CY1115666T1 - Τραζοδονη και υδροχλωρικη τραζοδονη σε κεκαθαρμενη μορφη - Google Patents
Τραζοδονη και υδροχλωρικη τραζοδονη σε κεκαθαρμενη μορφηInfo
- Publication number
- CY1115666T1 CY1115666T1 CY20141100896T CY141100896T CY1115666T1 CY 1115666 T1 CY1115666 T1 CY 1115666T1 CY 20141100896 T CY20141100896 T CY 20141100896T CY 141100896 T CY141100896 T CY 141100896T CY 1115666 T1 CY1115666 T1 CY 1115666T1
- Authority
- CY
- Cyprus
- Prior art keywords
- trazodone
- hydrochloride
- purified form
- preparing
- aqueous phase
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
Abstract
Μια διαδικασία παρασκευής τραζοδόνης ή υδροχλωρικής τραζοδόνης, η οποία περιλαμβάνει τα στάδια (a) παρασκευής μιας οργανικής φάσης που περιέχει τραζοδόνη σε τουλάχιστον έναν οργανικό διαλύτη, (b) παρασκευής μιας υδατικής φάσης που περιέχει τουλάχιστον μια βασική ένωση, (c) ανάμιξης της αναφερθείσας υδατικής φάσης με την αναφερθείσα οργανική φάση, (d) θέρμανσης σε θερμοκρασία τουλάχιστον 40°C για τουλάχιστον 30 λεπτά, (e) ανάκτησης της αναφερθείσας τραζοδόνης και προαιρετικά (f) επεξεργασίας της αναφερθείσας τραζοδόνης με υδροχλωρικό οξύ για να προκύψει η υδροχλωρική τραζοδόνη. Τραζοδόνη ή υδροχλωρική τραζοδόνη που περιέχει λιγότερο από 15 ppm αλκυλιούχων ουσιών και μια φαρμακευτική σύνθεση που περιέχει την αναφερθείσα υδροχλωρική τραζοδόνη.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT001603A ITMI20071603A1 (it) | 2007-08-03 | 2007-08-03 | Trazodone e trazodone cloridrato in forma purificata |
US97653507P | 2007-10-01 | 2007-10-01 | |
EP08775309.1A EP2178850B1 (en) | 2007-08-03 | 2008-07-23 | Trazodone and trazodone hydrochloride in purified form |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1115666T1 true CY1115666T1 (el) | 2017-01-25 |
Family
ID=39064326
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20141100896T CY1115666T1 (el) | 2007-08-03 | 2014-10-30 | Τραζοδονη και υδροχλωρικη τραζοδονη σε κεκαθαρμενη μορφη |
Country Status (23)
Country | Link |
---|---|
US (19) | US8133893B2 (el) |
EP (1) | EP2178850B1 (el) |
JP (3) | JP5635401B2 (el) |
KR (2) | KR101505522B1 (el) |
CN (1) | CN101772490B (el) |
AR (1) | AR067773A1 (el) |
BR (1) | BRPI0814448B8 (el) |
CA (1) | CA2693095C (el) |
CY (1) | CY1115666T1 (el) |
DK (1) | DK2178850T3 (el) |
EA (1) | EA017019B1 (el) |
ES (1) | ES2517871T3 (el) |
GE (2) | GEP20135915B (el) |
HK (1) | HK1139405A1 (el) |
HR (1) | HRP20140978T1 (el) |
IL (2) | IL203294A (el) |
IT (1) | ITMI20071603A1 (el) |
MX (1) | MX2010001094A (el) |
PL (1) | PL2178850T3 (el) |
PT (1) | PT2178850E (el) |
SI (1) | SI2178850T1 (el) |
UA (1) | UA103597C2 (el) |
WO (1) | WO2009019133A1 (el) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITMI20071573A1 (it) | 2007-07-31 | 2009-02-01 | Acraf | Composizione farmaceutica liquida stabile a base di trazodone |
ITMI20071603A1 (it) * | 2007-08-03 | 2009-02-04 | Acraf | Trazodone e trazodone cloridrato in forma purificata |
WO2012072665A1 (en) | 2010-11-30 | 2012-06-07 | Pharmaneuroboost N.V. | Compositions comprising pipamperone and serotonin antagonist reuptake inhibitors |
