CU24350B1 - DERIVADOS DE 5-HETEROARIL-4-FENIL-4,5-DIHIDROPIRROLO(3,4-c)PIRAZOL-6-ONA ACTIVOS COMO INHIBIDORES DE BET - Google Patents
DERIVADOS DE 5-HETEROARIL-4-FENIL-4,5-DIHIDROPIRROLO(3,4-c)PIRAZOL-6-ONA ACTIVOS COMO INHIBIDORES DE BETInfo
- Publication number
- CU24350B1 CU24350B1 CUP2015000163A CU20150163A CU24350B1 CU 24350 B1 CU24350 B1 CU 24350B1 CU P2015000163 A CUP2015000163 A CU P2015000163A CU 20150163 A CU20150163 A CU 20150163A CU 24350 B1 CU24350 B1 CU 24350B1
- Authority
- CU
- Cuba
- Prior art keywords
- active
- derivatives
- dihidropirrolo
- heteroaril
- fenil
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
<p>La presente invención proporciona un compuesto de la fórmula (I)</p> <p>(ESPACIO PARA LA FÓRMULA)</p> <p>o una sal farmacéuticamente aceptable del mismo, que corresponde con derivados de 5 heteroaril-4-fenil-4,5-dihidropirrolo (3,4-c)pirazol-6-ona activos como inhibidores de BET, que tienen potencial terapéutico en varias condiciones o enfermedades humanas como cáncer; composiciones farmacéuticas de los mismos y combinaciones con agentes farmacológicamente activos.</p>
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13169364 | 2013-05-27 | ||
EP13177673 | 2013-07-23 | ||
PCT/IB2014/061717 WO2014191896A1 (en) | 2013-05-27 | 2014-05-26 | Pyrazolopyrrolidine derivatives and their use in the treatment of disease |
Publications (2)
Publication Number | Publication Date |
---|---|
CU20150163A7 CU20150163A7 (es) | 2016-05-30 |
CU24350B1 true CU24350B1 (es) | 2018-06-05 |
Family
ID=50979827
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CUP2015000163A CU24350B1 (es) | 2013-05-27 | 2014-05-26 | DERIVADOS DE 5-HETEROARIL-4-FENIL-4,5-DIHIDROPIRROLO(3,4-c)PIRAZOL-6-ONA ACTIVOS COMO INHIBIDORES DE BET |
Country Status (37)
Country | Link |
---|---|
US (2) | US8975417B2 (es) |
EP (1) | EP3004110B1 (es) |
JP (1) | JP6181862B2 (es) |
KR (1) | KR20160012196A (es) |
CN (1) | CN105408335B (es) |
AU (1) | AU2014272776C1 (es) |
BR (1) | BR112015029512A8 (es) |
CA (1) | CA2913223A1 (es) |
CL (1) | CL2015003395A1 (es) |
CR (1) | CR20150628A (es) |
CU (1) | CU24350B1 (es) |
CY (1) | CY1119490T1 (es) |
DK (1) | DK3004110T3 (es) |
EA (1) | EA029515B1 (es) |
EC (1) | ECSP15053445A (es) |
ES (1) | ES2651843T3 (es) |
HK (1) | HK1216251A1 (es) |
HR (1) | HRP20171613T1 (es) |
HU (1) | HUE036674T2 (es) |
IL (1) | IL242610A0 (es) |
LT (1) | LT3004110T (es) |
ME (1) | ME02906B (es) |
MX (1) | MX364205B (es) |
NO (1) | NO3004110T3 (es) |
PE (1) | PE20160005A1 (es) |
PH (2) | PH12015502628B1 (es) |
PL (1) | PL3004110T3 (es) |
PT (1) | PT3004110T (es) |
RS (1) | RS56522B1 (es) |
SG (1) | SG11201509474SA (es) |
SI (1) | SI3004110T1 (es) |
SV (1) | SV2015005115A (es) |
TN (1) | TN2015000505A1 (es) |
UA (1) | UA116017C2 (es) |
UY (1) | UY35586A (es) |
WO (1) | WO2014191896A1 (es) |
ZA (1) | ZA201508259B (es) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6171003B2 (ja) | 2012-05-24 | 2017-07-26 | ノバルティス アーゲー | ピロロピロリジノン化合物 |
