HRP20110129T1 - Sastavi koji sadrže kristalni trans-(+/-)-delta-9-tetrahidrokanabinol - Google Patents
Sastavi koji sadrže kristalni trans-(+/-)-delta-9-tetrahidrokanabinol Download PDFInfo
- Publication number
- HRP20110129T1 HRP20110129T1 HR20110129T HRP20110129T HRP20110129T1 HR P20110129 T1 HRP20110129 T1 HR P20110129T1 HR 20110129 T HR20110129 T HR 20110129T HR P20110129 T HRP20110129 T HR P20110129T HR P20110129 T1 HRP20110129 T1 HR P20110129T1
- Authority
- HR
- Croatia
- Prior art keywords
- trans
- tetrahydrocannabinol
- composition
- crystalline
- dosage form
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 58
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 18
- 239000003937 drug carrier Substances 0.000 claims abstract 13
- 239000003814 drug Substances 0.000 claims abstract 10
- 239000002552 dosage form Substances 0.000 claims 35
- 239000012071 phase Substances 0.000 claims 21
- 229930003827 cannabinoid Natural products 0.000 claims 18
- 239000003557 cannabinoid Substances 0.000 claims 18
- 239000012074 organic phase Substances 0.000 claims 18
- 239000003518 caustics Substances 0.000 claims 15
- 239000003495 polar organic solvent Substances 0.000 claims 12
- 239000002253 acid Substances 0.000 claims 10
- 238000013270 controlled release Methods 0.000 claims 10
- 230000002051 biphasic effect Effects 0.000 claims 9
- 239000000843 powder Substances 0.000 claims 8
- 241000124008 Mammalia Species 0.000 claims 7
- 229940065144 cannabinoids Drugs 0.000 claims 7
- 238000002425 crystallisation Methods 0.000 claims 6
- 230000008025 crystallization Effects 0.000 claims 6
- 238000002156 mixing Methods 0.000 claims 6
- 238000000926 separation method Methods 0.000 claims 6
- 230000001476 alcoholic effect Effects 0.000 claims 5
- 239000011159 matrix material Substances 0.000 claims 5
- 239000000126 substance Substances 0.000 claims 5
- 239000008187 granular material Substances 0.000 claims 4
- 210000004072 lung Anatomy 0.000 claims 4
- 239000011859 microparticle Substances 0.000 claims 4
- 239000002105 nanoparticle Substances 0.000 claims 4
- 208000002193 Pain Diseases 0.000 claims 3
- 206010047700 Vomiting Diseases 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 238000002360 preparation method Methods 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- 239000000725 suspension Substances 0.000 claims 3
- 208000016261 weight loss Diseases 0.000 claims 3
- 230000004580 weight loss Effects 0.000 claims 3
- 229920001800 Shellac Polymers 0.000 claims 2
- 230000004596 appetite loss Effects 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 229920001477 hydrophilic polymer Polymers 0.000 claims 2
- 229920001600 hydrophobic polymer Polymers 0.000 claims 2
- 208000019017 loss of appetite Diseases 0.000 claims 2
- 235000021266 loss of appetite Nutrition 0.000 claims 2
- 229940071648 metered dose inhaler Drugs 0.000 claims 2
- -1 multiparticles Substances 0.000 claims 2
- 239000006199 nebulizer Substances 0.000 claims 2
- 239000003921 oil Substances 0.000 claims 2
- 150000002894 organic compounds Chemical class 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000002685 pulmonary effect Effects 0.000 claims 2
- 235000013874 shellac Nutrition 0.000 claims 2
- 239000007921 spray Substances 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 239000001993 wax Substances 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 230000008021 deposition Effects 0.000 claims 1
