AR066266A1 - DERIVADOS DE CROMENO Y DE TETRAHIDRONAFTALENO uTILES PARA EL TRATAMIENTO DEL DOLOR - Google Patents
DERIVADOS DE CROMENO Y DE TETRAHIDRONAFTALENO uTILES PARA EL TRATAMIENTO DEL DOLORInfo
- Publication number
- AR066266A1 AR066266A1 ARP080101710A ARP080101710A AR066266A1 AR 066266 A1 AR066266 A1 AR 066266A1 AR P080101710 A ARP080101710 A AR P080101710A AR P080101710 A ARP080101710 A AR P080101710A AR 066266 A1 AR066266 A1 AR 066266A1
- Authority
- AR
- Argentina
- Prior art keywords
- 6alkyl
- 6alkoxy
- acid
- 6haloalkyl
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Abstract
Composicion farmacéutica que contiene dichos compuestos y uso de dichos compuestos en la terapia. La presente se relaciona además con el proceso para la preparacion de dichos compuestos y con los nuevos productos intermedios utiles en la preparacionde los mismos Reivindicacion 1: Un compuesto de formula 1, donde: X es O o CH2; R1 es piridinil, pirazolil, isoxazolil, pirimidinil, piridazinil, imidazopiridinil o pirazinil, el cual puede ser independientemente mono-, bi-o tri-sustituido con R11,R12, y/o R13; donde R11, R12 y R13 son independientemente seleccionados de halogeno, C1-6alquil, C1-6alcoxi, C3-6cicloalquil, C 1-6hidroxialquil, C3-6cicloalquiloxi, C3-6cicloaIquil C1-6alcoxi, ciano, hidroxi, C1-6 haloalquil, C 1-6haloalcoxi, C1-6haloalcoxi C1-6alcoxi, C1-6haloalcoxi C1-6alquil, ácido C1-6alquilsulfonico-, ácido C1-6haloalquilsulfonico-, ácido C3-6cicloalquilsulfonico-, ácido C3-6halocicloalquilsulfonico-, ácido C3-6cicloalquil C1-6alquilsulfonico-, ácido C3-6halocicloalquil C 1-6alquilsulfonico-, C1-6alquilsulfoniI-, C1-6haloalquilsulfonil-, C3-6cicloalquilsulfoniI-, C3-6halocicloalquilsulfoniI-, C3-6cicloalquil C1-6alquilsulfonil, C3-6halocicloalquil C1-6alquil-sulfonil, fenil, fenilC1-6alquil-,fenoxi, C1-6aquilfenil-, C1-6alcoxifenil-, C1-6alquilamina, C1-6haloalquilamina, -C(O)NHC1-6alquil, -C(O)N(C1-6alquil)2 y -C(O)NH2; R2 es pirazinil, fenil, piridinil, quinoxalinil, triazolil, piridonil, naftiridinil, pirimidinil o quinolinil, elcual puede ser independientemente mono-, bi-, o tri-sustituido con R14, R15 y/o R16; donde R14, R15 y R16 son independientemente seleccionados de halogeno, C1-6alquil, C2-6alquenil, C3-6alquinil, C1-6alcoxi, C2-6alqueniloxi, C3-6alquiniloxi, C3-6cicloalquil, C3-6heterocicloalquil, C3-6cicloalquiloxi, C3-6heterocicIoalquiloxi, C3-6cicloalquil C1-6alcoxi, C1-6alquil-C3-6cicloalquil C1-6alcoxi, C3-6heterocicloalquil C1-6alcoxi, C1-6alquil-C3-6heterocicloaIquil C1-6alcoxi, C1-6alcoxi C1-6alcoxi, C1-6alcoxi C1-6alquil, C1-6hidroxialquil, C1-6haloalquil, C1-6haloalcoxi, C1-6haloalcoxi C1-6alcoxi, C1-6haloalcoxi C1-6alquil, ciano, hidroxil, NR4R5, ácido C1-6alquilsulfonico-, ácido C1-6haloalquilsulfonico-, ácido C3-6cicloalquilsulfonico-, ácido C3-6halocicloalquilsulfonico-, ácido C3-6cicIoalquil C1-6alquilsulfonico-, ácido C3-6halocicloalquil