PT2752428T - Humanização de anticorpos de coelho com utilização de um framework de anticorpos universal - Google Patents

Humanização de anticorpos de coelho com utilização de um framework de anticorpos universal

Info

Publication number
PT2752428T
PT2752428T PT141626648T PT14162664T PT2752428T PT 2752428 T PT2752428 T PT 2752428T PT 141626648 T PT141626648 T PT 141626648T PT 14162664 T PT14162664 T PT 14162664T PT 2752428 T PT2752428 T PT 2752428T
Authority
PT
Portugal
Prior art keywords
humanization
antibody framework
rabbit antibodies
universal antibody
universal
Prior art date
Application number
PT141626648T
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PT2752428T publication Critical patent/PT2752428T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PT141626648T 2008-06-25 2009-06-25 Humanização de anticorpos de coelho com utilização de um framework de anticorpos universal PT2752428T (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US7569208P 2008-06-25 2008-06-25
US7569708P 2008-06-25 2008-06-25
US15510509P 2009-02-24 2009-02-24
US15504109P 2009-02-24 2009-02-24
CH8322009 2009-06-02

Publications (1)

Publication Number Publication Date
PT2752428T true PT2752428T (pt) 2020-02-14

Family

ID=53532693

Family Applications (2)

Application Number Title Priority Date Filing Date
PT141626648T PT2752428T (pt) 2008-06-25 2009-06-25 Humanização de anticorpos de coelho com utilização de um framework de anticorpos universal
PT97686950T PT2307458T (pt) 2008-06-25 2009-06-25 Humanização de anticorpos de coelho utilizando uma estrutura de anticorpos universal

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT97686950T PT2307458T (pt) 2008-06-25 2009-06-25 Humanização de anticorpos de coelho utilizando uma estrutura de anticorpos universal

Country Status (9)

Country Link
JP (5) JP2015120746A (pt)
KR (2) KR20210097819A (pt)
CL (1) CL2010001539A1 (pt)
ES (1) ES2771150T3 (pt)
HU (1) HUE047678T2 (pt)
PH (2) PH12013502219A1 (pt)
PT (2) PT2752428T (pt)
RU (2) RU2696202C1 (pt)
ZA (3) ZA201008592B (pt)

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE253593T1 (de) * 1996-07-16 2003-11-15 Plueckthun Andreas Prof Dr Immunglobulin-superfamilie domainen und fragmente mit erhöhter löslichkeit
IL154751A0 (en) * 2000-08-03 2003-10-31 Humanized antibodies, recombination vectors, transgenic vectors and methods for the preparation of humanized antibodies from transgenic animals
WO2002086093A2 (en) * 2001-04-25 2002-10-31 Weigel Paul H Methods of using a hyaluronan receptor
US20040110226A1 (en) * 2002-03-01 2004-06-10 Xencor Antibody optimization
DK1506236T3 (da) * 2002-05-22 2013-03-04 Esbatech A Novartis Co Llc Immunglobulin-frameworks, der udviser forbedret stabilitet i det intracellulære miljø og fremgangsmåder til identifikation deraf
AU2003264009A1 (en) 2002-08-15 2004-03-03 Epitomics, Inc. Humanized rabbit antibodies
CN100415765C (zh) 2003-08-07 2008-09-03 宜康公司 兔单克隆抗体的人源化方法
JP2007528723A (ja) * 2003-08-22 2007-10-18 メディミューン，インコーポレーテッド 抗体のヒト化
US7431927B2 (en) * 2005-03-24 2008-10-07 Epitomics, Inc. TNFα-neutralizing antibodies
KR101457223B1 (ko) * 2005-06-07 2014-11-04 에스바테크 - 어 노바티스 컴파니 엘엘씨 ＴＮＦα를 억제하는 안정적이고 가용성인 항체
JP5196654B2 (ja) * 2005-06-20 2013-05-15 ジェネンテック， インコーポレイテッド 腫瘍の診断と治療のための組成物と方法
GB0520436D0 (en) * 2005-10-07 2005-11-16 Photobiotics Ltd Biological materials and uses thereof
WO2008004834A1 (en) * 2006-07-06 2008-01-10 Isu Abxis Co., Ltd Humanized monoclonal antibody highly binding to epidermal growth factor receptor, egf receptor
JP5721951B2 (ja) * 2007-03-22 2015-05-20 バイオジェン アイデック マサチューセッツ インコーポレイテッド 抗体、抗体誘導体、および抗体断片を含む、ｃｄ１５４に特異的に結合する結合タンパク質ならびにその使用

Also Published As

Publication number Publication date
JP2020114260A (ja) 2020-07-30
RU2019119412A (ru) 2020-12-21
ZA201008592B (en) 2014-02-26
KR102284435B1 (ko) 2021-08-02
JP6903083B2 (ja) 2021-07-14
ZA201308755B (en) 2015-08-26
KR20190091578A (ko) 2019-08-06
JP2017190352A (ja) 2017-10-19
JP6568557B2 (ja) 2019-08-28
JP2016135815A (ja) 2016-07-28
JP2019065050A (ja) 2019-04-25
KR20210097819A (ko) 2021-08-09
ES2771150T3 (es) 2020-07-06
JP2015120746A (ja) 2015-07-02
RU2696202C1 (ru) 2019-07-31
HUE047678T2 (hu) 2020-05-28
ZA201503267B (en) 2016-07-27
PH12013502219A1 (en) 2016-01-25
CL2010001539A1 (es) 2012-02-03
PH12018501715A1 (en) 2019-08-19
PT2307458T (pt) 2018-07-18

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