HRP20100541T1 - Derivati bifeniloksioctene kiseline za liječenje respiratornih bolesti - Google Patents
Derivati bifeniloksioctene kiseline za liječenje respiratornih bolesti Download PDFInfo
- Publication number
- HRP20100541T1 HRP20100541T1 HR20100541T HRP20100541T HRP20100541T1 HR P20100541 T1 HRP20100541 T1 HR P20100541T1 HR 20100541 T HR20100541 T HR 20100541T HR P20100541 T HRP20100541 T HR P20100541T HR P20100541 T1 HRP20100541 T1 HR P20100541T1
- Authority
- HR
- Croatia
- Prior art keywords
- oxy
- biphenyl
- acetic acid
- sulfonyl
- halogen
- Prior art date
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- MAKUMOXHJKKTDP-UHFFFAOYSA-N 2-(2-phenylphenoxy)acetic acid Chemical class OC(=O)COC1=CC=CC=C1C1=CC=CC=C1 MAKUMOXHJKKTDP-UHFFFAOYSA-N 0.000 title description 2
- 208000023504 respiratory system disease Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 25
- 229910052736 halogen Inorganic materials 0.000 claims abstract 12
- 125000005843 halogen group Chemical group 0.000 claims abstract 10
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 10
- 239000001257 hydrogen Substances 0.000 claims abstract 10
- 150000002367 halogens Chemical class 0.000 claims abstract 9
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims abstract 8
- 150000002825 nitriles Chemical class 0.000 claims abstract 6
- 125000004429 atom Chemical group 0.000 claims abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims abstract 4
- 150000003839 salts Chemical class 0.000 claims abstract 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 3
- 125000000217 alkyl group Chemical group 0.000 claims abstract 2
- 125000003118 aryl group Chemical group 0.000 claims abstract 2
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 2
- 229910052717 sulfur Inorganic materials 0.000 claims abstract 2
- 201000010099 disease Diseases 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 27
- -1 {5-Chloro-3'-fluoro-4'-[(4-fluorophenyl)sulfonyl]biphenyl-2-yl}oxy Chemical group 0.000 claims 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- VNQMVQRNFMHTSY-ZDUSSCGKSA-N (2s)-2-[2-[4-(benzenesulfonyl)-2-chlorophenyl]-4-fluorophenoxy]propanoic acid Chemical compound OC(=O)[C@H](C)OC1=CC=C(F)C=C1C1=CC=C(S(=O)(=O)C=2C=CC=CC=2)C=C1Cl VNQMVQRNFMHTSY-ZDUSSCGKSA-N 0.000 claims 1
- RREARAFIZIMPPV-ZDUSSCGKSA-N (2s)-2-[2-[4-(benzenesulfonyl)-3-chlorophenyl]-4-fluorophenoxy]propanoic acid Chemical compound OC(=O)[C@H](C)OC1=CC=C(F)C=C1C1=CC=C(S(=O)(=O)C=2C=CC=CC=2)C(Cl)=C1 RREARAFIZIMPPV-ZDUSSCGKSA-N 0.000 claims 1
- KGLRJNVVYWUKAN-ZDUSSCGKSA-N (2s)-2-[2-[4-(benzenesulfonyl)-3-fluorophenyl]-4-fluorophenoxy]propanoic acid Chemical compound OC(=O)[C@H](C)OC1=CC=C(F)C=C1C1=CC=C(S(=O)(=O)C=2C=CC=CC=2)C(F)=C1 KGLRJNVVYWUKAN-ZDUSSCGKSA-N 0.000 claims 1
- GQWRODHBWFTHMM-LBPRGKRZSA-N (2s)-2-[4-chloro-2-[2-fluoro-4-(4-fluorophenyl)sulfonylphenyl]phenoxy]propanoic acid Chemical compound OC(=O)[C@H](C)OC1=CC=C(Cl)C=C1C1=CC=C(S(=O)(=O)C=2C=CC(F)=CC=2)C=C1F GQWRODHBWFTHMM-LBPRGKRZSA-N 0.000 claims 1
- SRGXJMZKXJIPJZ-ZDUSSCGKSA-N (2s)-2-[4-chloro-2-[4-(4-fluorophenyl)sulfonylphenyl]phenoxy]propanoic acid Chemical compound OC(=O)[C@H](C)OC1=CC=C(Cl)C=C1C1=CC=C(S(=O)(=O)C=2C=CC(F)=CC=2)C=C1 SRGXJMZKXJIPJZ-ZDUSSCGKSA-N 0.000 claims 1
- QUPFAUMGPXZZSQ-LBPRGKRZSA-N (2s)-2-[4-fluoro-2-[3-fluoro-4-(2-fluorophenyl)sulfonylphenyl]phenoxy]propanoic acid Chemical compound OC(=O)[C@H](C)OC1=CC=C(F)C=C1C1=CC=C(S(=O)(=O)C=2C(=CC=CC=2)F)C(F)=C1 QUPFAUMGPXZZSQ-LBPRGKRZSA-N 0.000 claims 1
