RS57244B1 - Supstituisani policiklički derivati karbamoilpiridona - Google Patents

Supstituisani policiklički derivati karbamoilpiridona

Info

Publication number
RS57244B1
RS57244B1 RS20180596A RSP20180596A RS57244B1 RS 57244 B1 RS57244 B1 RS 57244B1 RS 20180596 A RS20180596 A RS 20180596A RS P20180596 A RSP20180596 A RS P20180596A RS 57244 B1 RS57244 B1 RS 57244B1
Authority
RS
Serbia
Prior art keywords
substituted polycyclic
polycyclic carbamoylpyridone
carbamoylpyridone derivative
derivative
substituted
Prior art date
Application number
RS20180596A
Other languages
English (en)
Inventor
Toshiyuki Akiyama
Kenji Takaya
Makoto Kawai
Yoshiyuki Taoda
Minako Mikamiyama
Kenji Morimoto
Chika Kageyama
Kenji Tomita
Hidenori Mikamiyama
Naoyuki Suzuki
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43356386&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RS57244(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of RS57244B1 publication Critical patent/RS57244B1/sr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Coloring (AREA)
RS20180596A 2009-06-15 2010-06-14 Supstituisani policiklički derivati karbamoilpiridona RS57244B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2009142166 2009-06-15
EP10789443.8A EP2444400B1 (en) 2009-06-15 2010-06-14 Substituted polycyclic carbamoylpyridone derivative
PCT/JP2010/060006 WO2010147068A1 (ja) 2009-06-15 2010-06-14 置換された多環性カルバモイルピリドン誘導体

Publications (1)

Publication Number Publication Date
RS57244B1 true RS57244B1 (sr) 2018-07-31

Family

ID=43356386

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20180596A RS57244B1 (sr) 2009-06-15 2010-06-14 Supstituisani policiklički derivati karbamoilpiridona

Country Status (16)

Country Link
US (3) US8927710B2 (sr)
EP (1) EP2444400B1 (sr)
JP (2) JP5737691B2 (sr)
CN (1) CN102803260B (sr)
DK (1) DK2444400T3 (sr)
ES (1) ES2671550T3 (sr)
HR (1) HRP20180885T1 (sr)
HU (1) HUE038837T2 (sr)
LT (1) LT2444400T (sr)
PL (1) PL2444400T3 (sr)
PT (1) PT2444400T (sr)
RS (1) RS57244B1 (sr)
SI (1) SI2444400T1 (sr)
TR (1) TR201808501T4 (sr)
TW (1) TWI520959B (sr)
WO (1) WO2010147068A1 (sr)