CN103853790B (zh) * | 2012-12-06 | 2016-04-06 | 腾讯科技(深圳)有限公司 | 移动终端浏览器的上传信息处理方法及装置 |
EP3097099A4 (en) * | 2014-01-21 | 2017-08-23 | Piramal Enterprises Limited | An improved process for the preparation of trazodone and hydrochloride salt thereof |
CN105777745A (zh) * | 2016-03-29 | 2016-07-20 | 深圳市泛谷药业股份有限公司 | 一种盐酸曲唑酮的制备方法 |
PT3749668T (pt) | 2018-02-07 | 2022-06-02 | Aziende Chimiche Riunite Angelini Francesco A C R | Processo contínuo para a preparação de trazodona |
RU2706700C1 (ru) | 2019-09-24 | 2019-11-20 | Общество с ограниченной ответственностью "Научно-производственная компания "СКиФФ" | Фармацевтическая композиция для коррекции поведения кошек и собак в стрессовых ситуациях |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR8135E (el) | ||||
IT1066857B (it) * | 1965-12-15 | 1985-03-12 | Acraf | Derivati della s ipiazolo 4.3 a piridina e processi per la loro preparazione |
GB1117068A (en) * | 1965-12-15 | 1968-06-12 | Acraf | S-triazole-[4,3-a]-pyridine derivatives and processes for their preparation |
FR8135M (el) * | 1968-12-31 | 1970-08-10 | ||
IT1047702B (it) * | 1975-07-24 | 1980-10-20 | Acraf | Nuova sintesi degli psicofarmaci denominati trazodone ed eteroperidone |
US4465683A (en) * | 1979-09-14 | 1984-08-14 | Mead Johnson & Company | Anti-psychotic agents |
US4252806A (en) * | 1979-09-24 | 1981-02-24 | Mead Johnson & Company | Triazoloquinolones |
US4254124A (en) * | 1979-09-24 | 1981-03-03 | Mead Johnson & Company | Antidepressant agent |
IT1211095B (it) * | 1981-08-17 | 1989-09-29 | Roma Aziende Chimiche Riunite | Impiego del trazodone nel trattamento delle ulcere gastroduodenali. |
IT1233412B (it) * | 1987-12-02 | 1992-03-30 | Acraf | Uso del trazodone |
IT1314283B1 (it) * | 1999-12-16 | 2002-12-06 | Acraf | Trazodone cloridrato ed un procedimento per prepararlo. |
AU2004230915B2 (en) * | 2003-04-08 | 2008-08-07 | Algorx Pharmaceuticals, Inc. | Preparation and purification of synthetic capsaicin |
WO2007048219A2 (en) * | 2005-09-09 | 2007-05-03 | Labopharm Inc. | Sustained drug release composition |
ITMI20071573A1 (it) | 2007-07-31 | 2009-02-01 | Acraf | Composizione farmaceutica liquida stabile a base di trazodone |
ITMI20071603A1 (it) * | 2007-08-03 | 2009-02-04 | Acraf | Trazodone e trazodone cloridrato in forma purificata |
-
2007
- 2007-08-03 IT IT001603A patent/ITMI20071603A1/it unknown
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2008
- 2008-07-23 PT PT08775309T patent/PT2178850E/pt unknown
- 2008-07-23 KR KR1020107004790A patent/KR101505522B1/ko active IP Right Grant
- 2008-07-23 KR KR1020147027643A patent/KR20140133901A/ko not_active Application Discontinuation
- 2008-07-23 EA EA201070228A patent/EA017019B1/ru not_active IP Right Cessation
- 2008-07-23 GE GEAP200812416A patent/GEP20135915B/en unknown
- 2008-07-23 PL PL08775309T patent/PL2178850T3/pl unknown
- 2008-07-23 GE GEAP200811709A patent/GEP20135926B/en unknown
- 2008-07-23 US US12/513,048 patent/US8133893B2/en active Active
- 2008-07-23 CN CN2008801018236A patent/CN101772490B/zh active Active
- 2008-07-23 DK DK08775309.1T patent/DK2178850T3/en active
- 2008-07-23 BR BRPI0814448A patent/BRPI0814448B8/pt active IP Right Grant