C1-6alquilsulfonico-, C1-6alquilsulfonil-, C1-6haloalquilsulfonil-, C3-6cicloalquilsulfonil-, C3-6halocicloalquilsulfonil-, C3-6cicloalquil- C1-6alquil-sulfonil, C3-6halocicloalquil-C1-6alquil-sulfonil, fenil, fenilC1-6alquil-, fenoxi, C1-6alquilfenil-, C1-6alcoxifenil-, -C(O)NR4R5, -C(O)C3-6cicloalquil, -C(O)C3-6heterocicloalquil, -C(O)C3-6cicloalquilC1-6alcoxi, -C(O)C3-6heterocicloalquilC1-6:alcoxi, -C(O)C3-6cicloalquilC1-6alquil y -C(O)C3-6heterocicloalquilC1-6alquiI; y R4 y R5 son independientemente seleccionados de hidrogeno, C1-6alquil, C1-6haloalquil, C1-6hidroxialquil, C1-6alcoxiC1-6alquil, C3-6cicloalquil, C3-6halocicloalquil, C3-6heterocicloalquil y C3-6heterocicloalquilC1-6alquil, o sales farmacéuticamente aceptables de los mismos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91331207P | 2007-04-23 | 2007-04-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR066266A1 true AR066266A1 (es) | 2009-08-05 |
Family
ID=39876087
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080101710A AR066266A1 (es) | 2007-04-23 | 2008-04-23 | DERIVADOS DE CROMENO Y DE TETRAHIDRONAFTALENO uTILES PARA EL TRATAMIENTO DEL DOLOR |
Country Status (23)
Country | Link |
---|---|
US (2) | US8143408B2 (es) |
EP (1) | EP2158198B1 (es) |
JP (1) | JP2010525056A (es) |
KR (1) | KR20100015827A (es) |
CN (1) | CN101687860B (es) |
AR (1) | AR066266A1 (es) |
AU (1) | AU2008241610B2 (es) |
BR (1) | BRPI0810354A2 (es) |
CA (1) | CA2685141A1 (es) |
CL (1) | CL2008001170A1 (es) |
CO (1) | CO6251361A2 (es) |
EC (1) | ECSP099706A (es) |
IL (1) | IL201309A0 (es) |
MX (1) | MX2009011364A (es) |
MY (1) | MY146662A (es) |
NZ (1) | NZ581353A (es) |
PE (1) | PE20090727A1 (es) |
RU (1) | RU2460730C2 (es) |
SA (1) | SA08290245B1 (es) |
TW (1) | TW200848037A (es) |
UY (1) | UY31046A1 (es) |
WO (1) | WO2008130320A2 (es) |
ZA (1) | ZA200907137B (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SA08290245B1 (ar) * | 2007-04-23 | 2012-02-12 | استرازينيكا ايه بي | مشتقات كربو كساميد جديدة من -n (8-اريل رباعي هيدرو نفثالين غير متجانس- 2- يل) أو -n (5-اريل كرومان غير متجانس -3-يل) لعلاج الألم |
AR074760A1 (es) * | 2008-12-18 | 2011-02-09 | Metabolex Inc | Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico. |
EP2942346B1 (en) | 2009-02-17 | 2020-05-06 | Syntrix Biosystems, Inc. | Pyridinecarboxamides as cxcr2 modulators |
KR20120091240A (ko) * | 2009-10-26 | 2012-08-17 | 시그날 파마소티칼 엘엘씨 | 헤테로아릴 화합물의 합성 및 정제 방법 |
UA103272C2 (uk) | 2009-12-11 | 2013-09-25 | Ф. Хоффманн-Ля Рош Аг | 2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2 |
WO2011093501A1 (ja) | 2010-02-01 | 2011-08-04 | 日本ケミファ株式会社 | Gpr119作動薬 |
WO2012027289A1 (en) | 2010-08-23 | 2012-03-01 | Syntrix Biosystems Inc. | Aminopyridine- and aminopyrimidinecarboxamides as cxcr2 modulators |
WO2012039657A1 (en) * | 2010-09-22 | 2012-03-29 | Astrazeneca Ab | Novel chromane compound for the treatment of pain disorders |
CN102408385B (zh) * | 2011-06-20 | 2014-06-18 | 雅本化学股份有限公司 | 一种2-取代-2h-1,2,3-三氮唑衍生物的制备方法 |
CN102408386B (zh) * | 2011-07-27 | 2014-05-07 | 雅本化学股份有限公司 | 2,4-二取代-2h-1,2,3-三氮唑衍生物的制备方法 |
CN102603659B (zh) * | 2012-03-01 | 2014-03-26 | 雅本化学股份有限公司 | 1-取代-4-溴-1h-1,2,3-三氮唑-5-羧酸及其制备方法 |
