina; 4-(2’-ciklopentiloksi-3,5-difluoro-4’-metoksi-bifenil-4-ilsulfanil)-maslačna kiselina; 4-(3-fluoro-2’-izopropoksi-4’-metoksi-bifenil-4-ilsulfanil)-maslačna kiselina; 4-[4-(2-ciklopentiloksi-5-metil-piridin-3-il)-2-fluoro-fenilsulfanil]-maslačna kiselina; 4-[2-fluoro-4-(2-izopropoksi-5-metil-piridin-3-il)-fenilsulfanil]-maslačna kiselina; 4-(3,5’-difluoro-2’-izopropoksi-bifenil-4-ilsulfanil)-maslačna kiselina; 4-[4-(2-ciklopentiloksi-6-metil-piridin-3-il)-2-fluoro-fenilsulfanil]-maslačna kiselina; 4-(3,3’-difluoro-2’-izopropoksi-5’-metil-bifenil-4-ilsulfanil)-maslačna kiselina; 4-(3,3’-difluoro-5’-metil-2’-propoksi-bifenil-4-ilsulfanil)-maslačna kiselina; 4-(3-fluoro-2’,4’-dipropoksi-bifenil-4-ilsulfanil)-maslačna kiselina; 4-(6’-ciklopentiloksi-3,2’-difluoro-3’-metil-bifenil-4-ilsulfanil)-maslačna kiselina; 4-(2’-ciklopentiloksi-3,3’-difluoro-bifenil-4-ilsulfanil)-maslačna kiselina; 4-(2’-ciklopentiloksi-3,3’-difluoro-5’-metil-bifenil-4-ilsulfanil)-maslačna kiselina; 5-[4-(2-ciklobutilmetoksi-piridin-3-il)-2,6-difluoro-fenoksi]-pentanoična kiselina; 5-[4-(2-ciklopropoksi-piridin-3-il)-2,6-difluoro-fenoksi]-pentanoična kiselina; 4-[4-(2-ciklopentiloksi-5-metil-piridin-3-il)-2,6-difluoro-fenilsulfanil]-maslačna kiselina; 4-[4-(2-ciklopentiloksi-piridin-3-il)-fenilsulfanil]-pentanoična kiselina; 4-[4-(2-izopropoksi-piridin-3-il)-fenilsulfanil]-pentanoična kiselina; 4-[4-(2-ciklopentiloksi-piridin-3-il)-2,6-difluoro-fenilsulfanil]-pentanoična kiselina; 4-[4-(2-ciklopentilsulfanil-piridin-3-il)-2,6-difluoro-fenilsulfanil]-pentanoična kiselina; 4-[4-[2-(2-dimetilaminoetiloksi)-3-piridil]-2,6-difluoro-fenoksi]butanoična kiselina; 4-[2,6-difluoro-4-(2-propilsulfanil-piridin-3-il)-fenoksi]-butanoična kiselina; 4-[4-(2-ciklopropilsulfanil-piridin-3-il)-2,6-difluoro-fenoksi]-butanoična kiselina; 4-[4-(2-etilsulfanil-piridin-3-il)-2,6-difluoro-fenoksi]-butanoična kiselina; 4-[4-(2-butilsulfanil-piridin-3-il)-2,6-difluoro-fenoksi]-butanoična kiselina; 4-(2’-ciklopentilamino-bifenil-4-ilsulfanil)-maslačna kiselina; 4-[4-(2-ciklopentiloksi-5-metil-piridin-3-il)-2,6-difluoro-fenoksi]-maslačna kiselina; 4-[4-(6-izopropilsulfanil-2-piridil)fenoksi]butanoična kiselina; 4-[2,6-difluoro-4-(3-fenoksifenil)fenoksi]butanoična kiselina; 4-[4-[6-[3-(dimetilamino)pirolidin-1-il]-2-piridil]-2,6-difluoro-fenoksi]butanoična kiselina; 5-[2,6-difluoro-4-(2-izopropoksi-piridin-3-il)-fenoksi]-pentanoična kiselina 5-[4-(2-ciklobutoksil-piridin-3-il)-2,6-difluoro-fenoksi]-pentanoična kiselina 4-[4-[2-(3,3-difluoropirolidin-1-il)-3-piridil]-2,6-difluoro-fenoksi]butanoična kiselina; 4-[2,6-difluoro-4-[2-(4-metilpiperazin-1-il)-3-piridil]fenoksi]butanoična kiselina; 4-[2,6-difluoro-4-[2-(5-metilizoksazol-3-il)oksi-3-piridil]fenoksi]butanoična kiselina; 4-[4-[2-[2-(aziridin-1-il)etoksi]-3-piridil]-2,6-difluoro-fenoksi]butanoična kiselina; 4-[2,6-difluoro-4-[2-(3-furilmetoksi)-3-piridil]fenoksi]butanoična kiselina; 4-[2,6-difluoro-4-[2-(2-furilmetoksi)-3-piridil]fenoksi]butanoična kiselina; 