RU2015141767A - Композиции и способы для местной доставки простагландинов в подкожный жир - Google Patents
Композиции и способы для местной доставки простагландинов в подкожный жир Download PDFInfo
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- RU2015141767A RU2015141767A RU2015141767A RU2015141767A RU2015141767A RU 2015141767 A RU2015141767 A RU 2015141767A RU 2015141767 A RU2015141767 A RU 2015141767A RU 2015141767 A RU2015141767 A RU 2015141767A RU 2015141767 A RU2015141767 A RU 2015141767A
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- Prior art keywords
- composition according
- concentration
- prostaglandins
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- methods
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Claims (20)
1. Композиция, содержащая латанопрост, изопропилмиристат и вазелин.
2. Композиция по п. 1, отличающаяся тем, что по существу состоит из латанопроста, изопропилмиристата и вазелина.
3. Композиция по п. 1, отличающаяся тем, что концентрация латанопроста составляет от 0,01% до 0,5% мас./мас.
4. Композиция по п. 3, отличающаяся тем, что концентрация латанопроста составляет от 0,03% до 0,1% мас./мас.
5. Композиция по п. 2, отличающаяся тем, что концентрация латанопроста составляет от 0,01% до 0,5% мас./мас.
6. Композиция по п. 5, отличающаяся тем, что концентрация латанопроста составляет от 0,03% до 0,1% мас./мас.
7. Композиция по п. 1, отличающаяся тем, что концентрация изопропилмиристата составляет от 1% до 20% мас./мас.
8. Композиция по п. 7, отличающаяся тем, что концентрация изопропилмиристата составляет от 1% до 10% мас./мас.
9. Композиция по п. 7, отличающаяся тем, что концентрация изопропилмиристата составляет от 5% до 15% мас./мас.
10. Композиция по п. 2, отличающаяся тем, что концентрация изопропилмиристата составляет от 1% до 20% мас./мас.
11. Композиция по п. 10, отличающаяся тем, что концентрация изопропилмиристата составляет от 1% до 10% мас./мас.
12. Композиция по п. 10, отличающаяся тем, что концентрация изопропилмиристата составляет от 5% до 15% мас./мас.
13. Композиция по п. 1, отличающаяся тем, что концентрация вазелина составляет от 70% до 99% мас./мас.
14. Композиция по п. 2, отличающаяся тем, что концентрация вазелина составляет от 70% до 99% мас./мас.
15. Композиция по п. 1, отличающаяся тем, что дополнительно содержит консервант.
16. Композиция по п. 2, отличающаяся тем, что дополнительно содержит консервант.
17. Композиция по п. 1, отличающаяся тем, что композиция является стерильной.
18. Композиция по п. 2, отличающаяся тем, что композиция является стерильной.
19. Композиция по п. 1, отличающаяся тем, что концентрация латанопроста составляет от 0,01% до 0,5% мас./мас.; концентрация изопропилмиристата составляет от 1% до 10% мас./мас. и концентрация вазелина составляет от 70% до 99% мас./мас.
