HRP20180441T1 - Farmaceutski pripravci s hidratizirajućom i lubrikantnom aktivnošću - Google Patents
Farmaceutski pripravci s hidratizirajućom i lubrikantnom aktivnošću Download PDFInfo
- Publication number
- HRP20180441T1 HRP20180441T1 HRP20180441TT HRP20180441T HRP20180441T1 HR P20180441 T1 HRP20180441 T1 HR P20180441T1 HR P20180441T T HRP20180441T T HR P20180441TT HR P20180441 T HRP20180441 T HR P20180441T HR P20180441 T1 HRP20180441 T1 HR P20180441T1
- Authority
- HR
- Croatia
- Prior art keywords
- hyaluronic acid
- pharmaceutical preparations
- esterified
- treatment
- benzyl alcohol
- Prior art date
Links
- 230000000887 hydrating effect Effects 0.000 title 1
- 230000001050 lubricating effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims 15
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 12
- 229920002674 hyaluronan Polymers 0.000 claims 12
- 229960003160 hyaluronic acid Drugs 0.000 claims 12
- 239000000825 pharmaceutical preparation Substances 0.000 claims 9
- 208000004746 Atrophic Vaginitis Diseases 0.000 claims 6
- 206010003693 Atrophic vulvovaginitis Diseases 0.000 claims 6
- 206010047791 Vulvovaginal dryness Diseases 0.000 claims 6
- 201000010808 postmenopausal atrophic vaginitis Diseases 0.000 claims 6
- 235000019445 benzyl alcohol Nutrition 0.000 claims 5
- 241000195940 Bryophyta Species 0.000 claims 2
- 239000006260 foam Substances 0.000 claims 2
- 235000011929 mousse Nutrition 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 1
- 229920002807 Thiomer Polymers 0.000 claims 1
- 206010046914 Vaginal infection Diseases 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 229940031663 carbomer-974p Drugs 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000003599 detergent Substances 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 239000003349 gelling agent Substances 0.000 claims 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 239000003380 propellant Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/122—Foams; Dry foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (9)
1. Farmaceutski pripravci u obliku gela, globule, spemnika s aplikatorom, pjene, musa, koji sadrže hijaluronsku kiselinu, naznačeno time da je 50% karboksilnih skupina hijaluronske kiseline esterificirano benzilnim alkoholom, za lokalnu upotrebu u liječenju vaginalne suhoće i/ili atrofičnog vaginitisa.
2. Farmaceutski pripravci za upotrebu kako je prijavljeno u patentnom zahtjevu 1 naznačeno time da hijaluronska kiselina ima prosječnu molekulsku masu u rasponu između 100000 i 250000 Da, preferirano između 180000 i 230000 Da.
3. Farmaceutski pripravci za upotrebu kako je prijavljeno u patentnom zahtjevu 2, naznačeno time da hijaluronska kiselina 50% esterificirana benzilnim alkoholom ima koncentraciju u rasponu između 0.1 i 1%, preferirano između 0.2 i 5%, najpreferiranije 0.2% w/w.
4. Farmaceutski pripravci kako je prijavljeno u patentnim zahtjevima 1-3, za upotrebu u liječenju bakterijskih ili gljivičnih vaginalnih infekcija koje prate vaginalnu suhoću i/ili atrofični vaginitis.
5. Farmaceutski pripravci prema patentnom zahtjevu 1 u obliku gela za lokalnu upotrebu u liječenju vaginalne suhoće i/ili atrofičnog vaginitisa, koji sadrži hijaluronsku kiselinu 50% esterificiranu benzilnim alkoholom u koncentraciji 0.2% w/w, naznačeno time da polazna hijaluronska kiselina ima prosječnu molekulsku masu u rasponu između 180000 i 230000 Da te da dalje sadrži Carbomer 974P kao sredstvo za geliranje i farmaceutski prihvatljive ekscipijense.
6. Farmaceutski pripravci za upotrebu kako je prijavljeno u patentnom zahtjevu 5, ne sadrže parabenske konzervanse.
7. Farmaceutski pripravci prema patentnom zahtjevu 1 u obliku hidrofilnih vaginalnih globula za lokalnu upotrebu u liječenju vaginalne suhoće i/ili atrofičnog vaginitisa, koji sadrži hijaluronsku kiselinu 50% esterificiranu benzilnim alkoholom u koncentraciji 0.2% w/w, naznačeno time da polazna hijaluronska kiselina ima prosječnu molekulsku masu u rasponu između 180000 i 230000 Da, te da može sadržavati gelirajuće i mukoadhezivne polimere i dalje sadrži farmaceutski prihvatljive ekscipijense.
