HRP20130632T1 - Stabilna i topiva antitijela koja inhibiraju tnf(alfa) - Google Patents
Stabilna i topiva antitijela koja inhibiraju tnf(alfa) Download PDFInfo
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- HRP20130632T1 HRP20130632T1 HRP20130632TT HRP20130632T HRP20130632T1 HR P20130632 T1 HRP20130632 T1 HR P20130632T1 HR P20130632T T HRP20130632T T HR P20130632TT HR P20130632 T HRP20130632 T HR P20130632T HR P20130632 T1 HRP20130632 T1 HR P20130632T1
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- antibody
- tnfα
- antibody derivative
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- 230000002401 inhibitory effect Effects 0.000 title 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 9
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 9
- 201000010099 disease Diseases 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 229940079593 drug Drugs 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 238000002360 preparation method Methods 0.000 claims 3
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 2
- 206010013774 Dry eye Diseases 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 206010046851 Uveitis Diseases 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 201000008482 osteoarthritis Diseases 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000010367 cloning Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Claims (24)
1. Stabilno i topivo antitijelo ili derivat antitijela koji specifično vezuje TNFα, pri čemu spomenuto antitijelo ili derivat antitijela sadrži jednu varijabilnu domenu lakog lanca (VL) SEQ ID NO:1 koja je kombinirana s varijabilnom domenom teškog lanca (VH) SEQ ID NO: 2.
2. Derivat antitijela prema zahtjevu 1, koji je jednolančani varijabilni fragment scFv, naznačen time da su domene VL i VH spojene jednim linkerom.
3. Antitijelo scFv prema zahtjevu 2, koje sadrži jednu sekvencu VL-linker-VH.
4. Antitijelo scFv prema zahtjevu 2 ili 3, naznačeno time da dotični linker ima identifikacijski broj sekvence SEQ ID NO: 10 ili je izveden iz spomenute sekvence.
5. Antitijelo scFv prema zahtjevu 4, naznačeno time da je najmanje jedan G spomenutog linkera promijenjen u višepolarnu ili aminokiselinu s nabojem.
6. Derivat antitijela prema zahtjevu 1, koji je Fab fragment, naznačen time da je domena VL fuzionirana s konstantnom regijom humanog lg kappa lanca, domena VH je fuzionirana na domenu CH1 humanog IgG, a dva fuzijska polipeptida su spojena jednim međulančanim disulfidskim mostom.
7. Antitijelo ili derivat antitijela prema bilo kojem od zahtjeva 1-6, koji su označeni ili kemijski modificirani.
8. DNK sekvenca koja kodira antitijelo ili derivat antitijela prema bilo kojem od zahtjeva 1-6.
9. Klonirajući ili eksprimirajući vektor koji sadrži DNK sekvencu prema zahtjevu 8.
10. Neka prikladna stanica domaćin, transformirana s nekim eksprimirajućim vektorom prema zahtjevu 9.
11. Stanica domaćin prema zahtjevu 10, koja je stanica kvasca E- coli, neke biljke, kukca ili sisavca.
12. Metoda za proizvodnju molekule antitijela ili derivata antitijela prema bilo kojem od zahtjeva 1-6, koja uključuje uzgoj stanice domaćina iz zahtjeva 10 ili 11 pod uvjetima koji omogućavaju sintezu spomenute molekule antitijela i njeno izdvajanje iz spomenute kulture.
13. Antitijelo ili derivat antitijela prema bilo kojem od zahtjeva 1-7, kao farmaceutski proizvod.
14. Antitijelo ili derivat antitijela prema bilo kojem od zahtjeva 1-7 za uporabu u jednoj metodi liječenja bolesti vezanih uz TNFα.
15. Antitijelo ili derivat antitijela prema bilo kojem od zahtjeva 1-7 za uporabu u jednoj metodi liječenja bolesti vezanih uz TNFα prema zahtjevu 14, naznačeni time da je ta bolest, koja je vezana uz TNFα, osteoartritis, sindrom suhog oka, uveitis, neka od upalnih bolesti koje napadaju kožu, psorijaza ili upalna bolest crijeva.
16. Antitijelo ili derivat antitijela prema bilo kojem od zahtjeva 1-7, za uporabu u jednoj metodi liječenja bolesti vezanih uz TNFα, gdje se to antitijelo ili derivat antitijela primjenjuju lokalno ili topički.
17. Uporaba antitijela ili derivata antitijela prema bilo kojem od zahtjeva 1-7, za proizvodnju jednog medikamenta za liječenje ili kao in vitro dijagnostičko sredstvo za otkrivanje bolesti vezanih uz TNFα.
18. Uporaba iz zahtjeva 17, u kojoj se dotični medikament koristi za liječenje neke bolesti vezane uz TNFα i gdje se to antitijelo ili derivat antitijela primjenjuju lokalno ili topički.
19. Uporaba iz zahtjeva 17 ili 18, gdje je dotična bolest vezana uz TNFα osteoartritis, uveitis, upalna bolest crijeva, sindrom suhog oka, neka od upalnih bolesti koje napadaju kožu ili psorijaza.
20. Dijagnostički ili terapeutski pripravak koji sadrži antitijelo iz bilo kojeg od zahtjeva 1-7, u kombinaciji s nekim farmaceutski prihvatljivim nosačem, razrjeđivačem ili pomoćnim sredstvom.
21. Kombinirani pripravak koji sadrži antitijelo iz bilo kojeg od zahtjeva 1-7, zajedno s još najmanje jednim drugim spojem.