20. Композиция по п. 2, отличающаяся тем, что концентрация латанопроста составляет от 0,01% до 0,5% мас./мас.; концентрация изопропилмиристата составляет от 1% до 10% мас./мас. и концентрация вазелина составляет от 70% до 99% мас./мас.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361822139P | 2013-05-10 | 2013-05-10 | |
| US61/822,139 | 2013-05-10 | ||
| PCT/US2014/037512 WO2014183045A2 (en) | 2013-05-10 | 2014-05-09 | Compositions and methods for topical delivery of prostaglandins to subcutaneous fat |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017139109A Division RU2017139109A (ru) | 2014-05-09 | 2014-05-09 | Композиции и способы для местной доставки простагландинов в подкожный жир |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015141767A true RU2015141767A (ru) | 2017-04-06 |
| RU2635864C2 RU2635864C2 (ru) | 2017-11-16 |
Family
ID=50933526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015141767A RU2635864C2 (ru) | 2013-05-10 | 2014-05-09 | Композиции и способы для местной доставки простагландинов в подкожный жир |
Country Status (28)
| Country | Link |
|---|---|
| US (5) | US9040584B2 (ru) |
| EP (3) | EP2863886B1 (ru) |
| JP (2) | JP5930568B1 (ru) |
| KR (4) | KR102098987B1 (ru) |
| CN (2) | CN109966240A (ru) |
| AU (3) | AU2014262495B9 (ru) |
| BR (1) | BR112015028290A2 (ru) |
| CA (1) | CA2907721C (ru) |
| CL (1) | CL2015003270A1 (ru) |
| CR (1) | CR20150652A (ru) |
| CY (1) | CY1118654T1 (ru) |
| DK (2) | DK2863886T3 (ru) |
| ES (2) | ES2670323T3 (ru) |
| HK (1) | HK1213200A1 (ru) |
| HU (2) | HUE037405T2 (ru) |
| IL (2) | IL240807A (ru) |
| MX (2) | MX347969B (ru) |
| MY (1) | MY183193A (ru) |
| NO (1) | NO2753788T3 (ru) |
| NZ (1) | NZ712784A (ru) |
| PH (1) | PH12015502503A1 (ru) |
| PL (2) | PL2863886T3 (ru) |
| PT (2) | PT2863886T (ru) |
| RU (1) | RU2635864C2 (ru) |
| SG (2) | SG11201600068WA (ru) |
| SI (1) | SI2863886T1 (ru) |
| WO (1) | WO2014183045A2 (ru) |
| ZA (1) | ZA201507702B (ru) |
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| US7666912B2 (en) | 2006-03-23 | 2010-02-23 | Massachusetts Eye And Ear Infirmary | Compositions and methods for reducing body fat |
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| US9089579B2 (en) | 2011-01-19 | 2015-07-28 | Topokine Therapeutics, Inc. | Methods and compositions for treating metabolic syndrome |
| US8426471B1 (en) | 2011-12-19 | 2013-04-23 | Topokine Therapeutics, Inc. | Methods and compositions for reducing body fat and adipocytes |
| NO2753788T3 (ru) | 2013-05-10 | 2018-06-16 | ||
| WO2014186504A1 (en) | 2013-05-15 | 2014-11-20 | Topokine Therapeutics, Inc. | Methods and compositions for topical delivery of prostaglandins to subcutaneous fat |
| US10188661B2 (en) | 2014-06-27 | 2019-01-29 | Topokine Therapeutics, Inc. | Topical dosage regimen |
| MX2017013819A (es) * | 2015-04-30 | 2018-02-21 | Allergan Inc | Metodos para la reduccion de grasa. |
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| WO2016209619A1 (en) * | 2015-06-23 | 2016-12-29 | Thesan Pharmaceuticals, Inc. | 12h-benzo[a]xanthen-12-ones, compositions containing, and uses of, same |
| WO2016209596A1 (en) * | 2015-06-23 | 2016-12-29 | Thesan Pharmaceuticals, Inc. | 12h-benzo[b]xanthen-12-ones, compositions containing, and uses of, same |
| EP3368498A4 (en) | 2015-10-27 | 2019-06-12 | Cytozyme Animal Nutrition, Inc. | ANIMAL NUTRITIONAL COMPOSITIONS AND RELATED METHODS |
| US10674746B2 (en) | 2015-10-27 | 2020-06-09 | Cytozyme Animal Nutrition, Inc. | Animal nutrition compositions and related methods |
| CN107773758B (zh) * | 2016-08-31 | 2021-02-26 | 程辉 | 一种用于消除皮下脂肪沉积的组合物及其应用 |
| JP2022500543A (ja) * | 2018-09-19 | 2022-01-04 | モデルナティーエックス， インコーポレイテッド | 高純度ｐｅｇ脂質及びそれらの使用 |
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| PL427837A1 (pl) * | 2018-11-22 | 2020-06-01 | Gbj Pharma Spółka Z Ograniczoną Odpowiedzialnością | Systemy do ciągłego obwodowego podawania latanoprostu dla obniżania ciśnienia śródgałkowego |
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