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TWI518084B (zh) * 2009-03-26 2016-01-21 鹽野義製藥股份有限公司 哌喃酮與吡啶酮衍生物之製造方法
PT2444400T (pt) * 2009-06-15 2018-06-06 Shionogi & Co Derivado de carbamoilpiridona policíclico substituído
SI2620436T1 (en) 2010-09-24 2018-08-31 Shionogi & Co., Ltd. A prodrug substituted polycyclic carbamoyl pyridone derivative
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US9200009B2 (en) 2011-10-12 2015-12-01 Shionogi & Co., Ltd. Polycyclic pyridone derivative having integrase inhibitory activity
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CA2894642A1 (en) 2013-01-08 2014-07-17 Savira Pharmaceuticals Gmbh Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
NO2865735T3 (sr) 2013-07-12 2018-07-21
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DK3030549T3 (da) 2013-09-12 2019-05-13 Janssen Biopharma Inc Pyridazinonforbindelser og anvendelser deraf
TWI744723B (zh) 2014-06-20 2021-11-01 美商基利科學股份有限公司 多環型胺甲醯基吡啶酮化合物之合成
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JP2017521423A (ja) * 2014-07-07 2017-08-03 ザヴィラ ファーマシューティカルズ ゲーエムベーハー ピリドピラジン化合物及びインフルエンザの治療、改善又は予防におけるそれらの使用
EP3196201B1 (en) 2014-08-22 2021-04-28 Shionogi & Co., Ltd. Polycyclic pyridone derivative having integrase-inhibiting activity
EP3253767A2 (en) * 2015-02-06 2017-12-13 Mylan Laboratories Ltd. Processes for the preparation of dolute-gravir
EP3268368A4 (en) * 2015-03-11 2018-11-14 Alios Biopharma, Inc. Aza-pyridone compounds and uses thereof
CA2984130C (en) * 2015-04-28 2021-07-20 Shionogi & Co., Ltd. Substituted polycyclic pyridone derivative and prodrug thereof
HRP20230215T1 (hr) * 2015-04-28 2023-04-14 Shionogi & Co., Ltd. Supstituirani policiklički derivati piridona i njihov predlijek
WO2017072341A1 (en) 2015-10-30 2017-05-04 F. Hoffmann-La Roche Ag Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
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WO2017109088A1 (en) 2015-12-23 2017-06-29 Savira Pharmaceuticals Gmbh Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
JP6806413B2 (ja) * 2016-02-03 2021-01-06 塩野義製薬株式会社 多環性ピリドン誘導体およびそのプロドラッグ
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WO2017158151A1 (en) 2016-03-18 2017-09-21 Savira Pharmaceuticals Gmbh Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
WO2017158147A1 (en) 2016-03-18 2017-09-21 Savira Pharmaceuticals Gmbh Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
SG11201810655QA (en) 2016-06-20 2019-01-30 Shionogi & Co Method for producing substituted polycyclic pyridone derivative and crystal of same
CN110494141A (zh) 2016-08-10 2019-11-22 盐野义制药株式会社 含有被取代的多环性吡啶酮衍生物及其前药的药物组合物
JOP20170169A1 (ar) 2016-08-29 2019-01-30 Novartis Ag مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو
AU2018331172B2 (en) * 2017-09-18 2022-12-01 Sunshine Lake Pharma Co., Ltd. Influenza virus replication inhibitor and use thereof
CA3078442A1 (en) 2017-10-06 2019-04-11 Shionogi & Co., Ltd. Stereoselective process for preparing substituted polycyclic pyridone derivatives
SG11202011447UA (en) 2018-01-17 2020-12-30 Jiangxi Caishi Pharmaceutical Technology Co Ltd Pyridone derivative, composition and use as antiviral drug thereof
CN109503625A (zh) * 2018-01-19 2019-03-22 赵蕾 一种多环吡啶酮化合物及其药物组合和用途
US10596171B2 (en) * 2018-01-22 2020-03-24 Taigen Biotechnology Co., Ltd. Cap-dependent endonuclease inhibitors
CR20200372A (es) * 2018-02-28 2020-10-26 Novartis Ag Derivados de 10-(di(fenil)metil)-4-hidroxi8,9,9a,10-tetrahidro-7h-pirrolo (1`, 2`:4-5) pirazino (1,2-b) piridazina-3, 5-diona y compuestos relacionados como inhibidores de la replicación del ortomixo virus para el tratamiento de la influenza
CN110357850A (zh) * 2018-03-26 2019-10-22 广东东阳光药业有限公司 一种含硫杂环化合物的制备方法
EP3815689A4 (en) 2018-06-27 2022-04-20 National University Corporation Hokkaido University ARENAVIRUS GROWTH INHIBITOR COMPRISING A POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE
WO2020015669A1 (zh) * 2018-07-17 2020-01-23 南京明德新药研发有限公司 抗流感病毒三并环衍生物
WO2020055858A1 (en) * 2018-09-10 2020-03-19 Cocrystal Pharma, Inc. Pyridopyrazine and pyridotriazine inhibitors of influenza virus replication
CN113195502A (zh) * 2018-10-10 2021-07-30 詹森生物制药有限公司 大环流感内切核酸酶抑制剂
CN111410661B (zh) * 2019-01-04 2023-05-05 周雨恬 帽依赖性内切核酸酶抑制剂及其用途
KR20210137140A (ko) 2019-03-12 2021-11-17 시오노기 앤드 컴파니, 리미티드 인플루엔자 및 합병증 위험 인자를 갖는 대상체에서 치환된 폴리사이클릭 피리돈 유도체 및 그의 전구약물을 사용한 인플루엔자 치료
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Also Published As

Publication number Publication date
EP2444400A4 (en) 2014-12-24
HUE038837T2 (hu) 2018-11-28
SI2444400T1 (en) 2018-06-29
US20120184734A1 (en) 2012-07-19
US9469638B2 (en) 2016-10-18
PT2444400T (pt) 2018-06-06
EP2444400A1 (en) 2012-04-25
EP2444400B1 (en) 2018-03-28
HRP20180885T1 (hr) 2018-07-13
JP5737691B2 (ja) 2015-06-17
LT2444400T (lt) 2018-06-11
TWI520959B (zh) 2016-02-11
CN102803260B (zh) 2016-02-10
JP6004552B2 (ja) 2016-10-12
WO2010147068A1 (ja) 2010-12-23
US9815835B2 (en) 2017-11-14
ES2671550T3 (es) 2018-06-07
TW201103934A (en) 2011-02-01
CN102803260A (zh) 2012-11-28
TR201808501T4 (tr) 2018-07-23
US20150065485A1 (en) 2015-03-05
US20160368921A1 (en) 2016-12-22
PL2444400T3 (pl) 2018-08-31
JPWO2010147068A1 (ja) 2012-12-06
US8927710B2 (en) 2015-01-06
JP2015145409A (ja) 2015-08-13
DK2444400T3 (en) 2018-06-18

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