HRP20191871T1 - Ionski vodeni pripravci - Google Patents
Ionski vodeni pripravci Download PDFInfo
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- HRP20191871T1 HRP20191871T1 HRP20191871TT HRP20191871T HRP20191871T1 HR P20191871 T1 HRP20191871 T1 HR P20191871T1 HR P20191871T T HRP20191871T T HR P20191871TT HR P20191871 T HRP20191871 T HR P20191871T HR P20191871 T1 HRP20191871 T1 HR P20191871T1
- Authority
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- Croatia
- Prior art keywords
- use according
- pharmaceutical preparation
- carrageenan
- extract
- polysaccharide
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 14
- 150000004676 glycans Chemical class 0.000 claims 10
- 229920001282 polysaccharide Polymers 0.000 claims 10
- 239000005017 polysaccharide Substances 0.000 claims 10
- 229920001525 carrageenan Polymers 0.000 claims 5
- 239000000679 carrageenan Substances 0.000 claims 5
- 229940113118 carrageenan Drugs 0.000 claims 5
- 229930182830 galactose Natural products 0.000 claims 4
- 241000195628 Chlorophyta Species 0.000 claims 3
- 241000199919 Phaeophyceae Species 0.000 claims 3
- 239000007864 aqueous solution Substances 0.000 claims 3
- 206010001076 Acute sinusitis Diseases 0.000 claims 2
- 229920000855 Fucoidan Polymers 0.000 claims 2
- 241000206572 Rhodophyta Species 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 235000010418 carrageenan Nutrition 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 208000027157 chronic rhinosinusitis Diseases 0.000 claims 2
- 230000003020 moisturizing effect Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 210000001533 respiratory mucosa Anatomy 0.000 claims 2
- 210000002345 respiratory system Anatomy 0.000 claims 2
- 201000009890 sinusitis Diseases 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical group [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims 2
- 235000016425 Arthrospira platensis Nutrition 0.000 claims 1
- 240000002900 Arthrospira platensis Species 0.000 claims 1
- 241000206576 Chondrus Species 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims 1
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims 1
- 235000004866 D-panthenol Nutrition 0.000 claims 1
- 239000011703 D-panthenol Substances 0.000 claims 1
- 241001467355 Gigartina Species 0.000 claims 1
- 241000016511 Kappaphycus cottonii Species 0.000 claims 1
- SHZGCJCMOBCMKK-PQMKYFCFSA-N L-Fucose Natural products C[C@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@@H]1O SHZGCJCMOBCMKK-PQMKYFCFSA-N 0.000 claims 1
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 claims 1
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 240000002657 Thymus vulgaris Species 0.000 claims 1
- 235000007303 Thymus vulgaris Nutrition 0.000 claims 1
- 241001261506 Undaria pinnatifida Species 0.000 claims 1
- ZNOZWUKQPJXOIG-XSBHQQIPSA-L [(2r,3s,4r,5r,6s)-6-[[(1r,3s,4r,5r,8s)-3,4-dihydroxy-2,6-dioxabicyclo[3.2.1]octan-8-yl]oxy]-4-[[(1r,3r,4r,5r,8s)-8-[(2s,3r,4r,5r,6r)-3,4-dihydroxy-6-(hydroxymethyl)-5-sulfonatooxyoxan-2-yl]oxy-4-hydroxy-2,6-dioxabicyclo[3.2.1]octan-3-yl]oxy]-5-hydroxy-2-( Chemical compound O[C@@H]1[C@@H](O)[C@@H](OS([O-])(=O)=O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H]2OC[C@H]1O[C@H](O[C@H]1[C@H]([C@@H](CO)O[C@@H](O[C@@H]3[C@@H]4OC[C@H]3O[C@H](O)[C@@H]4O)[C@@H]1O)OS([O-])(=O)=O)[C@@H]2O ZNOZWUKQPJXOIG-XSBHQQIPSA-L 0.000 claims 1
- 230000009798 acute exacerbation Effects 0.000 claims 1
- 239000000048 adrenergic agonist Substances 0.000 claims 1
