HRP20201506T1 - Uporaba kanabidiolne kiseline u liječenju epilepsije - Google Patents
Uporaba kanabidiolne kiseline u liječenju epilepsije Download PDFInfo
- Publication number
- HRP20201506T1 HRP20201506T1 HRP20201506TT HRP20201506T HRP20201506T1 HR P20201506 T1 HRP20201506 T1 HR P20201506T1 HR P20201506T T HRP20201506T T HR P20201506TT HR P20201506 T HRP20201506 T HR P20201506T HR P20201506 T1 HRP20201506 T1 HR P20201506T1
- Authority
- HR
- Croatia
- Prior art keywords
- cbda
- effective amount
- therapeutically effective
- use according
- epilepsy
- Prior art date
Links
- WVOLTBSCXRRQFR-DLBZAZTESA-N cannabidiolic acid Chemical compound OC1=C(C(O)=O)C(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)=C)CCC(C)=C1 WVOLTBSCXRRQFR-DLBZAZTESA-N 0.000 title claims 26
- 206010015037 epilepsy Diseases 0.000 title claims 5
- WVOLTBSCXRRQFR-SJORKVTESA-N Cannabidiolic acid Natural products OC1=C(C(O)=O)C(CCCCC)=CC(O)=C1[C@@H]1[C@@H](C(C)=C)CCC(C)=C1 WVOLTBSCXRRQFR-SJORKVTESA-N 0.000 title 1
- QHMBSVQNZZTUGM-UHFFFAOYSA-N Trans-Cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1C1C(C(C)=C)CCC(C)=C1 QHMBSVQNZZTUGM-UHFFFAOYSA-N 0.000 claims 4
- QHMBSVQNZZTUGM-ZWKOTPCHSA-N cannabidiol Chemical compound OC1=CC(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)=C)CCC(C)=C1 QHMBSVQNZZTUGM-ZWKOTPCHSA-N 0.000 claims 4
- 229950011318 cannabidiol Drugs 0.000 claims 4
- ZTGXAWYVTLUPDT-UHFFFAOYSA-N cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1C1C(C(C)=C)CC=C(C)C1 ZTGXAWYVTLUPDT-UHFFFAOYSA-N 0.000 claims 4
- PCXRACLQFPRCBB-ZWKOTPCHSA-N dihydrocannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)C)CCC(C)=C1 PCXRACLQFPRCBB-ZWKOTPCHSA-N 0.000 claims 4
- 241000218236 Cannabis Species 0.000 claims 2
- UCONUSSAWGCZMV-HZPDHXFCSA-N Delta(9)-tetrahydrocannabinolic acid Chemical compound C([C@H]1C(C)(C)O2)CC(C)=C[C@H]1C1=C2C=C(CCCCC)C(C(O)=O)=C1O UCONUSSAWGCZMV-HZPDHXFCSA-N 0.000 claims 2
- CYQFCXCEBYINGO-UHFFFAOYSA-N THC Natural products C1=C(C)CCC2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3C21 CYQFCXCEBYINGO-UHFFFAOYSA-N 0.000 claims 2
- 239000001961 anticonvulsive agent Substances 0.000 claims 2
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 claims 2
- 229960004242 dronabinol Drugs 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 206010010904 Convulsion Diseases 0.000 claims 1
- 241000792859 Enema Species 0.000 claims 1
- 208000003078 Generalized Epilepsy Diseases 0.000 claims 1
- 208000034308 Grand mal convulsion Diseases 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 229930003827 cannabinoid Natural products 0.000 claims 1
- 239000003557 cannabinoid Substances 0.000 claims 1
- 229940065144 cannabinoids Drugs 0.000 claims 1
- 239000007920 enema Substances 0.000 claims 1
- 229940095399 enema Drugs 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 201000001993 idiopathic generalized epilepsy Diseases 0.000 claims 1
- -1 inhaler Substances 0.000 claims 1
- 239000006193 liquid solution Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- 239000006200 vaporizer Substances 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (13)
1. Terapijski efikasna količina kanabidiolne kiseline (CBDA) za uporabu u liječenju epilepsije, naznačena time što je CBDA u obliku visoko pročišćenog ekstrakta kanabisa, tako da je CBDA prisutna u više od 98% ukupnog ekstrakta (tež./tež.) ili je proizvedena sintetički.
2. Terapijski efikasna količina CBDA za uporabu prema patentnom zahtjevu 1, naznačena time što je epilepsija generalizirana epilepsija.
3. Terapijski efikasna količina CBDA za uporabu prema patentnom zahtjevu 1 ili patentnom zahtjevu 2, naznačena time što epilepsiju karakteriziraju toničko-klonički napadaji.
