HRP20040619A2 - Combination of cytochome p<sub>450</sub> dependent protease inhibitors - Google Patents
Combination of cytochome p<sub>450</sub> dependent protease inhibitors Download PDFInfo
- Publication number
- HRP20040619A2 HRP20040619A2 HR20040619A HRP20040619A HRP20040619A2 HR P20040619 A2 HRP20040619 A2 HR P20040619A2 HR 20040619 A HR20040619 A HR 20040619A HR P20040619 A HRP20040619 A HR P20040619A HR P20040619 A2 HRP20040619 A2 HR P20040619A2
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- HR
- Croatia
- Prior art keywords
- het1
- het2
- alkyl
- aryl
- cycloalkyl
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01204841 | 2001-12-12 | ||
| PCT/EP2002/014277 WO2003049746A2 (en) | 2001-12-12 | 2002-12-12 | Combination of cytochome p450 dependent protease inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20040619A2 true HRP20040619A2 (en) | 2005-08-31 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20040619A HRP20040619A2 (en) | 2001-12-12 | 2004-07-07 | Combination of cytochome p<sub>450</sub> dependent protease inhibitors |
Country Status (28)
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| US (1) | US20050119338A1 (ja) |
| EP (1) | EP1458447B1 (ja) |
| JP (1) | JP2005511723A (ja) |
| KR (1) | KR100974921B1 (ja) |
| CN (1) | CN100335060C (ja) |
| AR (1) | AR037797A1 (ja) |
| AT (1) | ATE442189T1 (ja) |
| AU (1) | AU2002358713B2 (ja) |
| BR (1) | BR0215043A (ja) |
| CA (1) | CA2469343C (ja) |
| CY (1) | CY1110604T1 (ja) |
| DE (1) | DE60233677D1 (ja) |
| DK (1) | DK1458447T3 (ja) |
| ES (1) | ES2333206T3 (ja) |
| HK (1) | HK1070008A1 (ja) |
| HR (1) | HRP20040619A2 (ja) |
| HU (1) | HUP0402644A3 (ja) |
| IL (1) | IL162353A0 (ja) |
| MX (1) | MXPA04005755A (ja) |
| NO (1) | NO20042666L (ja) |
| NZ (1) | NZ533826A (ja) |
| PL (1) | PL373072A1 (ja) |
| PT (1) | PT1458447E (ja) |
| RU (1) | RU2329050C2 (ja) |
| SI (1) | SI1458447T1 (ja) |
| TW (1) | TWI286476B (ja) |
| WO (1) | WO2003049746A2 (ja) |
| ZA (1) | ZA200404633B (ja) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
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| KR101090102B1 (ko) * | 2003-09-30 | 2011-12-07 | 티보텍 파마슈티컬즈 | 벤조옥사졸 설폰아미드 화합물 및 그의 중간체를 제조하는방법 |
| US20070104740A1 (en) * | 2003-12-23 | 2007-05-10 | Voorspoels Jody Firmin M | Self-microemulsifying drug delivery systems of a hiv protease inhibitor |
| MXPA06012909A (es) * | 2004-05-07 | 2007-09-06 | Sequoia Pharmaceuticals Inc | Inhibidores de proteasa retroviral repelente de resistencia. |
| WO2006005720A1 (en) * | 2004-07-08 | 2006-01-19 | Tibotec Pharmaceuticals Ltd. | Combination of anti-hiv reverse transcriptase and protease inhibitors |
| ES2331257T3 (es) | 2005-02-25 | 2009-12-28 | Tibotec Pharmaceuticals | Sintesis de precursores de inhibidores de proteasas. |
| US20070003608A1 (en) * | 2005-04-08 | 2007-01-04 | Almond Merrick R | Compounds, compositions and methods for the treatment of viral infections and other medical disorders |
| AR053845A1 (es) | 2005-04-15 | 2007-05-23 | Tibotec Pharm Ltd | 5-tiazolilmetil[(1s,2r)-3-[[(2-amino-6-benzoxazolil)sulfonil)](2-metilpropil)amino]-2-hidroxi-1-(fenilmetil)propil]carbamato como mejorador de farmacos metabolizados por el citocromo p450 |
| TWI432438B (zh) * | 2005-11-28 | 2014-04-01 | Tibotec Pharm Ltd | 作為ｈｉｖ蛋白酶抑制劑之經取代的胺基苯基磺醯胺化合物及衍生物 |
| TWI385173B (zh) * | 2005-11-28 | 2013-02-11 | Tibotec Pharm Ltd | 作為ｈｉｖ蛋白酶抑制劑之經取代的胺基苯基磺醯胺化合物 |
| EP1976517A1 (en) * | 2005-12-30 | 2008-10-08 | Gilead Sciences, Inc. | Methods for improving the pharmacokinetics of hiv integrase inhibitors |
| JO2841B1 (en) * | 2006-06-23 | 2014-09-15 | تيبوتيك فارماسيوتيكالز ليمتد | 2-(substituted-amino) -benzothiazole sulfonamide as protease inhibitors HIV (HIV) |
| US8048871B2 (en) | 2006-08-18 | 2011-11-01 | Sequoia Pharmaceuticals, Inc. | Compositions and methods for inhibiting cytochrome P450 |
| EP2139883A4 (en) * | 2007-03-23 | 2011-06-22 | Univ Massachusetts | INHIBITORS OF HIV-1 PROTEASE |
| UA103013C2 (uk) | 2007-12-06 | 2013-09-10 | Тиботек Фармасьютикелз | Амідні сполуки як активатори противірусних препаратів |
| GT200800303A (es) | 2007-12-24 | 2009-09-18 | Combinacion anti-retroviral | |
| EP3085377A1 (en) | 2008-01-25 | 2016-10-26 | Chimerix, Inc. | Methods of treating viral infections |
| NZ591951A (en) | 2008-10-07 | 2013-02-22 | Janssen R & D Ireland | New amide compounds as boosters of antivirals |
| WO2010132494A1 (en) * | 2009-05-11 | 2010-11-18 | Ghosh Arun K | Compounds and methods for treating aids and hiv infections |
