HRP20110399T1 - Mikrofluidički uređaj i postupak za određivanje vremena koagulacije fluida - Google Patents
Mikrofluidički uređaj i postupak za određivanje vremena koagulacije fluida Download PDFInfo
- Publication number
- HRP20110399T1 HRP20110399T1 HR20110399T HRP20110399T HRP20110399T1 HR P20110399 T1 HRP20110399 T1 HR P20110399T1 HR 20110399 T HR20110399 T HR 20110399T HR P20110399 T HRP20110399 T HR P20110399T HR P20110399 T1 HRP20110399 T1 HR P20110399T1
- Authority
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- Croatia
- Prior art keywords
- region
- fluid medium
- specified
- microfluidic device
- reagent
- Prior art date
Links
- 239000012530 fluid Substances 0.000 title claims abstract 29
- 238000000034 method Methods 0.000 title claims abstract 8
- 206010053567 Coagulopathies Diseases 0.000 title abstract 2
- 230000035602 clotting Effects 0.000 title abstract 2
- 239000008280 blood Substances 0.000 claims abstract 8
- 210000004369 blood Anatomy 0.000 claims abstract 8
- 238000012544 monitoring process Methods 0.000 claims abstract 4
- 238000004519 manufacturing process Methods 0.000 claims abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 13
- 230000015271 coagulation Effects 0.000 claims 12
- 238000005345 coagulation Methods 0.000 claims 12
- 239000000758 substrate Substances 0.000 claims 7
- 230000003287 optical effect Effects 0.000 claims 5
- 238000001514 detection method Methods 0.000 claims 3
- 238000003908 quality control method Methods 0.000 claims 3
- 238000013022 venting Methods 0.000 claims 3
- PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 claims 1
- 108010094028 Prothrombin Proteins 0.000 claims 1
- 102100027378 Prothrombin Human genes 0.000 claims 1
- 108010000499 Thromboplastin Proteins 0.000 claims 1
- 102000002262 Thromboplastin Human genes 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 238000012806 monitoring device Methods 0.000 claims 1
- 229940039716 prothrombin Drugs 0.000 claims 1
- 230000023555 blood coagulation Effects 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4905—Determining clotting time of blood
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00594—Quality control, including calibration or testing of components of the analyser
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
- Y10T156/10—Methods of surface bonding and/or assembly therefor
- Y10T156/1002—Methods of surface bonding and/or assembly therefor with permanent bending or reshaping or surface deformation of self sustaining lamina
- Y10T156/1039—Surface deformation only of sandwich or lamina [e.g., embossed panels]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Ecology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Clinical Laboratory Science (AREA)
- Dispersion Chemistry (AREA)
- Quality & Reliability (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Reciprocating Pumps (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07380258A EP2040073A1 (en) | 2007-09-20 | 2007-09-20 | Microfluidic device and method for fluid clotting time determination |
