BR122019021332A2 - - Google Patents

Info

Publication number
BR122019021332A2
BR122019021332A2 BR122019021332A BR122019021332A BR122019021332A2 BR 122019021332 A2 BR122019021332 A2 BR 122019021332A2 BR 122019021332 A BR122019021332 A BR 122019021332A BR 122019021332 A BR122019021332 A BR 122019021332A BR 122019021332 A2 BR122019021332 A2 BR 122019021332A2
Authority
BR
Brazil
Application number
BR122019021332A
Other languages
Portuguese (pt)
Other versions
BR122019021332A8 (pt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of BR122019021332A2 publication Critical patent/BR122019021332A2/pt
Publication of BR122019021332A8 publication Critical patent/BR122019021332A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
BR122019021332A 2007-11-15 2008-11-14 Processo de síntese de oligômeros de morfolino BR122019021332A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98820007P 2007-11-15 2007-11-15
US98819207P 2007-11-15 2007-11-15
PCT/US2008/012804 WO2009064471A1 (en) 2007-11-15 2008-11-14 Method of synthesis of morpholino oligomers

Publications (2)

Publication Number Publication Date
BR122019021332A2 true BR122019021332A2 (enExample) 2015-05-26
BR122019021332A8 BR122019021332A8 (pt) 2022-12-06

Family

ID=40293764

Family Applications (1)

Application Number Title Priority Date Filing Date
BR122019021332A BR122019021332A8 (pt) 2007-11-15 2008-11-14 Processo de síntese de oligômeros de morfolino

Country Status (13)

Country Link
EP (1) EP2207779B1 (enExample)
JP (3) JP5512533B2 (enExample)
KR (1) KR101617472B1 (enExample)
CN (1) CN101861318A (enExample)
BR (1) BR122019021332A8 (enExample)
CA (2) CA2704261C (enExample)
DK (1) DK2207779T3 (enExample)
ES (1) ES2479393T3 (enExample)
HR (1) HRP20140646T1 (enExample)
IL (1) IL205776A0 (enExample)
MX (1) MX2010004955A (enExample)
RU (1) RU2606627C2 (enExample)
WO (1) WO2009064471A1 (enExample)