4-[2,6-difluoro-4-[2-[(3-metiloksetan-3-il)metoksi]-3-piridil]fenoksi] butanoična kiselina; 4-[2,6-difluoro-4-[2-(tetrahidrofuran-3-ilmetoksi)-3-piridil]fenoksi] butanoična kiselina; 4-[2,6-difluoro-4-[2-(tetrahidrofuran-2-ilmetoksi)-3-piridil]fenoksi] butanoična kiselina; 4-[4-(2-ciklobutilmetoksi-piridin-3-il)-2,6-difluoro-fenoksi]-maslačna kiselina; 4-[4-(2-ciklopropoksi-piridin-3-il)-2,6-difluoro-fenoksi]-maslačna kiselina; 4-{2,6-difluoro-4-[2-(3-hidroksi-ciklopentiloksi)-piridin-3-il]-fenoksi}-maslačna kiselina; 4-[4-(2-cikloheksiloksi-piridin-3-il)-2,6-difluoro-fenoksi]-maslačna kiselina; 4-[4-(2-ciklopentilmetoksi-piridin-3-il)-2,6-difluoro-fenoksi]-maslačna kiselina; 4-[2,6-difluoro-4-(2-izobutoksi-piridin-3-il)-fenoksi]-maslačna kiselina; 4-{4-[2-(2,2-dimeti-propoksi)-piridin-3-il]-2,6-difluoro-fenoksi}-maslačna kiselina; 5-[4-(2-ciklopentiloksi-piridin-3-il)-2,6-difluoro-fenoksi]-pentanoična kiselina; 5-[4-(2-ciklobutilsulfanil-3-piridil)-2,6-difluoro-fenoksi]pentanoična kiselina; 5-[4-(2-ciklopentilsulfanil-3-piridil)-2,6-difluoro-fenoksi]pentanoična kiselina; 5-[2,6-difluoro-4-(2-izopropilsulfanil-3-piridil)fenoksi]pentanoična kiselina; 5-[2,6-difluoro-4-(2-propilsulfanil-3-piridil)fenoksi]pentanoična kiselina; 5-[2,6-difluoro-4-(6-izopropilsulfanil-2-piridil)fenoksi]pentanoična kiselina; 5-[2,6-difluoro-4-(6-izopropoksi-2-piridil)fenoksi]pentanoična kiselina; 5-[4-[2-(ciklopropilmetoksi)-3-piridil]-2,6-difluoro-fenoksi]pentanoična kiselina; 5-[2,6-difluoro-4-(2-tetrahidrofuran-3-iloksi-3-piridil)fenoksi]pentanoična kiselina; 5-[2,6-difluoro-4-(2-tetrahidropiran-4-iloksi-3-piridil)fenoksi]pentanoična kiselina; 4-[2,6-difluoro-4-(2-izopropoksi-piridin-3-il)-fenilsulfanil]-pentanoična kiselina; 4-[4-(2-ciklopentilsulfanil-piridin-3-il)-fenilsulfanil]-pentanoična kiselina; 4-{2-fluoro-4-[2-(tetrahidro-piran-4-iloksi)-piridin-3-il]-fenilsulfanil}-maslačna kiselina; 4-{2-fluoro-4-[2-(tetrahidrofuran-3-iloksi)-piridin-3-il]-fenilsulfanil}-maslačna kiselina; 4-[4-(2-ciklobutilmetoksi-piridin-3-il)-2-fluoro-fenilsulfanil]-maslačna kiselina; 4-{2,6-difluoro-4-[2-(2,2,2-trifluoro-etoksi)-piridin-3-il]-fenilsulfanil}-maslačna kiselina; 4-[4-(2-ciklobutilmetoksi-piridin-3-il)-2,6-difluoro-fenilsulfanil]-maslačna kiselina; 4-[4-(2-ciklopentilamino-piridin-3-il)-2,6-difluoro-fenilsulfanil]-maslačna kiselina; 4-[2,6-difluoro-4-(2-izopropilamino-piridin-3-il)-fenilsulfanil]-maslačna kiselina; 4-{4-[2-(ciklopropilmetil-amino)-piridin-3-il]-2,6-difluoro-fenilsulfanil}-maslačna kiselina; 5-[4-(2-ciklopentiloksi-piridin-3-il)-2,6-difluoro-fenilsulfanil]-pentanoična kiselina; 5-[2,6-difluoro-4-(2-izopropoksi-piridin-3-il)-fenilsulfanil]-pentanoična kiselina; 5-[4-(2-ciklopentiloksi-piridin-3-il)-fenilsulfanil]-pentanoična kiselina; 5-[4-(2-izopropoksi-piridin-3-il)-fenilsulfanil]-pentanoična kiselina; 5-[4-(2-ciklopentilsulfanil-piridin-3-il)-2,6-difluoro-fenilsulfanil]-pentanoična kiselina; 5-[2,6-difluoro-4-(2-propilsulfanil-piridin-3-il)-fenilsulfanil]-pentanoična kiselina; 