| JO3090B1 (ar) * | 2009-12-11 | 2017-03-15 | Janssen Sciences Ireland Uc | 5- امينو-4- هيدروكسي-بنتويل اميدات |
| WO2011100698A2 (en) | 2010-02-12 | 2011-08-18 | Chimerix, Inc. | Methods of treating viral infection |
| WO2011139709A2 (en) | 2010-04-26 | 2011-11-10 | Chimerix, Inc. | Methods of treating retroviral infections and related dosage regimes |
| EP2576544A4 (en) * | 2010-06-01 | 2013-09-11 | Angion Biomedica Corp | INHIBITORS OF CYTOCHROMES P450 AND USES THEREOF |
| KR101817991B1 (ko) | 2011-07-07 | 2018-01-12 | 얀센 사이언시즈 아일랜드 유씨 | 다루나비어 제제 |
| BR112014000290B1 (pt) | 2011-07-07 | 2022-05-10 | Gilead Sciences, Inc. | Forma de dosagem oral de combinação de darunavir, processo para preparação de uma forma de dosagem oral e uso de granulado de darunavir |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7973994A (en) * | 1993-10-13 | 1995-05-04 | Merck & Co., Inc. | Combination therapy for hiv infection |
| US6037157A (en) * | 1995-06-29 | 2000-03-14 | Abbott Laboratories | Method for improving pharmacokinetics |
| EP0915700B1 (en) * | 1996-08-05 | 2006-03-22 | Myriad Genetics, Inc. | Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors |
| US6180634B1 (en) * | 1997-11-13 | 2001-01-30 | Merck & Co., Inc. | Combination therapy for the treatment of AIDS |
| US6436989B1 (en) * | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
| CA2336160C (en) * | 1998-06-23 | 2015-02-17 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Use of compounds for treating hiv |
| WO1999067254A2 (en) * | 1998-06-23 | 1999-12-29 | The United States Of America Represented By The Secretary, Department Of Health And Human Services | Multi-drug resistant retroviral protease inhibitors and use thereof |
| CO5090830A1 (es) * | 1998-07-20 | 2001-10-30 | Abbott Lab | Poliformo de un agente farmaceutico |
| EP1159278B1 (en) * | 1999-02-12 | 2005-11-30 | Vertex Pharmaceuticals Incorporated | Inhibitors of aspartyl protease |
| TNSN00027A1 (fr) * | 1999-02-12 | 2005-11-10 | Vertex Pharma | Inhibiteurs de l'aspartyle protease |
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2002
- 2002-12-11 AR ARP020104805A patent/AR037797A1/es unknown
- 2002-12-11 TW TW091135882A patent/TWI286476B/zh not_active IP Right Cessation
- 2002-12-12 WO PCT/EP2002/014277 patent/WO2003049746A2/en active Application Filing
- 2002-12-12 RU RU2004121144/15A patent/RU2329050C2/ru not_active IP Right Cessation
- 2002-12-12 AU AU2002358713A patent/AU2002358713B2/en not_active Revoked
- 2002-12-12 BR BR0215043-3A patent/BR0215043A/pt not_active Application Discontinuation
- 2002-12-12 DE DE60233677T patent/DE60233677D1/de not_active Expired - Lifetime
- 2002-12-12 IL IL16235302A patent/IL162353A0/xx unknown
- 2002-12-12 PL PL02373072A patent/PL373072A1/xx not_active IP Right Cessation
- 2002-12-12 KR KR1020047008830A patent/KR100974921B1/ko not_active IP Right Cessation
- 2002-12-12 HU HU0402644A patent/HUP0402644A3/hu unknown
- 2002-12-12 NZ NZ533826A patent/NZ533826A/en not_active IP Right Cessation
- 2002-12-12 JP JP2003550795A patent/JP2005511723A/ja active Pending
- 2002-12-12 ES ES02793018T patent/ES2333206T3/es not_active Expired - Lifetime
- 2002-12-12 DK DK02793018.9T patent/DK1458447T3/da active
- 2002-12-12 SI SI200230865T patent/SI1458447T1/sl unknown
- 2002-12-12 PT PT02793018T patent/PT1458447E/pt unknown
- 2002-12-12 AT AT02793018T patent/ATE442189T1/de not_active IP Right Cessation
- 2002-12-12 CN CNB028249119A patent/CN100335060C/zh not_active Expired - Fee Related
- 2002-12-12 US US10/498,024 patent/US20050119338A1/en not_active Abandoned
- 2002-12-12 CA CA002469343A patent/CA2469343C/en not_active Expired - Fee Related
- 2002-12-12 EP EP02793018A patent/EP1458447B1/en not_active Revoked
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2004
- 2004-06-10 ZA ZA200404633A patent/ZA200404633B/en unknown
- 2004-06-14 MX MXPA04005755A patent/MXPA04005755A/es active IP Right Grant
- 2004-06-24 NO NO20042666A patent/NO20042666L/no not_active Application Discontinuation
- 2004-07-07 HR HR20040619A patent/HRP20040619A2/hr not_active Application Discontinuation
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2005
- 2005-03-18 HK HK05102399.8A patent/HK1070008A1/xx not_active IP Right Cessation
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- 2009-12-09 CY CY20091101283T patent/CY1110604T1/el unknown
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