BR112015019180A2 - ácidos tetrahidrocanabinol-11-óico ultrapuros - Google Patents

ácidos tetrahidrocanabinol-11-óico ultrapuros

Info

Publication number
BR112015019180A2
BR112015019180A2 BR112015019180A BR112015019180A BR112015019180A2 BR 112015019180 A2 BR112015019180 A2 BR 112015019180A2 BR 112015019180 A BR112015019180 A BR 112015019180A BR 112015019180 A BR112015019180 A BR 112015019180A BR 112015019180 A2 BR112015019180 A2 BR 112015019180A2
Authority
BR
Brazil
Prior art keywords
scleroderma
ultrapure
pulmonary fibrosis
tetrahydrocannabinol
fibrosis
Prior art date
Application number
BR112015019180A
Other languages
English (en)
Other versions
BR112015019180A8 (pt
Inventor
Tepper Mark
Original Assignee
Corbus Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corbus Pharmaceuticals Inc filed Critical Corbus Pharmaceuticals Inc
Publication of BR112015019180A2 publication Critical patent/BR112015019180A2/pt
Publication of BR112015019180A8 publication Critical patent/BR112015019180A8/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

resumo da patente de invenã§ã£o para: “ãcidos tetrahidrocanabinol-11-ã“ico ultrapuros”. este pedido estã¡ no campo da quã­mica mã©dica e refere-se ao ã¡cido ajulãªmico ultrapuro, a sua sã­ntese, composiã§ãµes farmacãªuticas e mã©todos de utilizaã§ã£o dos mesmos para o tratamento e/ou prevenã§ã£o de inflamaã§ã£o, dor, e doenã§as fibrã³ticas, incluindo esclerodermia, esclerose sistãªmica, distãºrbios tipo esclerodermia, esclerodermia sine, cirrose hepã¡tica, fibrose pulmonar intersticial, fibrose pulmonar idiopã¡tica, contratura de dupuytren, queloides, doenã§a renal crã´nica, rejeiã§ã£o crã´nica do enxerto, e outras anormalidades de cicatrizaã§ã£o de cicatrizes-feridas, aderãªncias pã³s-operatã³rio e fibrose reativa.
BR112015019180A 2013-02-12 2014-02-12 ácidos tetrahidrocanabinol-11-óicos ultrapuros BR112015019180A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361763630P 2013-02-12 2013-02-12
US201361837743P 2013-06-21 2013-06-21
PCT/US2014/016050 WO2014127016A2 (en) 2013-02-12 2014-02-12 Ultrapure tetrahydrocannabinol-11-oic acids

Publications (2)

Publication Number Publication Date
BR112015019180A2 true BR112015019180A2 (pt) 2017-07-18
BR112015019180A8 BR112015019180A8 (pt) 2018-01-30

Family

ID=51354671

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015019180A BR112015019180A8 (pt) 2013-02-12 2014-02-12 ácidos tetrahidrocanabinol-11-óicos ultrapuros

Country Status (9)

Country Link
US (8) US20150141501A1 (pt)
EP (2) EP2956133A4 (pt)
JP (3) JP6689078B2 (pt)
KR (2) KR20190139327A (pt)
CN (2) CN110946854A (pt)
AU (2) AU2014216440B2 (pt)
BR (1) BR112015019180A8 (pt)
CA (1) CA2900982C (pt)
WO (1) WO2014127016A2 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2956133A4 (en) 2013-02-12 2016-12-21 Corbus Pharmaceuticals Inc ULTRAPURIC TETRAHYDROCANNABINOL-11-OIC ACIDS
CA3022391A1 (en) * 2016-04-29 2017-11-02 Corbus Pharmaceuticals, Inc. Methods for the treatment of infection
MX2019000348A (es) * 2016-07-11 2019-03-28 Intec Pharma Ltd Formulaciones gastrorretentivas orales y usos de las mismas.
US10239808B1 (en) 2016-12-07 2019-03-26 Canopy Holdings, LLC Cannabis extracts
US11202771B2 (en) 2018-01-31 2021-12-21 Treehouse Biotech, Inc. Hemp powder
EP3801505A4 (en) * 2018-05-31 2022-07-20 Corbus Pharmaceuticals, Inc. CANNABINOIDS AND THEIR USES
CA3119729A1 (en) 2018-10-10 2020-04-16 Treehouse Biotech, Inc. Synthesis of cannabigerol
US20200121614A1 (en) * 2018-10-18 2020-04-23 Bluegrass Farmacueticals, LLC Cannabinoid-infused transparent hydrogel skin patch
WO2020183456A1 (en) * 2019-03-10 2020-09-17 Bol Pharma Ltd. Cannabinoid combinations for treating chronic pain in dialysis patients
WO2021072325A1 (en) 2019-10-11 2021-04-15 Corbus Pharmaceuticals, Inc. Compositions of ajulemic acid and uses thereof
AR123027A1 (es) * 2020-07-21 2022-10-26 Np Pharma Holdings Llc Composiciones y métodos de cannabinoides para el tratamiento del dolor y la inflamación de las articulaciones

