HRP20110634T1 - KOMBINIRANA TERAPIJA LIGANADA α<SUB>2</SUB>δ I NSAID ZA POREMEĆAJE DONJEG URINARNOG TRAKTA - Google Patents
KOMBINIRANA TERAPIJA LIGANADA α<SUB>2</SUB>δ I NSAID ZA POREMEĆAJE DONJEG URINARNOG TRAKTA Download PDFInfo
- Publication number
- HRP20110634T1 HRP20110634T1 HR20110634T HRP20110634T HRP20110634T1 HR P20110634 T1 HRP20110634 T1 HR P20110634T1 HR 20110634 T HR20110634 T HR 20110634T HR P20110634 T HRP20110634 T HR P20110634T HR P20110634 T1 HRP20110634 T1 HR P20110634T1
- Authority
- HR
- Croatia
- Prior art keywords
- aminomethyl
- nsaid
- methyl
- amino
- carboxymethyl
- Prior art date
Links
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 title claims abstract 25
- 239000003446 ligand Substances 0.000 title claims abstract 13
- 208000026723 Urinary tract disease Diseases 0.000 title claims abstract 4
- 208000014001 urinary system disease Diseases 0.000 title claims abstract 4
- 238000002648 combination therapy Methods 0.000 title 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims abstract 24
- 108090000312 Calcium Channels Proteins 0.000 claims abstract 6
- 102000003922 Calcium Channels Human genes 0.000 claims abstract 6
- 206010046543 Urinary incontinence Diseases 0.000 claims abstract 6
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 claims 10
- LUANXJIOUGKVRZ-UWVGGRQHSA-N (2s,4s)-4-(3-chlorophenoxy)pyrrolidine-2-carboxylic acid Chemical compound C1N[C@H](C(=O)O)C[C@@H]1OC1=CC=CC(Cl)=C1 LUANXJIOUGKVRZ-UWVGGRQHSA-N 0.000 claims 5
- GUEQOLSQPOTTME-RQJHMYQMSA-N (3s,5r)-3-amino-5-methylheptanoic acid Chemical compound CC[C@@H](C)C[C@H](N)CC(O)=O GUEQOLSQPOTTME-RQJHMYQMSA-N 0.000 claims 5
- XKWDZEJCUWTBOM-BDAKNGLRSA-N (3s,5r)-3-amino-5-methylnonanoic acid Chemical compound CCCC[C@@H](C)C[C@H](N)CC(O)=O XKWDZEJCUWTBOM-BDAKNGLRSA-N 0.000 claims 5
- MOEZPHHJIZLEKX-UHFFFAOYSA-N 3-[[1-(aminomethyl)cyclohexyl]methyl]-2h-1,2,4-oxadiazol-5-one Chemical compound N=1OC(=O)NC=1CC1(CN)CCCCC1 MOEZPHHJIZLEKX-UHFFFAOYSA-N 0.000 claims 5
- OHNKRFQIDUFFNJ-UHFFFAOYSA-N [1-(2h-tetrazol-5-ylmethyl)cyclohexyl]methanamine Chemical compound N=1N=NNC=1CC1(CN)CCCCC1 OHNKRFQIDUFFNJ-UHFFFAOYSA-N 0.000 claims 5
- 229960002870 gabapentin Drugs 0.000 claims 5
- JXEHXYFSIOYTAH-SFYZADRCSA-N imagabalin Chemical compound CCC[C@@H](C)C[C@H](N)CC(O)=O JXEHXYFSIOYTAH-SFYZADRCSA-N 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 229960001233 pregabalin Drugs 0.000 claims 5
- AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 claims 5
- RGFRGRZSMVXTLF-ONGXEEELSA-N (2s,4s)-4-[(3-fluorophenyl)methyl]pyrrolidine-2-carboxylic acid Chemical compound C1N[C@H](C(=O)O)C[C@@H]1CC1=CC=CC(F)=C1 RGFRGRZSMVXTLF-ONGXEEELSA-N 0.000 claims 4
- KRZJRNZICWNMOA-GXSJLCMTSA-N (3s,4r)-4,8-dihydroxy-3-methoxy-3,4-dihydro-2h-naphthalen-1-one Chemical compound C1=CC=C2[C@@H](O)[C@@H](OC)CC(=O)C2=C1O KRZJRNZICWNMOA-GXSJLCMTSA-N 0.000 claims 4
- KKXFMWXZXDUYBF-BDAKNGLRSA-N (3s,5r)-3-(aminomethyl)-5-methyloctanoic acid Chemical compound CCC[C@@H](C)C[C@H](CN)CC(O)=O KKXFMWXZXDUYBF-BDAKNGLRSA-N 0.000 claims 4
- JXSBZOVCVUSLIO-NQMVMOMDSA-N 2-[(1r,5r,6s)-6-(aminomethyl)-6-bicyclo[3.2.0]heptanyl]acetic acid Chemical compound C1CC[C@H]2[C@@](CN)(CC(O)=O)C[C@H]21 JXSBZOVCVUSLIO-NQMVMOMDSA-N 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 210000001635 urinary tract Anatomy 0.000 claims 4
- 229940124638 COX inhibitor Drugs 0.000 claims 3
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 claims 3
- 229960000590 celecoxib Drugs 0.000 claims 3
- RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 claims 3
- 229960001259 diclofenac Drugs 0.000 claims 3