- 229920001971 elastomer Polymers 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000006186 oral dosage form Substances 0.000 claims 1
- 229940126701 oral medication Drugs 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 230000000144 pharmacologic effect Effects 0.000 claims 1
- 238000000634 powder X-ray diffraction Methods 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 239000005060 rubber Substances 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
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- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
- B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01B—CABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
- H01B3/00—Insulators or insulating bodies characterised by the insulating materials; Selection of materials for their insulating or dielectric properties
- H01B3/02—Insulators or insulating bodies characterised by the insulating materials; Selection of materials for their insulating or dielectric properties mainly consisting of inorganic substances
- H01B3/10—Insulators or insulating bodies characterised by the insulating materials; Selection of materials for their insulating or dielectric properties mainly consisting of inorganic substances metallic oxides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Nanotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Psychology (AREA)
- Otolaryngology (AREA)
- Ceramic Engineering (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Nutrition Science (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Inorganic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Manufacturing & Machinery (AREA)
- Diabetes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69136105P | 2005-06-16 | 2005-06-16 | |
| US72650905P | 2005-10-12 | 2005-10-12 | |
| PCT/EP2006/005761 WO2006133941A2 (en) | 2005-06-16 | 2006-06-14 | Cannabinoid active pharmaceutical ingredient for improved dosage forms |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110129T1 true HRP20110129T1 (hr) | 2011-03-31 |
Family
ID=36922253
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110129T HRP20110129T1 (hr) | 2005-06-16 | 2011-02-23 | Sastavi koji sadrže kristalni trans-(+/-)-delta-9-tetrahidrokanabinol |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US20070072939A1 (de) |
| EP (3) | EP2279735A3 (de) |
| JP (2) | JP2008543800A (de) |
| KR (3) | KR20100102237A (de) |
| AP (1) | AP2405A (de) |
| AR (1) | AR054064A1 (de) |
| AT (1) | ATE489085T1 (de) |
| AU (1) | AU2006257059C1 (de) |
| BR (1) | BRPI0612922A2 (de) |
| CA (1) | CA2612061A1 (de) |
| CR (2) | CR9662A (de) |
| CY (1) | CY1111446T1 (de) |
| DE (1) | DE602006018466D1 (de) |
| DK (1) | DK1901734T3 (de) |
| EA (1) | EA016813B1 (de) |
| EC (1) | ECSP078023A (de) |
| HK (1) | HK1118447A1 (de) |
| HR (1) | HRP20110129T1 (de) |
| IL (1) | IL188150A0 (de) |
| MA (1) | MA29630B1 (de) |
| MX (1) | MX2007016051A (de) |
| MY (1) | MY140576A (de) |
| NO (1) | NO20080284L (de) |
| NZ (2) | NZ563049A (de) |
| PL (1) | PL1901734T3 (de) |
| PT (1) | PT1901734E (de) |
| RS (1) | RS51569B (de) |
| SI (1) | SI1901734T1 (de) |
| TN (1) | TNSN07478A1 (de) |
| TW (1) | TWI366460B (de) |
| WO (1) | WO2006133941A2 (de) |