WO2014080290A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Cyclic amines as bromodomain inhibitors |
WO2014080291A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Biaryl derivatives as bromodomain inhibitors |
CA2895905A1 (en) | 2012-12-21 | 2014-06-26 | Zenith Epigenetics Corp. | Novel heterocyclic compounds as bromodomain inhibitors |
EP2948453B1 (en) | 2013-01-22 | 2017-08-02 | Novartis AG | Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the p53/mdm2 interaction |
SG10201707487VA (en) | 2013-03-15 | 2017-10-30 | Incyte Corp | Tricyclic heterocycles as bet protein inhibitors |
US9624247B2 (en) * | 2013-05-28 | 2017-04-18 | Novartis Ag | Pyrazolo-pyrrolidin-4-one derivatives as bet inhibitors and their use in the treatment of disease |
JP6461118B2 (ja) | 2013-06-21 | 2019-01-30 | ゼニス・エピジェネティクス・リミテッドZenith Epigenetics Ltd. | ブロモドメイン阻害剤としての新規の置換された二環式化合物 |
NZ714669A (en) | 2013-06-21 | 2021-07-30 | Zenith Epigenetics Ltd | Novel bicyclic bromodomain inhibitors |
WO2015006193A1 (en) | 2013-07-08 | 2015-01-15 | Incyte Corporation | Tricyclic heterocycles as bet protein inhibitors |
EA201690087A1 (ru) | 2013-07-31 | 2016-08-31 | Зенит Эпидженетикс Корп. | Новые квиназолиноны как ингибиторы бромодомена |
FI3640241T3 (fi) | 2013-10-18 | 2023-01-13 | Bromodomeeni-inhibiittorit | |
US9315501B2 (en) | 2013-11-26 | 2016-04-19 | Incyte Corporation | Bicyclic heterocycles as BET protein inhibitors |
WO2015081203A1 (en) | 2013-11-26 | 2015-06-04 | Incyte Corporation | Bicyclic heterocycles as bet protein inhibitors |
WO2015095492A1 (en) | 2013-12-19 | 2015-06-25 | Incyte Corporation | Tricyclic heterocycles as bet protein inhibitors |
SG11201608843TA (en) | 2014-04-23 | 2016-11-29 | Incyte Corp | 1H-PYRROLO[2,3-c]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-c]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS |
WO2016044130A1 (en) | 2014-09-15 | 2016-03-24 | Incyte Corporation | Tricyclic heterocycles for use as bet protein inhibitors |
WO2016087936A1 (en) | 2014-12-01 | 2016-06-09 | Zenith Epigenetics Corp. | Substituted pyridinones as bromodomain inhibitors |
CA2966303A1 (en) | 2014-12-01 | 2016-06-09 | Zenith Epigenetics Ltd. | Substituted pyridines as bromodomain inhibitors |
CA2966449A1 (en) | 2014-12-11 | 2016-06-16 | Zenith Epigenetics Ltd. | Substituted heterocycles as bromodomain inhibitors |
CN107406438B (zh) | 2014-12-17 | 2021-05-14 | 恒翼生物医药科技(上海)有限公司 | 溴结构域的抑制剂 |
GB201504694D0 (en) | 2015-03-19 | 2015-05-06 | Glaxosmithkline Ip Dev Ltd | Covalent conjugates |
US10836742B2 (en) | 2015-08-11 | 2020-11-17 | Neomed Institute | N-substituted bicyclic lactams, their preparation and their use as pharmaceuticals |
KR20180039117A (ko) | 2015-08-11 | 2018-04-17 | 네오메드 인스티튜트 | 아릴-치환된 디히드로퀴놀리논, 그의 제조법 및 제약으로서의 그의 용도 |
