HRP20180885T1 - Supstituirani policiklički derivat karbamoilpiridona - Google Patents

Supstituirani policiklički derivat karbamoilpiridona

Info

Publication number
HRP20180885T1
HRP20180885T1 HRP20180885TT HRP20180885T HRP20180885T1 HR P20180885 T1 HRP20180885 T1 HR P20180885T1 HR P20180885T T HRP20180885T T HR P20180885TT HR P20180885 T HRP20180885 T HR P20180885T HR P20180885 T1 HRP20180885 T1 HR P20180885T1
Authority
HR
Croatia
Prior art keywords
substituted polycyclic
polycyclic carbamoylpyridone
carbamoylpyridone derivative
derivative
substituted
Prior art date
Application number
HRP20180885TT
Other languages
English (en)
Inventor
Toshiyuki Akiyama
Kenji Takaya
Makoto Kawai
Yoshiyuki Taoda
Minako Mikamiyama
Kenji Morimoto
Chika Kageyama
Kenji Tomita
Hidenori Mikamiyama
Naoyuki Suzuki
Original Assignee
Shionogi & Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43356386&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20180885(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Shionogi & Co., Ltd. filed Critical Shionogi & Co., Ltd.
Publication of HRP20180885T1 publication Critical patent/HRP20180885T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Coloring (AREA)
  • Plural Heterocyclic Compounds (AREA)
HRP20180885TT 2009-06-15 2018-06-05 Supstituirani policiklički derivat karbamoilpiridona HRP20180885T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2009142166 2009-06-15
EP10789443.8A EP2444400B1 (en) 2009-06-15 2010-06-14 Substituted polycyclic carbamoylpyridone derivative
PCT/JP2010/060006 WO2010147068A1 (ja) 2009-06-15 2010-06-14 置換された多環性カルバモイルピリドン誘導体

Publications (1)

Publication Number Publication Date
HRP20180885T1 true HRP20180885T1 (hr) 2018-07-13

Family

ID=43356386

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20180885TT HRP20180885T1 (hr) 2009-06-15 2018-06-05 Supstituirani policiklički derivat karbamoilpiridona

Country Status (16)

Country Link
US (3) US8927710B2 (hr)
EP (1) EP2444400B1 (hr)
JP (2) JP5737691B2 (hr)
CN (1) CN102803260B (hr)
DK (1) DK2444400T3 (hr)
ES (1) ES2671550T3 (hr)
HR (1) HRP20180885T1 (hr)
HU (1) HUE038837T2 (hr)
LT (1) LT2444400T (hr)
PL (1) PL2444400T3 (hr)
PT (1) PT2444400T (hr)
RS (1) RS57244B1 (hr)
SI (1) SI2444400T1 (hr)
TR (1) TR201808501T4 (hr)
TW (1) TWI520959B (hr)
WO (1) WO2010147068A1 (hr)