- 230000000172 allergic effect Effects 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 229940125715 antihistaminic agent Drugs 0.000 claims 1
- 239000000739 antihistaminic agent Substances 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 229940124630 bronchodilator Drugs 0.000 claims 1
- 239000000168 bronchodilator agent Substances 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- 229960001334 corticosteroids Drugs 0.000 claims 1
- 239000000850 decongestant Substances 0.000 claims 1
- 229940124581 decongestants Drugs 0.000 claims 1
- 229960003949 dexpanthenol Drugs 0.000 claims 1
- 208000037916 non-allergic rhinitis Diseases 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000013535 sea water Substances 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- -1 steroid compounds Chemical class 0.000 claims 1
- 239000001585 thymus vulgaris Substances 0.000 claims 1
- 239000000341 volatile oil Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/748—Cyanobacteria, i.e. blue-green bacteria or blue-green algae, e.g. spirulina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
- A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
- A61K36/04—Rhodophycota or rhodophyta (red algae), e.g. Porphyra
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (15)
1. Farmaceutski pripravak za uporabu pomoću nazalne ili inhalacijske aplikacije koji sadrži:
ionsku vodenu otopinu; i
sulfatirani polisaharid prosječne molekulske težine od 4kDa do 5 MDa i koji sadrži L-fukozu
i sulfatne esterske skupine,
pri čemu ionska vodena otopina sadrži morsku vodu ili fiziološku otopinu i gdje je sulfatirani polisaharid izveden iz ekstrakta izoliranog od smeđih algi ili gdje je sulfatirani polisaharid sintetični fukoidan polisaharid.
2. Farmaceutski pripravak za uporabu prema zahtjevu 1, naznačen time, da je sulfatirani polisaharid dobiven iz ekstrakta izoliranog od smeđih algi fukoidan.
3. Farmaceutski pripravak za uporabu prema zahtjevu 2, naznačen time, da smeđe alge predstavljaju Undaria pinnatifida.
4. Farmaceutski pripravak za uporabu prema bilo kojem od zahtjeva 1 do 3, naznačen time, da nadalje sadrži ekstrakt plavih/zelenih algi.
5. Farmaceutski pripravak za uporabu prema bilo kojem od zahtjeva 1 do 4, naznačen time, da nadalje sadrži barem jedno od sljedećeg:
- sulfatni polisaharid na bazi galaktoze čija je prosječna molekulska masa veća od 15 kDa;
- barem jednu supstancu odabranu od egzogenih soli, antimikrobnih sredstava, aminokiselina i esencijalnih ulja;
- ekstrakt timijana; i
- barem jedno hidratantno sredstvo.
6. Farmaceutski pripravak za uporabu prema bilo kojem od zahtjeva 1 do 4, naznačen time, da nadalje sadrži barem jednu supstancu odabranu između kortikosteroida, drugih steroidnih spojeva, antihistaminika, dekongestiva, bronhodilatatora, agonista ß2-adrenergičara i antibiotika.
7. Farmaceutski pripravak za uporabu prema bilo kojem od zahtjeva 1 do 6, naznačen time, da je sulfatirani polisaharid u rasponu od 0,1 do 10 mas.% pripravka, a kada je prisutan u farmaceutskom sastavu, ekstrakt plave/zelene boje alge je u rasponu od 0,1 do 10 mas.% sastava, a polisaharid na bazi galaktoze je u opsegu od 0,1 do 10 mas.% sastava.
8. Farmaceutski pripravak za uporabu prema bilo kojem od zahtjeva 4 do 7, naznačen time da je ekstrakt plave/zelene alge izoliran iz Spirulina platensis.
9. Farmaceutski pripravak za uporabu prema zahtjevu 5 ili zahtjevu 7, naznačen time, da je polisaharid na bazi galaktoze karagenan ili gdje je polisaharid na bazi galaktoze izveden iz ekstrakta izoliranog iz crvenih algi.