4. Terapijski efikasna količina CBDA za uporabu prema bilo kojem od prethodnih patentnih zahtjeva, naznačena time što je terapijski efikasna količina najmanje 0,1 mg.
5. Terapijski efikasna količina CBDA za uporabu prema patentnom zahtjevu 1, naznačena time što visoko pročišćeni ekstrakt sadrži manje od 1% (tež./tež.) tetrahidrokanabinola (THC) ili tetrahidrokanabinolne kiseline (THCA).
6. Terapijski efikasna količina CBDA za uporabu prema bilo kojem od prethodnih patentnih zahtjeva, naznačena time što se CBDA koristi istovremeno sa jednim ili više drugih kanabinoida.
7. Terapijski efikasna količina CBDA za uporabu prema patentnom zahtjevu 6, naznačena time što se CBDA koristi sa kanabidiolom (CBD).
8. Terapijski efikasna količina CBDA za uporabu prema patentnom zahtjevu 7, naznačena time što je odnos CBDA: CBD u opsegu od 9:1 do 1:9 (CBDA: CBD).
9. Terapijski efikasna količina CBDA za uporabu prema bilo kojem od prethodnih patentnih zahtjeva, naznačena time što se CBDA koristi istovremeno sa jednim ili više drugih antiepileptičkih lijekova (AED).
10. Terapijski efikasna količina CBDA za uporabu prema bilo kojem od prethodnih patentnih zahtjeva, naznačena time što se CBDA koristi u dozi manjoj od 400 mg.
11. Terapijski efikasna količina CBDA za uporabu prema patentnom zahtjevu 10, naznačena time što se CBDA koristi u dozi od 1 mg do 100 mg.
12. Pripravak za uporabu u liječenju epilepsije koji sadrži terapijski efikasnu količinu kanabidiolne kiseline (CBDA), i jedan ili više farmaceutski prihvatljivih ekscipijenata, naznačena time što je CBDA u obliku visoko pročišćenog ekstrakta kanabisa, tako da je CBDA prisutna u više od 98% ukupnog ekstrakta (tež./tež.) ili je proizvedena sintetički.
13. Pripravak za uporabu prema patentnom zahtjevu 12, koji je formuliran za dostavu u vidu oralne tekuće otopine, čvrste supstance, polu-čvrste supstance, gela, spreja, aerosola, inhalatora, isparivača, klistira ili čepića.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1514079.1A GB2541191A (en) | 2015-08-10 | 2015-08-10 | Use of cannabinoids in the treatment of epilepsy |
| PCT/GB2016/052340 WO2017025712A1 (en) | 2015-08-10 | 2016-07-29 | Use of cannabinoids in the treatment of epilepsy |
| EP16747593.8A EP3334422B1 (en) | 2015-08-10 | 2016-07-29 | Use of cannabidiolic acid in the treatment of epilepsy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20201506T1 true HRP20201506T1 (hr) | 2021-02-05 |
Family
ID=54200465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20201506TT HRP20201506T1 (hr) | 2015-08-10 | 2020-09-21 | Uporaba kanabidiolne kiseline u liječenju epilepsije |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US11147783B2 (hr) |
| EP (2) | EP3769755B1 (hr) |
| JP (2) | JP6949822B2 (hr) |
| AU (1) | AU2016305545B2 (hr) |
| CA (1) | CA2992802C (hr) |
| CY (1) | CY1123351T1 (hr) |
| DK (1) | DK3334422T3 (hr) |
| ES (1) | ES2820333T3 (hr) |
| GB (1) | GB2541191A (hr) |
| HR (1) | HRP20201506T1 (hr) |
| HU (1) | HUE051476T2 (hr) |
| LT (1) | LT3334422T (hr) |
| MX (2) | MX2018001472A (hr) |
| PL (1) | PL3334422T3 (hr) |
| PT (1) | PT3334422T (hr) |
| RS (1) | RS60852B1 (hr) |
| SI (1) | SI3334422T1 (hr) |
| WO (1) | WO2017025712A1 (hr) |
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| GB2531278A (en) | 2014-10-14 | 2016-04-20 | Gw Pharma Ltd | Use of cannabidiol in the treatment of intractable epilepsy |
| GB2531282A (en) | 2014-10-14 | 2016-04-20 | Gw Pharma Ltd | Use of cannabinoids in the treatment of epilepsy |
| GB2539472A (en) | 2015-06-17 | 2016-12-21 | Gw Res Ltd | Use of cannabinoids in the treatment of epilepsy |
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| GB2548873B (en) | 2016-03-31 | 2020-12-02 | Gw Res Ltd | Use of Cannabidiol in the Treatment of SturgeWeber Syndrome |
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| GB2541191A (en) | 2017-02-15 |
| SI3334422T1 (sl) | 2020-11-30 |
| CY1123351T1 (el) | 2021-12-31 |
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