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2186485B (en) 1986-02-13 1988-09-07 Ethical Pharma Ltd Slow release formulation
US5338753A (en) 1992-07-14 1994-08-16 Sumner H. Burstein (3R,4R)-Δ6 -tetrahydrocannabinol-7-oic acids useful as antiinflammatory agents and analgesics
US8586767B2 (en) 1999-03-22 2013-11-19 Craig Rick Travis Method for treatment of HIV and diseases of immune dysregulation
US6566560B2 (en) 1999-03-22 2003-05-20 Immugen Pharmaceuticals, Inc. Resorcinolic compounds
US6974835B2 (en) 2000-05-17 2005-12-13 Indevus Pharmaceuticals, Inc. Methods for decreasing cell proliferation based on (3r,4r)-Δ8-tetrahydrocannabinol-11-oic acids
US7507767B2 (en) 2001-02-08 2009-03-24 Schering Corporation Cannabinoid receptor ligands
EP1409473A2 (en) * 2001-03-07 2004-04-21 Websar Innovations Inc. CONVERSION OF CBD TO $g(D)?8 -THC AND $g(D)?9 -THC
IL153277A0 (en) * 2002-12-04 2003-07-06 Pharmos Corp High enantiomeric purity dexanabinol for pharmaceutical compositions
EP1567513A2 (en) * 2002-12-04 2005-08-31 Pharmos Corporation High enantiomeric purity dexanabinol for pharmaceutical copositions
AU2003297074A1 (en) 2002-12-13 2004-07-09 Euro-Celtique S.A. Transdermal buprenorphine to treat pain in sickle cell crisis
US20040186166A1 (en) * 2002-12-19 2004-09-23 Burstein Sumner H. Cannabinoid analogs as peroxisome proliferator activated nuclear receptor gamma activators
WO2004100893A2 (en) 2003-05-12 2004-11-25 Indevus Pharmaceuticals, Inc. Methods for treatment of inflammatory diseases using ct-3 or analogs thereof
US20050009903A1 (en) * 2003-06-10 2005-01-13 Martin Billy R. CB2-selective cannabinoid analogues
CA2605413C (en) 2005-04-21 2014-06-10 Orphan Medical, Inc. Ultrapure 4-methylpyrazole
TWI366460B (en) * 2005-06-16 2012-06-21 Euro Celtique Sa Cannabinoid active pharmaceutical ingredient for improved dosage forms
US20070037873A1 (en) 2005-08-08 2007-02-15 Zurier Robert B Airway remodeling treatments
US20070060639A1 (en) 2005-09-09 2007-03-15 University Of Kentucky Compositions and methods for intranasal delivery of tricyclic cannabinoids
WO2007055806A1 (en) * 2005-10-31 2007-05-18 Indevus Pharmaceuticals, Inc. Anti-emetic uses of (3r,4r)-δ8-tetrahydrocannabinol-11-oic acids
GB2432312A (en) * 2005-11-01 2007-05-23 Gw Pharma Ltd Pharmaceutical compositions for the treatment of pain
US20070104741A1 (en) 2005-11-07 2007-05-10 Murty Pharmaceuticals, Inc. Delivery of tetrahydrocannabinol
US20080054300A1 (en) 2006-06-30 2008-03-06 Philip Gene Nikkel Body contact structure and method for the reduction of drain lag and gate lag in field effect transistors
US8058227B2 (en) 2006-10-03 2011-11-15 Medical University Of South Carolina Method of treating fibrosis in a subject in need thereof comprising administering a composition comprising a CSD
US8044071B2 (en) 2007-10-18 2011-10-25 Abbott Laboratories Method for reducing side effects of CB2 receptor agonist therapy using a combination of a selective CB2 receptor agonist and a selective CB1 receptor antagonist
WO2009158499A2 (en) 2008-06-25 2009-12-30 University Of North Texas Health Science Center At Fort Worth Prevention of bacterial growth and biofilm formation by ligands that act on cannabinoidergic systems
US8877188B2 (en) 2010-05-04 2014-11-04 The Brigham And Women's Hospital, Inc. Detection and treatment of non-dermal fibrosis
US20130338220A1 (en) 2010-10-05 2013-12-19 Mark Tepper Compositions, dosages, and methods of using tetrahydrocannabinol derivatives
US20120309820A1 (en) 2011-06-04 2012-12-06 Jb Therapeutics Inc. Methods of treating fibrotic diseases using tetrahydrocannabinol-11-oic acids
EP2956133A4 (en) 2013-02-12 2016-12-21 Corbus Pharmaceuticals Inc ULTRAPURIC TETRAHYDROCANNABINOL-11-OIC ACIDS
US20150328198A1 (en) 2014-05-16 2015-11-19 The University Of North Carolina At Chapel Hill Methods of treating methicillin-resistant staphylococcus aureus (mrsa) using ppar-gamma agonists

