CY1118654T1 - Συνθεσεις και μεθοδοι για τοπικη χορηγηση προσταγλανδινων σε υποδοριο λιπος - Google Patents
Συνθεσεις και μεθοδοι για τοπικη χορηγηση προσταγλανδινων σε υποδοριο λιποςInfo
- Publication number
- CY1118654T1 CY1118654T1 CY20161101214T CY161101214T CY1118654T1 CY 1118654 T1 CY1118654 T1 CY 1118654T1 CY 20161101214 T CY20161101214 T CY 20161101214T CY 161101214 T CY161101214 T CY 161101214T CY 1118654 T1 CY1118654 T1 CY 1118654T1
- Authority
- CY
- Cyprus
- Prior art keywords
- methods
- skin
- compositions
- substitute
- subject
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Περιγραφόμενες στο παρόν είναι συνθέσεις που περιλαμβάνουν μια ένωση αγωνιστή του υποδοχέα προσταγλανδίνης FP (PFPRA) και έναν εστέρα λιπαρού οξέος (π.χ., μυριστικό ισοπροπυλεστέρα), που προαιρετικά περιλαμβάνει μια βάση αλοιφής, όπως μια βάση υδρογονάνθρακα (π.χ. βαζελίνη) και/ή μια οργανική αλκοόλη (π.χ. προπυλενογλυκόλη), η οποία, όταν εφαρμόζεται τοπικά στο δέρμα, παρέχει τοπικά μια θεραπευτικώς αποτελεσματική ποσότητα της ένωσης PFPRA στο υποδόριο λίπος κάτω από το δέρμα, και μεθόδους παρασκευής. Το θεραπευτικό αποτέλεσμα είναι, για παράδειγμα, η μείωση του υποδόριου λίπους κάτω από το δέρμα. Περαιτέρω παρέχονται μέθοδοι για τη μείωση του σωματικού λίπους σε ένα υποκείμενο που περιλαμβάνουν την τοπική χορήγηση της σύνθεσης στο υποκείμενο.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361822139P | 2013-05-10 | 2013-05-10 | |
PCT/US2014/037512 WO2014183045A2 (en) | 2013-05-10 | 2014-05-09 | Compositions and methods for topical delivery of prostaglandins to subcutaneous fat |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1118654T1 true CY1118654T1 (el) | 2017-07-12 |
Family
ID=50933526
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20161101214T CY1118654T1 (el) | 2013-05-10 | 2016-11-23 | Συνθεσεις και μεθοδοι για τοπικη χορηγηση προσταγλανδινων σε υποδοριο λιπος |
Country Status (28)
Country | Link |
---|---|
US (5) | US9040584B2 (el) |
EP (3) | EP3124015B1 (el) |
JP (2) | JP5930568B1 (el) |
KR (4) | KR102098987B1 (el) |
CN (2) | CN109966240A (el) |
AU (3) | AU2014262495B9 (el) |
BR (1) | BR112015028290A2 (el) |
CA (1) | CA2907721C (el) |
CL (1) | CL2015003270A1 (el) |
CR (1) | CR20150652A (el) |
CY (1) | CY1118654T1 (el) |
DK (2) | DK2863886T3 (el) |
ES (2) | ES2604160T3 (el) |
HK (1) | HK1213200A1 (el) |
HU (2) | HUE037405T2 (el) |
IL (2) | IL240807A (el) |
MX (2) | MX347969B (el) |
MY (1) | MY183193A (el) |
NO (1) | NO2753788T3 (el) |
NZ (1) | NZ712784A (el) |
PH (1) | PH12015502503B1 (el) |
PL (2) | PL2863886T3 (el) |
PT (2) | PT2863886T (el) |
RU (1) | RU2635864C2 (el) |
SG (2) | SG11201600068WA (el) |
SI (1) | SI2863886T1 (el) |
WO (1) | WO2014183045A2 (el) |
ZA (1) | ZA201507702B (el) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7666912B2 (en) | 2006-03-23 | 2010-02-23 | Massachusetts Eye And Ear Infirmary | Compositions and methods for reducing body fat |
CN102724951A (zh) | 2009-11-09 | 2012-10-10 | 阿勒根公司 | 用于刺激毛发生长的组合物和方法 |
US9089579B2 (en) | 2011-01-19 | 2015-07-28 | Topokine Therapeutics, Inc. | Methods and compositions for treating metabolic syndrome |
US8426471B1 (en) | 2011-12-19 | 2013-04-23 | Topokine Therapeutics, Inc. | Methods and compositions for reducing body fat and adipocytes |