MX368833B (es) * | 2013-01-31 | 2019-10-18 | Vertex Pharma | Derivados de quinolina y quinazolina amidas como inhibidores de canales de sodio nav1.8 y el uso de los mismos en el tratamiento del dolor. |
US10561676B2 (en) | 2013-08-02 | 2020-02-18 | Syntrix Biosystems Inc. | Method for treating cancer using dual antagonists of CXCR1 and CXCR2 |
US10046002B2 (en) | 2013-08-02 | 2018-08-14 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists |
US8969365B2 (en) | 2013-08-02 | 2015-03-03 | Syntrix Biosystems, Inc. | Thiopyrimidinecarboxamides as CXCR1/2 modulators |
US9452986B2 (en) * | 2014-02-06 | 2016-09-27 | Abbvie Inc. | 6-heteroaryloxy- or 6-aryloxy-quinoline-2-carboxamides and method of use |
KR102412146B1 (ko) | 2015-02-11 | 2022-06-22 | 주식회사 아이엔테라퓨틱스 | 소디움 채널 차단제 |
AU2016351526B2 (en) | 2015-11-13 | 2019-02-21 | In Therapeutics | Sodium channel blocker |
CN105541774B (zh) * | 2016-01-13 | 2018-06-15 | 华中师范大学 | 3,4-二氢香豆素类化合物及其制备方法和用途 |
KR20200020911A (ko) * | 2017-06-30 | 2020-02-26 | 바이엘 애니멀 헬스 게엠베하 | 새로운 아자퀴놀린 유도체 |
JP7401439B2 (ja) | 2018-01-19 | 2023-12-19 | サイトキネティックス, インコーポレイテッド | 心筋節阻害剤としてのジヒドロベンゾフランおよびインデンアナログ |
WO2019170543A1 (en) | 2018-03-07 | 2019-09-12 | Bayer Aktiengesellschaft | Identification and use of erk5 inhibitors |
BR112021001608A2 (pt) | 2018-09-10 | 2021-04-27 | Kaken Pharmaceutical Co., Ltd. | derivado de amida heteroaromático inovador e medicamento contendo o mesmo |
WO2020234103A1 (en) | 2019-05-21 | 2020-11-26 | Bayer Aktiengesellschaft | Identification and use of kras inhibitors |
US11919909B2 (en) | 2021-03-04 | 2024-03-05 | Cytokinetics, Inc. | Cardiac sarcomere inhibitors |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE8904361D0 (sv) * | 1989-12-22 | 1989-12-22 | Astra Ab | New chroman and thiochroman derivatives |
WO1994012493A1 (en) * | 1992-11-25 | 1994-06-09 | Sandoz, Ltd. | 2,2-dialkyl- and 2,2-dialkyl-3,4-dihydro-3-hydroxy-2h-1-benzopyr ans, their use as pharmaceuticals |
JPH0827153A (ja) * | 1994-07-12 | 1996-01-30 | Nippon Kayaku Co Ltd | アザクロマン誘導体及びその用途 |
SE9601110D0 (sv) * | 1996-03-22 | 1996-03-22 | Astra Ab | Substituted 1,2,3,4-tetrahydronaphthalene derivatives |
GB9713804D0 (en) * | 1997-06-30 | 1997-09-03 | Novo Nordisk As | Particulate polymeric materials and their use |
JPH1135569A (ja) | 1997-07-22 | 1999-02-09 | Meiji Milk Prod Co Ltd | ポリフェノール化合物及びこれを含有する医薬 |
SE9702799D0 (sv) | 1997-07-25 | 1997-07-25 | Astra Ab | New compounds |
SE9703378D0 (sv) * | 1997-09-18 | 1997-09-18 | Astra Ab | New compounds |
SE9703377D0 (sv) * | 1997-09-18 | 1997-09-18 | Astra Ab | New compounds |
NZ579370A (en) | 2003-08-08 | 2011-06-30 | Vertex Pharma | Heteroarylaminosulfonylphenyl derivatives for use as sodium or calcium channel blockers in the treatment of pain |
US7615563B2 (en) * | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
JP2008540443A (ja) * | 2005-05-04 | 2008-11-20 | バーテックス ファーマシューティカルズ インコーポレイテッド | イオンチャネルのモジュレーターとして有用なピリミジンおよびピラジン |
CN101490002A (zh) * | 2006-07-12 | 2009-07-22 | 阿斯利康(瑞典)有限公司 | 作为止痛剂的3-氧代异二氢吲哚-1-甲酰胺衍生物 |
