TR201808501T4 - Sübstitüe polisiklik karbamoilpiridon türevi. - Google Patents

Sübstitüe polisiklik karbamoilpiridon türevi. Download PDF

Info

Publication number
TR201808501T4
TR201808501T4 TR2018/08501T TR201808501T TR201808501T4 TR 201808501 T4 TR201808501 T4 TR 201808501T4 TR 2018/08501 T TR2018/08501 T TR 2018/08501T TR 201808501 T TR201808501 T TR 201808501T TR 201808501 T4 TR201808501 T4 TR 201808501T4
Authority
TR
Turkey
Prior art keywords
substituted polycyclic
polycyclic carbamoylpyridone
carbamoylpyridone derivative
substituted
present
Prior art date
Application number
TR2018/08501T
Other languages
English (en)
Inventor
Akiyama Toshiyuki
Takaya Kenji
Kawai Makoto
Taoda Yoshiyuki
Mikamiyama Minako
Morimoto Kenji
Kageyama Chika
Tomita Kenji
Mikamiyama Hidenori
Suzuki Naoyuki
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43356386&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR201808501(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of TR201808501T4 publication Critical patent/TR201808501T4/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Coloring (AREA)

Abstract

Bu buluş, antiviral aktivitelere, özellikle de influenza virüsünü inhibe etme aktivitesine sahip bileşikler sunar; daha çok tercihen, bu buluş, cap-bağımlı endonükleaz inhibe edici aktiviteye sahip sübstitüe ikame edilmiş 3-hidroksi-4-piridon türevleri sunar.
TR2018/08501T 2009-06-15 2010-06-14 Sübstitüe polisiklik karbamoilpiridon türevi. TR201808501T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2009142166 2009-06-15

Publications (1)

Publication Number Publication Date
TR201808501T4 true TR201808501T4 (tr) 2018-07-23

Family

ID=43356386

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2018/08501T TR201808501T4 (tr) 2009-06-15 2010-06-14 Sübstitüe polisiklik karbamoilpiridon türevi.

Country Status (16)