10. Farmaceutski pripravak za uporabu u skladu s patentnim zahtjevom 9, naznačen time da je karagenan izabran iz skupine koja se sastoji od jota-karagenana, kappa-karagenana i lambda-karagenana (npr. jota-karagenana).
11. Farmaceutski pripravak za uporabu prema zahtjevu 9, naznačen time, da crvene alge su odabrane iz skupine koja se sastoji od Gigartina stellata, Chondrus chrispus, Kappaphycus cottonii.
12. Farmaceutski pripravak za uporabu prema bilo kojem od zahtjeva 1 do 11, naznačen time, da je ionska vodena otopina u rasponu od 10 do 99,9% masenog pripravka.
13. Farmaceutski pripravak za uporabu prema zahtjevu 5, naznačen time, da hidratantno sredstvo je ekspantenol ili pantetenska kiselina i gdje su dekspantenol ili pantetenska kiselina prisutni u koncentraciji u rasponu od 0,25-2,5% w/w.
14. Farmaceutski pripravak za uporabu prema bilo kojem od zahtjeva 1 do 13, naznačen time, da se upotrebljava za ublažavanje stanja dišnog trakta i/ili respiratorne sluzokože, gdje se stanje respiratornog trakta i/ili respiratorna sluznica bira iz skupine koja se sastoji od akutnog rinosinusitisa, rekurentnog akutnog rinosinusitisa, subakutnog rinosinusitisa, kroničnog rinosinusitisa, akutnog pogoršanja kroničnog rinosinusitisa, sinusitisa, alergijskiog i nealergijskog rinitisa, astme, cistične fibroze i kronične opstruktivne plućne bolesti (KOPB).
15. Upakirani uređaj koji sadrži farmaceutski pripravak za uporabu prema bilo kojem od zahtjeva 1 do 13, opcijski zajedno s uputama za upotrebu.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361911071P | 2013-12-03 | 2013-12-03 | |
| EP14805880.3A EP3076983B1 (en) | 2013-12-03 | 2014-11-28 | Ionic aqueous compositions |
| PCT/EP2014/075983 WO2015082356A1 (en) | 2013-12-03 | 2014-11-28 | Ionic aqueous compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20191871T1 true HRP20191871T1 (hr) | 2020-01-10 |
Family
ID=52002945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20191871TT HRP20191871T1 (hr) | 2013-12-03 | 2019-10-15 | Ionski vodeni pripravci |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US10485819B2 (hr) |
| EP (1) | EP3076983B1 (hr) |
| CN (2) | CN114569549B (hr) |
| AU (1) | AU2014359488B2 (hr) |
| CA (1) | CA2932237C (hr) |
| CY (1) | CY1122189T1 (hr) |
| DK (1) | DK3076983T3 (hr) |
| EA (1) | EA031541B1 (hr) |
| ES (1) | ES2753218T3 (hr) |
| HR (1) | HRP20191871T1 (hr) |
| HU (1) | HUE045990T2 (hr) |
| IL (1) | IL245920B (hr) |
| LT (1) | LT3076983T (hr) |
| PL (1) | PL3076983T3 (hr) |
| PT (1) | PT3076983T (hr) |
| RS (1) | RS59437B1 (hr) |
| SI (1) | SI3076983T1 (hr) |
| WO (1) | WO2015082356A1 (hr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114569549B (zh) * | 2013-12-03 | 2024-03-15 | 格罗力马托斯国际有限公司 | 离子水性组合物 |
| EP2985027B1 (en) | 2014-08-16 | 2021-03-31 | Church & Dwight Co., Inc. | Nasal composition comprising mixture of hyaluronic acids and saline solution |
| EP2985019B1 (en) | 2014-08-16 | 2021-10-20 | Church & Dwight Co., Inc. | Nasal composition having anti-viral properties |
| BR112018016651A2 (pt) * | 2016-02-17 | 2018-12-26 | Ent Tech Pty Ltd | composições e métodos para tratamento de doença e distúrbios de sinusite |