5-[4-(2-ciklopentilsulfanil-piridin-3-il)-fenilsulfanil]-pentanoična kiselina; 5-[4-(2-ciklobutilsulfanil-piridin-3-il)-fenilsulfanil]-pentanoična kiselina; 5-[4-(2-ciklobutilmetoksi-piridin-3-il)-2,6-difluoro-fenilsulfanil]-pentanoična kiselina; 5-[4-(2-ciklobutoksil-piridin-3-il)-2,6-difluoro-fenilsulfanil]-pentanoična kiselina; 6-[4-(2-ciklopentiloksi-piridin-3-il)-2,6-difluoro-fenoksi]-heksanoična kiselina; 7-[4-(2-ciklopentiloksi-piridin-3-il)-2,6-difluoro-fenoksi]-heptanoic kiselina; 5-[2-fluoro-4-(2-izopropoksi-piridin-3-il)-fenoksi]-pentanoična kiselina; 5-[4-(2-ciklopentilsulfanil-piridin-3-il)-2-fluoro-fenoksi]-pentanoična kiselina; 5-[4-(2-ciklobutilsulfanil-piridin-3-il)-2-fluoro-fenoksi]-pentanoična kiselina; 5-[4-(2-ciklopentiloksi-piridin-3-il)-2-fluoro-fenoksi]-pentanoična kiselina; 4-[2,6-difluoro-4-(2-metoksi-piridin-3-il)-fenoksi]-maslačna kiselina; 4-[4-(2-alliloksi-piridin-3-il)-2,6-difluoro-fenoksi]-maslačna kiselina; 4-[4-(2-but-2-iniloksi-piridin-3-il)-2,6-difluoro-fenoksi]-maslačna kiselina; 6-[4-[2-(ciklobutoksil)-3-piridil]-2,6-difluoro-fenoksi]heksanoična kiselina; 6-[4-[2-(ciklobutilmetoksi)-3-piridil]-2,6-difluoro-fenoksi]heksanoična kiselina; 6-[4-[2-(ciklopropilmetoksi)-3-piridil]-2,6-difluoro-fenoksi]heksanoična kiselina; 6-[4-(2-ciklobutilsulfanil-3-piridil)-2,6-difluoro-fenoksi]heksanoična kiselina; 6-[4-(2-ciklopentilsulfanil-3-piridil)-2,6-difluoro-fenoksi]heksanoična kiselina; 6-[4-(2-ciklopentiloksi-piridin-3-il)-2,6-difluoro-fenilsulfanil]-heksanoična kiselina; 6-[4-(2-ciklopentilsulfanil-piridin-3-il)-2,6-difluoro-fenilsulfanil]-heksanoična kiselina; 6-[4-(2-ciklobutilsulfanil-piridin-3-il)-2,6-difluoro-fenilsulfanil]-heksanoična kiselina; i 6-[2,6-difluoro-4-(2-propilsulfanil-piridin-3-il)-fenilsulfanil]-heksanoična kiselina.
2. Farmaceutski pripravak kao agonist GPR120, naznačen time da sadrži biarilni derivat, farmaceutski prihvatljivu sol ili E- ili Z-izomer, ili njegov R- ili S-izomer prema zahtjevu 1 i farmaceutski prihvatljiv nosač.
3. Farmaceutski pripravak za uporabu u sprječavanju ili liječenju dijabetesa, komplikacija dijabetesa, pretilosti, masne jetre koja nije uzrokovana alkoholizmom, steatohepatitisa, osteoporoze ili upale, naznačen time da sadrži biarilni derivat, farmaceutski prihvatljivu sol ili E- ili Z-izomer, ili R- ili S -izomer istog prema zahtjevu 1, i farmaceutski prihvatljiv nosač.
4. Pripravak za uporabu za snižavanje razine glukoze u krvi, naznačen time da sadrži biarilni derivat, farmaceutski prihvatljivu sol ili E- ili Z-izomer, ili njegov R- ili S-izomer prema zahtjevu 1 i farmaceutski prihvatljiv nosač.
5. Postupak za pripremu pripravka za upotrebu u prevenciji ili liječenju dijabetesa, komplikacija dijabetesa, pretilosti, bezalkoholnih masnih jetre, steatohepatitisa, osteoporoze ili upale, koji obuhvaća korak miješanja derivata biarila, farmaceutski prihvatljive soli ili E- ili Z-izomer, ili njegov R- ili S-izomer prema zahtjevu 1 s farmaceutski prihvatljivim nosačem.
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