HRP20150773T1 - Protutijela koja neutraliziraju ljudski äśimbenik stimuliranja kolonija makrofaga - Google Patents
Protutijela koja neutraliziraju ljudski äśimbenik stimuliranja kolonija makrofaga Download PDFInfo
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- HRP20150773T1 HRP20150773T1 HRP20150773TT HRP20150773T HRP20150773T1 HR P20150773 T1 HRP20150773 T1 HR P20150773T1 HR P20150773T T HRP20150773T T HR P20150773TT HR P20150773 T HRP20150773 T HR P20150773T HR P20150773 T1 HRP20150773 T1 HR P20150773T1
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- 101000746373 Homo sapiens Granulocyte-macrophage colony-stimulating factor Proteins 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 22
- 239000012634 fragment Substances 0.000 claims 11
- 239000002157 polynucleotide Substances 0.000 claims 7
- 102000040430 polynucleotide Human genes 0.000 claims 7
- 108091033319 polynucleotide Proteins 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 3
- 208000003343 Antiphospholipid Syndrome Diseases 0.000 claims 2
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 206010065159 Polychondritis Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 208000006454 hepatitis Diseases 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 208000009169 relapsing polychondritis Diseases 0.000 claims 2
- 208000004476 Acute Coronary Syndrome Diseases 0.000 claims 1
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010008909 Chronic Hepatitis Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010018364 Glomerulonephritis Diseases 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 206010046851 Uveitis Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 206010009887 colitis Diseases 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 230000000399 orthopedic effect Effects 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 230000004083 survival effect Effects 0.000 claims 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/243—Colony Stimulating Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
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- Gastroenterology & Hepatology (AREA)
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Claims (11)
1. Ljudsko monoklonsko protutijelo, ili njegov fragment, naznačeno time što sadrži:
(a) varijabilno područje lakog lanca, koje sadrži aminokiselinski slijed kao što je iznijet u SEQ ID NO: 19 i dodatno sadrži varijabilno područje teškog lanca, koje se bira između:
(i) aminokiselinskog slijeda kao što je iznijet u SEQ ID NO: 21;
(ii) aminokiselinskog slijeda kao što je iznijet u SEQ ID NO: 22;
(iii) aminokiselinskog slijeda kao što je iznijet u SEQ ID NO: 52; i
(iv) aminokiselinskog slijeda kao što je iznijet u SEQ ID NO: 53;
ili
(b) varijabilno područje lakog lanca, koje sadrži aminokiselinski slijed kao što je iznijet u SEQ ID NO: 54 i dodatno sadrži varijabilno područje teškog lanca, koje se bira između:
(i) aminokiselinskog slijeda kao što je iznijet u SEQ ID NO: 23;
(ii) aminokiselinskog slijeda kao što je iznijet u SEQ ID NO: 26; i
(iii) aminokiselinski slijed kao što je iznijet u SEQ ID NO: 28;
ili
(c) varijabilno područje lakog lanca, koje sadrži aminokiselinski slijed kao što je iznijet u SEQ ID NO: 55 i dodatno sadrži varijabilno područje teškog lanca, koje se bira između:
(i) aminokiselinskog slijeda kao što je iznijet u SEQ ID NO: 21; i
(ii) aminokiselinskog slijeda kao što je iznijet u SEQ ID NO: 22;
ili
(d) laki lanac, koji sadrži aminokiselinski slijed kao što je iznijet u SEQ ID NO: 34 i dodatno sadrži teški lanac, koji se bira između:
(i) aminokiselinskog slijeda kao što je iznijet u SEQ ID NO: 35;
(ii) aminokiselinskog slijeda kao što je iznijet u SEQ ID NO: 37;
(iii) aminokiselinskog slijeda kao što je iznijet u SEQ ID NO: 40;
(iv) aminokiselinskog slijeda kao što je iznijet u SEQ ID NO: 42; i
(v) aminokiselinskog slijeda kao što je iznijet u SEQ ID NO: 48.
2. Ljudsko monoklonsko protutijelo, ili njegov fragment, u skladu s patentnim zahtjevom 1, naznačeno time što sadrži varijabilno područje lakog lanca, koje sadrži aminokiselinski slijed kao što je iznijet u SEQ ID NO: 19 i dodatno sadrži varijabilno područje teškog lanca, koje se bira iz aminokiselinskog slijeda kao što je iznijet u SEQ ID NO: 21 i 52.
3. Ljudsko monoklonsko protutijelo, ili njegov fragment, u skladu s patentnim zahtjevom 1, naznačeno time što sadrži laki lanac koji sadrži aminokiselinski slijed kao što je iznijet u SEQ ID NO: 34 i sadrži teški lanac koji sadrži aminokiselinski slijed kao što je iznijet u SEQ ID NO: 35.