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CN102712928B (zh) 2009-11-13 2017-08-04 萨雷普塔治疗公司 反义抗病毒化合物及治疗流感病毒感染的方法
NZ603606A (en) 2010-05-28 2015-06-26 Sarepta Therapeutics Inc Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups
TWI541024B (zh) 2010-09-01 2016-07-11 日本新藥股份有限公司 反義核酸
WO2012031243A2 (en) 2010-09-03 2012-03-08 Avi Biopharma, Inc. dsRNA MOLECULES COMPRISING OLIGONUCLEOTIDE ANALOGS HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS
JP5831455B2 (ja) * 2010-09-30 2015-12-09 日本新薬株式会社 モルホリノ核酸誘導体
WO2012064991A1 (en) 2010-11-12 2012-05-18 Avi Biopharma, Inc. Antisense antibacterial compounds and methods
JP6478632B2 (ja) 2011-05-05 2019-03-06 サレプタ セラピューティクス， インコーポレイテッド ペプチドオリゴヌクレオチドコンジュゲート
WO2013012752A2 (en) 2011-07-15 2013-01-24 Sarepta Therapeutics, Inc. Methods and compositions for manipulating translation of protein isoforms from alternative initiation start sites
US20130085139A1 (en) 2011-10-04 2013-04-04 Royal Holloway And Bedford New College Oligomers
AU2012340390B2 (en) 2011-11-18 2016-11-24 Sarepta Therapeutics, Inc. Functionally-modified oligonucleotides and subunits thereof
US9944926B2 (en) 2011-11-30 2018-04-17 Sarepta Therapeutics, Inc. Induced exon inclusion in spinal muscle atrophy
WO2013082548A1 (en) 2011-11-30 2013-06-06 Sarepta Therapeutics, Inc. Oligonucleotides for treating expanded repeat diseases
TR201809173T4 (tr) 2011-12-08 2018-07-23 Sarepta Therapeutics Inc İnsan LMNA'sını hedef alan oligonükleotid analogları.
CN108611349A (zh) 2011-12-28 2018-10-02 日本新药株式会社 反义核酸
WO2013142087A1 (en) 2012-03-20 2013-09-26 Sarepta Therapeutics, Inc. Boronic acid conjugates of oligonucleotide analogues
CN102702265A (zh) * 2012-05-14 2012-10-03 天津特安化学科技有限公司 一种固相合成磷酰二胺吗啉代寡核苷酸及方法
WO2014113540A1 (en) 2013-01-16 2014-07-24 Iowa State University Research Foundation, Inc. A deep intronic target for splicing correction on spinal muscular atrophy gene
JP6477464B2 (ja) * 2013-05-24 2019-03-06 味の素株式会社 モルフォリノオリゴヌクレオチドの製造方法
US20150197534A1 (en) 2013-09-05 2015-07-16 Sarepta Therapeutics, Inc. Antisense-induced exon2 inclusion in acid alpha-glucosidase
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AU2015264449B2 (en) 2014-05-19 2022-05-05 Board Of Regents, The University Of Texas System Antisense antibacterial compounds and methods
CN111575282B (zh) 2014-06-17 2024-05-14 日本新药株式会社 反义核酸
EP3208277A4 (en) 2014-10-14 2018-06-13 Ajinomoto Co., Inc. Morpholino oligonucleotide manufacturing method
US11293024B2 (en) 2014-12-31 2022-04-05 Board Of Regents, The University Of Texas System Antisense antibacterial compounds and methods
MA41795A (fr) 2015-03-18 2018-01-23 Sarepta Therapeutics Inc Exclusion d'un exon induite par des composés antisens dans la myostatine
CA2986228A1 (en) 2015-05-19 2016-11-24 Sarepta Therapeutics, Inc. Peptide oligonucleotide conjugates
US10849917B2 (en) 2015-06-01 2020-12-01 Sarepta Therapeutics, Inc. Antisense-induced exon exclusion in type VII collagen
US11020417B2 (en) 2015-06-04 2021-06-01 Sarepta Therapeutics, Inc Methods and compounds for treatment of lymphocyte-related diseases and conditions
MD3331891T2 (ro) 2015-08-05 2022-04-30 Eisai R&D Man Co Ltd Procedeu de obţinere a unui oligomer de fosforodiamidat substanțial diastereomeric pur, a unui oligomer de fosforodiamidat obţinut printr-un astfel de procedeu și a unei compoziții farmaceutice care conţine un astfel de oligomer de fosforodiamidat
MX2018002090A (es) 2015-08-24 2018-09-12 Halo Bio Rnai Therapeutics Inc Nanoparticulas de polinucleótido para modulación de expresión génica y sus usos.
CN108026531B (zh) 2015-09-15 2021-09-14 日本新药株式会社 反义核酸
JP6875684B2 (ja) 2015-09-16 2021-05-26 日本新薬株式会社 筋萎縮症治療用アンチセンス核酸
EP3359668A4 (en) 2015-10-09 2019-06-05 Sarepta Therapeutics, Inc. COMPOSITIONS AND METHODS OF TREATING DUCHENNE MUSCLE DYSTROPHY AND ASSOCIATED ILLNESSES THEREOF
JP2018538302A (ja) 2015-12-15 2018-12-27 サレプタ セラピューティクス， インコーポレイテッド ペプチドオリゴヌクレオチド複合体
EP3394262B1 (en) 2015-12-23 2024-08-28 Oregon State University Antisense antibacterial compounds and methods
EP3394261A4 (en) 2015-12-23 2019-11-27 Oregon State University ANTIBACTERIAL ANTISENSE COMPOUNDS AND METHOD
WO2017184529A1 (en) 2016-04-18 2017-10-26 Sarepta Therapeutics, Inc. Antisense oligomers and methods of using the same for treating diseases associated with the acid alpha-glucosidase gene
