DK3697795T3 - Salts of (r)-9-(2,5-difluorophenethyl)-4-ethyl-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one - Google Patents

Salts of (r)-9-(2,5-difluorophenethyl)-4-ethyl-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one Download PDF

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Publication number
DK3697795T3
DK3697795T3 DK18796360.8T DK18796360T DK3697795T3 DK 3697795 T3 DK3697795 T3 DK 3697795T3 DK 18796360 T DK18796360 T DK 18796360T DK 3697795 T3 DK3697795 T3 DK 3697795T3
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Prior art keywords
difluorophenethyl
undecan
diazaspiro
oxa
salts
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DK18796360.8T
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English (en)
Inventor
Carmen Almansa-Rosales
Nicolas Tesson
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Acondicionamiento Tarrasense
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Publication of DK3697795T3 publication Critical patent/DK3697795T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK18796360.8T 2017-10-17 2018-10-16 Salts of (r)-9-(2,5-difluorophenethyl)-4-ethyl-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one DK3697795T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17382695 2017-10-17
PCT/EP2018/000470 WO2019076475A1 (en) 2017-10-17 2018-10-16 (R) -9- (2,5-DIFLUOROPHENETHYL) -4-ETHYL-2-METHYL-1-OXA-4,9-DIAZASPIRO SALTS [5.5] UNDECAN-3-ONE

Publications (1)

Publication Number Publication Date
DK3697795T3 true DK3697795T3 (da) 2024-02-26

Family

ID=60201976

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18796360.8T DK3697795T3 (da) 2017-10-17 2018-10-16 Salts of (r)-9-(2,5-difluorophenethyl)-4-ethyl-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one

Country Status (24)

Country Link
US (1) US11236110B2 (da)
EP (1) EP3697795B1 (da)
JP (1) JP2020537648A (da)
KR (1) KR20200071107A (da)
CN (1) CN111263764A (da)
AR (1) AR113770A1 (da)
AU (1) AU2018353107B2 (da)
BR (1) BR112020007359A2 (da)
CA (1) CA3076765A1 (da)
CO (1) CO2020005710A2 (da)
DK (1) DK3697795T3 (da)
ES (1) ES2974331T3 (da)
FI (1) FI3697795T3 (da)
IL (1) IL273751B2 (da)
LT (1) LT3697795T (da)
MA (1) MA50395A (da)
MX (1) MX2020004214A (da)
PH (1) PH12020550104A1 (da)
PT (1) PT3697795T (da)
RU (1) RU2020115274A (da)
SG (1) SG11202002731YA (da)
SI (1) SI3697795T1 (da)
TW (1) TWI835755B (da)
WO (1) WO2019076475A1 (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021018824A1 (en) * 2019-07-31 2021-02-04 Esteve Pharmaceuticals, S.A. Use of (r)-9-(2,5-difluorophenethyl)-4-ethyl-2-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one for the treatment of nociceptive pain, neuropathic pain, osteoarthritis pain and cancer pain, while having reduced side effects compared to opioids
WO2024105225A1 (en) 2022-11-18 2024-05-23 Universitat De Barcelona Synergistic combinations of a sigma receptor 1 (s1r) antagonist and a soluble epoxide hydrolase inhibitor (sehi) and their use in the treatment of pain

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4332804A (en) 1981-03-23 1982-06-01 Syntex (U.S.A.) Inc. 9-[2-(3-Indolyl)ethyl]-1oxa-4,9-diazaspiro[5.5]undecan-3-ones
US4353900A (en) 1981-10-19 1982-10-12 Syntex (U.S.A.) Inc. 9-(Arylalkyl or aroylalkyl)-1-oxa-4,9-diazaspiro(5.5)undecan-3-ones
US6114541A (en) 1997-03-10 2000-09-05 Hoffmann-La Roche Inc. Method for the preparation of α-Bromo-Lactam derivatives
DE102005030051A1 (de) 2005-06-27 2006-12-28 Grünenthal GmbH Substituierte 1-Oxa-3,8-diazaspiro[4,5]-decan-2-on-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
ES2407115T3 (es) 2005-11-18 2013-06-11 Ono Pharmaceutical Co., Ltd. Compuesto que contiene un grupo básico y uso del mismo
CA2679530C (en) 2007-03-01 2012-09-25 Mitsubishi Tanabe Pharma Corporation Benzimidazole compound and pharmaceutical use thereof
EP1982714A1 (en) 2007-04-16 2008-10-22 Laboratorios del Dr. Esteve S.A. Pyrano-pyrazole-amines
EP2020414A1 (en) 2007-06-20 2009-02-04 Laboratorios del Dr. Esteve S.A. spiro[piperidine-4,4'-thieno[3,2-c]pyran] derivatives and related compounds as inhibitors of the sigma receptor for the treatment of psychosis
US20110190280A1 (en) 2007-08-29 2011-08-04 George Adjabeng Thiazole And Oxazole Kinase Inhibitors
PL2242759T3 (pl) 2008-02-06 2013-06-28 Astrazeneca Ab Związki
MX347982B (es) 2011-03-14 2017-05-22 Vertex Pharma Morfolina-piperidina espirociclica-amidas como moduladores de canales ionicos.
GB201107985D0 (en) 2011-05-13 2011-06-29 Astrazeneca Ab Process
TN2015000474A1 (en) * 2013-04-23 2017-04-06 Esteve Labor Dr PYRAZINO[1,2-a]INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS
US9751881B2 (en) 2013-07-31 2017-09-05 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
JP2017100951A (ja) * 2014-04-04 2017-06-08 大正製薬株式会社 オキサゾリジノン及びオキサジナノン誘導体
TWI685497B (zh) * 2014-06-02 2020-02-21 西班牙商伊史帝夫製藥公司 具有多重模式抗疼痛活性的１-氧雜-４,９-二氮雜螺十一烷化合物之烷基衍生物
TW201615642A (zh) 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性的１－氧雜－４，９－二氮雜螺十一烷化合物之醯胺衍生物
TW201615643A (zh) 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性之１－氧雜－４，９－二氮雜螺十一烷化合物之烷基與芳基衍生物

Also Published As

Publication number Publication date
TW201922752A (zh) 2019-06-16
IL273751B2 (en) 2024-02-01
RU2020115274A (ru) 2021-11-01
CN111263764A (zh) 2020-06-09
CO2020005710A2 (es) 2020-05-29
WO2019076475A1 (en) 2019-04-25
TWI835755B (zh) 2024-03-21
IL273751A (en) 2020-05-31
AR113770A1 (es) 2020-06-10
EP3697795A1 (en) 2020-08-26
BR112020007359A2 (pt) 2020-09-29
LT3697795T (lt) 2024-04-10
US20200331929A1 (en) 2020-10-22
AU2018353107B2 (en) 2023-07-06
EP3697795B1 (en) 2023-11-22
MA50395A (fr) 2020-08-26
IL273751B1 (en) 2023-10-01
SI3697795T1 (sl) 2024-05-31
ES2974331T3 (es) 2024-06-26
FI3697795T3 (fi) 2024-02-23
KR20200071107A (ko) 2020-06-18
CA3076765A1 (en) 2019-04-25
JP2020537648A (ja) 2020-12-24
RU2020115274A3 (da) 2022-04-29
SG11202002731YA (en) 2020-05-28
MX2020004214A (es) 2020-08-13
US11236110B2 (en) 2022-02-01
PT3697795T (pt) 2024-02-29
PH12020550104A1 (en) 2021-01-25
AU2018353107A1 (en) 2020-04-23

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