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 claims 3
- 229960000616 diflunisal Drugs 0.000 claims 3
- HUPFGZXOMWLGNK-UHFFFAOYSA-N diflunisal Chemical compound C1=C(O)C(C(=O)O)=CC(C=2C(=CC(F)=CC=2)F)=C1 HUPFGZXOMWLGNK-UHFFFAOYSA-N 0.000 claims 3
- 229960002390 flurbiprofen Drugs 0.000 claims 3
- SYTBZMRGLBWNTM-UHFFFAOYSA-N flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 claims 3
- 229960002009 naproxen Drugs 0.000 claims 3
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 claims 3
- 229960000965 nimesulide Drugs 0.000 claims 3
- HYWYRSMBCFDLJT-UHFFFAOYSA-N nimesulide Chemical compound CS(=O)(=O)NC1=CC=C([N+]([O-])=O)C=C1OC1=CC=CC=C1 HYWYRSMBCFDLJT-UHFFFAOYSA-N 0.000 claims 3
- 229960000894 sulindac Drugs 0.000 claims 3
- MLKXDPUZXIRXEP-MFOYZWKCSA-N sulindac Chemical compound CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(S(C)=O)C=C1 MLKXDPUZXIRXEP-MFOYZWKCSA-N 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- -1 (3S,4S)-(1-aminomethyl-1-carboxymethyl) -3,4-dimethyl-cyclopentane Chemical compound 0.000 claims 1
- KKXFMWXZXDUYBF-GKAPJAKFSA-N (3s)-3-(aminomethyl)-5-methyloctanoic acid Chemical compound CCCC(C)C[C@H](CN)CC(O)=O KKXFMWXZXDUYBF-GKAPJAKFSA-N 0.000 claims 1
- JXSBZOVCVUSLIO-HUWCLSLFSA-N 2-[(1r,6s)-6-(aminomethyl)-6-bicyclo[3.2.0]heptanyl]acetic acid Chemical compound C1CCC2[C@@](CN)(CC(O)=O)C[C@H]21 JXSBZOVCVUSLIO-HUWCLSLFSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 208000012931 Urologic disease Diseases 0.000 abstract 2
- 208000024891 symptom Diseases 0.000 abstract 2
- 230000000996 additive effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000002301 combined effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87171906P | 2006-12-22 | 2006-12-22 | |
PCT/EP2007/011313 WO2008077599A1 (en) | 2006-12-22 | 2007-12-21 | COMBINATION THERAPY OF LOWER URINARY TRACT DISORDERS WITH α2δ LIGANDS AND NSAIDS |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20110634T1 true HRP20110634T1 (hr) | 2011-10-31 |
Family
ID=39272500
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20110634T HRP20110634T1 (hr) | 2006-12-22 | 2011-09-07 | KOMBINIRANA TERAPIJA LIGANADA α<SUB>2</SUB>δ I NSAID ZA POREMEĆAJE DONJEG URINARNOG TRAKTA |
Country Status (26)
Country | Link |
---|---|
US (1) | US20080153888A1 (ja) |
EP (1) | EP2125021B8 (ja) |
JP (1) | JP5308350B2 (ja) |
KR (1) | KR20090092307A (ja) |
CN (2) | CN101600458A (ja) |
AT (1) | ATE511860T1 (ja) |
AU (1) | AU2007338367B2 (ja) |
BR (1) | BRPI0720351A2 (ja) |
CA (1) | CA2673545A1 (ja) |
CY (1) | CY1111783T1 (ja) |
DK (1) | DK2125021T3 (ja) |
EA (1) | EA017171B1 (ja) |
ES (1) | ES2367881T3 (ja) |
HK (1) | HK1155663A1 (ja) |
HR (1) | HRP20110634T1 (ja) |
IL (1) | IL198891A (ja) |
MX (1) | MX2009006575A (ja) |
NO (1) | NO20092581L (ja) |
NZ (1) | NZ577097A (ja) |
PL (1) | PL2125021T3 (ja) |
PT (1) | PT2125021E (ja) |
RS (1) | RS51940B (ja) |
SI (1) | SI2125021T1 (ja) |
UA (1) | UA94979C2 (ja) |
WO (1) | WO2008077599A1 (ja) |
ZA (1) | ZA200905038B (ja) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2735913A1 (en) | 2008-09-04 | 2010-03-11 | Neurosearch A/S | A method for combating adverse effects arising from antipsychotic treatment |
US9415048B2 (en) * | 2010-07-08 | 2016-08-16 | Wellesley Pharmaceuticals, Llc | Pharmaceutical formulation for reducing frequency of urination and method of use thereof |
US20130323288A1 (en) * | 2010-07-08 | 2013-12-05 | Wellesley Pharmaceuticals, Llc | Pharmaceutical formulation for bedwetting and method of use thereof |
CN102648915B (zh) * | 2011-02-28 | 2015-04-15 | 鲁南制药集团股份有限公司 | 一种治疗或预防神经病理性疼痛的药物组合物 |
