HRP20120968T1 - Spojevi - Google Patents
Spojevi Download PDFInfo
- Publication number
- HRP20120968T1 HRP20120968T1 HRP20120968AT HRP20120968T HRP20120968T1 HR P20120968 T1 HRP20120968 T1 HR P20120968T1 HR P20120968A T HRP20120968A T HR P20120968AT HR P20120968 T HRP20120968 T HR P20120968T HR P20120968 T1 HRP20120968 T1 HR P20120968T1
- Authority
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- Croatia
- Prior art keywords
- alkyl
- formula
- independently selected
- cycloalkyl
- compound
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims 36
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 32
- 229910020008 S(O) Inorganic materials 0.000 claims 30
- 150000003839 salts Chemical class 0.000 claims 30
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 30
- 125000001424 substituent group Chemical group 0.000 claims 28
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 27
- 229910052736 halogen Inorganic materials 0.000 claims 27
- 150000002367 halogens Chemical class 0.000 claims 27
- 229910052739 hydrogen Inorganic materials 0.000 claims 17
- 239000001257 hydrogen Substances 0.000 claims 17
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 16
- 229910052717 sulfur Inorganic materials 0.000 claims 16
- 229910052760 oxygen Inorganic materials 0.000 claims 14
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 125000005842 heteroatom Chemical group 0.000 claims 12
- 150000002431 hydrogen Chemical class 0.000 claims 12
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 11
- 125000001931 aliphatic group Chemical group 0.000 claims 11
- 125000004093 cyano group Chemical group *C#N 0.000 claims 11
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 11
- 125000004432 carbon atom Chemical group C* 0.000 claims 10
- 238000006243 chemical reaction Methods 0.000 claims 8
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 claims 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 7
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 6
- 238000010511 deprotection reaction Methods 0.000 claims 6
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 125000006239 protecting group Chemical group 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 3
- 125000004429 atom Chemical group 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 239000003638 chemical reducing agent Substances 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 239000011737 fluorine Substances 0.000 claims 3
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 125000006413 ring segment Chemical group 0.000 claims 2
- MIOPJNTWMNEORI-GMSGAONNSA-N (S)-camphorsulfonic acid Chemical compound C1C[C@@]2(CS(O)(=O)=O)C(=O)C[C@@H]1C2(C)C MIOPJNTWMNEORI-GMSGAONNSA-N 0.000 claims 1
- BWJNPOUSYPYNOE-ZKZUTQDZSA-N (e)-but-2-enedioic acid;7-[(1r)-2-[2-[2-fluoro-5-[[4-(2-propan-2-yl-1,3-thiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]ethylamino]-1-hydroxyethyl]-4-hydroxy-3h-1,3-benzothiazol-2-one Chemical compound OC(=O)\C=C\C(O)=O.S1C(C(C)C)=NC(C(=O)N2CC3(CCN(CC=4C=C(CCNC[C@H](O)C=5C=6SC(=O)NC=6C(O)=CC=5)C(F)=CC=4)CC3)OCC2)=C1 BWJNPOUSYPYNOE-ZKZUTQDZSA-N 0.000 claims 1
- JTUIRONQUPEAHX-UHFFFAOYSA-N 1-oxa-4,9-diazaspiro[5.5]undecan-4-yl-(2-propan-2-yl-1,3-thiazol-4-yl)methanone Chemical compound S1C(C(C)C)=NC(C(=O)N2CC3(CCNCC3)OCC2)=C1 JTUIRONQUPEAHX-UHFFFAOYSA-N 0.000 claims 1
- RRGKLLSQTYKKQM-MHZLTWQESA-N 7-[(1r)-2-[2-[2-fluoro-5-[[4-(2-propan-2-yl-1,3-thiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]ethylamino]-1-hydroxyethyl]-4-hydroxy-3h-1,3-benzothiazol-2-one Chemical compound S1C(C(C)C)=NC(C(=O)N2CC3(CCN(CC=4C=C(CCNC[C@H](O)C=5C=6SC(=O)NC=6C(O)=CC=5)C(F)=CC=4)CC3)OCC2)=C1 RRGKLLSQTYKKQM-MHZLTWQESA-N 0.000 claims 1
- JYBWEWABRHZJJB-LPCSYZHESA-N 7-[(1r)-2-[2-[2-fluoro-5-[[4-(2-propan-2-yl-1,3-thiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]ethylamino]-1-hydroxyethyl]-4-hydroxy-3h-1,3-benzothiazol-2-one;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.S1C(C(C)C)=NC(C(=O)N2CC3(CCN(CC=4C=C(CCNC[C@H](O)C=5C=6SC(=O)NC=6C(O)=CC=5)C(F)=CC=4)CC3)OCC2)=C1 JYBWEWABRHZJJB-LPCSYZHESA-N 0.000 claims 1
- RRGKLLSQTYKKQM-UHFFFAOYSA-N 7-[2-[2-[2-fluoro-5-[[4-(2-propan-2-yl-1,3-thiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]methyl]phenyl]ethylamino]-1-hydroxyethyl]-4-hydroxy-3h-1,3-benzothiazol-2-one Chemical compound S1C(C(C)C)=NC(C(=O)N2CC3(CCN(CC=4C=C(CCNCC(O)C=5C=6SC(=O)NC=6C(O)=CC=5)C(F)=CC=4)CC3)OCC2)=C1 RRGKLLSQTYKKQM-UHFFFAOYSA-N 0.000 claims 1
- 102000009410 Chemokine receptor Human genes 0.000 claims 1
- 108050000299 Chemokine receptor Proteins 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 102000003676 Glucocorticoid Receptors Human genes 0.000 claims 1
- 108090000079 Glucocorticoid Receptors Proteins 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 102000015005 beta-adrenergic receptor activity proteins Human genes 0.000 claims 1
- 108040006818 beta-adrenergic receptor activity proteins Proteins 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003862 glucocorticoid Substances 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 230000003637 steroidlike Effects 0.000 claims 1
- 229940037128 systemic glucocorticoids Drugs 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
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GB0613154D0 (en) * | 2006-06-30 | 2006-08-09 | Novartis Ag | Organic Compounds |
KR20090094149A (ko) | 2006-12-20 | 2009-09-03 | 아스트라제네카 아베 | 아민 유도체 및 베타-2-아드레날린 수용체 매개된 질환에서의 그의 용도 |
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GB0913345D0 (en) | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | New combination 802 |
GB0913342D0 (en) | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | Compounds - 801 |
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