Families Citing this family (106)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8449908B2 (en) | 2000-12-22 | 2013-05-28 | Alltranz, Llc | Transdermal delivery of cannabidiol |
| TWI369203B (en) | 2004-11-22 | 2012-08-01 | Euro Celtique Sa | Methods for purifying trans-(-)-△9-tetrahydrocannabinol and trans-(+)-△9-tetrahydrocannabinol |
| EA200701246A1 (ru) * | 2004-12-09 | 2008-06-30 | Инсис Терапьютикс, Инк. | Стабильные при комнатной температуре составы дронабинола |
| KR100753959B1 (ko) * | 2006-01-12 | 2007-08-31 | 에이펫(주) | 기판 건조장치를 이용한 기판 건조방법 |
| US20100184848A1 (en) * | 2006-07-14 | 2010-07-22 | William Abraham Wine | Transdermal formulations of synthetic cannabinoids and nano colloidal silica |
| AU2007275034A1 (en) * | 2006-07-21 | 2008-01-24 | Lab International Srl | Hydrophilic abuse deterrent delivery system |
| EP2046290A4 (de) * | 2006-08-04 | 2011-08-17 | Insys Therapeutics Inc | Wässrige dronabinolformulierungen |
| US8039509B2 (en) | 2006-11-10 | 2011-10-18 | Johnson Matthey Public Limited Company | Composition comprising (−)-Δ9-trans-tetrahydrocannabinol |
| US8980940B2 (en) | 2006-11-10 | 2015-03-17 | Johnson Matthey Public Limited Company | Stable cannabinoid compositions and methods for making and storing them |
| CA2694325C (en) | 2007-07-30 | 2015-09-22 | Alltranz Inc. | Prodrugs of cannabidiol, compositions comprising prodrugs of cannabidiol and methods of using the same |
| US8222292B2 (en) | 2007-08-06 | 2012-07-17 | Insys Therapeutics, Inc. | Liquid cannabinoid formulations |
| US20090181080A1 (en) * | 2007-08-06 | 2009-07-16 | Insys Therapeutics Inc. | Oral cannabinnoid liquid formulations and methods of treatment |
| EP2534958A1 (de) | 2007-12-14 | 2012-12-19 | AeroDesigns, Inc | Abgabe von Aerosol-sprühbaren Nahrungsmittelprodukten |
| GB0807915D0 (en) * | 2008-05-01 | 2008-06-04 | Resolution Chemicals Ltd | Production of delta 9 tetrahydrocannabinol |
| KR101701544B1 (ko) * | 2009-06-29 | 2017-02-01 | 벤더 아날리티컬 홀딩 비.브이. | 폴리옥사졸린 및 생리활성제를 포함하는 약물 전달 시스템 |
| GB2471523A (en) | 2009-07-03 | 2011-01-05 | Gw Pharma Ltd | Use of tetrahydrocannibivarin (THCV) and optionally cannabidiol (CBD) in the treatment of epilepsy |
| TWI583374B (zh) | 2010-03-30 | 2017-05-21 | Ｇｗ伐瑪有限公司 | 使用植物大麻素次大麻二酚（ｃｂｄｖ）來治療癲癇之用途 |
| AU2011252040C1 (en) | 2010-05-10 | 2015-04-02 | Euro-Celtique S.A. | Manufacturing of active-free granules and tablets comprising the same |
| NZ700732A (en) | 2010-05-10 | 2015-08-28 | Euro Celtique Sa | Pharmaceutical compositions comprising hydromorphone and naloxone |
| BR112012028656A2 (pt) | 2010-05-10 | 2016-08-09 | Euro Celtique Sa | combinação de grânulos carregados ativos com ativos adicionais |
| US8703727B2 (en) * | 2010-08-24 | 2014-04-22 | Aphios Corporation | Nanotechnology formulation of poorly soluble compounds |
| US8629177B2 (en) * | 2010-08-24 | 2014-01-14 | Aphios Corporation | Nanoencapsulated delta-9-tetrahydrocannabinol |
| WO2012148432A1 (en) | 2011-04-28 | 2012-11-01 | Acme Specialty Products, Llc | Taste masking compositions and edible forms thereof |
| US8758826B2 (en) * | 2011-07-05 | 2014-06-24 | Wet Inc. | Cannabinoid receptor binding agents, compositions, and methods |
| GB2495118B (en) | 2011-09-29 | 2016-05-18 | Otsuka Pharma Co Ltd | A pharmaceutical composition comprising the phytocannabinoids cannabidivarin (CBDV) and cannabidiol (CBD) |