8. Farmaceutski pripravci prema patentnom zahtjevu 1 u obliku vaginalnih spemnika s aplikatorom za lokalnu upotrebu u liječenju vaginalne suhoće i/ili atrofičnog vaginitisa, koji sadrži hijaluronsku kiselinu 50% esterificiranu benzilnim alkoholom u koncentraciji 0.2% w/w, naznačeno time da polazna hijaluronska kiselina ima prosječnu molekulsku masu u rasponu između 180000 i 230000 Da, te da može sadržavati detergente.
9. Farmaceutski pripravci prema patentnom zahtjevu 1 u obliku pjena ili museva za lokalnu upotrebu u liječenju vaginalne suhoće i/ili atrofičnog vaginitisa, koji sadrži hijaluronsku kiselinu 50% esterificiranu benzilnim alkoholom u koncentraciji 0.2% w/w, naznačeno time da polazna hijaluronska kiselina ima prosječnu molekulsku masu u rasponu između 180000 i 230000 Da, te da može sadržavati propelante.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT001971A ITMI20131971A1 (it) | 2013-11-26 | 2013-11-26 | Composizioni farmaceutiche ad attività idratante e lubrificante |
| PCT/EP2014/074736 WO2015078713A1 (en) | 2013-11-26 | 2014-11-17 | Pharmaceutical compositions with hydrating and lubricating activity |
| EP14806555.0A EP3074023B1 (en) | 2013-11-26 | 2014-11-17 | Pharmaceutical compositions with hydrating and lubricating activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20180441T1 true HRP20180441T1 (hr) | 2018-04-20 |
Family
ID=49841735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20180441TT HRP20180441T1 (hr) | 2013-11-26 | 2018-03-15 | Farmaceutski pripravci s hidratizirajućom i lubrikantnom aktivnošću |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20170020913A1 (hr) |
| EP (1) | EP3074023B1 (hr) |
| KR (1) | KR102353716B1 (hr) |
| CA (1) | CA2931370C (hr) |
| EA (1) | EA031959B1 (hr) |
| ES (1) | ES2658047T3 (hr) |
| HR (1) | HRP20180441T1 (hr) |
| IL (1) | IL245811B (hr) |
| IT (1) | ITMI20131971A1 (hr) |
| MX (1) | MX363993B (hr) |
| SI (1) | SI3074023T1 (hr) |
| WO (1) | WO2015078713A1 (hr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITUB20160508A1 (it) * | 2016-01-22 | 2017-07-22 | Bios S R L Unipersonale | Dispositivo a radiofrequenza per la lassità e il rimodellamento vaginale |
| CN111194218B (zh) * | 2017-09-19 | 2024-02-20 | 香港科技大学 | 生物可相容材料以及用于制备和使用所述生物可相容材料的方法 |
| WO2019226548A1 (en) * | 2018-05-22 | 2019-11-28 | Weinberg Assa | Methods for prevention and treatment of urogenital atrophy of menopause by contact vasodilators |
| WO2020123312A1 (en) | 2018-12-09 | 2020-06-18 | Weinberg Assa | Method to prevent and treat macular degeneration by vasodilators |
| IT201900019762A1 (it) | 2019-10-24 | 2021-04-24 | Fidia Farm Spa | Composizione farmaceutica per uso nel trattamento della cistite di varia eziologia |
| EP4101437A4 (en) * | 2020-02-12 | 2023-05-10 | Shenzhen Eulikan Biotechnology Co., Ltd. | BACTERIOSTATIC COMPOSITION, METHOD FOR PREPARATION AND USE |
| IT202000004582A1 (it) * | 2020-03-06 | 2021-09-06 | Alfasigma Spa | Composizione farmaceutica utile per il trattamento e la prevenzione dell’atrofia e della secchezza vaginale. |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO169637C (no) | 1983-10-11 | 1992-07-22 | Fidia Spa | Fremgangsmaate for fremstilling av terapeutisk aktive hyaluronsyre-fraksjoner |
| US4851521A (en) | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