| PCT/EP2008/062642 WO2009037361A1 (en) | 2007-09-20 | 2008-09-22 | Microfluidic device and method for fluid clotting time determination |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110399T1 true HRP20110399T1 (hr) | 2011-06-30 |
Family
ID=39135160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110399T HRP20110399T1 (hr) | 2007-09-20 | 2011-05-27 | Mikrofluidički uređaj i postupak za određivanje vremena koagulacije fluida |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US8961903B2 (zh) |
| EP (3) | EP2040073A1 (zh) |
| JP (2) | JP5579607B2 (zh) |
| KR (2) | KR101439404B1 (zh) |
| CN (2) | CN101868723B (zh) |
| AT (1) | ATE504832T1 (zh) |
| AU (1) | AU2008300501B2 (zh) |
| BR (2) | BRPI0817105B1 (zh) |
| CA (2) | CA2700073C (zh) |
| DE (1) | DE602008006108D1 (zh) |
| DK (1) | DK2201365T3 (zh) |
| ES (1) | ES2364568T3 (zh) |
| HK (1) | HK1181697A1 (zh) |
| HR (1) | HRP20110399T1 (zh) |
| IL (2) | IL204571A (zh) |
| MX (1) | MX2010003037A (zh) |
| NZ (2) | NZ600747A (zh) |
| PL (1) | PL2201365T3 (zh) |
| PT (1) | PT2201365E (zh) |
| RU (2) | RU2477480C2 (zh) |
| SI (1) | SI2201365T1 (zh) |
| WO (1) | WO2009037361A1 (zh) |
| ZA (2) | ZA201001950B (zh) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2040073A1 (en) | 2007-09-20 | 2009-03-25 | Iline Microsystems, S.L. | Microfluidic device and method for fluid clotting time determination |
| US8622987B2 (en) | 2008-06-04 | 2014-01-07 | The University Of Chicago | Chemistrode, a plug-based microfluidic device and method for stimulation and sampling with high temporal, spatial, and chemical resolution |
| CA2730000A1 (en) * | 2008-08-06 | 2010-02-11 | F. Hoffmann La-Roche Ag | Medical system comprising a compact barcode reader for consumable items |
| US20120077260A1 (en) * | 2009-03-30 | 2012-03-29 | Fraunhofer Usa, Inc. | Reservoir-buffered mixers and remote valve switching for microfluidic devices |
| KR101763119B1 (ko) * | 2009-04-13 | 2017-07-31 | 마이크로닉스 인코포레이티드. | 미세유체 임상 분석기 |
| WO2010122158A1 (en) * | 2009-04-23 | 2010-10-28 | Dublin City University | A lateral flow assay device for coagulation monitoring and method thereof |
| EP2451577A1 (en) * | 2010-01-24 | 2012-05-16 | Instytut Chemii Fizycznej Polskiej Akademii Nauk | System and method for automated generation and handling of liquid mixtures |
| WO2011094577A2 (en) | 2010-01-29 | 2011-08-04 | Micronics, Inc. | Sample-to-answer microfluidic cartridge |
| DK2553470T3 (da) * | 2010-03-30 | 2016-08-22 | Casyso Ag C A | Sammensætning til bestemmelse af koaguleringskarakteristika af en prøvevæske |
| JP5592144B2 (ja) * | 2010-04-27 | 2014-09-17 | 日本電信電話株式会社 | 凝固活性測定装置および測定方法 |
| WO2012011074A2 (en) | 2010-07-22 | 2012-01-26 | Hach Company | Lab-on-a-chip for alkalinity analysis |
| EP2490020A1 (en) | 2011-02-18 | 2012-08-22 | Koninklijke Philips Electronics N.V. | Measurement chip, microfluidic device and method of measurement chip manufacture |
| DE102011004805A1 (de) * | 2011-02-28 | 2012-08-30 | Siemens Aktiengesellschaft | Miniaturisierte magnetische Durchflusszytometrie |
