HRP20100558T1 - Transdermalna formulacija steroida - Google Patents
Transdermalna formulacija steroida Download PDFInfo
- Publication number
- HRP20100558T1 HRP20100558T1 HR20100558T HRP20100558T HRP20100558T1 HR P20100558 T1 HRP20100558 T1 HR P20100558T1 HR 20100558 T HR20100558 T HR 20100558T HR P20100558 T HRP20100558 T HR P20100558T HR P20100558 T1 HRP20100558 T1 HR P20100558T1
- Authority
- HR
- Croatia
- Prior art keywords
- compound
- patch according
- adhesive
- ester
- weight
- Prior art date
Links
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 150000003431 steroids Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 15
- 239000000853 adhesive Substances 0.000 claims abstract 9
- 230000001070 adhesive effect Effects 0.000 claims abstract 9
- 150000002148 esters Chemical class 0.000 claims abstract 9
- 239000000178 monomer Substances 0.000 claims abstract 5
- 229920001577 copolymer Polymers 0.000 claims abstract 4
- HFCUBKYHMMPGBY-UHFFFAOYSA-N 2-methoxyethyl prop-2-enoate Chemical compound COCCOC(=O)C=C HFCUBKYHMMPGBY-UHFFFAOYSA-N 0.000 claims abstract 3
- 125000005843 halogen group Chemical group 0.000 claims abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 3
- 125000004043 oxo group Chemical group O=* 0.000 claims abstract 3
- 125000003396 thiol group Chemical group [H]S* 0.000 claims abstract 3
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 2
- 125000004104 aryloxy group Chemical group 0.000 claims abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 2
- PBOSTUDLECTMNL-UHFFFAOYSA-N lauryl acrylate Chemical compound CCCCCCCCCCCCOC(=O)C=C PBOSTUDLECTMNL-UHFFFAOYSA-N 0.000 claims abstract 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 4
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 3
- 238000010521 absorption reaction Methods 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 229940095095 2-hydroxyethyl acrylate Drugs 0.000 claims 2
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 claims 2
- 208000001132 Osteoporosis Diseases 0.000 claims 2
- 239000012790 adhesive layer Substances 0.000 claims 2
- 208000028867 ischemia Diseases 0.000 claims 2
- 210000002569 neuron Anatomy 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 230000011164 ossification Effects 0.000 claims 2
- 230000002093 peripheral effect Effects 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- WSCUHXPGYUMQEX-KCZNZURUSA-N 11beta-hydroxyandrost-4-ene-3,17-dione Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 WSCUHXPGYUMQEX-KCZNZURUSA-N 0.000 claims 1
- FZEAQJIXYCPBLD-UHFFFAOYSA-N 11beta-hydroxyandrostenedione Natural products C1C(=O)CCC2(C)C3C(O)CC(C)(C(CC4)=O)C4C3CCC21 FZEAQJIXYCPBLD-UHFFFAOYSA-N 0.000 claims 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims 1
- VFPMCLQMAUVEHD-UHFFFAOYSA-N 7alpha hydroxy isoandrosterone Natural products C1C(O)CCC2(C)C3CCC(C)(C(CC4)=O)C4C3C(O)CC21 VFPMCLQMAUVEHD-UHFFFAOYSA-N 0.000 claims 1
- OLPSAOWBSPXZEA-JIEICEMKSA-N 7alpha-hydroxydehydroepiandrosterone Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3[C@H](O)C=C21 OLPSAOWBSPXZEA-JIEICEMKSA-N 0.000 claims 1
- VFPMCLQMAUVEHD-UCPSWNCLSA-N 7beta-hydroxyepiandrosterone Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3[C@@H](O)C[C@H]21 VFPMCLQMAUVEHD-UCPSWNCLSA-N 0.000 claims 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims 1