- OJYRPSHAWFSTKU-LBPRGKRZSA-N (2s)-2-[4-fluoro-2-[3-fluoro-4-(3-fluorophenyl)sulfonylphenyl]phenoxy]propanoic acid Chemical compound OC(=O)[C@H](C)OC1=CC=C(F)C=C1C1=CC=C(S(=O)(=O)C=2C=C(F)C=CC=2)C(F)=C1 OJYRPSHAWFSTKU-LBPRGKRZSA-N 0.000 claims 1
- FJFSRGZFCYDEPR-ZDUSSCGKSA-N (2s)-2-[4-fluoro-2-[3-fluoro-4-(4-methoxyphenyl)sulfonylphenyl]phenoxy]propanoic acid Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)C1=CC=C(C=2C(=CC=C(F)C=2)O[C@@H](C)C(O)=O)C=C1F FJFSRGZFCYDEPR-ZDUSSCGKSA-N 0.000 claims 1
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 1
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims 1
- ISWSXSNHKLNPOG-UHFFFAOYSA-N 2-[2-[4-(benzenesulfonyl)-2-fluorophenyl]-4-chlorophenoxy]acetic acid Chemical compound OC(=O)COC1=CC=C(Cl)C=C1C1=CC=C(S(=O)(=O)C=2C=CC=CC=2)C=C1F ISWSXSNHKLNPOG-UHFFFAOYSA-N 0.000 claims 1
- KROXGGPWHQTARO-UHFFFAOYSA-N 2-[2-[4-(benzenesulfonyl)-2-fluorophenyl]-4-fluorophenoxy]acetic acid Chemical compound OC(=O)COC1=CC=C(F)C=C1C1=CC=C(S(=O)(=O)C=2C=CC=CC=2)C=C1F KROXGGPWHQTARO-UHFFFAOYSA-N 0.000 claims 1
- TYRXLUSFQPXRFN-UHFFFAOYSA-N 2-[2-[4-(benzenesulfonyl)-3,5-difluorophenyl]-4-chlorophenoxy]acetic acid Chemical compound OC(=O)COC1=CC=C(Cl)C=C1C1=CC(F)=C(S(=O)(=O)C=2C=CC=CC=2)C(F)=C1 TYRXLUSFQPXRFN-UHFFFAOYSA-N 0.000 claims 1
- KQASONHOPDYLTE-UHFFFAOYSA-N 2-[2-[4-(benzenesulfonyl)-3-(trifluoromethyl)phenyl]-4-fluorophenoxy]acetic acid Chemical compound OC(=O)COC1=CC=C(F)C=C1C1=CC=C(S(=O)(=O)C=2C=CC=CC=2)C(C(F)(F)F)=C1 KQASONHOPDYLTE-UHFFFAOYSA-N 0.000 claims 1
- XKSKEAXWWLKTNF-UHFFFAOYSA-N 2-[2-[4-(benzenesulfonyl)-3-fluorophenyl]-4-fluorophenoxy]acetic acid Chemical compound OC(=O)COC1=CC=C(F)C=C1C1=CC=C(S(=O)(=O)C=2C=CC=CC=2)C(F)=C1 XKSKEAXWWLKTNF-UHFFFAOYSA-N 0.000 claims 1
- ZXKZARMMAVBFRA-UHFFFAOYSA-N 2-[2-[4-(benzenesulfonyl)-3-fluorophenyl]-4-methylphenoxy]acetic acid Chemical compound CC1=CC=C(OCC(O)=O)C(C=2C=C(F)C(=CC=2)S(=O)(=O)C=2C=CC=CC=2)=C1 ZXKZARMMAVBFRA-UHFFFAOYSA-N 0.000 claims 1
- ZADWPVOZWHYYLG-UHFFFAOYSA-N 2-[2-[4-(benzenesulfonyl)phenyl]-4-chlorophenoxy]acetic acid Chemical compound OC(=O)COC1=CC=C(Cl)C=C1C1=CC=C(S(=O)(=O)C=2C=CC=CC=2)C=C1 ZADWPVOZWHYYLG-UHFFFAOYSA-N 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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GB0520324A GB0520324D0 (en) | 2005-10-06 | 2005-10-06 | Novel compounds |
GB0525082A GB0525082D0 (en) | 2005-12-09 | 2005-12-09 | Novel compounds |
GB0602800A GB0602800D0 (en) | 2006-02-11 | 2006-02-11 | Novel Compounds |
PCT/GB2006/003697 WO2007039741A1 (en) | 2005-10-06 | 2006-10-05 | Biphenyloxyacetic acid derivatives for the treatment of respiratory disease |
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HRP20100541T1 true HRP20100541T1 (hr) | 2010-11-30 |
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HR20100541T HRP20100541T1 (hr) | 2005-10-06 | 2010-10-05 | Derivati bifeniloksioctene kiseline za liječenje respiratornih bolesti |
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GB0415320D0 (en) | 2004-07-08 | 2004-08-11 | Astrazeneca Ab | Novel compounds |
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GB0422057D0 (en) * | 2004-10-05 | 2004-11-03 | Astrazeneca Ab | Novel compounds |
PT1817282E (pt) | 2004-11-23 | 2011-09-19 | Astrazeneca Ab | Derivados do ácido fenoxiacético úteis para tratar doenças respiratórias |
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TW200745003A (en) | 2005-10-06 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
