HRP20050185A2 - -3 (sulfonamidoethyl)-indole derivatives for use as glucocorticoid mimetics in the treatment of inflammatory, allergic and proliferative diseases - Google Patents

-3 (sulfonamidoethyl)-indole derivatives for use as glucocorticoid mimetics in the treatment of inflammatory, allergic and proliferative diseases Download PDF

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Publication number
HRP20050185A2
HRP20050185A2 HR20050185A HRP20050185A HRP20050185A2 HR P20050185 A2 HRP20050185 A2 HR P20050185A2 HR 20050185 A HR20050185 A HR 20050185A HR P20050185 A HRP20050185 A HR P20050185A HR P20050185 A2 HRP20050185 A2 HR P20050185A2
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Croatia
Prior art keywords
indol
methylethyl
benzenesulfonamide
group
alkyl
Prior art date
Application number
HR20050185A
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English (en)
Croatian (hr)
Inventor
R. Marshall Daniel
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Boehringer Ingelheim Pharmaceuticals Inc.
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Application filed by Boehringer Ingelheim Pharmaceuticals Inc. filed Critical Boehringer Ingelheim Pharmaceuticals Inc.
Publication of HRP20050185A2 publication Critical patent/HRP20050185A2/hr

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
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  • Urology & Nephrology (AREA)
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  • Hospice & Palliative Care (AREA)
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HR20050185A 2002-08-29 2005-02-25 -3 (sulfonamidoethyl)-indole derivatives for use as glucocorticoid mimetics in the treatment of inflammatory, allergic and proliferative diseases HRP20050185A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40743802P 2002-08-29 2002-08-29
PCT/US2003/025062 WO2004019935A1 (en) 2002-08-29 2003-08-12 -3 (sulfonamidoethyl) -indole derivaties for use as glucocorticoid mimetics in the treatment of inflammatory, allergic and proliferative diseases

Publications (1)

Publication Number Publication Date
HRP20050185A2 true HRP20050185A2 (en) 2006-05-31

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ID=31978485

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HR20050185A HRP20050185A2 (en) 2002-08-29 2005-02-25 -3 (sulfonamidoethyl)-indole derivatives for use as glucocorticoid mimetics in the treatment of inflammatory, allergic and proliferative diseases

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Country Link
US (1) US20040097574A1 (zh)
EP (1) EP1539141B1 (zh)
JP (1) JP4619786B2 (zh)
KR (1) KR20050036982A (zh)
CN (1) CN1678306A (zh)
AT (1) ATE473740T1 (zh)
AU (1) AU2003255259A1 (zh)
BR (1) BR0313923A (zh)
CA (1) CA2496580A1 (zh)
CO (1) CO5550451A2 (zh)
DE (1) DE60333371D1 (zh)
EA (1) EA011095B1 (zh)
EC (1) ECSP055611A (zh)
ES (1) ES2349164T3 (zh)
HR (1) HRP20050185A2 (zh)
MX (1) MXPA05002297A (zh)
NO (1) NO20051527D0 (zh)
NZ (1) NZ538932A (zh)
PL (1) PL375513A1 (zh)
RS (1) RS20050174A (zh)
UA (1) UA82675C2 (zh)
WO (1) WO2004019935A1 (zh)
ZA (1) ZA200500153B (zh)

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