HRP20140978T1 - Trazodon i trazodon hidroklorid u proäśišä†enom obliku - Google Patents

Trazodon i trazodon hidroklorid u proäśišä†enom obliku Download PDF

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Publication number
HRP20140978T1
HRP20140978T1 HRP20140978AT HRP20140978T HRP20140978T1 HR P20140978 T1 HRP20140978 T1 HR P20140978T1 HR P20140978A T HRP20140978A T HR P20140978AT HR P20140978 T HRP20140978 T HR P20140978T HR P20140978 T1 HRP20140978 T1 HR P20140978T1
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trazodone
aqueous phase
phase
organic
process according
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HRP20140978AT
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Inventor
Marcello Marchetti
Tommaso Iacoangeli
Giovanni Battista Ciottoli
Giuseppe Biondi
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Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.
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Application filed by Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. filed Critical Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.
Publication of HRP20140978T1 publication Critical patent/HRP20140978T1/hr

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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  • Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
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  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Pain & Pain Management (AREA)
  • Inorganic Chemistry (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
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  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Claims (6)

1. Postupak za proizvodnju trazodona i trazodon-hidroklorida, naznačen time, da obuhvaća slijedeće korake: (a) pripremanje organske faze koja sadrži od 10 g do 50 g trazodona na 100 g organske faze, u najmanje jednom organskom otapalu koje je odabrano iz skupine koju čine alkoholi, eteri, ugljikovodici, ketoni i esteri; (b) pripremanje vodene faze koja sadrži barem jednu baznu smjesu odabranu iz skupine koja sadrži najmanje jednu anorgansku bazu, najmanje jednu organsku bazu, ili njihove smjese; (c) miješanje navedene vodene faze s navedenom organskom fazom, pri čemu je vodena faza dodana u količini od 30 g do 100 g na 100 g organske faze, i pri čemu je spomenuta bazna smjesa dodana u količini od 0,05 do 1 mola po molu trazodona; (d) zagrijavanje na temperaturi od minimalno 40°C u trajanju od najmanje 30 minuta; (e) dobivanje navedenog trazodona; i po izboru, (f) izlaganje navedenog trazodona klorovodičnoj kiselini, kako bi se dobio trazodon-hidroklorid.
2. Postupak za proizvodnju sukladan zahtjevu 1, naznačen time, da je navedena organska baza odabrana iz skupine koju čine alifatski amini i aromatski amini.
3. Postupak za proizvodnju sukladan bilo kojem od prethodnih zahtjeva, naznačen time, da navedena vodena faza sadrži katalizator faznog prijelaza.
4. Postupak za proizvodnju sukladan zahtjevu 3, naznačen time, da je navedeni katalizator faznog prijelaza odabran iz skupine koju čine kvarterne amonijeve soli i kvarterne fosfonijeve soli.
5. Postupak za proizvodnju sukladan bilo kojem od zahtjeva 3 do 4, naznačen time, da navedena vodena faza sadrži katalizator faznog prijelaza, u količini od 0.05 g do 0.5 g na 100 g vodene faze.
6. Postupak za proizvodnju sukladan bilo kojem od prethodnih zahtjeva, naznačen time, da se zagrijavanje u navedenom koraku(d), provodi na temperaturi između 40°C i točke vrelišta smjese organske faze i vodene faze, u vremenskom periodu između 30 i 300 minuta.
HRP20140978AT 2007-08-03 2014-10-14 Trazodon i trazodon hidroklorid u proäśišä†enom obliku HRP20140978T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT001603A ITMI20071603A1 (it) 2007-08-03 2007-08-03 Trazodone e trazodone cloridrato in forma purificata
US97653507P 2007-10-01 2007-10-01
PCT/EP2008/059640 WO2009019133A1 (en) 2007-08-03 2008-07-23 Trazodone and trazodone hydrochloride in purified form

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HRP20140978T1 true HRP20140978T1 (hr) 2014-12-05

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HRP20140978AT HRP20140978T1 (hr) 2007-08-03 2014-10-14 Trazodon i trazodon hidroklorid u proäśišä†enom obliku

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US (19) US8133893B2 (hr)
EP (1) EP2178850B1 (hr)
JP (3) JP5635401B2 (hr)
KR (2) KR101505522B1 (hr)
CN (1) CN101772490B (hr)
AR (1) AR067773A1 (hr)
BR (1) BRPI0814448B8 (hr)
CA (1) CA2693095C (hr)
CY (1) CY1115666T1 (hr)
DK (1) DK2178850T3 (hr)
EA (1) EA017019B1 (hr)
ES (1) ES2517871T3 (hr)
GE (2) GEP20135915B (hr)
HK (1) HK1139405A1 (hr)
HR (1) HRP20140978T1 (hr)
IL (2) IL203294A (hr)
IT (1) ITMI20071603A1 (hr)
MX (1) MX2010001094A (hr)
PL (1) PL2178850T3 (hr)
PT (1) PT2178850E (hr)
SI (1) SI2178850T1 (hr)
UA (1) UA103597C2 (hr)
WO (1) WO2009019133A1 (hr)