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical compound CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 claims 1
- 229940088644 n,n-dimethylacrylamide Drugs 0.000 claims 1
- YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical compound CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 claims 1
- 229940117958 vinyl acetate Drugs 0.000 claims 1
- GMSCBRSQMRDRCD-UHFFFAOYSA-N dodecyl 2-methylprop-2-enoate Chemical compound CCCCCCCCCCCCOC(=O)C(C)=C GMSCBRSQMRDRCD-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0409498.3A GB0409498D0 (en) | 2004-04-28 | 2004-04-28 | Transdermal steroid formulation |
| PCT/GB2005/001596 WO2005105104A1 (en) | 2004-04-28 | 2005-04-28 | Transdermal steroid formulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20100558T1 true HRP20100558T1 (hr) | 2010-11-30 |
Family
ID=32408193
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20100558T HRP20100558T1 (hr) | 2004-04-28 | 2010-10-13 | Transdermalna formulacija steroida |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20070231373A1 (no) |
| EP (1) | EP1748779B1 (no) |
| JP (1) | JP4849478B2 (no) |
| KR (1) | KR101139023B1 (no) |
| CN (1) | CN1997375B (no) |
| AT (1) | ATE480241T1 (no) |
| AU (1) | AU2005237285B2 (no) |
| CA (1) | CA2563830C (no) |
| CY (1) | CY1111318T1 (no) |
| DE (1) | DE602005023436D1 (no) |
| DK (1) | DK1748779T3 (no) |
| ES (1) | ES2352202T3 (no) |
| GB (1) | GB0409498D0 (no) |
| HK (1) | HK1096606A1 (no) |
| HR (1) | HRP20100558T1 (no) |
| IL (1) | IL178781A (no) |
| NO (1) | NO337073B1 (no) |
| NZ (1) | NZ550784A (no) |
| PL (1) | PL1748779T3 (no) |
| PT (1) | PT1748779E (no) |
| RU (1) | RU2371183C2 (no) |
| SI (1) | SI1748779T1 (no) |
| TW (1) | TWI354557B (no) |
| WO (1) | WO2005105104A1 (no) |
| ZA (1) | ZA200608878B (no) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0523550D0 (en) * | 2005-11-18 | 2005-12-28 | Hunter Fleming Ltd | Therapeutic uses of steroidal compounds |
| KR20090086272A (ko) * | 2006-11-30 | 2009-08-11 | 헌터-플레밍 리미티드 | 프로스타글란딘／시클로옥시게나제 대사 경로의 조절 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0370220B1 (de) * | 1988-10-27 | 1996-01-10 | Schering Aktiengesellschaft | Mittel zur transdermalen Applikation enthaltend Gestoden |
| US4978532A (en) * | 1989-08-11 | 1990-12-18 | Pharmedic Co. | Dosage form for administration of dehydroepiandrosterone |
| EP0698612B1 (en) * | 1993-05-18 | 2001-07-25 | Ltt Institute Co., Ltd. | Osteogenesis promoter and osteoporosis remedy |
| US5460820B1 (en) * | 1993-08-03 | 1999-08-03 | Theratech Inc | Method for providing testosterone and optionally estrogen replacement therapy to women |
| DE4405898A1 (de) * | 1994-02-18 | 1995-08-24 | Schering Ag | Transdermale therapeutische Systeme enthaltend Sexualsteroide |
| AU5671496A (en) * | 1995-05-15 | 1996-11-29 | Beth Israel Hospital | Use of dihydrotestosterone compounds for treating male sexual dysfunction |
| US5783208A (en) * | 1996-07-19 | 1998-07-21 | Theratech, Inc. | Transdermal drug delivery matrix for coadministering estradiol and another steroid |
| KR100215027B1 (ko) * | 1997-01-27 | 1999-08-16 | 성재갑 | 스테로이드계 약물의 경피흡수투여용 조성물 및 이를 포함하는 경피흡수투여용 제형 |
| US20010023261A1 (en) * | 1997-01-27 | 2001-09-20 | Lg Chemical Limited. | Novel composition for the transdermal administration of drugs |
| DE19728517C2 (de) * | 1997-07-04 | 1999-11-11 | Sanol Arznei Schwarz Gmbh | TTS zur Verabreichung von Sexualsteroidhormonen und Verfahren zu seiner Herstellung |
