ZA201503267B - Humanization of rabbit antibodies using a universal antibody framework - Google Patents

Humanization of rabbit antibodies using a universal antibody framework

Info

Publication number
ZA201503267B
ZA201503267B ZA2015/03267A ZA201503267A ZA201503267B ZA 201503267 B ZA201503267 B ZA 201503267B ZA 2015/03267 A ZA2015/03267 A ZA 2015/03267A ZA 201503267 A ZA201503267 A ZA 201503267A ZA 201503267 B ZA201503267 B ZA 201503267B
Authority
ZA
South Africa
Prior art keywords
humanization
antibody framework
rabbit antibodies
universal antibody
universal
Prior art date
Application number
ZA2015/03267A
Inventor
David Urech
Leonardo Borras
Original Assignee
Esbatech Alcon Biomed Res Unit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esbatech Alcon Biomed Res Unit filed Critical Esbatech Alcon Biomed Res Unit
Publication of ZA201503267B publication Critical patent/ZA201503267B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
ZA2015/03267A 2008-06-25 2015-05-11 Humanization of rabbit antibodies using a universal antibody framework ZA201503267B (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US7569208P 2008-06-25 2008-06-25
US7569708P 2008-06-25 2008-06-25
US15510509P 2009-02-24 2009-02-24
US15504109P 2009-02-24 2009-02-24
CH8322009 2009-06-02

Publications (1)

Publication Number Publication Date
ZA201503267B true ZA201503267B (en) 2016-07-27

Family

ID=53532693

Family Applications (3)

Application Number Title Priority Date Filing Date
ZA2010/08592A ZA201008592B (en) 2008-06-25 2010-11-30 Humanization of rabbit antibodies using a universal antibody framework
ZA2013/08755A ZA201308755B (en) 2008-06-25 2013-11-21 Humanization of rabbit antibodies using a universal antibody framework
ZA2015/03267A ZA201503267B (en) 2008-06-25 2015-05-11 Humanization of rabbit antibodies using a universal antibody framework

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ZA2010/08592A ZA201008592B (en) 2008-06-25 2010-11-30 Humanization of rabbit antibodies using a universal antibody framework
ZA2013/08755A ZA201308755B (en) 2008-06-25 2013-11-21 Humanization of rabbit antibodies using a universal antibody framework

Country Status (9)

Country Link
JP (5) JP2015120746A (en)
KR (2) KR20210097819A (en)
CL (1) CL2010001539A1 (en)
ES (1) ES2771150T3 (en)
HU (1) HUE047678T2 (en)
PH (2) PH12013502219A1 (en)
PT (2) PT2752428T (en)
RU (2) RU2696202C1 (en)
ZA (3) ZA201008592B (en)

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000516452A (en) * 1996-07-16 2000-12-12 プリュックテュン，アンドレアス Immunoglobulin superfamily domains and fragments with increased solubility
EA013564B1 (en) * 2000-08-03 2010-06-30 Терапеутик Хьюман Поликлоналз Инк. Humanized immunoglobulin and pharmaceutical composition comprising thereof
AU2002303496A2 (en) * 2001-04-25 2002-11-05 Weigel, Janet A Methods of using a hyaluronan receptor
WO2003074679A2 (en) * 2002-03-01 2003-09-12 Xencor Antibody optimization
US8853362B2 (en) * 2002-05-22 2014-10-07 Esbatech, An Alcon Biomedical Research Unit Llc Immunoglobulin frameworks which demonstrate enhanced stability in the intracellular environment and methods of identifying same
CA2492524A1 (en) 2002-08-15 2004-02-26 Epitomics, Inc. Humanized rabbit antibodies
CA2533830A1 (en) * 2003-08-07 2005-02-24 Epitomics, Inc. Methods for humanizing rabbit monoclonal antibodies
EP1660534A2 (en) * 2003-08-22 2006-05-31 MedImmune, Inc. Humanization of antibodies
US7431927B2 (en) * 2005-03-24 2008-10-07 Epitomics, Inc. TNFα-neutralizing antibodies
EP2390267B1 (en) * 2005-06-07 2013-06-05 ESBATech - a Novartis Company LLC Stable and soluble antibodies inhibiting TNF(alpha)
NZ563370A (en) * 2005-06-20 2010-10-29 Genentech Inc Compositions and methods for the diagnosis and treatment of tumor
GB0520436D0 (en) * 2005-10-07 2005-11-16 Photobiotics Ltd Biological materials and uses thereof
WO2008004834A1 (en) * 2006-07-06 2008-01-10 Isu Abxis Co., Ltd Humanized monoclonal antibody highly binding to epidermal growth factor receptor, egf receptor
NZ580245A (en) * 2007-03-22 2012-01-12 Biogen Idec Inc Binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind cd154 and uses thereof

Also Published As

Publication number Publication date
PT2752428T (en) 2020-02-14
RU2696202C1 (en) 2019-07-31
HUE047678T2 (en) 2020-05-28
JP2015120746A (en) 2015-07-02
ZA201308755B (en) 2015-08-26
PH12013502219A1 (en) 2016-01-25
JP2016135815A (en) 2016-07-28
JP2020114260A (en) 2020-07-30
PH12018501715A1 (en) 2019-08-19
CL2010001539A1 (en) 2012-02-03
JP2017190352A (en) 2017-10-19
JP6903083B2 (en) 2021-07-14
ZA201008592B (en) 2014-02-26
KR102284435B1 (en) 2021-08-02
JP6568557B2 (en) 2019-08-28
KR20190091578A (en) 2019-08-06
JP2019065050A (en) 2019-04-25
KR20210097819A (en) 2021-08-09
ES2771150T3 (en) 2020-07-06
RU2019119412A (en) 2020-12-21
PT2307458T (en) 2018-07-18

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