| ITUA20164387A1 (it) * | 2016-06-15 | 2017-12-15 | Neilos S R L | Composizione farmaceutica comprendente Cetraria islandica Ach., sodio ialuronato e una soluzione salina per il trattamento di affezioni dell'apparato respiratorio. |
| IT201600078342A1 (it) * | 2016-07-26 | 2018-01-26 | Farm S R L C U S | Processo per la ristrutturazione idroionica delle acque termali e marine |
| FR3056911B1 (fr) * | 2016-10-03 | 2019-07-19 | Ys Lab | Composition aqueuse derivee d’eau de mer et d’algues marines |
| KR101840758B1 (ko) | 2016-10-19 | 2018-03-21 | 국립해양생물자원관 | 두켜부채 추출물을 유효성분으로 함유하는 비용종 질환 예방 또는 치료용 조성물 |
| EP3415154A1 (en) * | 2017-06-16 | 2018-12-19 | Sofibel S.A.S. | Nasal composition |
| CN107308183A (zh) * | 2017-07-13 | 2017-11-03 | 深圳市新量子科技有限公司 | 一种辅助治疗血液病的中药或食物氢氧根负离子水剂 |
| EP3441062B1 (en) * | 2017-08-07 | 2023-11-29 | Corbinos Pubill, Maria Teresa | Seawater and salt powder balancing formulations and nutritional and pharmaceutical compositions |
| AT16516U1 (de) * | 2019-03-18 | 2019-11-15 | Ulrich Sekotill Mba | Nasenspray |
| FR3099051A1 (fr) * | 2019-07-25 | 2021-01-29 | Laboratoires Grimberg | Composition pour pulvérisation nasale ou buccale contenant du soufre |
| WO2021224790A1 (en) * | 2020-05-04 | 2021-11-11 | Milstein Joseph | Vsv (vitamin c-spirulina-vitamin d) composition, kit and method |
| EP3932411A1 (en) * | 2020-06-30 | 2022-01-05 | GSK Consumer Healthcare SARL | Antiviral pharmaceutical composition |
| CN111743922B (zh) * | 2020-07-14 | 2022-03-29 | 华熙生物科技股份有限公司 | 一种提高益生菌在鼻腔中的定植和活性的组合物及在鼻腔护理中的应用 |
| RU2760825C1 (ru) * | 2020-11-30 | 2021-11-30 | Федеральное государственное бюджетное образовательное учреждение дополнительного профессионального образования «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской Федерации | Способ лечения больных аллергическим ринитом в сочетании с хроническим риносинуситом бактериальной этиологии с использованием отечественного топического иммунокорректора |
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| AU2014359488B2 (en) | 2020-01-23 |
| IL245920A0 (en) | 2016-07-31 |
| US20200061100A1 (en) | 2020-02-27 |
| SI3076983T1 (sl) | 2019-12-31 |
| CN105792835A (zh) | 2016-07-20 |
| AU2014359488A1 (en) | 2016-06-16 |
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| US20170000817A1 (en) | 2017-01-05 |
| EP3076983A1 (en) | 2016-10-12 |
| PT3076983T (pt) | 2019-10-31 |
| IL245920B (en) | 2019-10-31 |
| DK3076983T3 (da) | 2019-10-28 |
| CN114569549B (zh) | 2024-03-15 |
| US11672821B2 (en) | 2023-06-13 |
| HUE045990T2 (hu) | 2020-02-28 |
| EA031541B1 (ru) | 2019-01-31 |
| CY1122189T1 (el) | 2020-11-25 |
| US10485819B2 (en) | 2019-11-26 |
| WO2015082356A1 (en) | 2015-06-11 |
| RS59437B1 (sr) | 2019-11-29 |
| ES2753218T3 (es) | 2020-04-07 |
| CN114569549A (zh) | 2022-06-03 |
| CA2932237C (en) | 2022-12-13 |
| LT3076983T (lt) | 2019-11-11 |
| EP3076983B1 (en) | 2019-08-21 |
| CA2932237A1 (en) | 2015-06-11 |
| CN105792835B (zh) | 2022-03-25 |
| EA201691147A1 (ru) | 2016-10-31 |
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