| JPH0649257B2 (ja) * | 1985-08-29 | 1994-06-29 | 豊田工機株式会社 | 手動ハンドルを備えた工作機械 |
| IT1254704B (it) | 1991-12-18 | 1995-10-09 | Mini Ricerca Scient Tecnolog | Tessuto non tessuto essenzialmente costituito da derivati dell'acido ialuronico |
| IT1259090B (it) * | 1992-04-17 | 1996-03-11 | Fidia Spa | Biomaterialli per protesi d'osso |
| US6824793B1 (en) * | 1998-06-01 | 2004-11-30 | Chiron Corporation | Use of hyaluronic acid polymers for mucosal delivery of vaccine antigens and adjuvants |
| IT1317359B1 (it) * | 2000-08-31 | 2003-06-16 | Fidia Advanced Biopolymers Srl | Polisaccaridi percarbossilati, quali l'acido ialuronico, processo perla loro preparazione e loro impiego in campo farmaceutico e |
| US7238677B2 (en) * | 2003-03-28 | 2007-07-03 | Kimberly-Clark Worldwide, Inc. | Prevention of urogenital infections |
| US20050095219A1 (en) * | 2003-10-29 | 2005-05-05 | Shu-Ping Yang | Compositions for promoting vaginal cell proliferation and maturation |
| US20050181057A1 (en) * | 2004-02-13 | 2005-08-18 | Rosenberg Paul K. | Vaginal lubricant |
| WO2006089561A1 (en) * | 2005-02-23 | 2006-08-31 | Abbas Abdelsalam Ghazi | Pharmaceutical compositions containing organic acids useful for softening and ripening uterine cervix. |
| ITMI20071724A1 (it) * | 2007-09-05 | 2009-03-06 | Fidia Farmaceutici | Formulazioni topiche antivirali in forma di gel bioadesivo |
| US8039024B2 (en) * | 2008-01-23 | 2011-10-18 | Apr Applied Pharma Research, S.A. | Device and composition for the delivery of a preservative-free balsamic cream |
| IT1402385B1 (it) | 2010-09-09 | 2013-09-04 | Fidia Farmaceutici | Processo per la produzione di acido ialuronico in escherichia coli o bacillus subtilis |
-
2013
- 2013-11-26 IT IT001971A patent/ITMI20131971A1/it unknown
-
2014
- 2014-11-17 US US15/038,924 patent/US20170020913A1/en not_active Abandoned
- 2014-11-17 CA CA2931370A patent/CA2931370C/en active Active
- 2014-11-17 SI SI201430623T patent/SI3074023T1/en unknown
- 2014-11-17 EP EP14806555.0A patent/EP3074023B1/en active Active
- 2014-11-17 WO PCT/EP2014/074736 patent/WO2015078713A1/en active Application Filing
- 2014-11-17 EA EA201690854A patent/EA031959B1/ru not_active IP Right Cessation
- 2014-11-17 KR KR1020167013794A patent/KR102353716B1/ko active IP Right Grant
- 2014-11-17 ES ES14806555.0T patent/ES2658047T3/es active Active
- 2014-11-17 MX MX2016006727A patent/MX363993B/es active IP Right Grant
-
2016
- 2016-05-24 IL IL245811A patent/IL245811B/en active IP Right Grant
-
2018
- 2018-03-15 HR HRP20180441TT patent/HRP20180441T1/hr unknown
-
2019
- 2019-10-04 US US16/593,616 patent/US11197886B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2931370C (en) | 2022-07-05 |
| EP3074023A1 (en) | 2016-10-05 |
| EP3074023B1 (en) | 2017-12-27 |
| MX2016006727A (es) | 2016-08-11 |
| US20200030365A1 (en) | 2020-01-30 |
| ITMI20131971A1 (it) | 2015-05-27 |
| SI3074023T1 (en) | 2018-04-30 |
| KR102353716B1 (ko) | 2022-01-20 |
| IL245811B (en) | 2019-03-31 |
| US20170020913A1 (en) | 2017-01-26 |
| KR20160100296A (ko) | 2016-08-23 |
| WO2015078713A1 (en) | 2015-06-04 |
| CA2931370A1 (en) | 2015-06-04 |
| IL245811A0 (en) | 2016-07-31 |
| MX363993B (es) | 2019-04-10 |
| EA201690854A1 (ru) | 2016-10-31 |
| ES2658047T3 (es) | 2018-03-08 |
| EA031959B1 (ru) | 2019-03-29 |
| US11197886B2 (en) | 2021-12-14 |
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