| GB201109203D0 (en) * | 2011-06-01 | 2011-07-13 | Carclo Technical Plastics Ltd | Fluid flow control |
| FI124169B (fi) * | 2011-06-14 | 2014-04-15 | Sandvik Mining & Constr Oy | Menetelmä poraussuunnitelman laatimiseksi |
| US9772310B2 (en) * | 2011-07-28 | 2017-09-26 | Kyocera Corporation | Biosensor |
| KR101193566B1 (ko) * | 2011-08-10 | 2012-10-22 | 고려대학교 산학협력단 | 마이크로칩 기반 혈소판 복합기능 검사 장치 |
| GB201113992D0 (en) * | 2011-08-12 | 2011-09-28 | Molecular Vision Ltd | Device |
| JP5592324B2 (ja) * | 2011-09-05 | 2014-09-17 | 日本電信電話株式会社 | 凝固活性測定装置および測定方法 |
| JP5607593B2 (ja) * | 2011-09-05 | 2014-10-15 | 日本電信電話株式会社 | 凝固活性測定装置、測定チップおよび測定方法 |
| WO2013086074A1 (en) | 2011-12-06 | 2013-06-13 | Medtronic Inc. | Clot protection and detection algorithm for activated clotting time testing |
| EP2805158B8 (en) | 2012-01-16 | 2020-10-07 | Abram Scientific, Inc. | Methods and devices for measuring physical properties of fluid |
| EP2825881B1 (en) * | 2012-03-12 | 2018-05-30 | Biosurfit, S.A. | Liquid sample imaging device and method |
| US9180449B2 (en) | 2012-06-12 | 2015-11-10 | Hach Company | Mobile water analysis |
| US9709579B2 (en) * | 2012-06-27 | 2017-07-18 | Colorado School Of Mines | Microfluidic flow assay and methods of use |
| US9551699B2 (en) * | 2012-07-16 | 2017-01-24 | Micropoint Bioscience, Inc. | Testing of blood coagulation characteristics |
| US10088477B2 (en) * | 2012-07-30 | 2018-10-02 | The Regents Of The University Of California | Biomolecular detection test strip design |
| EA021562B1 (ru) * | 2012-08-15 | 2015-07-30 | Общество С Ограниченной Ответственностью "Гематологическая Корпорация" | Устройство мониторинга пространственного свертывания крови и ее компонентов |
| JP6010434B2 (ja) * | 2012-11-15 | 2016-10-19 | 株式会社オーイーエムシステム | 体液成分分析装置および体液成分分析方法 |
| USD768872S1 (en) | 2012-12-12 | 2016-10-11 | Hach Company | Cuvette for a water analysis instrument |
| HU1200732D0 (hu) * | 2012-12-14 | 2014-06-30 | Haemoglobal Ltd | Egyszer használatos IVD eszköz a véralvadást jellemzõ INR érték otthoni ellenõrzõ méréséhez |
| US9297816B1 (en) | 2012-12-21 | 2016-03-29 | University Of South Florida | Devices and methods for measuring blood coagulation |
| WO2014100732A1 (en) | 2012-12-21 | 2014-06-26 | Micronics, Inc. | Fluidic circuits and related manufacturing methods |
| KR20150097764A (ko) | 2012-12-21 | 2015-08-26 | 마이크로닉스 인코포레이티드. | 휴대형 형광 검출 시스템 및 미량분석 카트리지 |
| CN107824233B (zh) | 2012-12-21 | 2020-06-30 | 珀金埃尔默健康科学有限公司 | 用于微流体用途的低弹性膜 |
| EP2941642B1 (en) * | 2013-01-03 | 2020-05-13 | Brigham and Women's Hospital, Inc. | System and method for a biomimetic fluid processing |
| JP6093950B2 (ja) * | 2013-04-26 | 2017-03-15 | 東洋インキＳｃホールディングス株式会社 | 液体分析部材用粘着シートおよび液体分析部材 |
| EP2994543B1 (en) | 2013-05-07 | 2018-08-15 | Micronics, Inc. | Device for preparation and analysis of nucleic acids |
| WO2014182831A1 (en) | 2013-05-07 | 2014-11-13 | Micronics, Inc. | Methods for preparation of nucleic acid-containing samples using clay minerals and alkaline solutions |