EP3334719B1 (en) | 2015-08-12 | 2021-09-15 | Neomed Institute | Substituted benzimidazoles, their preparation and their use as pharmaceuticals |
WO2017066876A1 (en) | 2015-10-21 | 2017-04-27 | Neomed Institute | Substituted imidazopyridines, their preparation and their use as pharmaceuticals |
US20170121347A1 (en) | 2015-10-29 | 2017-05-04 | Incyte Corporation | Amorphous solid form of a bet protein inhibitor |
WO2017127930A1 (en) * | 2016-01-28 | 2017-08-03 | Neomed Institute | Substituted [1,2,4]triazolo[4,3-a]pyridines, their preparation and their use as pharmaceuticals |
AU2017220611A1 (en) | 2016-02-15 | 2018-08-30 | Cemm - Forschungszentrum Für Molekulare Medizin Gmbh | TAF1 inhibitors for the therapy of cancer |
WO2017201449A1 (en) | 2016-05-20 | 2017-11-23 | Genentech, Inc. | Protac antibody conjugates and methods of use |
US11298354B2 (en) * | 2016-06-09 | 2022-04-12 | Dana-Farber Cancer Institute, Inc. | Methods of use and pharmaceutical combinations of HDAC inhibitors with BET inhibitors |
IL263824B2 (en) | 2016-06-20 | 2023-10-01 | Incyte Corp | Crystals in solid form in the presence of an inhibitor |
ES2903283T3 (es) | 2016-08-31 | 2022-03-31 | Jiangsu Hengrui Medicine Co | Derivado de oxipicolinamida, método de preparación y uso farmacéutico del mismo |
WO2018087401A2 (en) | 2016-11-14 | 2018-05-17 | Cemm - Forschungszentrum Für Molekulare Medizin Gmbh | Combination of a brd4 inhibitor and an antifolate for the therapy of cancer |
CN109232301B (zh) * | 2018-10-15 | 2021-01-01 | 天津希恩思生化科技有限公司 | 一种四异丙基肼的制备方法 |
JP2022053557A (ja) * | 2019-02-08 | 2022-04-06 | マルホ株式会社 | ピリドン誘導体 |
KR20220054293A (ko) * | 2019-07-12 | 2022-05-02 | 시닉 이뮤놀러지 비.브이. | Isoqc 및/또는 qc 효소의 억제제로서 n-치환된-3,4-(융합된 5-환)-5-페닐-피롤리딘-2-온 화합물 |
KR20220077138A (ko) | 2019-09-30 | 2022-06-08 | 쿄와 기린 가부시키가이샤 | Bet 분해제 |
CN112625036A (zh) * | 2019-10-08 | 2021-04-09 | 上海海和药物研究开发股份有限公司 | 一类具有brd4抑制活性的化合物、其制备方法及用途 |
US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
EP4281452A1 (en) * | 2021-01-21 | 2023-11-29 | Beijing Tiantan Hospital | Modulators of fpr1 and methods of using the same |
IL310395A (en) | 2021-08-02 | 2024-03-01 | Syngenta Crop Protection Ag | Microbiocidal pyrazole derivatives |
WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
CN118368986A (zh) | 2021-12-17 | 2024-07-19 | 先正达农作物保护股份公司 | 杀微生物的吡唑衍生物 |
WO2023233130A1 (en) | 2022-05-30 | 2023-12-07 | AdoRx Therapeutics Limited | Cd73 inhibitor compounds |
WO2024068947A1 (en) | 2022-09-30 | 2024-04-04 | Syngenta Crop Protection Ag | Microbiocidal pyrazole derivatives |
WO2024156886A1 (en) | 2023-01-27 | 2024-08-02 | Syngenta Crop Protection Ag | Microbiocidal pyrazole derivatives |
WO2024160801A1 (en) | 2023-02-01 | 2024-08-08 | Syngenta Crop Protection Ag | Fungicidal compositions |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5508300A (en) | 1994-01-14 | 1996-04-16 | Pfizer Inc. | Dihydro pyrazolopyrroles, compositions and use |