SG11201809468XA (en) 2016-04-29 2018-11-29 Sarepta Therapeutics Inc Oligonucleotide analogues targeting human lmna
MA45362A (fr) 2016-05-24 2019-04-10 Sarepta Therapeutics Inc Procédés de préparation d'oligomères morpholino de phosphorodiamidate
WO2017205879A2 (en) 2016-05-24 2017-11-30 Sarepta Therapeutics, Inc. Processes for preparing phosphorodiamidate morpholino oligomers
WO2017205496A1 (en) 2016-05-24 2017-11-30 Sarepta Therapeutics, Inc. Processes for preparing oligomers
US11472824B2 (en) 2016-05-24 2022-10-18 Sarepta Therapeutics, Inc. Processes for preparing phosphorodiamidate morpholino oligomers
DK3464306T3 (da) 2016-05-24 2024-05-21 Sarepta Therapeutics Inc Fremgangsmåder til fremstilling af phosphorodiamidat-morpholino-oligomerer
MA45183A (fr) 2016-05-24 2019-04-10 Sarepta Therapeutics Inc Procédés de préparation d'oligomères morpholino de phosphorodiamidate
US20190275072A1 (en) 2016-05-24 2019-09-12 Sarepta Therapeutics, Inc. Pharmaceutical compositions comprising eteplirsen
CN109937042B (zh) * 2016-09-20 2023-06-27 科罗拉多州立大学董事会法人团体 使用亚磷酰胺化学法合成主链修饰的吗啉代寡核苷酸和嵌合体
SG10202012839TA (en) 2016-12-19 2021-01-28 Sarepta Therapeutics Inc Exon skipping oligomer conjugates for muscular dystrophy
MD3554554T2 (ro) 2016-12-19 2022-12-31 Sarepta Therapeutics Inc Conjugați de oligomeri de omitere a exonului, pentru distrofie musculară
BR112019012664A2 (pt) 2016-12-19 2020-01-21 Sarepta Therapeutics Inc conjugados de oligômero de salto de éxon para distrofia muscular
JP7679175B2 (ja) 2017-04-20 2025-05-19 エータイアー ファーマ， インコーポレイテッド 肺の炎症を治療するための組成物および方法
EA201991450A1 (ru) 2017-09-22 2019-12-30 Сарепта Терапьютикс, Инк. Конъюгаты олигомеров для пропуска экзона при мышечной дистрофии
ES2963336T3 (es) * 2017-09-25 2024-03-26 Sarepta Therapeutics Inc Procesos para preparar oligómeros de fosforodiamidato morfolino mediante síntesis de flujo rápido
EP3697910A4 (en) 2017-10-18 2021-07-14 Sarepta Therapeutics, Inc. ANTISENSE OLIGOMER COMPOUNDS
SG11202011094PA (en) 2018-05-10 2020-12-30 Nippon Shinyaku Co Ltd Method for preparing oligonucleic acid compound
US10758629B2 (en) 2018-05-29 2020-09-01 Sarepta Therapeutics, Inc. Exon skipping oligomer conjugates for muscular dystrophy
EP3806868A4 (en) 2018-06-13 2022-06-22 Sarepta Therapeutics, Inc. EXON SKIPPING OLIGOMERS FOR MUSCULAR DYSTROPHY
MY209148A (en) 2018-06-26 2025-06-24 Nippon Shinyaku Co Ltd Composition comprising antisense oligonucleotide and use thereof for treatment of duchenne muscular dystrophy
TW202020153A (zh) 2018-07-27 2020-06-01 美商薩羅塔治療公司 用於肌肉萎縮症之外顯子跳躍寡聚物
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WO2021025899A1 (en) 2019-08-02 2021-02-11 Sarepta Therapeutics, Inc. Phosphorodiamidate morpholino oligomer pharmaceutical compositions
WO2021095875A1 (ja) 2019-11-13 2021-05-20 日本新薬株式会社 オリゴ核酸化合物の製造方法
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KR20220122673A (ko) 2019-12-26 2022-09-02 니뽄 신야쿠 가부시키가이샤 엑손 50의 스키핑을 유도하는 안티센스 핵산
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US20240254158A1 (en) 2021-04-28 2024-08-01 Nippon Shinyaku Co., Ltd. Method for producing oligonucleic acid compound
WO2022239863A1 (ja) 2021-05-13 2022-11-17 国立大学法人千葉大学 アンチセンスオリゴマー
CN117500925A (zh) 2021-05-28 2024-02-02 住友制药株式会社 反义核酸
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US20250011777A1 (en) 2021-09-03 2025-01-09 Sarepta Therapeutics, Inc. Delivery of anitsense oligomers by mirror image peptides
JP2024537711A (ja) 2021-09-30 2024-10-16 サレプタ セラピューティクス， インコーポレイテッド １つ以上の脱塩基ユニットを有するアンチセンスオリゴヌクレオチド
US20240318179A1 (en) 2021-10-22 2024-09-26 Murdoch University Morpholino oligomers for treatment of peripheral myelin protein 22 related diseases
US20250066396A1 (en) 2021-12-27 2025-02-27 Nippon Shinyaku Co., Ltd. Method for producing oligonucleic acid compound
WO2023167908A1 (en) * 2022-03-01 2023-09-07 Eisai R&D Management Co., Ltd. Bis-protected, activated guanine monomers
WO2024064237A2 (en) 2022-09-21 2024-03-28 Sarepta Therapeutics, Inc. Dmd antisense oligonucleotide-mediated exon skipping efficiency
TW202442246A (zh) 2023-04-27 2024-11-01 美商薩羅塔治療公司 用於治療慢性腎病之反義寡聚物
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SI2735568T1 (en) * 2006-05-10 2018-01-31 Sarepta Therapeutics, Inc. Analogues of the oligonucleotide, with cationic links between subunits