| WO2014182844A1 (en) | 2013-05-07 | 2014-11-13 | Micronics, Inc. | Microfluidic devices and methods for performing serum separation and blood cross-matching |
| EP3418390A1 (en) | 2013-05-14 | 2018-12-26 | Struszym S.L. | Test strips for determining coagulation factor activities |
| JP6034238B2 (ja) * | 2013-05-17 | 2016-11-30 | 日本電信電話株式会社 | 血液凝固検査方法 |
| CN105229472B (zh) * | 2013-05-23 | 2016-10-26 | 日本电信电话株式会社 | 血液凝固检测方法 |
| JP2016534714A (ja) * | 2013-10-16 | 2016-11-10 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 全血凝固のリアルタイムの臨床モニタリングおよび定量的評価 |
| WO2015153451A1 (en) | 2014-03-31 | 2015-10-08 | Brigham And Women's Hospital, Inc. | Systems and methods for biomimetic fluid processing |
| EP3130920B1 (en) * | 2014-04-08 | 2020-02-12 | Fujimori Kogyo Co., Ltd. | Microchip for assay of blood properties, and device for assay of blood properties |
| WO2015173916A1 (ja) * | 2014-05-14 | 2015-11-19 | 株式会社オーイーエムシステム | 体液成分分析装置および体液成分分析方法 |
| WO2015193076A1 (en) * | 2014-06-16 | 2015-12-23 | Koninklijke Philips N.V. | Cartridge for fast sample intake |
| BR112017004506B1 (pt) * | 2014-09-09 | 2023-12-19 | Perosphere Technologies Inc | Microchip de ensaio para a medição de coagulação em uma amostra de sangue ou plasma, dispositivo de microensaio para a medição de coagulação em uma amostra de sangue ou plasma de um indíviduo e método para medição de tempo de coagulação |
| WO2016043903A1 (en) * | 2014-09-15 | 2016-03-24 | The University Of North Carolina At Chapel Hill | Method for the assembly of functional thermoplastic nanofluidic devices |
| EP3250504B1 (en) | 2015-01-30 | 2019-09-11 | Hewlett-Packard Development Company, L.P. | Microfluidic chip for coagulation sensing |
| DK3279310T3 (da) | 2015-04-03 | 2021-08-02 | Aist | Celledyrkningsapparat og fremgangsmåde til celledyrkning |
| US9891209B2 (en) * | 2015-05-29 | 2018-02-13 | C A Casyso Gmbh | Electrode assembly for measurement of platelet function in whole blood |
| JP6701338B2 (ja) | 2015-08-10 | 2020-05-27 | エッセンリックス コーポレーション | ステップが簡略化され、試料が少なく、スピードアップし、使いやすい、生化学的／化学的なアッセイ装置及び方法 |
| KR101712429B1 (ko) * | 2015-09-24 | 2017-03-08 | 대한민국(관리부서 질병관리본부장) | 표면-증강 라만 산란 기반의 탄저균 검출용 미세유체칩 및 이를 이용한 탄저균 검출 방법 |
| KR101787407B1 (ko) | 2015-09-30 | 2017-10-18 | 명지대학교 산학협력단 | 미립화된 수용액 방울의 증발냉각을 이용한 미소유체 냉각장치 |
| JP2017078664A (ja) * | 2015-10-21 | 2017-04-27 | 東洋製罐グループホールディングス株式会社 | 免疫学的測定デバイス |
| WO2017079507A1 (en) * | 2015-11-06 | 2017-05-11 | Regents Of The University Of Michigan | Droplet-based microfluidic rheometer system |
| EP3384275A2 (en) | 2015-12-02 | 2018-10-10 | Maastricht University | Method for determining haemostasis under shear |
| WO2017123266A1 (en) | 2016-01-16 | 2017-07-20 | Hewlett-Packard Development Company, L.P. | Blood characteristic measurement |
| CN105842432B (zh) * | 2016-04-29 | 2019-01-22 | 诺泰科生物科技（苏州）有限公司 | 一种血栓弹力仪 |
| GB2567529B (en) * | 2016-07-12 | 2021-03-31 | Emulate Inc | Additive channels |