JP4555547B2 (ja) | 2000-08-10 | 2010-10-06 | ファイザー イタリア ソシエタ ア レスポンサビリタ リミタータ | キナーゼ阻害剤としての二環式ピラゾール、それらを製造するための方法およびそれらを含む医薬組成物 |
DE60221392T2 (de) * | 2001-05-24 | 2008-04-17 | Eli Lilly And Co., Indianapolis | Neue pyrrolderivate als pharmazeutische mittel |
WO2003051359A1 (en) | 2001-12-18 | 2003-06-26 | F.Hoffmann-La Roche Ag | Cis-2,4,5- triphenyl-imidazolines and their use in the treatment of tumors |
US20060189511A1 (en) | 2002-05-13 | 2006-08-24 | Koblish Holly K | Method for cytoprotection through mdm2 and hdm2 inhibition |
JP2007524596A (ja) | 2003-02-28 | 2007-08-30 | トランスフォーム・ファーマシューティカルズ・インコーポレイテッド | 共結晶医薬組成物 |
KR20080027969A (ko) | 2004-05-18 | 2008-03-28 | 에프. 호프만-라 로슈 아게 | 신규 cis-이미다졸린 |
US20060069085A1 (en) | 2004-09-28 | 2006-03-30 | Rulin Zhao | Preparation of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones |
US20060160869A1 (en) | 2005-01-05 | 2006-07-20 | Rigel Pharmaceuticals, Inc. | Ubiquitin ligase inhibitors |
WO2007068637A1 (en) | 2005-12-12 | 2007-06-21 | Nerviano Medical Sciences S.R.L. | Substituted pyrrolo-pyrazole derivatives active as kinase inhibitors |
WO2007096334A1 (en) | 2006-02-24 | 2007-08-30 | Pfizer Italia Srl | Pyrrolopyrrolones active as kinase inhibitors |
WO2008034039A2 (en) | 2006-09-15 | 2008-03-20 | Nexuspharma Inc. | Novel tetrahydro-isoquinolines |
CN101679246A (zh) | 2007-03-30 | 2010-03-24 | 盐野义制药株式会社 | 新型吡咯啉酮衍生物以及包含其的药物组合物 |
WO2009086303A2 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
UY31982A (es) | 2008-07-16 | 2010-02-26 | Boehringer Ingelheim Int | Derivados de 1,2-dihidropiridin-3-carboxamidas n-sustituidas |
TW201016702A (en) | 2008-09-25 | 2010-05-01 | Shionogi & Co | Novel pyrrolinone derivative and pharmaceutical composition comprising the same |
US20120208204A1 (en) | 2009-06-03 | 2012-08-16 | The Brigham And Women's Hospital, Inc. | Compositions and Methods for Inhibiting Tumor Growth |
GB0919423D0 (en) * | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
US8440693B2 (en) | 2009-12-22 | 2013-05-14 | Novartis Ag | Substituted isoquinolinones and quinazolinones |
WO2011143651A1 (en) * | 2010-05-14 | 2011-11-17 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for modulating metabolism |
WO2011161031A1 (en) | 2010-06-22 | 2011-12-29 | Glaxosmithkline Llc | Benzotriazolodiazepine compounds inhibitors of bromodomains |
US20120065210A1 (en) | 2010-09-15 | 2012-03-15 | Xin-Jie Chu | Substituted hexahydropyrrolo[1,2-c]imidazolones |
GB201016880D0 (en) | 2010-10-07 | 2010-11-17 | Riotech Pharmaceuticals Ltd | Phosphodiesterase inhibitors |
AR084070A1 (es) * | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
US9422292B2 (en) | 2011-05-04 | 2016-08-23 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
WO2012174487A2 (en) | 2011-06-17 | 2012-12-20 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
EP2721008B1 (en) | 2011-06-20 | 2015-04-29 | Novartis AG | Hydroxy substituted isoquinolinone derivatives as p53 (mdm2 or mdm4) inhibitors |