Also Published As

Publication number Publication date
CA2704261C (en) 2015-05-26
BRPI0819828A8 (pt) 2022-12-27
CA2884340A1 (en) 2009-05-22
IL205776A0 (en) 2010-11-30
BRPI0819828A2 (pt) 2015-05-26
CA2704261A1 (en) 2009-05-22
EP2207779B1 (en) 2014-04-09
WO2009064471A1 (en) 2009-05-22
AU2008321409A1 (en) 2009-05-22
BR122019021332A8 (pt) 2022-12-06
RU2010123958A (ru) 2011-12-20
ES2479393T3 (es) 2014-07-24
JP5512533B2 (ja) 2014-06-04
EP2207779A1 (en) 2010-07-21
DK2207779T3 (da) 2014-07-14
KR101617472B1 (ko) 2016-05-02
CA2884340C (en) 2017-07-25
AU2008321409B2 (en) 2014-08-14
JP2014159432A (ja) 2014-09-04
JP2016196494A (ja) 2016-11-24
RU2606627C2 (ru) 2017-01-10
MX2010004955A (es) 2010-06-30
JP2011503184A (ja) 2011-01-27
HRP20140646T1 (hr) 2014-09-26
CN101861318A (zh) 2010-10-13
KR20100090681A (ko) 2010-08-16
JP6178744B2 (ja) 2017-08-09
HK1144424A1 (en) 2011-02-18

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Legal Events

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07B Technical examination (opinion): publication cancelled [chapter 7.2 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 7.4 NA RPI NO 2560 DE 28/01/2020 POR TER SIDO INDEVIDA.

B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 12A ANUIDADE

B08G Application fees: restoration [chapter 8.7 patent gazette]
B25D Requested change of name of applicant approved

Owner name: SAREPTA THERAPEUTICS, INC. (US)

B25G Requested change of headquarter approved

Owner name: SAREPTA THERAPEUTICS, INC. (US)

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]