Also Published As

Publication number Publication date
JP2016510340A (ja) 2016-04-07
JP2021185166A (ja) 2021-12-09
US9801849B2 (en) 2017-10-31
AU2018258159A1 (en) 2018-11-22
US9820964B2 (en) 2017-11-21
US20200093784A1 (en) 2020-03-26
US20190091200A1 (en) 2019-03-28
JP2019031505A (ja) 2019-02-28
EP2956133A4 (en) 2016-12-21
EP3851101A1 (en) 2021-07-21
CN105228613A (zh) 2016-01-06
US10085964B2 (en) 2018-10-02
US10369131B2 (en) 2019-08-06
WO2014127016A2 (en) 2014-08-21
CA2900982A1 (en) 2014-08-21
CA2900982C (en) 2021-06-01
AU2014216440B2 (en) 2018-08-09
KR20190139327A (ko) 2019-12-17
AU2014216440A1 (en) 2015-08-20
BR112015019180A8 (pt) 2018-01-30
AU2018258159B2 (en) 2020-01-02
US20170071898A1 (en) 2017-03-16
US20180177757A1 (en) 2018-06-28
US11052066B2 (en) 2021-07-06
US10154986B2 (en) 2018-12-18
WO2014127016A3 (en) 2015-11-26
CN110946854A (zh) 2020-04-03
JP6689078B2 (ja) 2020-04-28
US20150141501A1 (en) 2015-05-21
US20170071900A1 (en) 2017-03-16
KR20160002709A (ko) 2016-01-08
US20170071899A1 (en) 2017-03-16
EP2956133A2 (en) 2015-12-23
US20220117931A1 (en) 2022-04-21

Similar Documents

Publication Publication Date Title
BR112015019180A2 (pt) ácidos tetrahidrocanabinol-11-óico ultrapuros
ZA202001057B (en) Inhibiting ubiquitin specific peptidase 30
CY1122189T1 (el) Ιονικες υδατικες συνθεσεις
EP4230623A3 (en) Pyridine compounds as allosteric shp2 inhibitors
WO2017087608A8 (en) Modulators of ror-gamma
IL255203B (en) Topical pharmaceutical emulsion compositions comprising 3,5-dihydroxy-4-isopropyl-trans-stilbene and use thereof in the treatment or prophylaxis of dermatological conditions or disorders
EP3682875A3 (en) Methods of treating pediatric metabolic syndrome
SG10201808104RA (en) Cenicriviroc for the treatment of fibrosis
MY171929A (en) Corticosteroids for the treatment of joint pain
EA201790124A1 (ru) Соли берберина, соли урсодезоксихолевой кислоты и их комбинации, способы получения и применения
EP3329965A3 (en) Dosing regimen of anti-alpha4beta7-antikörper
BR112015021931A8 (pt) usos de composições farmacêuticas para prevenção e/ou tratamento de complicações do pulmão induzidas por radiação e da função pulmonar
WO2009147201A3 (en) Anti-inflammatory agents
EA201890842A1 (ru) Комбинация гликозаминогликанов и антацидного агента и содержащие их композиции
EP4234568A3 (en) Solid forms of berberine ursodeoxycholate and compositions and methods thereof
BR112018013227A2 (pt) ?composições farmacêuticas ou kit para o uso, métodos para tratar câncer em um mamífero e uso de uma composição?
WO2013148686A3 (en) Stable igg4 binding agent formulations
WO2015019304A3 (fr) Compositions à libération continue à base d'acide hyaluronique, et leurs applications thérapeutiques
BR112014030534A2 (pt) composições de galacto-ramnogalacturonato para o tratamento de doenças associadas com óxido nítrico sintase induzível elevada
WO2016140933A3 (en) Immediate release soluble ibuprofen compositions
RU2016112257A (ru) Композиция для лечения гипертензии и/или фиброза
WO2015106215A3 (en) Pharmaceutical compositions comprising 15-hepe and methods of treating asthma and lung disorders using same
BR112014027213A2 (pt) nova composição de alfentanil para o tratamento da dor aguda
BR112015019776A2 (pt) comprimidos de duplo uso oral em composições farmacêuticas de sais de sulfato e métodos de uso dos comprimidos
MX2017010277A (es) Cenicriviroc para el tratamiento de la fibrosis.

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]