4. Fragment ljudskog monoklonskog protutijela u skladu s bilo kojim od patentnih zahtjeva 1 do 3, naznačen time što je navedeni fragment scFv, Fv, dijatijelo, tandemno dijatijelo, Fab, Fab’ ili F(ab)2.
5. Polinukleotidna molekula, naznačena time što sadrži nukleotidni slijed koji kodira ljudsko monoklonsko protutijelo, ili njegov fragment, kao što je iznijet u bilo kojem od patentnih zahtjeva 1-3.
6. Farmaceutski pripravak, naznačen time što sadrži ljudsko monoklonsko protutijelo, ili njegov fragment, u skladu s bilo kojim od patentnih zahtjeva 1-4 ili polinukleotidnu molekulu u skladu s patentnim zahtjevom 5.
7. Ljudsko monoklonsko protutijelo, ili njegov fragment, u skladu s bilo kojim od patentnih zahtjeva 1-4 ili polinukleotidna molekula u skladu s patentnim zahtjevom 5, naznačeni time što mogu sadržavati jedno ili više dodatnih protuupalnih sredstava, namijenjenih upotrebi u postupku liječenja upalnih bolesti.
8. Ljudsko monoklonsko protutijelo, ili njegov fragment, ili polinukleotidna molekula namijenjeni upotrebi u skladu s patentnim zahtjevom 7, naznačeni time što se navedene upalne bolesti bira iz skupine koju čine reumatoidni artritis (RA) (uključujući RA otporan na liječenje neutralizatorima TNFα), astma, multipla skleroza (MS), kronična opstruktivna plućna bolest (COPD), akutni sindrom dišnog distresa (ARDS), idiopatska plućna fibroza (IPF), upalna crijevna bolest (IBD), uveitis, degeneracija makule, kolitis, psorijaza, Wallerova degeneracija, antifosfolipidni sindrom (APS), akutni koronarni sindrom, restenoza, ateroskleroza, recidivirajući polihondritis (RP), akutni ili kronični hepatitis, neuspjeli ortopedski usadci, glomerulonefritis, lupus ili autoimuni poremećaji.
9. Ljudsko monoklonsko protutijelo, ili njegov fragment, u skladu s bilo kojim od patentnih zahtjeva 1-4 ili polinukleotidna molekula u skladu s patentnim zahtjevom 5, naznačeni time što mogu sadržavati jedno ili više dodatnih antitumorskih sredstava, namijenjenih upotrebi u postupku liječenja tumorskih bolesti ili drugih stanja s odgođenom staničnom apoptozom, povećanim preživljenjem ili proliferacijom stanica.
10. Ljudsko monoklonsko protutijelo, ili njegov fragment, ili polinukleotidna molekula namijenjeni upotrebi u skladu s patentnim zahtjevom 9, naznačeni time što je navedena tumorska bolest rak.
11. Ljudsko monoklonsko protutijelo, ili njegov fragment, ili polinukleotidna molekula namijenjeni upotrebi u skladu s patentnim zahtjevom 10, naznačeni time što je navedeni rak leukemija, multipli mijelom, karcinom želuca ili karcinom kože.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05008410 | 2005-04-18 | ||
| EP06724392.3A EP1874819B1 (en) | 2005-04-18 | 2006-04-18 | Antibody neutralizers of human granulocyte macrophage colony stimulating factor |
| PCT/EP2006/003528 WO2006111353A2 (en) | 2005-04-18 | 2006-04-18 | Antibody neutralizers of human granulocyte macrophage colony stimulating factor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20150773T1 true HRP20150773T1 (hr) | 2015-08-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20150773TT HRP20150773T1 (hr) | 2005-04-18 | 2015-07-14 | Protutijela koja neutraliziraju ljudski äśimbenik stimuliranja kolonija makrofaga |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US8017748B2 (hr) |
| EP (2) | EP1874819B1 (hr) |
| JP (1) | JP5085533B2 (hr) |
| KR (2) | KR20150091193A (hr) |
| CN (2) | CN101184777B (hr) |
| AU (1) | AU2006237159B2 (hr) |
| BR (1) | BRPI0608281B8 (hr) |
| CA (1) | CA2605402C (hr) |
| CY (1) | CY1116632T1 (hr) |
| DK (1) | DK1874819T3 (hr) |
| EA (2) | EA017420B9 (hr) |
| ES (1) | ES2545769T3 (hr) |
| HK (2) | HK1112003A1 (hr) |
| HR (1) | HRP20150773T1 (hr) |
| HU (1) | HUE025134T2 (hr) |
| IL (2) | IL186486A0 (hr) |
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| MX (1) | MX2007012569A (hr) |
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| SI (1) | SI1874819T1 (hr) |
| UA (1) | UA94403C2 (hr) |
| WO (1) | WO2006111353A2 (hr) |
| ZA (1) | ZA200708201B (hr) |
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