PH12013502219A1 - Humanization of rabbit antibodies using a universal antibody framework - Google Patents

Humanization of rabbit antibodies using a universal antibody framework

Info

Publication number
PH12013502219A1
PH12013502219A1 PH12013502219A PH12013502219A PH12013502219A1 PH 12013502219 A1 PH12013502219 A1 PH 12013502219A1 PH 12013502219 A PH12013502219 A PH 12013502219A PH 12013502219 A PH12013502219 A PH 12013502219A PH 12013502219 A1 PH12013502219 A1 PH 12013502219A1
Authority
PH
Philippines
Prior art keywords
universal antibody
humanization
rabbit antibodies
antibody framework
antibodies
Prior art date
Application number
PH12013502219A
Inventor
Borras Leonardo
Urech David
Original Assignee
Esbatech Alcon Biomed Res Unit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CH2009/000222 external-priority patent/WO2009155726A2/en
Application filed by Esbatech Alcon Biomed Res Unit filed Critical Esbatech Alcon Biomed Res Unit
Publication of PH12013502219A1 publication Critical patent/PH12013502219A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators

Abstract

The present invention relates to an universal antibody acceptor framework and to methods for grafting non-human antibodies, e.g., rabbit antibodies, using a universal antibody acceptor framework. Antibodies generated by the methods of the invention are useful in a variety of diagnostic and therapeutic applications.
PH12013502219A 2008-06-25 2013-10-25 Humanization of rabbit antibodies using a universal antibody framework PH12013502219A1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US7569208P 2008-06-25 2008-06-25
US7569708P 2008-06-25 2008-06-25
US15510509P 2009-02-24 2009-02-24
US15504109P 2009-02-24 2009-02-24
CH8322009 2009-06-02
PCT/CH2009/000222 WO2009155726A2 (en) 2008-06-25 2009-06-25 Humanization of rabbit antibodies using a universal antibody framework

Publications (1)

Publication Number Publication Date
PH12013502219A1 true PH12013502219A1 (en) 2016-01-25

Family

ID=53532693

Family Applications (2)

Application Number Title Priority Date Filing Date
PH12013502219A PH12013502219A1 (en) 2008-06-25 2013-10-25 Humanization of rabbit antibodies using a universal antibody framework
PH12018501715A PH12018501715A1 (en) 2008-06-25 2018-08-13 Humanization of rabbit antibodies using a universal antibody framework

Family Applications After (1)

Application Number Title Priority Date Filing Date
PH12018501715A PH12018501715A1 (en) 2008-06-25 2018-08-13 Humanization of rabbit antibodies using a universal antibody framework

Country Status (9)

Country Link
JP (5) JP2015120746A (en)
KR (2) KR20210097819A (en)
CL (1) CL2010001539A1 (en)
ES (1) ES2771150T3 (en)
HU (1) HUE047678T2 (en)
PH (2) PH12013502219A1 (en)
PT (2) PT2752428T (en)
RU (2) RU2696202C1 (en)
ZA (3) ZA201008592B (en)

