HRP20211354T1 - Tekuće kompozicije tiourilena - Google Patents

Tekuće kompozicije tiourilena Download PDF

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Publication number
HRP20211354T1
HRP20211354T1 HRP20211354TT HRP20211354T HRP20211354T1 HR P20211354 T1 HRP20211354 T1 HR P20211354T1 HR P20211354T T HRP20211354T T HR P20211354TT HR P20211354 T HRP20211354 T HR P20211354T HR P20211354 T1 HRP20211354 T1 HR P20211354T1
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HR
Croatia
Prior art keywords
composition
use according
vol
combinations
group
Prior art date
Application number
HRP20211354TT
Other languages
English (en)
Inventor
Louise Reynolds
Manish UMRETHIA
Original Assignee
Norbrook Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norbrook Laboratories Limited filed Critical Norbrook Laboratories Limited
Publication of HRP20211354T1 publication Critical patent/HRP20211354T1/hr
Publication of HRP20211354T8 publication Critical patent/HRP20211354T8/hr

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/325Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A61P5/16Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (13)

1. Oralna tekuća kompozicija koja sadrži: i) 0.25% do 1% tež./vol. metimazola, njegove farmaceutski prihvatljive soli, njegovog solvata, ili njihovih kombinacija; ii) najmanje 0.2% tež./vol. anionskog polisaharida, koji predstavlja gumu; i iii) tekući nosač, za uporabu u liječenju ili prevenciji hipertireoze kod mačaka.
2. Kompozicija za uporabu prema patentnom zahtjevu 1, koja sadrži najmanje oko 0.2% tež./vol. ksantan gume.
3. Kompozicija za uporabu prema bilo kojem od prethodnih patentnih zahtjeva, koja dodatno sadrži sredstvo za zgušnjavanje.
4. Kompozicija za uporabu prema patentnom zahtjevu 3, naznačena time što sredstvo za zgušnjavanje iznosi najmanje oko 0.5% tež./vol. ukupne zapremine kompozicije.
5. Kompozicija za uporabu prema patentnom zahtjevu 3 ili 4, naznačena time što je sredstvo za zgušnjavanje odabrano iz grupe koja se sastoji od aluminij distearata, glicerola, hidrogeniziranog ricinusovog ulja, polivinilpirolidona i njihovih kombinacija.
6. Kompozicija za uporabu prema bilo kojem od prethodnih patentnih zahtjeva, koja dodatno sadrži sredstvo za vlaženje.
7. Kompozicija za uporabu prema patentnom zahtjevu 6, naznačena time što sredstvo za vlaženje iznosi 0.1% do oko 1.0 % tež./vol. ukupne zapremine kompozicije.
8. Kompozicija za uporabu prema patentnom zahtjevu 6 ili 7, naznačena time što je sredstvo za vlaženje odabrano iz grupe koja se sastoji od polisorbata 80, simetikon emulzije i njihovih kombinacija.
9. Kompozicija za uporabu prema bilo kojem od prethodnih patentnih zahtjeva, koja dodatno sadrži otopinu za puferiranje pH.
10. Kompozicija za uporabu prema patentnom zahtjevu 9, naznačena time što je otopina za puferiranje pH odabrana iz skupine koja se sastoji od limunske kiseline, dinatrij fosfat dihidrata, natrij dihidrogen fosfat dihidrata i njihovih kombinacija.
11. Kompozicija za uporabu prema patentnom zahtjevu 9, naznačena time što je pH vrijednost kompozicije najmanje oko 4.3 ili veća.
12. Kompozicija za uporabu prema bilo kojem od prethodnih patentnih zahtjeva, koja dodatno sadrži konzervans.
13. Kompozicija za uporabu prema patentnom zahtjevu 12, naznačena time što konzervans sadrži natrij benzoat.
HRP20211354TT 2014-06-25 2021-08-25 Tekuće kompozicije tiourilena HRP20211354T8 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1411310.4A GB2527555B (en) 2014-06-25 2014-06-25 Stable methimazole liquid compositions
EP18197341.3A EP3441063B1 (en) 2014-06-25 2015-06-23 Thioureylene liquid compositions

Publications (2)

Publication Number Publication Date
HRP20211354T1 true HRP20211354T1 (hr) 2021-11-26
HRP20211354T8 HRP20211354T8 (hr) 2022-03-04

Family

ID=51410113

Family Applications (2)

