HRP20040587B1 - Injection solution comprising an lhrh antagonist - Google Patents
Injection solution comprising an lhrh antagonistInfo
- Publication number
- HRP20040587B1 HRP20040587B1 HR20040587A HRP20040587A HRP20040587B1 HR P20040587 B1 HRP20040587 B1 HR P20040587B1 HR 20040587 A HR20040587 A HR 20040587A HR P20040587 A HRP20040587 A HR P20040587A HR P20040587 B1 HRP20040587 B1 HR P20040587B1
- Authority
- HR
- Croatia
- Prior art keywords
- lhrh antagonist
- gluconic acid
- injection solution
- adjuvant
- surfactant
- Prior art date
Links
- 229940124041 Luteinizing hormone releasing hormone (LHRH) antagonist Drugs 0.000 title abstract 4
- 239000002474 gonadorelin antagonist Substances 0.000 title abstract 4
- 238000002347 injection Methods 0.000 title 1
- 239000007924 injection Substances 0.000 title 1
- 239000000243 solution Substances 0.000 title 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 abstract 4
- RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 abstract 4
- 235000012208 gluconic acid Nutrition 0.000 abstract 4
- 239000000174 gluconic acid Substances 0.000 abstract 4
- 239000002671 adjuvant Substances 0.000 abstract 2
- 239000004094 surface-active agent Substances 0.000 abstract 2
- NOENHWMKHNSHGX-IZOOSHNJSA-N (2s)-1-[(2s)-2-[[(2s)-2-[[(2r)-2-[[(2r)-2-[[(2s)-2-[[(2r)-2-[[(2s)-2-[[(2r)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-6-(ca Chemical compound C([C@H](C(=O)N[C@H](CCCCNC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(O)C=C1 NOENHWMKHNSHGX-IZOOSHNJSA-N 0.000 abstract 1
- KATZUZNTRINHDT-HALMFYTRSA-N (2s)-1-[(2s)-2-[[(2s)-2-[[(2r)-2-[[(2s)-2-[[(2s)-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]-methylamino]-3-(4-hydroxyphenyl)propanoyl]amino Chemical compound C([C@@H](C(=O)N[C@H](CCCCNC(N)=O)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)N(C)C(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(O)C=C1 KATZUZNTRINHDT-HALMFYTRSA-N 0.000 abstract 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- 108010023617 abarelix Proteins 0.000 abstract 1
- AIWRTTMUVOZGPW-HSPKUQOVSA-N abarelix Chemical compound C([C@@H](C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)N(C)C(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(O)C=C1 AIWRTTMUVOZGPW-HSPKUQOVSA-N 0.000 abstract 1
- 229960002184 abarelix Drugs 0.000 abstract 1
- 108010070670 antarelix Proteins 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 229940127233 azaline B Drugs 0.000 abstract 1
- 108700008462 cetrorelix Proteins 0.000 abstract 1
- 229960003230 cetrorelix Drugs 0.000 abstract 1
- SBNPWPIBESPSIF-MHWMIDJBSA-N cetrorelix Chemical compound C([C@@H](C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(O)C=C1 SBNPWPIBESPSIF-MHWMIDJBSA-N 0.000 abstract 1
- 125000000422 delta-lactone group Chemical group 0.000 abstract 1
- 108700032141 ganirelix Proteins 0.000 abstract 1
- 229960003794 ganirelix Drugs 0.000 abstract 1
- GJNXBNATEDXMAK-PFLSVRRQSA-N ganirelix Chemical compound C([C@@H](C(=O)N[C@H](CCCCN=C(NCC)NCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN=C(NCC)NCC)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(O)C=C1 GJNXBNATEDXMAK-PFLSVRRQSA-N 0.000 abstract 1
- QRYFGTULTGLGHU-NBERXCRTSA-N iturelix Chemical compound C([C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)NC(=O)[C@H](CCCCNC(=O)C=1C=NC=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)CCCNC(=O)C1=CC=CN=C1 QRYFGTULTGLGHU-NBERXCRTSA-N 0.000 abstract 1
- 108010083551 iturelix Proteins 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 abstract 1
- 229920000053 polysorbate 80 Polymers 0.000 abstract 1
- 229950011372 teverelix Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Reproductive Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10157628A DE10157628A1 (de) | 2001-11-26 | 2001-11-26 | Injektionslösung eines LHRH-Antagonisten |
| PCT/EP2002/012798 WO2003045419A1 (de) | 2001-11-26 | 2002-11-15 | Injektionslösung eines lhrh-antagonisten |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20040587A2 HRP20040587A2 (en) | 2004-10-31 |
| HRP20040587B1 true HRP20040587B1 (en) | 2008-01-31 |
Family
ID=7706799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20040587A HRP20040587B1 (en) | 2001-11-26 | 2004-06-24 | Injection solution comprising an lhrh antagonist |
Country Status (33)
| Country | Link |
|---|---|
| EP (1) | EP1448221B1 (xx) |
| JP (1) | JP4343693B2 (xx) |
| KR (1) | KR100936636B1 (xx) |
| CN (1) | CN100404068C (xx) |
| AR (1) | AR037424A1 (xx) |