22. Kombinirani pripravak iz zahtjeva 21, u kojem taj drugi spoj nije neko antitijelo specifično za TNFα.
23. Kombinirani pripravak iz zahtjeva 21 za uporabu kao medikament.
24. Vektor iz zahtjeva 9 kao farmaceutsko sredstvo za genske terapeutske primjene kod ljudi i/ili životinja.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68797105P | 2005-06-07 | 2005-06-07 | |
| US78535306P | 2006-03-23 | 2006-03-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20130632T1 true HRP20130632T1 (hr) | 2013-11-22 |
Family
ID=37193351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20130632TT HRP20130632T1 (hr) | 2005-06-07 | 2013-07-04 | Stabilna i topiva antitijela koja inhibiraju tnf(alfa) |
Country Status (21)
| Country | Link |
|---|---|
| US (5) | US8067547B2 (hr) |
| EP (3) | EP2390267B1 (hr) |
| JP (2) | JP5089582B2 (hr) |
| KR (2) | KR101457223B1 (hr) |
| CN (2) | CN105153306B (hr) |
| AU (1) | AU2006255415B2 (hr) |
| BR (1) | BRPI0611765B1 (hr) |
| CA (1) | CA2609999C (hr) |
| DK (1) | DK2390267T3 (hr) |
| ES (1) | ES2424042T3 (hr) |
| HK (2) | HK1164891A1 (hr) |
| HR (1) | HRP20130632T1 (hr) |
| IL (2) | IL187503A0 (hr) |
| MX (1) | MX2007015280A (hr) |
| NZ (1) | NZ563580A (hr) |
| PH (1) | PH12012500758B1 (hr) |
| PL (1) | PL2390267T3 (hr) |
| PT (1) | PT2390267E (hr) |
| RS (1) | RS52861B (hr) |
| RU (1) | RU2415151C2 (hr) |
| WO (1) | WO2006131013A2 (hr) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7538195B2 (en) * | 2002-06-14 | 2009-05-26 | Immunogen Inc. | Anti-IGF-I receptor antibody |
| NZ563580A (en) | 2005-06-07 | 2010-09-30 | Esbatech An Alcon Biomedical R | Stable and soluble antibodies inhibiting TNFaplha |
| AU2016200367B2 (en) * | 2006-07-10 | 2017-10-12 | Novartis Ag | scFv antibodies which pass epithelial and/or endothelial layers |
| AU2007272224B2 (en) * | 2006-07-10 | 2013-05-02 | Novartis Ag | scFv antibodies which pass epithelial and/or endothelial layers |
| CA2680564C (en) | 2007-03-12 | 2018-05-01 | Esbatech Ag | Sequence based engineering and optimization of single chain antibodies |
| EP2068923A4 (en) * | 2007-03-30 | 2010-11-24 | Medimmune Llc | ANTIBODIES HAVING REDUCED DEAMIDATION PROFILES |
| DK2164961T3 (en) | 2007-06-25 | 2015-03-02 | Esbatech Alcon Biomed Res Unit | Sequence based forward position and optimization of single chain antibodies |
| WO2009000099A2 (en) * | 2007-06-25 | 2008-12-31 | Esbatech Ag | Methods of modifying antibodies, and modified antibodies with improved functional properties |
| KR20100084623A (ko) * | 2007-09-25 | 2010-07-27 | 인터벳 인터내셔널 비.브이. | 골관절염 치료용 백신 |
| EP2918605A1 (en) | 2007-11-12 | 2015-09-16 | U3 Pharma GmbH | Axl antibodies |
| US20110189790A1 (en) * | 2008-01-21 | 2011-08-04 | Karyn O'neil | Methods of Predicting Antibody Solubility |
| WO2009097704A1 (en) * | 2008-02-05 | 2009-08-13 | Esbatech Ag | Antigen-binding polypeptides against cartilage degeneration |
| KR20190133077A (ko) * | 2008-06-25 | 2019-11-29 | 에스바테크 - 어 노바티스 컴파니 엘엘씨 | ＴＮＦα를 저해하는 안정한 가용성 항체 |
| PT2752428T (pt) * | 2008-06-25 | 2020-02-14 | Novartis Ag | Humanização de anticorpos de coelho com utilização de um framework de anticorpos universal |
| DK3241843T3 (da) | 2008-06-25 | 2021-09-06 | Novartis Ag | Opløselighedsoptimering af immunbindere |
| AU2016273957C1 (en) * | 2008-06-25 | 2019-04-18 | Novartis Ag | STABLE AND SOLUBLE ANTIBODIES INHIBITING TNFa |
| KR101882352B1 (ko) | 2008-06-25 | 2018-07-26 | 에스바테크 - 어 노바티스 컴파니 엘엘씨 | 보편적 항체 프레임워크를 사용한 래빗 항체의 인간화 |
| EP2304033B1 (en) | 2008-06-30 | 2016-09-07 | ESBATech, an Alcon Biomedical Research Unit LLC | Functionalized polypeptides |
| CN102088958A (zh) * | 2008-07-10 | 2011-06-08 | 艾斯巴技术,爱尔康生物医药研究装置有限责任公司 | 用于大分子的增强的递送的方法和组合物 |
| EP2270053A1 (en) * | 2009-05-11 | 2011-01-05 | U3 Pharma GmbH | Humanized AXL antibodies |
| BRPI1013428A2 (pt) | 2009-05-11 | 2019-07-02 | U3 Pharma Gmbh | anticorpos humanizados para axl |
| KR20150038556A (ko) * | 2010-04-07 | 2015-04-08 | 애브비 인코포레이티드 | ＴＮＦ-α 결합 단백질 |
| UY33679A (es) | 2010-10-22 | 2012-03-30 | Esbatech | Anticuerpos estables y solubles |
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