Application Number Title Priority Date Filing Date
HRP20220078TT HRP20220078T1 (hr) 2014-06-25 2015-06-23 Tekuće kompozicije tioureilena
HRP20211354TT HRP20211354T8 (hr) 2014-06-25 2021-08-25 Tekuće kompozicije tiourilena

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HRP20220078TT HRP20220078T1 (hr) 2014-06-25 2015-06-23 Tekuće kompozicije tioureilena

Country Status (18)

Country Link
US (5) US10045967B2 (hr)
EP (2) EP3441063B1 (hr)
JP (1) JP6799465B2 (hr)
AU (1) AU2015278962B2 (hr)
CA (1) CA2952336C (hr)
CY (2) CY1124535T1 (hr)
DK (2) DK3160441T3 (hr)
ES (2) ES2905083T3 (hr)
GB (1) GB2527555B (hr)
HR (2) HRP20220078T1 (hr)
HU (1) HUE056787T2 (hr)
LT (2) LT3160441T (hr)
NZ (1) NZ728018A (hr)
PL (2) PL3160441T3 (hr)
PT (2) PT3160441T (hr)
RS (2) RS62850B1 (hr)
SI (2) SI3160441T1 (hr)
WO (1) WO2015198033A1 (hr)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4096174A (en) * 1977-07-01 1978-06-20 American Cyanamid Company Anionic naphthalene thioureido-diphenyloxides
DE3013839A1 (de) * 1979-04-13 1980-10-30 Freunt Ind Co Ltd Verfahren zur herstellung einer aktivierten pharmazeutischen zusammensetzung
US5310742A (en) 1992-11-30 1994-05-10 Elias Alan N Uses for thioureylenes
DE60139256D1 (de) * 2000-05-03 2009-08-27 Silva Joe D Verfahren und vorrichtung zur herstellung von flüssigen verabreichungsformen
US20050158367A1 (en) * 2004-01-16 2005-07-21 The Procter & Gamble Company Liquid compositions comprising one or more medicaments
US8993001B2 (en) * 2006-01-26 2015-03-31 Hill's Pet Nutrition, Inc. Methods and compositions for treating feline hyperthyroidism
JP5319691B2 (ja) 2007-11-15 2013-10-16 ノバルティス アーゲー プラジカンテル、マクロライドラクトン、シクロデキストリンおよび粘稠化剤を含む駆虫ペースト

Also Published As

Publication number Publication date
US20200405690A1 (en) 2020-12-31
LT3441063T (lt) 2021-10-11
PL3160441T3 (pl) 2022-02-28
GB2527555B (en) 2018-09-19
ES2884573T3 (es) 2021-12-10
JP2017519029A (ja) 2017-07-13
GB2527555A (en) 2015-12-30
PT3160441T (pt) 2022-01-28
NZ728018A (en) 2019-06-28
US20180318262A1 (en) 2018-11-08
CY1124961T1 (el) 2023-01-05
CY1124535T1 (el) 2022-07-22
CA2952336A1 (en) 2015-12-30
CA2952336C (en) 2023-02-14
US11738005B2 (en) 2023-08-29
ES2905083T3 (es) 2022-04-19
US20170135987A1 (en) 2017-05-18
AU2015278962B2 (en) 2019-07-04
RS62850B1 (sr) 2022-02-28
PT3441063T (pt) 2021-08-31
GB201411310D0 (en) 2014-08-06
EP3441063B1 (en) 2021-07-21
DK3441063T3 (da) 2021-08-30
HUE056787T2 (hu) 2022-03-28
LT3160441T (lt) 2022-02-25
SI3160441T1 (sl) 2022-04-29
SI3441063T1 (sl) 2021-12-31
HRP20220078T1 (hr) 2022-04-15
PL3441063T3 (pl) 2021-12-27
HRP20211354T8 (hr) 2022-03-04
AU2015278962A1 (en) 2016-12-22
DK3160441T3 (da) 2022-01-31
EP3441063A1 (en) 2019-02-13
US20210361623A1 (en) 2021-11-25
JP6799465B2 (ja) 2020-12-16
WO2015198033A1 (en) 2015-12-30
US10045967B2 (en) 2018-08-14
EP3160441A1 (en) 2017-05-03
US20230404978A1 (en) 2023-12-21
US11123327B2 (en) 2021-09-21
EP3160441B1 (en) 2022-01-12
RS62321B1 (sr) 2021-10-29

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