NO2753788T3 (el) | 2013-05-10 | 2018-06-16 | ||
WO2014186504A1 (en) | 2013-05-15 | 2014-11-20 | Topokine Therapeutics, Inc. | Methods and compositions for topical delivery of prostaglandins to subcutaneous fat |
WO2015200425A1 (en) | 2014-06-27 | 2015-12-30 | Topokine Therapeutics, Inc. | Topical dosage regimen |
EP3288559B1 (en) | 2015-04-30 | 2020-06-24 | Allergan, Inc. | Cosmetic method and therapeutic use for fat reduction |
WO2016200817A1 (en) * | 2015-06-09 | 2016-12-15 | Thesan Pharmaceuticals, Inc. | Beta-naphthoisoflavones, compositions containing, and uses of, same |
US20180179174A1 (en) * | 2015-06-23 | 2018-06-28 | Thesan Pharmaceuticals, Inc. | 12H-BENZO[b]XANTHEN-12-ONES, COMPOSITIONS CONTAINING, AND USES OF, SAME |
CA2990856A1 (en) * | 2015-06-23 | 2016-12-29 | Thesan Pharmaceuticals, Inc. | 12h-benzo[a]xanthen-12-ones, compositions containing, and uses of, same |
WO2017075289A1 (en) | 2015-10-27 | 2017-05-04 | Cytozyme Animal Nutrition, Inc. | Animal nutrition compositions and related methods |
US10674746B2 (en) | 2015-10-27 | 2020-06-09 | Cytozyme Animal Nutrition, Inc. | Animal nutrition compositions and related methods |
CN107773758B (zh) * | 2016-08-31 | 2021-02-26 | 程辉 | 一种用于消除皮下脂肪沉积的组合物及其应用 |
US20220031631A1 (en) * | 2018-09-19 | 2022-02-03 | Modernatx, Inc. | High-purity peg lipids and uses thereof |
EP3713551B1 (en) | 2018-10-16 | 2023-06-07 | Polithera, Inc. | Alcohol-based compositions and uses thereof |
PL427837A1 (pl) * | 2018-11-22 | 2020-06-01 | Gbj Pharma Spółka Z Ograniczoną Odpowiedzialnością | Systemy do ciągłego obwodowego podawania latanoprostu dla obniżania ciśnienia śródgałkowego |
US11452703B2 (en) * | 2020-05-21 | 2022-09-27 | Peregrine Ophthalmic PTE LTD. | Methods and compositions for reducing adipocyte numbers |
JP6855026B1 (ja) * | 2020-11-09 | 2021-04-07 | 東亜薬品株式会社 | タフルプロスト点眼液 |
US20230012087A1 (en) * | 2021-07-12 | 2023-01-12 | Ocusoft, Inc. | Skin moisturizing compositions |
Family Cites Families (95)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4270537A (en) | 1979-11-19 | 1981-06-02 | Romaine Richard A | Automatic hypodermic syringe |
US4599353A (en) | 1982-05-03 | 1986-07-08 | The Trustees Of Columbia University In The City Of New York | Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma |
US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
US4886499A (en) | 1986-12-18 | 1989-12-12 | Hoffmann-La Roche Inc. | Portable injection appliance |
GB8704027D0 (en) | 1987-02-20 | 1987-03-25 | Owen Mumford Ltd | Syringe needle combination |
US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
US4940460A (en) | 1987-06-19 | 1990-07-10 | Bioject, Inc. | Patient-fillable and non-invasive hypodermic injection device assembly |
EP0302147A1 (en) | 1987-08-03 | 1989-02-08 | The Procter & Gamble Company | Topical tanning compositions |
US5339163A (en) | 1988-03-16 | 1994-08-16 | Canon Kabushiki Kaisha | Automatic exposure control device using plural image plane detection areas |
DE03014533T1 (de) | 1988-09-06 | 2004-07-15 | Pharmacia Ab | Prostaglandinderivative zur Behandlung von Glaukom oder okuläre Hypertension |
