HRP20140646T1 - Postupak sinteze morfolino oligomera - Google Patents

Postupak sinteze morfolino oligomera Download PDF

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Publication number
HRP20140646T1
HRP20140646T1 HRP20140646AT HRP20140646T HRP20140646T1 HR P20140646 T1 HRP20140646 T1 HR P20140646T1 HR P20140646A T HRP20140646A T HR P20140646AT HR P20140646 T HRP20140646 T HR P20140646T HR P20140646 T1 HRP20140646 T1 HR P20140646T1
Authority
HR
Croatia
Prior art keywords
morpholino
group
nitrogen
protected
lower alkyl
Prior art date
Application number
HRP20140646AT
Other languages
English (en)
Croatian (hr)
Inventor
Christina Mary Josephine Fox
Matthew Dale Reeves
Dwight D. Weller
Yongfu Li
Original Assignee
Sarepta Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sarepta Therapeutics, Inc. filed Critical Sarepta Therapeutics, Inc.
Publication of HRP20140646T1 publication Critical patent/HRP20140646T1/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HRP20140646AT 2007-11-15 2008-11-14 Postupak sinteze morfolino oligomera HRP20140646T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98819207P 2007-11-15 2007-11-15
US98820007P 2007-11-15 2007-11-15
PCT/US2008/012804 WO2009064471A1 (en) 2007-11-15 2008-11-14 Method of synthesis of morpholino oligomers

Publications (1)

Publication Number Publication Date
HRP20140646T1 true HRP20140646T1 (hr) 2014-09-26

Family

ID=40293764

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20140646AT HRP20140646T1 (hr) 2007-11-15 2008-11-14 Postupak sinteze morfolino oligomera

Country Status (13)

Country Link
EP (1) EP2207779B1 (enExample)
JP (3) JP5512533B2 (enExample)
KR (1) KR101617472B1 (enExample)
CN (1) CN101861318A (enExample)
BR (1) BR122019021332A8 (enExample)
CA (2) CA2704261C (enExample)
DK (1) DK2207779T3 (enExample)
ES (1) ES2479393T3 (enExample)
HR (1) HRP20140646T1 (enExample)
IL (1) IL205776A0 (enExample)
MX (1) MX2010004955A (enExample)
RU (1) RU2606627C2 (enExample)
WO (1) WO2009064471A1 (enExample)

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Also Published As

Publication number Publication date
BRPI0819828A8 (pt) 2022-12-27
CN101861318A (zh) 2010-10-13
RU2010123958A (ru) 2011-12-20
JP2016196494A (ja) 2016-11-24
JP2011503184A (ja) 2011-01-27
WO2009064471A1 (en) 2009-05-22
CA2704261C (en) 2015-05-26
BRPI0819828A2 (pt) 2015-05-26
MX2010004955A (es) 2010-06-30
BR122019021332A2 (enExample) 2015-05-26
HK1144424A1 (en) 2011-02-18
KR101617472B1 (ko) 2016-05-02
EP2207779A1 (en) 2010-07-21
KR20100090681A (ko) 2010-08-16
CA2704261A1 (en) 2009-05-22
AU2008321409B2 (en) 2014-08-14
RU2606627C2 (ru) 2017-01-10
CA2884340C (en) 2017-07-25
BR122019021332A8 (pt) 2022-12-06
CA2884340A1 (en) 2009-05-22
DK2207779T3 (da) 2014-07-14
AU2008321409A1 (en) 2009-05-22
ES2479393T3 (es) 2014-07-24
IL205776A0 (en) 2010-11-30
EP2207779B1 (en) 2014-04-09
JP5512533B2 (ja) 2014-06-04
JP2014159432A (ja) 2014-09-04
JP6178744B2 (ja) 2017-08-09

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