| US20020012694A1 (en) * | 1997-09-17 | 2002-01-31 | Alfred J. Moo-Young | Transdermal administration of ment |
| US5869090A (en) * | 1998-01-20 | 1999-02-09 | Rosenbaum; Jerry | Transdermal delivery of dehydroepiandrosterone |
| DE19827732A1 (de) * | 1998-06-22 | 1999-12-23 | Rottapharm Bv | Transdermales System vom Matrix-Typ zur Abgabe von Wirkstoffen mit einer hohen Abgaberate von Steroid-Hormonen und die Verwendung eines derartigen Systems zur Hormonersatztherapie |
| GB2363984A (en) * | 2000-06-29 | 2002-01-16 | Hunter Fleming Ltd | Protection against neuronal damage using 3-hydroxy-7 -hydroxy steroids and 3-oxo-7 -hydroxy steroids |
| GB2363983A (en) * | 2000-06-29 | 2002-01-16 | Hunter Fleming Ltd | Protection against neuronal damage using 7-hydroxyepiandrosterone |
| EP1322336B1 (en) * | 2000-08-30 | 2013-07-03 | Unimed Pharmaceuticals, LLC | Method of increasing testosterone and related steroid concentrations in women |
| FR2818148B1 (fr) * | 2000-12-15 | 2005-06-24 | Oreal | Composition,notamment cosmetique, renfermant, la 7-hydroxy dhea et/ou la 7-ceto dhea et au moins un isoflavonoide |
| US6510801B2 (en) * | 2001-06-01 | 2003-01-28 | Hong Sin Tan | Pallet for shrinkwrapped packaging of block rubber |
| GB2378898A (en) * | 2001-08-14 | 2003-02-26 | Hunter Fleming Ltd | Prophylactic and therapeutic use of hydroxysteroids |
| JP4394071B2 (ja) * | 2003-03-27 | 2010-01-06 | コスメディ製薬株式会社 | 経皮吸収製剤用粘着剤、経皮吸収用粘着剤組成物及び経皮吸収製剤 |
-
2004
- 2004-04-28 US US11/568,387 patent/US20070231373A1/en not_active Abandoned
- 2004-04-28 GB GBGB0409498.3A patent/GB0409498D0/en not_active Ceased
-
2005
- 2005-04-27 TW TW094113457A patent/TWI354557B/zh not_active IP Right Cessation
- 2005-04-28 WO PCT/GB2005/001596 patent/WO2005105104A1/en active Application Filing
- 2005-04-28 PT PT05738733T patent/PT1748779E/pt unknown
- 2005-04-28 AT AT05738733T patent/ATE480241T1/de active
- 2005-04-28 CA CA2563830A patent/CA2563830C/en not_active Expired - Fee Related
- 2005-04-28 DK DK05738733.4T patent/DK1748779T3/da active
- 2005-04-28 EP EP05738733A patent/EP1748779B1/en active Active
- 2005-04-28 AU AU2005237285A patent/AU2005237285B2/en not_active Ceased
- 2005-04-28 KR KR1020067024617A patent/KR101139023B1/ko not_active IP Right Cessation
- 2005-04-28 DE DE602005023436T patent/DE602005023436D1/de active Active
- 2005-04-28 SI SI200531179T patent/SI1748779T1/sl unknown
- 2005-04-28 JP JP2007510103A patent/JP4849478B2/ja not_active Expired - Fee Related
- 2005-04-28 RU RU2006141830/15A patent/RU2371183C2/ru not_active IP Right Cessation
- 2005-04-28 NZ NZ550784A patent/NZ550784A/en not_active IP Right Cessation
- 2005-04-28 PL PL05738733T patent/PL1748779T3/pl unknown
- 2005-04-28 CN CN2005800175630A patent/CN1997375B/zh not_active Expired - Fee Related
- 2005-04-28 ES ES05738733T patent/ES2352202T3/es active Active
-
2006
- 2006-10-22 IL IL178781A patent/IL178781A/en not_active IP Right Cessation
- 2006-10-25 ZA ZA200608878A patent/ZA200608878B/xx unknown
- 2006-11-27 NO NO20065440A patent/NO337073B1/no not_active IP Right Cessation
-
2007
- 2007-04-10 HK HK07103709.9A patent/HK1096606A1/xx not_active IP Right Cessation
-
2010
- 2010-10-13 HR HR20100558T patent/HRP20100558T1/hr unknown
- 2010-12-01 CY CY20101101106T patent/CY1111318T1/el unknown
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