US5296504A (en) | 1988-09-06 | 1994-03-22 | Kabi Pharmacia | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
FR2638359A1 (fr) | 1988-11-03 | 1990-05-04 | Tino Dalto | Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau |
US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
US5011062A (en) | 1990-05-09 | 1991-04-30 | Delco Electronics Corporation | Ultrasonic welding mask |
US5190521A (en) | 1990-08-22 | 1993-03-02 | Tecnol Medical Products, Inc. | Apparatus and method for raising a skin wheal and anesthetizing skin |
US5527288A (en) | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
GB9118204D0 (en) | 1991-08-23 | 1991-10-09 | Weston Terence E | Needle-less injector |
SE9102652D0 (sv) | 1991-09-13 | 1991-09-13 | Kabi Pharmacia Ab | Injection needle arrangement |
US5328483A (en) | 1992-02-27 | 1994-07-12 | Jacoby Richard M | Intradermal injection device with medication and needle guard |
US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
US5972991A (en) | 1992-09-21 | 1999-10-26 | Allergan | Cyclopentane heptan(ene) oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents |
US5688819A (en) | 1992-09-21 | 1997-11-18 | Allergan | Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
US5569189A (en) | 1992-09-28 | 1996-10-29 | Equidyne Systems, Inc. | hypodermic jet injector |
US5334144A (en) | 1992-10-30 | 1994-08-02 | Becton, Dickinson And Company | Single use disposable needleless injector |
US5510383A (en) | 1993-08-03 | 1996-04-23 | Alcon Laboratories, Inc. | Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension |
JPH07138258A (ja) | 1993-11-16 | 1995-05-30 | Taiho Yakuhin Kogyo Kk | チアゾリジンジオン誘導体又はその塩 |
US5380760A (en) * | 1993-11-19 | 1995-01-10 | Minnesota Mining And Manufacturing Company | Transdermal prostaglandin composition |
WO1995024176A1 (en) | 1994-03-07 | 1995-09-14 | Bioject, Inc. | Ampule filling device |
US5466220A (en) | 1994-03-08 | 1995-11-14 | Bioject, Inc. | Drug vial mixing and transfer device |
US5631287A (en) | 1994-12-22 | 1997-05-20 | Alcon Laboratories, Inc. | Storage-stable prostaglandin compositions |
US5599302A (en) | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
US5730723A (en) | 1995-10-10 | 1998-03-24 | Visionary Medical Products Corporation, Inc. | Gas pressured needle-less injection device and method |
US5893397A (en) | 1996-01-12 | 1999-04-13 | Bioject Inc. | Medication vial/syringe liquid-transfer apparatus |
GB9607549D0 (en) | 1996-04-11 | 1996-06-12 | Weston Medical Ltd | Spring-powered dispensing device |
RU2157689C2 (ru) | 1996-07-24 | 2000-10-20 | Панацея Биотек Лтд. | Фармацевтические композиции терапевтического антивоспалительного и болеутоляющего средства для местного нанесения и способ их получения |
JP3480549B2 (ja) | 1996-12-26 | 2003-12-22 | 参天製薬株式会社 | ジフルオロプロスタグランジン誘導体およびその用途 |
WO1998033497A1 (en) | 1997-02-04 | 1998-08-06 | Johnstone Murray A | Method of enhancing hair growth |
US5993412A (en) | 1997-05-19 | 1999-11-30 | Bioject, Inc. | Injection apparatus |
US6646001B2 (en) | 1997-12-19 | 2003-11-11 | Alcon Manufacturing, Ltd. | Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension |
WO1999032441A1 (en) | 1997-12-22 | 1999-07-01 | Alcon Laboratories, Inc. | 13-oxa prostaglandins for the treatment of glaucoma and ocular hypertension |