US8859586B2 (en) | 2011-06-20 | 2014-10-14 | Novartis Ag | Cyclohexyl isoquinolinone compounds |
GB2492950A (en) | 2011-07-11 | 2013-01-23 | Cambridge Consultants | Measuring a luminescent property of a sample using a dual-modulated excitation beam |
WO2013033268A2 (en) | 2011-08-29 | 2013-03-07 | Coferon, Inc. | Bivalent bromodomain ligands, and methods of using same |
WO2013080141A1 (en) | 2011-11-29 | 2013-06-06 | Novartis Ag | Pyrazolopyrrolidine compounds |
UY34591A (es) | 2012-01-26 | 2013-09-02 | Novartis Ag | Compuestos de imidazopirrolidinona |
JP6171003B2 (ja) | 2012-05-24 | 2017-07-26 | ノバルティス アーゲー | ピロロピロリジノン化合物 |
-
2014
- 2014-05-20 US US14/282,515 patent/US8975417B2/en active Active
- 2014-05-26 PE PE2015002539A patent/PE20160005A1/es not_active Application Discontinuation
- 2014-05-26 EP EP14731799.4A patent/EP3004110B1/en active Active
- 2014-05-26 ME MEP-2017-248A patent/ME02906B/me unknown
- 2014-05-26 RS RS20171074A patent/RS56522B1/sr unknown
- 2014-05-26 EA EA201592250A patent/EA029515B1/ru not_active IP Right Cessation
- 2014-05-26 KR KR1020157036225A patent/KR20160012196A/ko not_active Application Discontinuation
- 2014-05-26 WO PCT/IB2014/061717 patent/WO2014191896A1/en active Application Filing
- 2014-05-26 CA CA2913223A patent/CA2913223A1/en not_active Abandoned
- 2014-05-26 HU HUE14731799A patent/HUE036674T2/hu unknown
- 2014-05-26 UY UY0001035586A patent/UY35586A/es not_active Application Discontinuation
- 2014-05-26 SI SI201430425T patent/SI3004110T1/sl unknown
- 2014-05-26 LT LTEP14731799.4T patent/LT3004110T/lt unknown
- 2014-05-26 TN TN2015000505A patent/TN2015000505A1/en unknown
- 2014-05-26 ES ES14731799.4T patent/ES2651843T3/es active Active
- 2014-05-26 JP JP2016516277A patent/JP6181862B2/ja not_active Expired - Fee Related
- 2014-05-26 AU AU2014272776A patent/AU2014272776C1/en not_active Ceased
- 2014-05-26 PT PT147317994T patent/PT3004110T/pt unknown
- 2014-05-26 DK DK14731799.4T patent/DK3004110T3/da active
- 2014-05-26 NO NO14731799A patent/NO3004110T3/no unknown
- 2014-05-26 MX MX2015016416A patent/MX364205B/es active IP Right Grant
- 2014-05-26 US US14/892,613 patent/US20160095843A1/en not_active Abandoned
- 2014-05-26 PL PL14731799T patent/PL3004110T3/pl unknown
- 2014-05-26 SG SG11201509474SA patent/SG11201509474SA/en unknown
- 2014-05-26 CN CN201480042021.8A patent/CN105408335B/zh not_active Expired - Fee Related
- 2014-05-26 BR BR112015029512A patent/BR112015029512A8/pt not_active Application Discontinuation
- 2014-05-26 CU CUP2015000163A patent/CU24350B1/es unknown
- 2014-05-26 UA UAA201510962A patent/UA116017C2/uk unknown
-
2015
- 2015-11-09 ZA ZA2015/08259A patent/ZA201508259B/en unknown
- 2015-11-16 IL IL242610A patent/IL242610A0/en unknown
- 2015-11-19 CL CL2015003395A patent/CL2015003395A1/es unknown
- 2015-11-25 PH PH12015502628A patent/PH12015502628B1/en unknown