Country Link
US (3) US8927710B2 (tr)
EP (1) EP2444400B1 (tr)
JP (2) JP5737691B2 (tr)
CN (1) CN102803260B (tr)
DK (1) DK2444400T3 (tr)
ES (1) ES2671550T3 (tr)
HR (1) HRP20180885T1 (tr)
HU (1) HUE038837T2 (tr)
LT (1) LT2444400T (tr)
PL (1) PL2444400T3 (tr)
PT (1) PT2444400T (tr)
RS (1) RS57244B1 (tr)
SI (1) SI2444400T1 (tr)
TR (1) TR201808501T4 (tr)
TW (1) TWI520959B (tr)
WO (1) WO2010147068A1 (tr)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI518084B (zh) * 2009-03-26 2016-01-21 鹽野義製藥股份有限公司 哌喃酮與吡啶酮衍生物之製造方法
PT2444400T (pt) * 2009-06-15 2018-06-06 Shionogi & Co Derivado de carbamoilpiridona policíclico substituído
SI2620436T1 (en) 2010-09-24 2018-08-31 Shionogi & Co., Ltd. A prodrug substituted polycyclic carbamoyl pyridone derivative
GB2487355B (en) 2011-01-13 2020-03-25 Advanced Risc Mach Ltd Processing apparatus, trace unit and diagnostic apparatus
US9200009B2 (en) 2011-10-12 2015-12-01 Shionogi & Co., Ltd. Polycyclic pyridone derivative having integrase inhibitory activity
KR102527797B1 (ko) 2012-12-21 2023-05-03 길리애드 사이언시즈, 인코포레이티드 폴리시클릭-카르바모일피리돈 화합물 및 그의 제약 용도
CA2894642A1 (en) 2013-01-08 2014-07-17 Savira Pharmaceuticals Gmbh Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
NO2865735T3 (tr) 2013-07-12 2018-07-21
PE20160661A1 (es) 2013-09-12 2016-08-05 Alios Biopharma Inc Compuesto de azapiridona y sus usos de los mismos
DK3030549T3 (da) 2013-09-12 2019-05-13 Janssen Biopharma Inc Pyridazinonforbindelser og anvendelser deraf
TWI744723B (zh) 2014-06-20 2021-11-01 美商基利科學股份有限公司 多環型胺甲醯基吡啶酮化合物之合成
NO2717902T3 (tr) 2014-06-20 2018-06-23
TW201613936A (en) 2014-06-20 2016-04-16 Gilead Sciences Inc Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
JP2017521423A (ja) * 2014-07-07 2017-08-03 ザヴィラ ファーマシューティカルズ ゲーエムベーハー ピリドピラジン化合物及びインフルエンザの治療、改善又は予防におけるそれらの使用
EP3196201B1 (en) 2014-08-22 2021-04-28 Shionogi & Co., Ltd. Polycyclic pyridone derivative having integrase-inhibiting activity
EP3253767A2 (en) * 2015-02-06 2017-12-13 Mylan Laboratories Ltd. Processes for the preparation of dolute-gravir
EP3268368A4 (en) * 2015-03-11 2018-11-14 Alios Biopharma, Inc. Aza-pyridone compounds and uses thereof
CA2984130C (en) * 2015-04-28 2021-07-20 Shionogi & Co., Ltd. Substituted polycyclic pyridone derivative and prodrug thereof
HRP20230215T1 (hr) * 2015-04-28 2023-04-14 Shionogi & Co., Ltd. Supstituirani policiklički derivati piridona i njihov predlijek
WO2017072341A1 (en) 2015-10-30 2017-05-04 F. Hoffmann-La Roche Ag Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
SG11201804348SA (en) 2015-12-15 2018-06-28 Shionogi & Co Medicine for treating influenza characterized by comprising combination of cap-dependent endonuclease inhibitor with anti-influenza drug
WO2017109088A1 (en) 2015-12-23 2017-06-29 Savira Pharmaceuticals Gmbh Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
JP6806413B2 (ja) * 2016-02-03 2021-01-06 塩野義製薬株式会社 多環性ピリドン誘導体およびそのプロドラッグ
US10858366B2 (en) 2016-03-08 2020-12-08 Novartis Ag Tricyclic compounds useful to treat orthomyxovirus infections
WO2017158151A1 (en) 2016-03-18 2017-09-21 Savira Pharmaceuticals Gmbh Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
WO2017158147A1 (en) 2016-03-18 2017-09-21 Savira Pharmaceuticals Gmbh Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
SG11201810655QA (en) 2016-06-20 2019-01-30 Shionogi & Co Method for producing substituted polycyclic pyridone derivative and crystal of same
CN110494141A (zh) 2016-08-10 2019-11-22 盐野义制药株式会社 含有被取代的多环性吡啶酮衍生物及其前药的药物组合物
JOP20170169A1 (ar) 2016-08-29 2019-01-30 Novartis Ag مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو
AU2018331172B2 (en) * 2017-09-18 2022-12-01 Sunshine Lake Pharma Co., Ltd. Influenza virus replication inhibitor and use thereof
CA3078442A1 (en) 2017-10-06 2019-04-11 Shionogi & Co., Ltd. Stereoselective process for preparing substituted polycyclic pyridone derivatives
SG11202011447UA (en) 2018-01-17 2020-12-30 Jiangxi Caishi Pharmaceutical Technology Co Ltd Pyridone derivative, composition and use as antiviral drug thereof