IT1298087B1 (it) | 1998-01-08 | 1999-12-20 | Fiderm S R L | Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni |
US6235781B1 (en) | 1998-07-14 | 2001-05-22 | Alcon Laboratories, Inc. | Prostaglandin product |
DE60135633D1 (de) | 2000-02-10 | 2008-10-16 | Massachusetts Eye & Ear Infirm | Photodynamische therapie zur behandlung von augenerkrankungen |
US20020172693A1 (en) | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
ES2172415B2 (es) | 2000-07-28 | 2003-11-16 | Univ Madrid Complutense | Tratamiento del glaucoma y la hipertension ocular por medio de un analogo de la melatonina. |
EA006556B1 (ru) | 2001-03-27 | 2006-02-24 | Те Риджентс Оф Те Юниверсити Оф Калифорния | Способы, соединения и композиции для борьбы с ожирением и регулирования метаболизма жирных кислот |
GB0202159D0 (en) | 2002-01-30 | 2002-03-20 | Sensor Highway Ltd | OPtical time domain reflectometry |
IL147921A0 (en) | 2002-01-31 | 2002-08-14 | Abdulrazik Mohammad | A method for treating central nervous system disorders by ocular dosing |
US7351404B2 (en) | 2002-02-04 | 2008-04-01 | Allergan, Inc. | Method of enhancing hair growth |
JP4387639B2 (ja) * | 2002-07-16 | 2009-12-16 | 久光製薬株式会社 | 経皮吸収製剤 |
US6864282B2 (en) | 2002-08-05 | 2005-03-08 | Allergan, Inc. | 9,11-cycloendoperoxide pro-drugs of prostaglandin analogues for treatment of ocular hypertension and glaucoma |
US20040115234A1 (en) | 2002-09-24 | 2004-06-17 | Gewirtz Joan T. | Cosmetic composition |
ATE539756T1 (de) | 2002-10-23 | 2012-01-15 | Sucampo Ag | Prostaglandinsubstanzen für die behandlung von fettsucht |
US7074827B2 (en) | 2002-10-24 | 2006-07-11 | Sucampo Ag (Usa) Inc. | Method for treating ocular hypertension and glaucoma |
KR101086147B1 (ko) | 2003-03-21 | 2011-11-25 | 넥스메드 홀딩스 인코포레이티드 | 조루증 치료용 조성물 및 치료 방법 |
US6933289B2 (en) | 2003-07-01 | 2005-08-23 | Allergan, Inc. | Inhibition of irritating side effects associated with use of a topical ophthalmic medication |
US20050058614A1 (en) | 2003-09-15 | 2005-03-17 | Allergan, Inc. | Methods for the treatment of gray hair using cyclopentane(ene) heptan(en)oic acid amides |
US7070768B2 (en) | 2003-09-25 | 2006-07-04 | Allergan, Inc. | Method for imparting artificial tan to human skin |
US7993634B2 (en) | 2004-04-30 | 2011-08-09 | Allergan, Inc. | Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods |
US8722097B2 (en) | 2004-04-30 | 2014-05-13 | Allergan, Inc. | Oil-in-water method for making polymeric implants containing a hypotensive lipid |
ES2660172T3 (es) | 2004-05-19 | 2018-03-21 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Composición inyectable que comprende desoxicolato de sodio |
ES2314354T3 (es) | 2004-11-09 | 2009-03-16 | Novagali Pharma S.A. | Emulsion de tipo aceite en agua con baja concentracion de agente cationico y potencial zeta positivo. |
EP1848541A4 (en) | 2005-02-07 | 2013-01-16 | Pharmalight Inc | METHOD AND DEVICE FOR OPHTHALMIC DELIVERY OF PHARMACEUTICALLY ACTIVE INGREDIENTS |
CN102293774A (zh) | 2005-03-31 | 2011-12-28 | 旭硝子株式会社 | 前列腺素F2α衍生物的应用 |
WO2007011743A2 (en) | 2005-07-14 | 2007-01-25 | Lipothera, Inc. | Sustained release enhanced lipolytic formulation for regional adipose tissue treatment |