SA08290245B1 (ar) * | 2007-04-23 | 2012-02-12 | استرازينيكا ايه بي | مشتقات كربو كساميد جديدة من -n (8-اريل رباعي هيدرو نفثالين غير متجانس- 2- يل) أو -n (5-اريل كرومان غير متجانس -3-يل) لعلاج الألم |
-
2008
- 2008-04-21 SA SA8290245A patent/SA08290245B1/ar unknown
- 2008-04-22 WO PCT/SE2008/050459 patent/WO2008130320A2/en active Application Filing
- 2008-04-22 CA CA002685141A patent/CA2685141A1/en not_active Abandoned
- 2008-04-22 NZ NZ581353A patent/NZ581353A/en not_active IP Right Cessation
- 2008-04-22 US US12/596,878 patent/US8143408B2/en not_active Expired - Fee Related
- 2008-04-22 CN CN2008800215491A patent/CN101687860B/zh not_active Expired - Fee Related
- 2008-04-22 JP JP2010506133A patent/JP2010525056A/ja active Pending
- 2008-04-22 BR BRPI0810354-2A2A patent/BRPI0810354A2/pt not_active IP Right Cessation
- 2008-04-22 EP EP08779260A patent/EP2158198B1/en active Active
- 2008-04-22 MY MYPI20094419A patent/MY146662A/en unknown
- 2008-04-22 RU RU2009138137/04A patent/RU2460730C2/ru not_active IP Right Cessation
- 2008-04-22 MX MX2009011364A patent/MX2009011364A/es active IP Right Grant
- 2008-04-22 KR KR1020097022164A patent/KR20100015827A/ko not_active Application Discontinuation
- 2008-04-22 AU AU2008241610A patent/AU2008241610B2/en not_active Ceased
- 2008-04-23 AR ARP080101710A patent/AR066266A1/es not_active Application Discontinuation
- 2008-04-23 PE PE2008000697A patent/PE20090727A1/es not_active Application Discontinuation
- 2008-04-23 UY UY31046A patent/UY31046A1/es not_active Application Discontinuation
- 2008-04-23 TW TW097114910A patent/TW200848037A/zh unknown
- 2008-04-23 CL CL2008001170A patent/CL2008001170A1/es unknown
-
2009
- 2009-10-01 IL IL201309A patent/IL201309A0/en unknown
- 2009-10-13 ZA ZA200907137A patent/ZA200907137B/xx unknown
- 2009-10-29 EC EC2009009706A patent/ECSP099706A/es unknown
- 2009-10-29 CO CO09122476A patent/CO6251361A2/es not_active Application Discontinuation
-
2012
- 2012-03-23 US US13/427,981 patent/US20120238579A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
RU2009138137A (ru) | 2011-05-27 |
CA2685141A1 (en) | 2008-10-30 |
UY31046A1 (es) | 2008-11-28 |
MX2009011364A (es) | 2009-11-05 |
SA08290245B1 (ar) | 2012-02-12 |
EP2158198B1 (en) | 2013-03-20 |
WO2008130320A3 (en) | 2008-12-18 |
KR20100015827A (ko) | 2010-02-12 |
BRPI0810354A2 (pt) | 2014-10-21 |
IL201309A0 (en) | 2010-05-31 |
US8143408B2 (en) | 2012-03-27 |
CO6251361A2 (es) | 2011-02-21 |
ZA200907137B (en) | 2010-07-28 |
ECSP099706A (es) | 2009-11-30 |
MY146662A (en) | 2012-09-14 |
US20120238579A1 (en) | 2012-09-20 |
PE20090727A1 (es) | 2009-07-23 |
CL2008001170A1 (es) | 2009-05-22 |
EP2158198A4 (en) | 2012-01-04 |
WO2008130320A2 (en) | 2008-10-30 |
CN101687860A (zh) | 2010-03-31 |
EP2158198A2 (en) | 2010-03-03 |
RU2460730C2 (ru) | 2012-09-10 |
NZ581353A (en) | 2012-02-24 |
CN101687860B (zh) | 2012-07-04 |
TW200848037A (en) | 2008-12-16 |
US20100137322A1 (en) | 2010-06-03 |
JP2010525056A (ja) | 2010-07-22 |
AU2008241610B2 (en) | 2011-08-18 |
AU2008241610A1 (en) | 2008-10-30 |
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