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000516452A (en) * 1996-07-16 2000-12-12 プリュックテュン，アンドレアス Immunoglobulin superfamily domains and fragments with increased solubility
EA013564B1 (en) * 2000-08-03 2010-06-30 Терапеутик Хьюман Поликлоналз Инк. Humanized immunoglobulin and pharmaceutical composition comprising thereof
AU2002303496A2 (en) * 2001-04-25 2002-11-05 Weigel, Janet A Methods of using a hyaluronan receptor
WO2003074679A2 (en) * 2002-03-01 2003-09-12 Xencor Antibody optimization
US8853362B2 (en) * 2002-05-22 2014-10-07 Esbatech, An Alcon Biomedical Research Unit Llc Immunoglobulin frameworks which demonstrate enhanced stability in the intracellular environment and methods of identifying same
CA2492524A1 (en) 2002-08-15 2004-02-26 Epitomics, Inc. Humanized rabbit antibodies
CA2533830A1 (en) * 2003-08-07 2005-02-24 Epitomics, Inc. Methods for humanizing rabbit monoclonal antibodies
EP1660534A2 (en) * 2003-08-22 2006-05-31 MedImmune, Inc. Humanization of antibodies
US7431927B2 (en) * 2005-03-24 2008-10-07 Epitomics, Inc. TNFα-neutralizing antibodies
EP2390267B1 (en) * 2005-06-07 2013-06-05 ESBATech - a Novartis Company LLC Stable and soluble antibodies inhibiting TNF(alpha)
NZ563370A (en) * 2005-06-20 2010-10-29 Genentech Inc Compositions and methods for the diagnosis and treatment of tumor
GB0520436D0 (en) * 2005-10-07 2005-11-16 Photobiotics Ltd Biological materials and uses thereof
WO2008004834A1 (en) * 2006-07-06 2008-01-10 Isu Abxis Co., Ltd Humanized monoclonal antibody highly binding to epidermal growth factor receptor, egf receptor
NZ580245A (en) * 2007-03-22 2012-01-12 Biogen Idec Inc Binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind cd154 and uses thereof

Also Published As

Publication number Publication date
PT2752428T (en) 2020-02-14
RU2696202C1 (en) 2019-07-31
HUE047678T2 (en) 2020-05-28
JP2015120746A (en) 2015-07-02
ZA201308755B (en) 2015-08-26
JP2016135815A (en) 2016-07-28
JP2020114260A (en) 2020-07-30
PH12018501715A1 (en) 2019-08-19
CL2010001539A1 (en) 2012-02-03
JP2017190352A (en) 2017-10-19
ZA201503267B (en) 2016-07-27
JP6903083B2 (en) 2021-07-14
ZA201008592B (en) 2014-02-26
KR102284435B1 (en) 2021-08-02
JP6568557B2 (en) 2019-08-28
KR20190091578A (en) 2019-08-06
JP2019065050A (en) 2019-04-25
KR20210097819A (en) 2021-08-09
ES2771150T3 (en) 2020-07-06
RU2019119412A (en) 2020-12-21
PT2307458T (en) 2018-07-18

Similar Documents

Publication Publication Date Title
AU2018200640B2 (en) Humanization of rabbit antibodies using a universal antibody framework
CY1126083T1 (en) RODEN MODELS AND THERAPEUTIC MOLECULES
CY1122278T1 (en) ANTI IL-36R ANTIBODIES
PH12015500125A1 (en) Anti-jagged 1/jagged 2 cross-reactive antibodies, activatable anti-jagged antibodies and methods of use thereof
HK1162119A1 (en) Animal models and therapeutic molecules
TN2014000120A1 (en) Cd27l antigen binding proteins
MX2011003855A (en) Methods for producing antibodies from plasma cells.
AU2012222463A8 (en) Cea antibodies
MX353144B (en) Heterodimeric antibody fc-containing proteins and methods for production thereof.
MY162791A (en) Anti-il-23 antibodies
MX2009000520A (en) Methods for producing fuels and solvents.
MX2009008140A (en) Vaccines based on targeting antigen to dcir expressed an antigen-presenting cells.
WO2010039900A3 (en) Non-human mammals for the production of chimeric antibodies
DE602006006200D1 (en) ANTIBODY AGAINST 25-HYDROXYVITAMINE D
GB201108236D0 (en) Method
WO2009052400A8 (en) Antibodies that bind to mammalian ngal and uses thereof
MY161909A (en) Anti-her3 antibodies and uses thereof
BRPI0916915A2 (en) bispecific cross-reactive anti-il-17a / f antibodies
BR112014005644A2 (en) anti-alphabet antibody
MX2009004167A (en) Antibodies that bind cxcr7 epitopes.
SG178886A1 (en) Humanized anti-cdcp1 antibodies
MX337203B (en) Novel jnk inhibitor molecules.
WO2009130459A3 (en) Epitopes of il-17a and il-17f and antibodies specific thereto
PH12018501715A1 (en) Humanization of rabbit antibodies using a universal antibody framework
MX2020010187A (en) Humanization of rabbit antibodies using a universal antibody framework.