WO2007011846A2 (en) * | 2005-07-18 | 2007-01-25 | Soundquest, Inc. | In-ear auditory device and methods of using same |
EP2452686A3 (en) | 2005-08-29 | 2012-09-05 | HealOr Ltd. | Methods and compositions for prevention and treatment of diabetic and aged skin |
US9393218B2 (en) | 2005-12-23 | 2016-07-19 | Epinamics Gmbh | Use of film-forming hair care polymers from the group of polyurethanes and pharmaceutical preparations and patches that contain these polymers |
US7666912B2 (en) * | 2006-03-23 | 2010-02-23 | Massachusetts Eye And Ear Infirmary | Compositions and methods for reducing body fat |
RU2325912C1 (ru) * | 2006-09-06 | 2008-06-10 | Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") | Фармацевтическая композиция противовоспалительного и антимикробного действия в форме мази на гидрофобной основе для лечения кожных заболеваний (варианты) |
US8796282B2 (en) | 2007-03-28 | 2014-08-05 | Case Western Reserve University | Method of treating dermatological disorders |
WO2008120249A1 (en) | 2007-03-30 | 2008-10-09 | Sifi S.P.A. | Pharmaceutical formulations based on apolar and polar lipids for ophthalmic use |
US20100074857A1 (en) * | 2008-09-23 | 2010-03-25 | Pamela Lipkin | Compositions and methods to treat epithelial-related conditions |
US20100104654A1 (en) | 2008-10-27 | 2010-04-29 | Allergan, Inc. | Prostaglandin and prostamide drug delivery systems and intraocular therapeutic uses thereof |
US8722739B2 (en) | 2008-10-29 | 2014-05-13 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
CN101427993A (zh) | 2008-11-20 | 2009-05-13 | 沈阳万爱普利德医药科技有限公司 | 前列腺素微乳凝胶制剂及其制备方法 |
EP2228058A1 (en) * | 2009-03-04 | 2010-09-15 | Novagali Pharma S.A. | Anionic oil-in-water emulsion containing prostaglandins and uses thereof |
CN102724951A (zh) | 2009-11-09 | 2012-10-10 | 阿勒根公司 | 用于刺激毛发生长的组合物和方法 |
EP2389939A1 (en) * | 2010-05-28 | 2011-11-30 | Novagali Pharma S.A. | Use of prostaglandins F2alpha and analogues for the healing of corneal and conjunctival lesions |
EP2640350B1 (en) | 2010-11-18 | 2018-09-26 | Steven Yoelin | Compositions and methods for hair growth |
WO2013172838A1 (en) | 2012-05-17 | 2013-11-21 | Steven Yoelin | Compositions and methods for hair growth |
US9089579B2 (en) | 2011-01-19 | 2015-07-28 | Topokine Therapeutics, Inc. | Methods and compositions for treating metabolic syndrome |
RU2599249C2 (ru) | 2011-02-14 | 2016-10-10 | Аллерган, Инк. | Композиции и способы применения сложноэфирных производных биматопроста |
US20120251613A1 (en) * | 2011-03-29 | 2012-10-04 | Agila Specialities Pvt. Ltd. | Method for treating vitiligo with a prostaglandin analogue |
JP2012250950A (ja) * | 2011-06-06 | 2012-12-20 | Santen Pharmaceut Co Ltd | アデノシン誘導体とプロスタグランジン類の組合せ剤 |
MX2014000781A (es) * | 2011-07-20 | 2014-04-30 | Allergan Inc | Dosis combinada fija de bimatoprost y brimonidina. |
US20130035338A1 (en) * | 2011-08-05 | 2013-02-07 | Gordon Tang | Eyelid treatment |
US8426471B1 (en) | 2011-12-19 | 2013-04-23 | Topokine Therapeutics, Inc. | Methods and compositions for reducing body fat and adipocytes |
KR20140043562A (ko) | 2012-09-24 | 2014-04-10 | 한국콜마주식회사 | 무복계면 라타노프로스트 및 그 제조방법 |