CN109503625A (zh) * 2018-01-19 2019-03-22 赵蕾 一种多环吡啶酮化合物及其药物组合和用途
US10596171B2 (en) * 2018-01-22 2020-03-24 Taigen Biotechnology Co., Ltd. Cap-dependent endonuclease inhibitors
CR20200372A (es) * 2018-02-28 2020-10-26 Novartis Ag Derivados de 10-(di(fenil)metil)-4-hidroxi8,9,9a,10-tetrahidro-7h-pirrolo (1`, 2`:4-5) pirazino (1,2-b) piridazina-3, 5-diona y compuestos relacionados como inhibidores de la replicación del ortomixo virus para el tratamiento de la influenza
CN110357850A (zh) * 2018-03-26 2019-10-22 广东东阳光药业有限公司 一种含硫杂环化合物的制备方法
EP3815689A4 (en) 2018-06-27 2022-04-20 National University Corporation Hokkaido University ARENAVIRUS GROWTH INHIBITOR COMPRISING A POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE
WO2020015669A1 (zh) * 2018-07-17 2020-01-23 南京明德新药研发有限公司 抗流感病毒三并环衍生物
WO2020055858A1 (en) * 2018-09-10 2020-03-19 Cocrystal Pharma, Inc. Pyridopyrazine and pyridotriazine inhibitors of influenza virus replication
CN113195502A (zh) * 2018-10-10 2021-07-30 詹森生物制药有限公司 大环流感内切核酸酶抑制剂
CN111410661B (zh) * 2019-01-04 2023-05-05 周雨恬 帽依赖性内切核酸酶抑制剂及其用途
KR20210137140A (ko) 2019-03-12 2021-11-17 시오노기 앤드 컴파니, 리미티드 인플루엔자 및 합병증 위험 인자를 갖는 대상체에서 치환된 폴리사이클릭 피리돈 유도체 및 그의 전구약물을 사용한 인플루엔자 치료
EP4122537A1 (en) 2019-03-22 2023-01-25 Gilead Sciences, Inc. Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use
EP3714889A1 (en) 2019-03-29 2020-09-30 F. Hoffmann-La Roche AG Baloxavir for the prevention of transmission of influenza virus
CN111909174B (zh) * 2019-05-08 2022-01-21 江西彩石医药科技有限公司 吡啶酮衍生物的晶型及制备方法和应用
CN112174955B (zh) * 2019-07-05 2023-01-13 广州南鑫药业有限公司 一种2-取代-5-六氢哒嗪酮-4-羧酸胺衍生物及其用途
CN112174956B (zh) * 2019-07-05 2023-01-13 广州南鑫药业有限公司 一种2-取代-5-六氢哒嗪酮-4-羧酸酯衍生物及其用途
CN112521386B (zh) * 2019-09-19 2023-05-26 周雨恬 具有抗病毒作用的多环吡啶酮化合物及其药物组合和用途
CN115135646B (zh) * 2019-12-23 2024-05-17 石家庄迪斯凯威医药科技有限公司 取代的多环化合物及其药物组合物和用途
US11697652B2 (en) 2020-02-24 2023-07-11 Gilead Sciences, Inc. Tetracyclic compounds and uses thereof
TW202146413A (zh) * 2020-06-12 2021-12-16 大陸商上海翰森生物醫藥科技有限公司 含吡啶酮稠環類衍生物抑制劑、其製備方法和應用
CN112062763B (zh) * 2020-09-10 2021-11-05 浙江大学 羟基吡啶酮并[1,2-b][1,2,5]三氮卓平衍生物及制备和应用
WO2022105669A1 (zh) * 2020-11-17 2022-05-27 南京明德新药研发有限公司 含Se大环类化合物
WO2022159387A1 (en) 2021-01-19 2022-07-28 Gilead Sciences, Inc. Substituted pyridotriazine compounds and uses thereof
CN118056834A (zh) * 2022-11-21 2024-05-21 合肥医工医药股份有限公司 稠环吡啶酮衍生物及其制备方法和用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2280435A (en) 1993-07-29 1995-02-01 Merck & Co Inc Anti-viral agent
US5475109A (en) 1994-10-17 1995-12-12 Merck & Co., Inc. Dioxobutanoic acid derivatives as inhibitors of influenza endonuclease
AU2003267098B2 (en) * 2002-09-11 2008-11-20 Merck & Co., Inc. Dihydroxypyridopyrazine-1,6-dione compounds useful as HIV integrase inhibitors
TW200510425A (en) 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
WO2005087766A1 (en) * 2004-03-09 2005-09-22 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Hiv integrase inhibitors
AU2005227258A1 (en) 2004-03-09 2005-10-06 Merck & Co., Inc. HIV integrase inhibitors
CA2634499A1 (en) 2004-12-23 2006-06-29 Virochem Pharma Inc. Hydroxydihydropyridopy razine-1,8-diones and methods for inhibiting hiv integrase
EP1852434B1 (en) 2005-02-21 2011-07-13 Shionogi Co., Ltd. Bicyclic carbamoylpyridone derivative having hiv integrase inhibiting activity
WO2006116764A1 (en) * 2005-04-28 2006-11-02 Smithkline Beecham Corporation Polycyclic carbamoylpyridone derivative having hiv integrase inhibitory activity
UA96568C2 (en) * 2005-04-28 2011-11-25 Глаксосмиткляйн Ллк Polycyclic carbamoyl pyridone derivative as hiv-integrase inhibitor
CA2626956A1 (en) * 2005-10-27 2007-05-03 Shionogi & Co., Ltd. Polycyclic carbamoylpyridone derivative having hiv integrase inhibitory activity
CN101346376A (zh) * 2005-10-27 2009-01-14 盐野义制药株式会社 具有hiv整合酶抑制活性的多环性氨基甲酰基吡啶酮衍生物
PT2444400T (pt) * 2009-06-15 2018-06-06 Shionogi & Co Derivado de carbamoilpiridona policíclico substituído
SI2620436T1 (en) * 2010-09-24 2018-08-31 Shionogi & Co., Ltd. A prodrug substituted polycyclic carbamoyl pyridone derivative