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ITMI20071573A1 (it) 2007-07-31 2009-02-01 Acraf Composizione farmaceutica liquida stabile a base di trazodone
ITMI20071603A1 (it) * 2007-08-03 2009-02-04 Acraf Trazodone e trazodone cloridrato in forma purificata
WO2012072665A1 (en) 2010-11-30 2012-06-07 Pharmaneuroboost N.V. Compositions comprising pipamperone and serotonin antagonist reuptake inhibitors
CN103853790B (zh) * 2012-12-06 2016-04-06 腾讯科技(深圳)有限公司 移动终端浏览器的上传信息处理方法及装置
WO2015110883A1 (en) * 2014-01-21 2015-07-30 Piramal Enterprises Limited An improved process for the preparation of trazodone and hydrochloride salt thereof
CN105777745A (zh) * 2016-03-29 2016-07-20 深圳市泛谷药业股份有限公司 一种盐酸曲唑酮的制备方法
JP7301858B2 (ja) * 2018-02-07 2023-07-03 アジェンデ・キミケ・リウニテ・アンジェリニ・フランチェスコ・ア・チ・エレ・ア・エフェ・ソシエタ・ペル・アチオニ トラゾドンの調製のための継続的なプロセス
RU2706700C1 (ru) 2019-09-24 2019-11-20 Общество с ограниченной ответственностью "Научно-производственная компания "СКиФФ" Фармацевтическая композиция для коррекции поведения кошек и собак в стрессовых ситуациях
CN117517545A (zh) * 2023-12-08 2024-02-06 重庆锐恩医药有限公司 一种盐酸曲唑酮有关物质检测方法

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BRPI0814448B8 (pt) 2021-05-25
CA2693095C (en) 2015-11-24
US20140057922A1 (en) 2014-02-27
SI2178850T1 (sl) 2014-12-31
US20160324853A1 (en) 2016-11-10
ES2517871T3 (es) 2014-11-04
JP6513911B2 (ja) 2019-05-15
US20200253965A1 (en) 2020-08-13
JP2014221788A (ja) 2014-11-27
HK1139405A1 (en) 2010-09-17
US20160113926A1 (en) 2016-04-28
EA201070228A1 (ru) 2010-06-30
CN101772490A (zh) 2010-07-07
US8314236B2 (en) 2012-11-20
IL203294A (en) 2013-05-30
US20170333425A1 (en) 2017-11-23
JP5635401B2 (ja) 2014-12-03
EA017019B1 (ru) 2012-09-28
KR20100046245A (ko) 2010-05-06
KR20140133901A (ko) 2014-11-20
KR101505522B1 (ko) 2015-03-30
BRPI0814448B1 (pt) 2019-04-02
AR067773A1 (es) 2009-10-21
PT2178850E (pt) 2014-10-07
EP2178850B1 (en) 2014-09-03
UA103597C2 (en) 2013-11-11
US20240139179A1 (en) 2024-05-02
GEP20135915B (en) 2013-08-26
US20190231774A1 (en) 2019-08-01
US20120142699A1 (en) 2012-06-07
US20210052577A1 (en) 2021-02-25
US20130012520A1 (en) 2013-01-10
PL2178850T3 (pl) 2015-03-31
US20150105402A1 (en) 2015-04-16
BRPI0814448A2 (pt) 2016-07-26
MX2010001094A (es) 2010-03-01
US20170128442A1 (en) 2017-05-11
US8133893B2 (en) 2012-03-13
AU2008285779A1 (en) 2009-02-12
CN101772490B (zh) 2013-11-06
GEP20135926B (en) 2013-10-10
US20200038396A1 (en) 2020-02-06
US20180161323A1 (en) 2018-06-14
IL225873A0 (en) 2013-06-27
WO2009019133A1 (en) 2009-02-12
JP2017141246A (ja) 2017-08-17
ITMI20071603A1 (it) 2009-02-04
US20150297589A1 (en) 2015-10-22
US20100056539A1 (en) 2010-03-04
US20130203771A1 (en) 2013-08-08
IL225873A (en) 2016-10-31
JP2010535170A (ja) 2010-11-18
US20180353503A1 (en) 2018-12-13
CY1115666T1 (el) 2017-01-25
EP2178850A1 (en) 2010-04-28
DK2178850T3 (en) 2014-11-17
CA2693095A1 (en) 2009-02-12

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