MX2015006390A (es) | 2012-11-21 | 2015-08-05 | Topokine Therapeutics Inc | Metodos y composiciones para incrementar localmente la grasa corporal. |
NO2753788T3 (el) | 2013-05-10 | 2018-06-16 | ||
WO2014186504A1 (en) * | 2013-05-15 | 2014-11-20 | Topokine Therapeutics, Inc. | Methods and compositions for topical delivery of prostaglandins to subcutaneous fat |
WO2015200425A1 (en) | 2014-06-27 | 2015-12-30 | Topokine Therapeutics, Inc. | Topical dosage regimen |
-
2012
- 2012-04-05 NO NO12829698A patent/NO2753788T3/no unknown
-
2014
- 2014-05-09 KR KR1020167022712A patent/KR102098987B1/ko active IP Right Grant
- 2014-05-09 HU HUE16177742A patent/HUE037405T2/hu unknown
- 2014-05-09 HU HUE14729803A patent/HUE030977T2/en unknown
- 2014-05-09 CA CA2907721A patent/CA2907721C/en active Active
- 2014-05-09 RU RU2015141767A patent/RU2635864C2/ru active
- 2014-05-09 CN CN201811245298.7A patent/CN109966240A/zh active Pending
- 2014-05-09 SG SG11201600068WA patent/SG11201600068WA/en unknown
- 2014-05-09 PT PT147298038T patent/PT2863886T/pt unknown
- 2014-05-09 JP JP2016513124A patent/JP5930568B1/ja not_active Expired - Fee Related
- 2014-05-09 BR BR112015028290A patent/BR112015028290A2/pt active Search and Examination
- 2014-05-09 KR KR1020217009848A patent/KR20210040180A/ko not_active Application Discontinuation
- 2014-05-09 SI SI201430090A patent/SI2863886T1/sl unknown
- 2014-05-09 KR KR1020207009488A patent/KR20200037458A/ko not_active Application Discontinuation
- 2014-05-09 DK DK14729803.8T patent/DK2863886T3/en active
- 2014-05-09 PT PT161777420T patent/PT3124015T/pt unknown
- 2014-05-09 ES ES14729803.8T patent/ES2604160T3/es active Active
- 2014-05-09 PL PL14729803T patent/PL2863886T3/pl unknown
- 2014-05-09 SG SG10201604659QA patent/SG10201604659QA/en unknown
- 2014-05-09 PL PL16177742T patent/PL3124015T3/pl unknown
- 2014-05-09 EP EP16177742.0A patent/EP3124015B1/en active Active
- 2014-05-09 EP EP14729803.8A patent/EP2863886B1/en active Active
- 2014-05-09 ES ES16177742.0T patent/ES2670323T3/es active Active
- 2014-05-09 MY MYPI2015703803A patent/MY183193A/en unknown
- 2014-05-09 AU AU2014262495A patent/AU2014262495B9/en not_active Ceased
- 2014-05-09 EP EP18162319.0A patent/EP3395328A1/en not_active Withdrawn
- 2014-05-09 DK DK16177742.0T patent/DK3124015T3/en active
- 2014-05-09 NZ NZ712784A patent/NZ712784A/en not_active IP Right Cessation
- 2014-05-09 WO PCT/US2014/037512 patent/WO2014183045A2/en active Application Filing
- 2014-05-09 MX MX2015015535A patent/MX347969B/es active IP Right Grant
- 2014-05-09 KR KR1020157032864A patent/KR101651450B1/ko active IP Right Grant
- 2014-05-09 CN CN201480027172.6A patent/CN105209015B/zh not_active Expired - Fee Related
- 2014-12-18 US US14/575,873 patent/US9040584B2/en active Active
-
2015
- 2015-05-01 US US14/702,365 patent/US9849179B2/en active Active
- 2015-08-25 IL IL240807A patent/IL240807A/en active IP Right Grant
- 2015-10-14 ZA ZA2015/07702A patent/ZA201507702B/en unknown
- 2015-10-30 PH PH12015502503A patent/PH12015502503B1/en unknown
- 2015-11-06 CL CL2015003270A patent/CL2015003270A1/es unknown
- 2015-11-09 MX MX2020002881A patent/MX2020002881A/es unknown
- 2015-12-10 CR CR20150652A patent/CR20150652A/es unknown
-
2016
