HRP20130128T1 - Supstituirani aromatski derivati karboksamida i ureje kao ligandi vaniloidnog receptora - Google Patents

Supstituirani aromatski derivati karboksamida i ureje kao ligandi vaniloidnog receptora Download PDF

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Publication number
HRP20130128T1
HRP20130128T1 HRP20130128AT HRP20130128T HRP20130128T1 HR P20130128 T1 HRP20130128 T1 HR P20130128T1 HR P20130128A T HRP20130128A T HR P20130128AT HR P20130128 T HRP20130128 T HR P20130128T HR P20130128 T1 HRP20130128 T1 HR P20130128T1
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HR
Croatia
Prior art keywords
methyl
alkyl
pyrazol
trifluoromethyl
chlorophenyl
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HRP20130128AT
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English (en)
Croatian (hr)
Inventor
Robert Frank
Gregor Bahrenberg
Thomas Christoph
Klaus Schiene
Jean De Vry
Nils Damann
Sven Frormann
Bernhard Lesch
Jeewoo Lee
Yong-Soo Kim
Myeong-Seop Kim
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Grünenthal GmbH
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Publication of HRP20130128T1 publication Critical patent/HRP20130128T1/hr

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    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biotechnology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
HRP20130128AT 2009-05-07 2010-05-06 Supstituirani aromatski derivati karboksamida i ureje kao ligandi vaniloidnog receptora HRP20130128T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17627709P 2009-05-07 2009-05-07
EP09006221 2009-05-07
PCT/EP2010/002785 WO2010127855A1 (en) 2009-05-07 2010-05-06 Substituted aromatic carboxamide and urea derivatives as vanilloid receptor ligands

Publications (1)

Publication Number Publication Date
HRP20130128T1 true HRP20130128T1 (hr) 2013-03-31

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ID=40848721

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20130128AT HRP20130128T1 (hr) 2009-05-07 2010-05-06 Supstituirani aromatski derivati karboksamida i ureje kao ligandi vaniloidnog receptora

Country Status (16)

Country Link
US (1) US8334315B2 (enExample)
EP (1) EP2427436B1 (enExample)
JP (1) JP5767631B2 (enExample)
AR (1) AR076753A1 (enExample)
AU (1) AU2010244684B2 (enExample)
BR (1) BRPI1011192A2 (enExample)
CA (1) CA2758289A1 (enExample)
DK (1) DK2427436T3 (enExample)
ES (1) ES2402805T3 (enExample)
HR (1) HRP20130128T1 (enExample)
MX (1) MX2011011800A (enExample)
PL (1) PL2427436T3 (enExample)
PT (1) PT2427436E (enExample)
SI (1) SI2427436T1 (enExample)
TW (1) TWI504589B (enExample)
WO (1) WO2010127855A1 (enExample)

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US8946204B2 (en) * 2009-05-07 2015-02-03 Gruenenthal Gmbh Substituted phenylureas and phenylamides as vanilloid receptor ligands
KR101746016B1 (ko) * 2009-05-07 2017-06-14 (주) 메디프론디비티 바닐로이드 수용체 리간드로서의 치환된 페닐우레아 및 페닐아미드
AU2011238616B2 (en) 2010-03-30 2016-08-04 Verseon Corporation Multisubstituted aromatic compounds as inhibitors of thrombin
BR112014001714A2 (pt) 2011-07-26 2017-02-14 Gruenenthal Gmbh derivados de carboxamida e ureia aromáticos bicíclicos substituídos como ligantes de receptor vaniloide
PE20140836A1 (es) 2011-07-26 2014-08-03 Gruenenthal Chemie Derivados de carboxamida y urea que contienen pirazol heteroaromatico sustituido como ligandos del receptor de vanilloide
EP2763673B1 (en) * 2011-09-15 2018-08-01 Taipei Medical University Use of indolyl hydroxamates for treating heart failure or neuronal injury
JP2014532746A (ja) 2011-11-09 2014-12-08 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング バニロイド受容体リガンドとしての、ｃｏ含有基で置換されたフェニル部分を担持する置換ピラゾリルをベースとするカルボキサミドおよび尿素誘導体
EP2776424A1 (en) 2011-11-09 2014-09-17 Grünenthal GmbH Substituted pyrazolyl-based carboxamide and urea derivatives bearing a phenyl moiety substituted with an n-cyclic group as vanilloid receptor ligands
AR088702A1 (es) * 2011-11-09 2014-06-25 Gruenenthal Gmbh Derivados de carboxamida y urea, basados en pirazolilo sustituido, que presentan una porcion fenilo sustituida con un grupo que contiene o como ligando de receptor vainilloide
CN104066720A (zh) 2011-11-09 2014-09-24 格吕伦塔尔有限公司 作为类香草素受体配体的具有被含so2-基团取代的苯基基团的被取代的基于吡唑基的羧酰胺和脲衍生物
CA2854935A1 (en) * 2011-11-09 2013-05-16 Grunenthal Gmbh Substituted pyrazolyl-based carboxamide and urea derivatives bearing a phenyl moiety substituted with an n-containing group as vanilloid receptor ligands
CN110423221A (zh) 2013-03-15 2019-11-08 维颂公司 作为凝血酶抑制剂的卤代吡唑
HUE042393T2 (hu) 2013-03-15 2019-06-28 Verseon Corp Multiszubsztituált aromás vegyületek, mint szerinproteáz inhibitorok
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CN107405333A (zh) 2015-02-27 2017-11-28 维颂公司 作为丝氨酸蛋白酶抑制剂的被取代的吡唑化合物
US20180194769A1 (en) 2015-07-06 2018-07-12 Rodin Therapeutics, Inc. Hetero-halo inhibitors of histone deacetylase
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