ITMI20121263A1 (it) | 2012-07-19 | 2014-01-20 | Recordati Ind Chimica E Farma Ceutica S P A | Forma farmaceutica multistrato |
US10792326B2 (en) | 2013-06-28 | 2020-10-06 | Wellesley Pharmaceuticals, Llc | Pharmaceutical formulation for bedwetting and method of use thereof |
CR20160573A (es) | 2014-06-16 | 2017-03-14 | Farmacéuticos Rayere S A | Composición farmaceutica que combina un anticonvulsivante y un derivado del ácido nicotínico |
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-
2007
- 2007-12-21 CN CNA2007800475013A patent/CN101600458A/zh active Pending
- 2007-12-21 AT AT07857036T patent/ATE511860T1/de active
- 2007-12-21 DK DK07857036.3T patent/DK2125021T3/da active
- 2007-12-21 BR BRPI0720351-9A patent/BRPI0720351A2/pt not_active IP Right Cessation
- 2007-12-21 PT PT07857036T patent/PT2125021E/pt unknown
- 2007-12-21 AU AU2007338367A patent/AU2007338367B2/en not_active Ceased
- 2007-12-21 UA UAA200907212A patent/UA94979C2/ru unknown
- 2007-12-21 KR KR1020097013512A patent/KR20090092307A/ko not_active Application Discontinuation
- 2007-12-21 CA CA002673545A patent/CA2673545A1/en not_active Abandoned
- 2007-12-21 ES ES07857036T patent/ES2367881T3/es active Active
- 2007-12-21 RS RS20110391A patent/RS51940B/en unknown
- 2007-12-21 WO PCT/EP2007/011313 patent/WO2008077599A1/en active Application Filing
- 2007-12-21 SI SI200730624T patent/SI2125021T1/sl unknown
- 2007-12-21 CN CN2010105071804A patent/CN102058885B/zh not_active Expired - Fee Related
- 2007-12-21 JP JP2009541901A patent/JP5308350B2/ja not_active Expired - Fee Related
- 2007-12-21 EA EA200900868A patent/EA017171B1/ru not_active IP Right Cessation
- 2007-12-21 NZ NZ577097A patent/NZ577097A/en not_active IP Right Cessation
- 2007-12-21 EP EP07857036A patent/EP2125021B8/en active Active
- 2007-12-21 MX MX2009006575A patent/MX2009006575A/es active IP Right Grant
- 2007-12-21 PL PL07857036T patent/PL2125021T3/pl unknown
- 2007-12-21 US US11/962,552 patent/US20080153888A1/en not_active Abandoned
-
2009
- 2009-05-21 IL IL198891A patent/IL198891A/en not_active IP Right Cessation
- 2009-07-08 NO NO20092581A patent/NO20092581L/no not_active Application Discontinuation
- 2009-07-20 ZA ZA200905038A patent/ZA200905038B/xx unknown
-
2011
- 2011-08-26 CY CY20111100820T patent/CY1111783T1/el unknown
- 2011-09-07 HR HR20110634T patent/HRP20110634T1/hr unknown
- 2011-09-22 HK HK11110016.6A patent/HK1155663A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
RS51940B (en) | 2012-02-29 |
SI2125021T1 (sl) | 2011-09-30 |
ES2367881T3 (es) | 2011-11-10 |
ATE511860T1 (de) | 2011-06-15 |
WO2008077599A1 (en) | 2008-07-03 |
NO20092581L (no) | 2009-07-08 |
CN101600458A (zh) | 2009-12-09 |
BRPI0720351A2 (pt) | 2019-05-14 |
AU2007338367A1 (en) | 2008-07-03 |
CN102058885A (zh) | 2011-05-18 |
CY1111783T1 (el) | 2015-10-07 |
CN102058885B (zh) | 2013-04-10 |
DK2125021T3 (da) | 2011-09-19 |
NZ577097A (en) | 2012-05-25 |
EP2125021A1 (en) | 2009-12-02 |
IL198891A (en) | 2013-04-30 |
PL2125021T3 (pl) | 2011-10-31 |
KR20090092307A (ko) | 2009-08-31 |
JP5308350B2 (ja) | 2013-10-09 |
UA94979C2 (uk) | 2011-06-25 |
AU2007338367B2 (en) | 2010-05-20 |
MX2009006575A (es) | 2009-07-02 |
EP2125021B8 (en) | 2012-02-15 |
HK1155663A1 (en) | 2012-05-25 |
CA2673545A1 (en) | 2008-07-03 |
PT2125021E (pt) | 2011-07-26 |
JP2010522139A (ja) | 2010-07-01 |
IL198891A0 (en) | 2010-02-17 |
ZA200905038B (en) | 2010-04-28 |
EA200900868A1 (ru) | 2009-12-30 |
EA017171B1 (ru) | 2012-10-30 |
EP2125021B1 (en) | 2011-06-08 |
US20080153888A1 (en) | 2008-06-26 |
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