| EP3582893B1 (en) | 2017-04-20 | 2021-03-31 | Hewlett-Packard Development Company, L.P. | Microfluidic reaction system |
| EP3583416B1 (en) | 2017-04-21 | 2024-05-29 | Hewlett-Packard Development Company, L.P. | Chip to chip fluidic interconnect |
| WO2018194665A1 (en) | 2017-04-21 | 2018-10-25 | Hewlett-Packard Development Company, L.P. | Microfluidic chip |
| US11364496B2 (en) | 2017-04-21 | 2022-06-21 | Hewlett-Packard Development Company, L.P. | Coplanar fluidic interconnect |
| WO2018194648A1 (en) | 2017-04-21 | 2018-10-25 | Hewlett-Packard Development Company | Coplanar microfluidic manipulation |
| JP6339274B1 (ja) * | 2017-06-19 | 2018-06-06 | 積水化学工業株式会社 | マイクロ流体デバイス |
| WO2019023508A1 (en) * | 2017-07-28 | 2019-01-31 | Massachusetts Institute Of Technology | METHODS AND DEVICES FOR DETECTION OF ANTICOAGULANTS IN PLASMA AND WHOLE BLOOD |
| CN109839349B (zh) * | 2017-11-28 | 2021-12-07 | 北京碧澄生物科技有限公司 | 检测液体相变的装置和方法 |
| CN108855256B (zh) * | 2018-04-25 | 2020-06-02 | 南开大学 | 一种检测红细胞变形性的微流控芯片及其方法 |
| US20220034914A1 (en) * | 2018-09-27 | 2022-02-03 | Siemens Healthcare Diagnostics Inc. | Multi-channel device for calculating coagulation characteristics of a patient's liquid test sample and methods of use related thereto |
| US11389799B2 (en) | 2019-01-17 | 2022-07-19 | The Regents Of The University Of Michigan | Microfluidic device for size and deformability measurements and applications thereof |
| BR102019004230A2 (pt) * | 2019-02-28 | 2020-09-08 | Univ Do Vale Do Rio Dos Sinos Unisinos | dispositivo analítico, processo de obtenção e uso do mesmo |
| CN110057890B (zh) * | 2019-03-26 | 2021-07-30 | 中国科学院苏州生物医学工程技术研究所 | 一种凝血检测芯片和电化学传感器 |
| WO2020231017A1 (ko) * | 2019-05-10 | 2020-11-19 | 포항공과대학교 산학협력단 | 폴리이미드계 필름 기반 합성-모듈, 이의 제조방법 및 이를 이용한 유기포스페이트계 화합물의 대량 생산방법 |
| US11465143B2 (en) * | 2019-06-07 | 2022-10-11 | Nippon Sheet Glass Company, Limited | Reaction processing vessel |
| KR102229025B1 (ko) * | 2019-07-19 | 2021-03-17 | 전북대학교산학협력단 | 소형 혈액점도측정 키트 및 그 카트리지 |
| USD989342S1 (en) * | 2020-02-04 | 2023-06-13 | Ut-Battelle, Llc | Microfluidic polymer chip interface bracket |
| USD993443S1 (en) * | 2020-02-04 | 2023-07-25 | Ut-Battelle, Llc | Microfluidic glass chip interface bracket |
| KR20210118295A (ko) * | 2020-03-20 | 2021-09-30 | 주식회사 제우스 | 이중관구조 플로우셀 장치 |
| CN116547538A (zh) * | 2020-11-27 | 2023-08-04 | 藤森工业株式会社 | 凝血检测用微芯片的制造方法 |
| EP4112736A1 (en) * | 2021-07-02 | 2023-01-04 | Vital Signs Solutions Limited | Device for testing blood plasma |
| CN113702649B (zh) * | 2021-08-25 | 2022-09-02 | 常州工程职业技术学院 | 一种用于测定血液凝结时间的微流体生物芯片 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5110727A (en) * | 1987-04-03 | 1992-05-05 | Cardiovascular Diagnostics, Inc. | Method for performing coagulation assays accurately, rapidly and simply, using dry chemical reagents and paramagnetic particles |
| DK15788D0 (da) * | 1988-01-14 | 1988-01-14 | Nordisk Gentofte | Fremgangsmaade og apparat til maaling af fuldblods koagulation |
| US5298224A (en) * | 1988-01-14 | 1994-03-29 | Novo Nordisk A/S | Apparatus for determination of the coagulation time of a blood sample |
