HUE047678T2 - Humanization of rabbit antibodies using a universal antibody framework - Google Patents

Humanization of rabbit antibodies using a universal antibody framework

Info

Publication number
HUE047678T2
HUE047678T2 HUE14162664A HUE14162664A HUE047678T2 HU E047678 T2 HUE047678 T2 HU E047678T2 HU E14162664 A HUE14162664 A HU E14162664A HU E14162664 A HUE14162664 A HU E14162664A HU E047678 T2 HUE047678 T2 HU E047678T2
Authority
HU
Hungary
Prior art keywords
humanization
antibody framework
rabbit antibodies
universal antibody
universal
Prior art date
Application number
HUE14162664A
Other languages
Hungarian (hu)
Inventor
Leonardo Borras
David Urech
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HUE047678T2 publication Critical patent/HUE047678T2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
HUE14162664A 2008-06-25 2009-06-25 Humanization of rabbit antibodies using a universal antibody framework HUE047678T2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US7569708P 2008-06-25 2008-06-25
US7569208P 2008-06-25 2008-06-25
US15510509P 2009-02-24 2009-02-24
US15504109P 2009-02-24 2009-02-24
CH8322009 2009-06-02

Publications (1)

Publication Number Publication Date
HUE047678T2 true HUE047678T2 (en) 2020-05-28

Family

ID=53532693

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE14162664A HUE047678T2 (en) 2008-06-25 2009-06-25 Humanization of rabbit antibodies using a universal antibody framework

Country Status (9)

Country Link
JP (5) JP2015120746A (en)
KR (2) KR20210097819A (en)
CL (1) CL2010001539A1 (en)
ES (1) ES2771150T3 (en)
HU (1) HUE047678T2 (en)
PH (2) PH12013502219A1 (en)
PT (2) PT2752428T (en)
RU (2) RU2696202C1 (en)
ZA (3) ZA201008592B (en)

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69726003T2 (en) * 1996-07-16 2004-08-26 Andreas Plückthun IMMUNGLOBULIN SUPERFAMILY DOMAINS AND FRAGMENTS WITH INCREASED SOLUBILITY
CN1468250A (en) * 2000-08-03 2004-01-14 ��ķһ����˹��̹ Production of humanized antibodies in transgenic animals
WO2002086093A2 (en) * 2001-04-25 2002-10-31 Weigel Paul H Methods of using a hyaluronan receptor
US20040110226A1 (en) * 2002-03-01 2004-06-10 Xencor Antibody optimization
CA2867542C (en) * 2002-05-22 2020-04-14 Esbatech, An Alcon Biomedical Research Unit Llc Immunoglobulin frameworks which demonstrate enhanced stability in the intracellular environment and methods of identifying same
US20040086979A1 (en) 2002-08-15 2004-05-06 Dongxiao Zhang Humanized rabbit antibodies
CA2533830A1 (en) 2003-08-07 2005-02-24 Epitomics, Inc. Methods for humanizing rabbit monoclonal antibodies
JP2007528723A (en) * 2003-08-22 2007-10-18 メディミューン，インコーポレーテッド Antibody humanization
US7431927B2 (en) * 2005-03-24 2008-10-07 Epitomics, Inc. TNFα-neutralizing antibodies
BRPI0611765B1 (en) * 2005-06-07 2022-09-27 Esbatech Ag STABLE AND SOLUBLE ANTIBODY OR FRAGMENT THAT SPECIFICALLY BINDS TO TNF-ALFA ITS USES AND DIAGNOSTIC OR THERAPEUTIC COMPOSITION
CN101948541B (en) * 2005-06-20 2014-08-06 健泰科生物技术公司 Compositions and methods for the diagnosis and treatment of tumor
GB0520436D0 (en) * 2005-10-07 2005-11-16 Photobiotics Ltd Biological materials and uses thereof
WO2008004834A1 (en) * 2006-07-06 2008-01-10 Isu Abxis Co., Ltd Humanized monoclonal antibody highly binding to epidermal growth factor receptor, egf receptor
BRPI0809042B1 (en) * 2007-03-22 2021-08-31 Biogen Ma Inc. ISOLATED CD154-BINDING PROTEIN, ITS USE, AND COMPOSITION

Also Published As

Publication number Publication date
PT2307458T (en) 2018-07-18
JP2015120746A (en) 2015-07-02
PH12018501715A1 (en) 2019-08-19
KR20190091578A (en) 2019-08-06
ES2771150T3 (en) 2020-07-06
RU2019119412A (en) 2020-12-21
KR102284435B1 (en) 2021-08-02
KR20210097819A (en) 2021-08-09
JP2017190352A (en) 2017-10-19
JP2019065050A (en) 2019-04-25
ZA201308755B (en) 2015-08-26
RU2696202C1 (en) 2019-07-31
ZA201008592B (en) 2014-02-26
JP2016135815A (en) 2016-07-28
ZA201503267B (en) 2016-07-27
PH12013502219A1 (en) 2016-01-25
JP6903083B2 (en) 2021-07-14
PT2752428T (en) 2020-02-14
JP2020114260A (en) 2020-07-30
CL2010001539A1 (en) 2012-02-03
JP6568557B2 (en) 2019-08-28

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