HRP20110804T1 - Benzocikloheptapiridini kao inhibitori receptora tirozin kinaze met - Google Patents

Benzocikloheptapiridini kao inhibitori receptora tirozin kinaze met Download PDF

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Publication number
HRP20110804T1
HRP20110804T1 HR20110804T HRP20110804T HRP20110804T1 HR P20110804 T1 HRP20110804 T1 HR P20110804T1 HR 20110804 T HR20110804 T HR 20110804T HR P20110804 T HRP20110804 T HR P20110804T HR P20110804 T1 HRP20110804 T1 HR P20110804T1
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HR
Croatia
Prior art keywords
cyclohepta
benzo
pyridin
oxo
methyl
Prior art date
Application number
HR20110804T
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English (en)
Croatian (hr)
Inventor
J. Dinsmore Christopher
Esther Ortega Gabarda Ana
J. Guerin David
P. Jewell James
D. Katz Jason
Lim Jongwon
R. Machacek Michelle
D. Otte Ryan
R. Young Jonathan
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Merck Sharp & Dohme Corp.
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Application filed by Merck Sharp & Dohme Corp. filed Critical Merck Sharp & Dohme Corp.
Publication of HRP20110804T1 publication Critical patent/HRP20110804T1/hr

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
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  • Pain & Pain Management (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
HR20110804T 2005-06-23 2011-11-02 Benzocikloheptapiridini kao inhibitori receptora tirozin kinaze met HRP20110804T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69322905P 2005-06-23 2005-06-23
US72906105P 2005-10-21 2005-10-21
PCT/US2006/024247 WO2007002254A2 (en) 2005-06-23 2006-06-22 Benzocycloheptapyridines as inhibitors of the receptor tyrosine kinase met

Publications (1)

Publication Number Publication Date
HRP20110804T1 true HRP20110804T1 (hr) 2011-11-30

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HR20110804T HRP20110804T1 (hr) 2005-06-23 2011-11-02 Benzocikloheptapiridini kao inhibitori receptora tirozin kinaze met

Country Status (11)

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US (2) US8207186B2 (ja)
EP (1) EP1896421B1 (ja)
JP (2) JP4119478B1 (ja)
AT (1) ATE524445T1 (ja)
AU (1) AU2006262172B2 (ja)
CA (1) CA2611530C (ja)
DK (1) DK1896421T3 (ja)
HR (1) HRP20110804T1 (ja)
RU (1) RU2408584C2 (ja)
SI (1) SI1896421T1 (ja)
WO (1) WO2007002254A2 (ja)

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WO2017161004A1 (en) * 2016-03-15 2017-09-21 University Of South Florida PKCδ INHIBITOR FORMULATIONS AND USES THEREOF CROSS-REFERENCE TO RELATED APPLICATIONS
WO2019099873A1 (en) 2017-11-17 2019-05-23 The Board Of Trustees Of The University Of Illinois Cancer therapy by degrading dual mek signaling
EA202192575A1 (ru) 2019-03-21 2022-01-14 Онксео Соединения dbait в сочетании с ингибиторами киназ для лечения рака
US20220401436A1 (en) 2019-11-08 2022-12-22 INSERM (Institute National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
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WO2007050380A2 (en) 2005-10-21 2007-05-03 Merck & Co., Inc. Tyrosine kinase inhibitors
JP2009512707A (ja) 2005-10-21 2009-03-26 メルク エンド カムパニー インコーポレーテッド チロシンキナーゼインヒビター
JP2009513580A (ja) 2005-10-21 2009-04-02 メルク エンド カムパニー インコーポレーテッド チロシンキナーゼ阻害剤
TW200813021A (en) 2006-07-10 2008-03-16 Merck & Co Inc Tyrosine kinase inhibitors

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RU2408584C2 (ru) 2011-01-10
DK1896421T3 (da) 2012-01-09
AU2006262172A1 (en) 2007-01-04
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JP5086762B2 (ja) 2012-11-28
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AU2006262172B2 (en) 2010-05-27
JP4119478B1 (ja) 2008-07-16
US20090197908A1 (en) 2009-08-06
US20060293358A1 (en) 2006-12-28
US8207186B2 (en) 2012-06-26
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SI1896421T1 (sl) 2012-01-31
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