| US5039617A (en) * | 1989-04-20 | 1991-08-13 | Biotrack, Inc. | Capillary flow device and method for measuring activated partial thromboplastin time |
| JPH03189194A (ja) * | 1989-12-20 | 1991-08-19 | Dainippon Printing Co Ltd | 熱転写シート |
| US5154082A (en) | 1991-05-20 | 1992-10-13 | International Technidyne Corporation | Microprocessor-controlled apparatus and method for detecting the coagulation of blood |
| DK0565665T3 (da) * | 1991-10-04 | 1998-09-28 | Dade Behring Inc | Fremstilling af prothrombin-tidsreagenser ud fra rekombinant human faktor og syntetiske phospholipider |
| US5447440A (en) * | 1993-10-28 | 1995-09-05 | I-Stat Corporation | Apparatus for assaying viscosity changes in fluid samples and method of conducting same |
| DE69521470T2 (de) * | 1994-04-28 | 2002-05-16 | Dade Behring Inc | Kalibrator für prothrombin-zeit-assays |
| US5418141A (en) * | 1994-05-06 | 1995-05-23 | Avocet Medical, Inc. | Test articles for performing dry reagent prothrombin time assays |
| US5504011A (en) * | 1994-10-21 | 1996-04-02 | International Technidyne Corporation | Portable test apparatus and associated method of performing a blood coagulation test |
| ATE264717T1 (de) * | 1997-05-16 | 2004-05-15 | Alberta Res Council | Mikrofluidisches system und verfahren zu dessen betrieb |
| EP1064532B1 (en) * | 1998-03-19 | 2010-03-17 | Inverness Medical Switzerland GmbH | Device for the determination of blood clotting by resistance |
| FR2779827B1 (fr) * | 1998-06-10 | 2000-08-11 | Junior Instruments | Appareil d'analyse automatique utilisable pour la determination du temps de coagulation du sang |
| US6830934B1 (en) * | 1999-06-15 | 2004-12-14 | Lifescan, Inc. | Microdroplet dispensing for a medical diagnostic device |
| WO2000006761A1 (en) | 1998-07-29 | 2000-02-10 | Hemosense, Inc. | Method and device for measuring blood coagulation or lysis by viscosity changes |
| CN1309770A (zh) * | 1998-07-31 | 2001-08-22 | 华莱士·E·卡罗尔 | 确定抗凝治疗因子的设备和方法 |
| FI106366B (fi) | 1999-02-17 | 2001-01-31 | Tamfelt Oyj Abp | Suodatinkangas |
| US6733985B1 (en) * | 1999-05-19 | 2004-05-11 | International Technidyne Corporation | Preparation of stable liquid and dried synthetic prothrombin time reagents |
| AU6933900A (en) * | 1999-09-03 | 2001-04-10 | Roche Diagnostics Corporation | Method, reagent and test cartridge for determining clotting time |
| US6750053B1 (en) * | 1999-11-15 | 2004-06-15 | I-Stat Corporation | Apparatus and method for assaying coagulation in fluid samples |
| US6908593B1 (en) * | 2000-03-31 | 2005-06-21 | Lifescan, Inc. | Capillary flow control in a fluidic diagnostic device |
| US6620310B1 (en) | 2000-12-13 | 2003-09-16 | Lifescan, Inc. | Electrochemical coagulation assay and device |
| GB0030929D0 (en) * | 2000-12-19 | 2001-01-31 | Inverness Medical Ltd | Analyte measurement |
| JP2003004752A (ja) | 2001-06-15 | 2003-01-08 | Minolta Co Ltd | マイクロチップおよび該マイクロチップを用いる検査装置 |