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TWI518084B (zh) * 2009-03-26 2016-01-21 鹽野義製藥股份有限公司 哌喃酮與吡啶酮衍生物之製造方法
WO2010147068A1 (ja) * 2009-06-15 2010-12-23 塩野義製薬株式会社 置換された多環性カルバモイルピリドン誘導体
MX2013003139A (es) * 2010-09-24 2013-06-18 Shionogi & Co Profarmaco de derivado de carbamoilpiridona policiclica substituida.
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ES2926068T3 (es) 2012-12-21 2022-10-21 Gilead Sciences Inc Compuestos de carbamoilpiridona policíclicos y su uso farmacéutico
US9045486B2 (en) 2013-01-08 2015-06-02 Savira Pharmaceuticals Gmbh Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
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TWI677489B (zh) 2014-06-20 2019-11-21 美商基利科學股份有限公司 多環型胺甲醯基吡啶酮化合物之合成
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US10730888B2 (en) * 2015-02-06 2020-08-04 Mylan Laboratories Limited Process for the preparation of dolutegravir
CN107531717B (zh) * 2015-03-11 2021-07-27 詹森生物制药有限公司 氮杂-吡啶酮化合物及其用途
LT3428170T (lt) * 2015-04-28 2021-02-10 Shionogi & Co., Ltd Policiklinis piridono darinys nuo gripo ir jo provaistas
CN113004304B (zh) 2015-04-28 2022-03-18 盐野义制药株式会社 经取代的多环性吡啶酮衍生物及其前药
US9988390B2 (en) 2015-10-30 2018-06-05 F. Hoffmann-La Roche Ag Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
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WO2017109088A1 (en) 2015-12-23 2017-06-29 Savira Pharmaceuticals Gmbh Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
JP6806413B2 (ja) * 2016-02-03 2021-01-06 塩野義製薬株式会社 多環性ピリドン誘導体およびそのプロドラッグ
JP6918819B2 (ja) * 2016-03-08 2021-08-11 ノバルティス アーゲー オルトミクソウイルス感染の処置に有用な三環式化合物
WO2017158151A1 (en) 2016-03-18 2017-09-21 Savira Pharmaceuticals Gmbh Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
WO2017158147A1 (en) 2016-03-18 2017-09-21 Savira Pharmaceuticals Gmbh Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
HRP20221540T1 (hr) * 2016-06-20 2023-03-03 Shionogi & Co., Ltd. Postupak za proizvodnju supstituiranog derivata policikličkog piridona i njegovog kristala
WO2018030463A1 (ja) * 2016-08-10 2018-02-15 塩野義製薬株式会社 置換された多環性ピリドン誘導体およびそのプロドラッグを含有する医薬組成物
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SG11202002789XA (en) 2017-10-06 2020-04-29 Shionogi & Co Stereoselective process for preparing substituted polycyclic pyridone derivatives
CN111848614B (zh) * 2018-01-17 2021-11-23 江西彩石医药科技有限公司 吡啶酮衍生物及抗流感病毒药物组合物
CN109503625A (zh) * 2018-01-19 2019-03-22 赵蕾 一种多环吡啶酮化合物及其药物组合和用途
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CN110357850A (zh) * 2018-03-26 2019-10-22 广东东阳光药业有限公司 一种含硫杂环化合物的制备方法
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WO2020015669A1 (zh) * 2018-07-17 2020-01-23 南京明德新药研发有限公司 抗流感病毒三并环衍生物
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CN111410661B (zh) * 2019-01-04 2023-05-05 周雨恬 帽依赖性内切核酸酶抑制剂及其用途
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CN115135646B (zh) * 2019-12-23 2024-05-17 石家庄迪斯凯威医药科技有限公司 取代的多环化合物及其药物组合物和用途
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Also Published As

Publication number Publication date
HUE038837T2 (hu) 2018-11-28
EP2444400A4 (en) 2014-12-24
PL2444400T3 (pl) 2018-08-31
WO2010147068A1 (ja) 2010-12-23
JPWO2010147068A1 (ja) 2012-12-06
US9469638B2 (en) 2016-10-18
JP5737691B2 (ja) 2015-06-17
DK2444400T3 (en) 2018-06-18
US20120184734A1 (en) 2012-07-19
US20160368921A1 (en) 2016-12-22
RS57244B1 (sr) 2018-07-31
US8927710B2 (en) 2015-01-06
EP2444400A1 (en) 2012-04-25
JP2015145409A (ja) 2015-08-13
ES2671550T3 (es) 2018-06-07
US9815835B2 (en) 2017-11-14
EP2444400B1 (en) 2018-03-28
CN102803260A (zh) 2012-11-28
US20150065485A1 (en) 2015-03-05
TR201808501T4 (tr) 2018-07-23
SI2444400T1 (en) 2018-06-29
TW201103934A (en) 2011-02-01
LT2444400T (lt) 2018-06-11
TWI520959B (zh) 2016-02-11
PT2444400T (pt) 2018-06-06
JP6004552B2 (ja) 2016-10-12
CN102803260B (zh) 2016-02-10

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