| US10350251B2 (en) * | 2012-03-28 | 2019-07-16 | Keith Gerald Freeman | Medical compositions, methods of making and using those compositions, and kits including those compositions |
| US9879058B2 (en) | 2012-05-30 | 2018-01-30 | Universidad Andres Bello | Use of compounds that selectively modulate astrocytic release of substances through hemichannels of connexins and pannexins, without influencing gap junctions, for the treatment of psychiatric disorders |
| US9345771B2 (en) | 2012-10-04 | 2016-05-24 | Insys Development Company, Inc. | Oral cannabinoid formulations |
| US11253472B2 (en) | 2012-10-04 | 2022-02-22 | Benuvia Therapeutics Llc | Oral cannabinoid formulations |
| US10265293B2 (en) | 2012-10-04 | 2019-04-23 | Insys Development Company, Inc. | Oral cannabinoid formulations |
| US9757395B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| US9757529B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| BR112015019180A8 (pt) | 2013-02-12 | 2018-01-30 | Corbus Pharmaceuticals Inc | ácidos tetrahidrocanabinol-11-óicos ultrapuros |
| WO2014178891A1 (en) | 2013-04-30 | 2014-11-06 | Otitopic Inc. | Dry powder formulations and methods of use |
| EP3001812B1 (de) | 2013-10-29 | 2016-11-02 | Echo Pharmaceuticals B.V. | Komprimierte tablette mit cannabidiol, verfahren zu deren herstellung und verwendung solch einer tablette bei der behandlung von psychosen oder angststörungen |
| CN105873566B (zh) | 2013-10-29 | 2019-06-07 | 艾克制药有限公司 | 含有δ9-四氢大麻酚的压制片剂、其制造方法及此类片剂在口服治疗中的用途 |
| BR112016009749A8 (pt) | 2013-11-13 | 2018-01-30 | Euro Celtique Sa | hidromorfona e naloxona para tratamento de dor e síndrome de disfunção intestinal opioide |
| JP6486950B2 (ja) * | 2014-01-13 | 2019-03-20 | カンナライフ・サイエンシーズ・インコーポレイテッドＫａｎｎａｌｉｆｅ Ｓｃｉｅｎｃｅｓ， Ｉｎｃ． | 新規の官能性１，３−ベンゼンジオール及び肝性脳症を治療するためのそれらの使用方法 |
| GB2530001B (en) | 2014-06-17 | 2019-01-16 | Gw Pharma Ltd | Use of cannabidiol in the reduction of convulsive seizure frequency in treatment-resistant epilepsy |
| WO2015200049A1 (en) | 2014-06-26 | 2015-12-30 | Island Breeze Systems Ca, Llc | Mdi related products and methods of use |
| AU2015281729B2 (en) * | 2014-06-27 | 2021-11-25 | National Research Council Of Canada (Nrc) | Cannabichromenic acid synthase from cannabis sativa |
| GB2527599A (en) | 2014-06-27 | 2015-12-30 | Gw Pharma Ltd | Use of 7-OH-Cannabidiol (7-OH-CBD) and/or 7-OH-Cannabidivarin (7-OH-CBDV) in the treatment of epilepsy |
| GB2531278A (en) | 2014-10-14 | 2016-04-20 | Gw Pharma Ltd | Use of cannabidiol in the treatment of intractable epilepsy |
| GB2531281A (en) | 2014-10-14 | 2016-04-20 | Gw Pharma Ltd | Use of cannabidiol in the treatment of intractable epilepsy |
| GB2531282A (en) | 2014-10-14 | 2016-04-20 | Gw Pharma Ltd | Use of cannabinoids in the treatment of epilepsy |
| US20160143972A1 (en) * | 2014-11-21 | 2016-05-26 | Cannamark Inc. | Method and apparatus for preparing a solid form of cannabinoid |
| EP3268043A4 (de) | 2015-03-10 | 2018-12-19 | Nanosphere Health Sciences, LLC | Lipidnanoteilchenzusammensetzungen und verfahren als träger von cannabinoiden in standardisierten präzisionsabgemessenen darreichungsformen |
| GB2539472A (en) * | 2015-06-17 | 2016-12-21 | Gw Res Ltd | Use of cannabinoids in the treatment of epilepsy |
| GB2541191A (en) | 2015-08-10 | 2017-02-15 | Gw Pharma Ltd | Use of cannabinoids in the treatment of epilepsy |
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