| US6844149B2 (en) * | 2001-06-29 | 2005-01-18 | International Business Machines Corporation | Method, system, and apparatus for measurement and recording of blood chemistry and other physiological measurements |
| US20060015261A1 (en) * | 2002-03-11 | 2006-01-19 | Mann Kenneth G | Blood clotting predictor |
| US7901939B2 (en) * | 2002-05-09 | 2011-03-08 | University Of Chicago | Method for performing crystallization and reactions in pressure-driven fluid plugs |
| CA2492486A1 (en) * | 2002-11-12 | 2004-05-27 | Inverness Medical Switzerland Gmbh | Photometric determination of coagulation time in undiluted whole blood |
| US7291310B2 (en) * | 2002-12-17 | 2007-11-06 | The Regents Of The University Of Michigan | Microsystem for determining clotting time of blood and low-cost, single-use device for use therein |
| US7419638B2 (en) * | 2003-01-14 | 2008-09-02 | Micronics, Inc. | Microfluidic devices for fluid manipulation and analysis |
| US7854897B2 (en) * | 2003-05-12 | 2010-12-21 | Yokogawa Electric Corporation | Chemical reaction cartridge, its fabrication method, and a chemical reaction cartridge drive system |
| US7235377B2 (en) * | 2003-06-09 | 2007-06-26 | The University Of Vermont And State Agriculture College | Global test of the hemostatic system |
| US7148067B2 (en) * | 2004-08-31 | 2006-12-12 | The Board Of Trustees Of The University Of Illinois | Thromboplastin reagents |
| US20090221011A1 (en) * | 2005-08-31 | 2009-09-03 | Matthias Stiene | Coagulation test system |
| EP1950567B1 (en) * | 2005-10-18 | 2016-05-18 | Fujimori Kogyo Co., Ltd. | Apparatus for monitoring thrombus formation and method of monitoring thrombus formation |
| US20070122849A1 (en) * | 2005-11-29 | 2007-05-31 | Peekhaus Norbert T | Rhesus monkey P2X7 purinergic receptor and uses thereof |
| FR2896589B1 (fr) * | 2006-01-25 | 2008-04-25 | Biocode Hycel France Sa Sa | Cuvette d'analyse polyvalente |
| JP2007222072A (ja) * | 2006-02-23 | 2007-09-06 | Tokyo Metropolitan Univ | 化学物質の並行微量分析法 |
| WO2007099736A1 (ja) * | 2006-03-03 | 2007-09-07 | Konica Minolta Medical & Graphic, Inc. | マイクロ検査チップ、光学的検出装置およびマイクロ総合分析システム |
| US7674616B2 (en) * | 2006-09-14 | 2010-03-09 | Hemosense, Inc. | Device and method for measuring properties of a sample |
| EP2101917A1 (en) * | 2007-01-10 | 2009-09-23 | Scandinavian Micro Biodevices A/S | A microfluidic device and a microfluidic system and a method of performing a test |
| JP4829828B2 (ja) * | 2007-03-28 | 2011-12-07 | シスメックス株式会社 | 血液凝固測定用試薬及び組織因子安定化方法 |
| EP2040073A1 (en) | 2007-09-20 | 2009-03-25 | Iline Microsystems, S.L. | Microfluidic device and method for fluid clotting time determination |
| DE102007062323A1 (de) * | 2007-12-21 | 2009-06-25 | Siemens Healthcare Diagnostics Products Gmbh | Langzeitstabiles Thromboplastin-Reagenz |
| JP2009162650A (ja) * | 2008-01-08 | 2009-07-23 | Sony Corp | 光学的測定装置 |
| WO2010009267A1 (en) * | 2008-07-16 | 2010-01-21 | International Technidyne Corporation | Cuvette-based apparatus for blood coagulation measurement and testing |
-
2007
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