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GB0409921D0 (en) | 2004-05-04 | 2004-06-09 | Novartis Ag | Organic compounds |
AU2005247110B2 (en) | 2004-05-29 | 2010-08-26 | 7Tm Pharma A/S | CRTH2 receptor ligands for medicinal uses |
GB0415320D0 (en) | 2004-07-08 | 2004-08-11 | Astrazeneca Ab | Novel compounds |
GB0418830D0 (en) * | 2004-08-24 | 2004-09-22 | Astrazeneca Ab | Novel compounds |
GB0422057D0 (en) * | 2004-10-05 | 2004-11-03 | Astrazeneca Ab | Novel compounds |
PT1817282E (pt) * | 2004-11-23 | 2011-09-19 | Astrazeneca Ab | Derivados do ácido fenoxiacético úteis para tratar doenças respiratórias |
GB0510584D0 (en) | 2005-05-24 | 2005-06-29 | Novartis Ag | Organic compounds |
US8148572B2 (en) * | 2005-10-06 | 2012-04-03 | Astrazeneca Ab | Compounds |
TW200745003A (en) | 2005-10-06 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
JP2009514935A (ja) | 2005-11-05 | 2009-04-09 | アストラゼネカ・アクチエボラーグ | 新規化合物 |
JP4872318B2 (ja) | 2005-11-16 | 2012-02-08 | パナソニック株式会社 | 紙幣識別装置 |
ES2380683T3 (es) * | 2005-12-15 | 2012-05-17 | Astrazeneca Ab | Difenil-éteres, -amidas, -sulfuros y - metanos sustituidos para el tratamiento de la enfermedad respiratoria |
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-
2006
- 2006-09-27 TW TW095135771A patent/TW200745003A/zh unknown
- 2006-10-04 UY UY29839A patent/UY29839A1/es not_active Application Discontinuation
- 2006-10-05 AT AT06794649T patent/ATE476414T1/de active
- 2006-10-05 US US12/089,276 patent/US8008350B2/en not_active Expired - Fee Related
- 2006-10-05 AR ARP060104385A patent/AR058077A1/es not_active Application Discontinuation
- 2006-10-05 DK DK06794649.1T patent/DK1937633T3/da active
- 2006-10-05 PL PL06794649T patent/PL1937633T3/pl unknown
- 2006-10-05 WO PCT/GB2006/003697 patent/WO2007039741A1/en active Application Filing
- 2006-10-05 CA CA002624343A patent/CA2624343A1/en not_active Abandoned
- 2006-10-05 DE DE602006015984T patent/DE602006015984D1/de active Active
- 2006-10-05 NZ NZ567070A patent/NZ567070A/en not_active IP Right Cessation
- 2006-10-05 PT PT06794649T patent/PT1937633E/pt unknown
- 2006-10-05 BR BRPI0616969-4A patent/BRPI0616969A2/pt not_active IP Right Cessation
- 2006-10-05 JP JP2008534073A patent/JP5114413B2/ja not_active Expired - Fee Related
- 2006-10-05 SI SI200630777T patent/SI1937633T1/sl unknown
- 2006-10-05 RS RSP-2010/0432A patent/RS51471B/en unknown
- 2006-10-05 ES ES06794649T patent/ES2347470T3/es active Active
- 2006-10-05 EP EP06794649A patent/EP1937633B8/en active Active
- 2006-10-05 AU AU2006298531A patent/AU2006298531B2/en not_active Ceased
- 2006-10-07 SA SA06270368A patent/SA06270368B1/ar unknown
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2008
- 2008-03-20 IL IL190338A patent/IL190338A0/en unknown
- 2008-04-04 KR KR1020087008244A patent/KR101275476B1/ko not_active IP Right Cessation
- 2008-04-30 EC EC2008008414A patent/ECSP088414A/es unknown
- 2008-05-06 NO NO20082124A patent/NO20082124L/no not_active Application Discontinuation
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2010
- 2010-10-05 HR HR20100541T patent/HRP20100541T1/hr unknown
- 2010-10-06 CY CY20101100891T patent/CY1110812T1/el unknown
- 2010-12-20 US US12/973,395 patent/US8349897B2/en not_active Expired - Fee Related
- 2010-12-22 AU AU2010257385A patent/AU2010257385C1/en not_active Ceased
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2011
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