- 2015-11-27 SV SV2015005115A patent/SV2015005115A/es unknown
- 2015-11-27 CR CR20150628A patent/CR20150628A/es unknown
- 2015-12-22 EC ECIEPI201553445A patent/ECSP15053445A/es unknown
-
2016
- 2016-04-13 HK HK16104211.7A patent/HK1216251A1/zh not_active IP Right Cessation
-
2017
- 2017-10-24 HR HRP20171613TT patent/HRP20171613T1/hr unknown
- 2017-10-25 CY CY20171101108T patent/CY1119490T1/el unknown
-
2018
- 2018-08-24 PH PH12018501807A patent/PH12018501807A1/en unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CU24350B1 (es) | DERIVADOS DE 5-HETEROARIL-4-FENIL-4,5-DIHIDROPIRROLO(3,4-c)PIRAZOL-6-ONA ACTIVOS COMO INHIBIDORES DE BET | |
CL2018000318A1 (es) | Compuestos derivados de piridinona, inhibidores de bromodominio; composición farmacéutica que los comprende; y su uso en el tratamiento de enfermedades del cáncer. (solicitud divisional 201600925) | |
PH12016500024A1 (en) | Bromodomain inhibitor | |
CU20160087A7 (es) | Indazolcarboxamidas, procedimientos para su preparación, preparaciones farmacéuticas que las contienen | |
EA201591003A1 (ru) | Производные бороновой кислоты и их терапевтическое применение | |
NI201300041A (es) | Antagonistas de mdm2 de espiro-oxindol | |
BR112015021983A2 (pt) | compostos heterocíclicos e usos dos mesmos | |
CU20150014A7 (es) | Análogos de piridazina 1,4-disustituida y métodos para el tratamiento de condiciones relacionadas con la deficiencia de smn | |
BR112015020389A8 (pt) | compostos carbazol úteis como inibidores de bromodomínio, seu uso, bem como composição e produto farmacêuticos compreendendo os mesmos | |
CU20160052A7 (es) | Amino-heteroaril-benzamidas como inhibidores de cinasa | |
UY35353A (es) | Un inhibidor de mdm2 derivado de ácido benzoico para el tratamiento del cáncer | |
UY35590A (es) | Nuevos compuestos para el tratamiento del cáncer | |
GT201200147A (es) | Antagonistas de espiro-oxindol de mdm2 | |
PE20151788A1 (es) | Inhibidores de bromodominios tetraciclicos | |
TR201904455T4 (tr) | Nükleer taşıma modülatörleri olarak 1,2,4-triazoller ve bunların kullanımları. | |
CR20200479A (es) | COMPUESTOS TERAPÉUTICAMENTE ACTIVOS Y SUS MÉTODOS DE USO (Divisional 2016-0069) | |
BR112015026023A2 (pt) | derivados de 2- aminopirido[4,3-d]pirimidin-5-ona e seu uso como inibidores de wee-1 | |
CO7141411A2 (es) | Formulaciones y métodos para la administración vaginal de antiprogestinas | |
EA202090860A1 (ru) | Аналоги тиадиазола и способы лечения состояний, связанных с дефицитом smn | |
MX2015016421A (es) | Derivados de pirazolo-pirrolidin-4-ona como inhibidores de bet y su uso en el tratamiento de enfermedades. | |
UY37843A (es) | Inhibidores de mcl-1 macrocíclicos y métodos de uso | |
MX2015016425A (es) | Derivados de pirazolo-pirrolidin-4-ona y su uso en el tratamiento de enfermedades. | |
DOP2015000170A (es) | Compuestos químicos | |
UY35209A (es) | Compuestos tricíclicos | |
CL2017000845A1 (es) | Inhibidores de gingipaina de lisina |