- 2016-02-04 HK HK16101285.4A patent/HK1213200A1/zh not_active IP Right Cessation
- 2016-04-25 JP JP2016086986A patent/JP2016135810A/ja active Pending
- 2016-11-23 CY CY20161101214T patent/CY1118654T1/el unknown
-
2017
- 2017-03-29 IL IL251448A patent/IL251448B/en active IP Right Grant
- 2017-12-15 US US15/843,272 patent/US10556012B2/en active Active
-
2019
- 2019-10-18 AU AU2019250230A patent/AU2019250230A1/en not_active Abandoned
-
2020
- 2020-02-10 US US16/785,892 patent/US20200282059A1/en not_active Abandoned
-
2021
- 2021-08-27 AU AU2021221900A patent/AU2021221900A1/en not_active Abandoned
- 2021-09-27 US US17/448,947 patent/US20220152206A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1118654T1 (el) | Συνθεσεις και μεθοδοι για τοπικη χορηγηση προσταγλανδινων σε υποδοριο λιπος | |
CY1118842T1 (el) | Αναισθητικες ενωσεις και σχετιζομενες μεθοδοι χρησεις | |
BR112015019657A2 (pt) | composições tópicas e métodos de uso das mesmas | |
CU24350B1 (es) | DERIVADOS DE 5-HETEROARIL-4-FENIL-4,5-DIHIDROPIRROLO(3,4-c)PIRAZOL-6-ONA ACTIVOS COMO INHIBIDORES DE BET | |
CY1120378T1 (el) | Υποκατεστημενα παραγωγα του διφαινυλο βουτανοϊκου φωσφονικου οξεος ως αναστολεις νερ (ουδετερης ενδοπεπτιδασης) | |
PE20140936A1 (es) | Composiciones transdermicas de ibuprofeno y metodos de uso de las mismas | |
BR112015026023A2 (pt) | derivados de 2- aminopirido[4,3-d]pirimidin-5-ona e seu uso como inibidores de wee-1 | |
BRPI0811956A8 (pt) | Solução tópica não aquosa de diclofenaco e processo para sua preparação | |
DOP2016000047A (es) | Compuestos y composiciones como inhibidores de la mek | |
BR112015022590B8 (pt) | Composição farmacêutica adequada para aplicação tópica à pele e/ou unhas, seu uso e método para melhorar a estabilidade de armazenamento de uma composição farmacêutica adequada para aplicação tópica à pele e/ou unhas | |
PH12017500136A1 (en) | Long-chain dimethylaniline derivative compounds, their preparation methods, self-assembled textures, and uses thereof | |
BR112015026238A8 (pt) | composto dihidropirazino-pirazina, composição farmacêutica que o compreende, uso do composto, métodos para inibir ou medir a fosforilação e para inibir a atividade da proteína quinase, bem como kit | |
CY1124294T1 (el) | Τοπικο σκευασμα | |
UY35651A (es) | Pirazolpiridinas sustituidas | |
CY1123805T1 (el) | Διαδερμικο σκευασμα που περιεχει αναστολεις cox | |
PH12018500910A1 (en) | Novel method of use and compositions | |
BR112017017643A2 (pt) | formulação farmacêutica tópica | |
AR094035A1 (es) | Estimulantes del colageno y su uso en el tratamiento de la piel | |
BR112015018200A2 (pt) | composição mastigável para administração oral e processo para preparar a mesma | |
PE20190707A1 (es) | Formulaciones de buprenorfina de liberacion sostenida | |
ECSP13012369A (es) | Agentes terapéuticos 976 | |
BR112015019307A8 (pt) | derivados de ácido butanóico substituído com bisfenila, seus usos, e composição farmacêutica | |
BR112014019442A8 (pt) | Composição injetável contendo fosfatidilcolina desprovida de deoxicolato de sódio e seu método de preparação | |
BR112018070064A2 (pt) | composições farmacêuticas estáveis para administração tópica e uso das mesmas | |
AR082366A1 (es) | Formulacion dermocorticoide |