Also Published As

Publication number Publication date
EP2444400A4 (en) 2014-12-24
HUE038837T2 (hu) 2018-11-28
SI2444400T1 (en) 2018-06-29
US20120184734A1 (en) 2012-07-19
US9469638B2 (en) 2016-10-18
PT2444400T (pt) 2018-06-06
EP2444400A1 (en) 2012-04-25
EP2444400B1 (en) 2018-03-28
HRP20180885T1 (hr) 2018-07-13
JP5737691B2 (ja) 2015-06-17
LT2444400T (lt) 2018-06-11
TWI520959B (zh) 2016-02-11
CN102803260B (zh) 2016-02-10
JP6004552B2 (ja) 2016-10-12
WO2010147068A1 (ja) 2010-12-23
US9815835B2 (en) 2017-11-14
ES2671550T3 (es) 2018-06-07
TW201103934A (en) 2011-02-01
CN102803260A (zh) 2012-11-28
US20150065485A1 (en) 2015-03-05
US20160368921A1 (en) 2016-12-22
PL2444400T3 (pl) 2018-08-31
JPWO2010147068A1 (ja) 2012-12-06
US8927710B2 (en) 2015-01-06
JP2015145409A (ja) 2015-08-13
RS57244B1 (sr) 2018-07-31
DK2444400T3 (en) 2018-06-18

Similar Documents

Publication Publication Date Title
TR201808501T4 (tr) Sübstitüe polisiklik karbamoilpiridon türevi.
UY34851A (es) Inhibidores macrocíclicos de virus flaviviridae
MY169043A (en) New dihydroquinoline-2-one derivatives
PH12015500263A1 (en) New bicyclic derivatives
PH12017500658B1 (en) Spirodiamine derivatives as aldosterone synthase inhibitors
BR112016024414A2 (pt) inibidores de irak e usos dos mesmos
PH12014502697B1 (en) New diazaspirocycloalkane and azaspirocycloalkane
CR20140106A (es) Compuestos y composiciones como inhibidores de la quinasa c-kit
MX365547B (es) Metodo para producir un conjugado de inmunoligando/carga util por medio de una enzima de transpeptidasa especifica de una secuencia.
PH12014501179B1 (en) New bicyclic dihydroisoquinoline-1-one derivatives
CL2012002979A1 (es) Derivados de n3-sustituido-n1-sulfonil-5-fluorpirimidinona.
BR112014006660A2 (pt) novos derivados de dihidroquinolina-2-ona bicíclicos
UA107822C2 (en) Certain triazolopyridines and triazolopyrazines, compositions thereof and methods of use therefor.
BR112017014970A2 (pt) macrociclos de piridazinona como inibidores de irak e usos dos mesmos
MX2014014531A (es) Derivados de aminoquinazolina y piridopirimidina.
MX343893B (es) Nuevos derivados de aril-quinolina.
MX2015001099A (es) Nuevos derivados biciclicos de piridina.
MY195343A (en) A Novel Phtalazinone Derivatives and Manufacturing Process Thereof
BRPI0909333A2 (pt) derivado de espiroindolinona
MX370253B (es) Composiciones de compuestos de jasmonato y métodos de uso de las mismas.
BR112017028549A2 (pt) derivados de pirimidina como inibidores de btk e usos dos mesmos
EA201170640A1 (ru) Дизамещенные фталазины-антагонисты сигнального пути hedgehog
UA107671C2 (en) N1-substityted-5-fluoro-2-oxopyrimidinone-1(2h)-carboxamide derivatives
UY33976A (es) Derivados de pirazolo-pirimidina.
BR112014030474A2 (pt) novos compostos bicíclicos de tiofenilamida