- 2008-07-23 SI SI200831322T patent/SI2178850T1/sl unknown
- 2008-07-23 UA UAA201000547A patent/UA103597C2/ru unknown
- 2008-07-23 JP JP2010518621A patent/JP5635401B2/ja active Active
- 2008-07-23 WO PCT/EP2008/059640 patent/WO2009019133A1/en active Application Filing
- 2008-07-23 EP EP08775309.1A patent/EP2178850B1/en active Active
- 2008-07-23 CA CA2693095A patent/CA2693095C/en active Active
- 2008-07-23 MX MX2010001094A patent/MX2010001094A/es active IP Right Grant
- 2008-07-23 ES ES08775309.1T patent/ES2517871T3/es active Active
- 2008-08-01 AR ARP080103346 patent/AR067773A1/es not_active Application Discontinuation
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2010
- 2010-01-13 IL IL203294A patent/IL203294A/en active IP Right Grant
- 2010-06-22 HK HK10106163.6A patent/HK1139405A1/xx unknown
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2012
- 2012-02-10 US US13/370,735 patent/US8314236B2/en active Active
- 2012-09-14 US US13/617,907 patent/US20130012520A1/en not_active Abandoned
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2013
- 2013-03-15 US US13/833,569 patent/US20130203771A1/en not_active Abandoned
- 2013-04-22 IL IL225873A patent/IL225873A/en active IP Right Grant
- 2013-11-06 US US14/073,130 patent/US20140057922A1/en not_active Abandoned
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2014
- 2014-06-16 US US14/305,135 patent/US20140296250A1/en not_active Abandoned
- 2014-06-30 JP JP2014135096A patent/JP6513911B2/ja active Active
- 2014-10-14 HR HRP20140978AT patent/HRP20140978T1/hr unknown
- 2014-10-30 CY CY20141100896T patent/CY1115666T1/el unknown
- 2014-12-18 US US14/574,445 patent/US20150105402A1/en not_active Abandoned
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2015
- 2015-06-29 US US14/753,435 patent/US20150297589A1/en not_active Abandoned
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2016
- 2016-01-04 US US14/987,153 patent/US20160113926A1/en not_active Abandoned
- 2016-07-18 US US15/212,715 patent/US20160324853A1/en not_active Abandoned
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2017
- 2017-01-25 US US15/414,837 patent/US20170128442A1/en not_active Abandoned
- 2017-03-08 JP JP2017044339A patent/JP2017141246A/ja active Pending
- 2017-08-09 US US15/672,725 patent/US20170333425A1/en not_active Abandoned
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2018
- 2018-02-07 US US15/890,596 patent/US20180161323A1/en not_active Abandoned
- 2018-08-22 US US16/108,482 patent/US20180353503A1/en not_active Abandoned
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2019
- 2019-04-09 US US16/378,773 patent/US20190231774A1/en not_active Abandoned
- 2019-10-15 US US16/601,762 patent/US20200038396A1/en not_active Abandoned
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2020
- 2020-04-29 US US16/861,503 patent/US20200253965A1/en not_active Abandoned
- 2020-10-28 US US17/082,669 patent/US20210052577A1/en not_active Abandoned
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2024
- 2024-01-12 US US18/411,219 patent/US20240139179A1/en active Pending
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