| AT (1) | ATE350050T1 (xx) |
| AU (1) | AU2002365504B2 (xx) |
| BR (1) | BRPI0214412B8 (xx) |
| CO (1) | CO5580793A2 (xx) |
| CY (1) | CY1106401T1 (xx) |
| DE (2) | DE10157628A1 (xx) |
| DK (1) | DK1448221T3 (xx) |
| EA (1) | EA010787B1 (xx) |
| ES (1) | ES2276970T3 (xx) |
| GE (1) | GEP20063861B (xx) |
| HK (1) | HK1073078A1 (xx) |
| HR (1) | HRP20040587B1 (xx) |
| HU (1) | HU230992B1 (xx) |
| IL (2) | IL161894A0 (xx) |
| IS (1) | IS2725B (xx) |
| ME (1) | ME00499B (xx) |
| MX (1) | MXPA04005018A (xx) |
| NO (1) | NO333364B1 (xx) |
| NZ (1) | NZ533712A (xx) |
| PL (1) | PL206199B1 (xx) |
| PT (1) | PT1448221E (xx) |
| RS (1) | RS51408B (xx) |
| RU (1) | RU2322969C2 (xx) |
| SI (1) | SI1448221T1 (xx) |
| TW (1) | TWI312283B (xx) |
| UA (1) | UA81612C2 (xx) |
| WO (1) | WO2003045419A1 (xx) |
| ZA (1) | ZA200404051B (xx) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7658938B2 (en) | 1999-02-22 | 2010-02-09 | Merrion Reasearch III Limited | Solid oral dosage form containing an enhancer |
| US8119159B2 (en) | 1999-02-22 | 2012-02-21 | Merrion Research Iii Limited | Solid oral dosage form containing an enhancer |
| EP2007397B1 (en) | 2006-04-07 | 2013-07-24 | Merrion Research III Limited | Solid oral dosage form containing an enhancer |
| US8999383B2 (en) | 2008-05-07 | 2015-04-07 | Merrion Research Iii Limited | Compositions of GnRH related compounds and processes of preparation |
| US9089484B2 (en) | 2010-03-26 | 2015-07-28 | Merrion Research Iii Limited | Pharmaceutical compositions of selective factor Xa inhibitors for oral administration |
| KR20140026354A (ko) | 2011-01-07 | 2014-03-05 | 메리온 리서치 Ⅲ 리미티드 | 경구 투여용 철의 제약 조성물 |
| CN103690560B (zh) * | 2013-12-17 | 2016-08-17 | 辽宁海思科制药有限公司 | 一种转化糖电解质注射液药物组合物及其制备方法 |
| JP7211704B2 (ja) | 2015-01-29 | 2023-01-24 | ノヴォ ノルディスク アー／エス | Ｇｌｐ－１アゴニスト及び腸溶コーティングを含む錠剤 |
| RU2614234C2 (ru) * | 2015-03-31 | 2017-03-23 | Федеральное государственное бюджетное учреждение науки Институт общей генетики им. Н.И. Вавилова Российской академии наук (ИОГЕН РАН) | Фармацевтическая композиция на основе 3-(4-Метилимидазол-1-ил)имидазо[1,2-b][1,2,4,5]тетразина в качестве противоопухолевого средства |
| AU2018212806A1 (en) * | 2017-01-30 | 2019-07-18 | Antev Limited | A composition comprising at least one GnRH antagonist |
| MD3811927T2 (ro) | 2019-10-24 | 2022-03-31 | Sun Pharmaceutical Ind Ltd | O formă de dozaj parenterală stabilă de acetat de cetrorelix |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001021194A2 (en) * | 1999-09-23 | 2001-03-29 | Zentaris Ag | Method for the therapeutic management of endometriosis and fallopian tube obstruction |
| WO2001087265A2 (de) * | 2000-05-18 | 2001-11-22 | Zentaris Ag | Pharmazeutische darreichungsform für peptide, verfahren zu deren herstellung und verwendung |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4800191A (en) * | 1987-07-17 | 1989-01-24 | Schally Andrew Victor | LHRH antagonists |
| US5300492A (en) * | 1988-02-10 | 1994-04-05 | Tap Pharmaceuticals | LHRH analogs |
| US5140009A (en) * | 1988-02-10 | 1992-08-18 | Tap Pharmaceuticals, Inc. | Octapeptide LHRH antagonists |
-
2001
- 2001-11-26 DE DE10157628A patent/DE10157628A1/de not_active Withdrawn
-
2002
- 2002-11-15 AT AT02790384T patent/ATE350050T1/de active
- 2002-11-15 PL PL369548A patent/PL206199B1/pl unknown
- 2002-11-15 CN CNB028234901A patent/CN100404068C/zh not_active Expired - Lifetime
- 2002-11-15 KR KR1020047007807A patent/KR100936636B1/ko active IP Right Grant
- 2002-11-15 BR BRPI0214412A patent/BRPI0214412B8/pt not_active IP Right Cessation
- 2002-11-15 AU AU2002365504A patent/AU2002365504B2/en not_active Expired
- 2002-11-15 NZ NZ533712A patent/NZ533712A/en not_active IP Right Cessation
- 2002-11-15 ME MEP-2008-800A patent/ME00499B/me unknown
- 2002-11-15 SI SI200230505T patent/SI1448221T1/sl unknown
- 2002-11-15 HU HU0401986A patent/HU230992B1/hu unknown
- 2002-11-15 ES ES02790384T patent/ES2276970T3/es not_active Expired - Lifetime
- 2002-11-15 JP JP2003546920A patent/JP4343693B2/ja not_active Expired - Lifetime
- 2002-11-15 MX MXPA04005018A patent/MXPA04005018A/es active IP Right Grant
- 2002-11-15 EP EP02790384A patent/EP1448221B1/de not_active Expired - Lifetime
- 2002-11-15 EA EA200400742A patent/EA010787B1/ru unknown
- 2002-11-15 WO PCT/EP2002/012798 patent/WO2003045419A1/de active IP Right Grant
- 2002-11-15 IL IL16189402A patent/IL161894A0/xx unknown
- 2002-11-15 UA UA20040503816A patent/UA81612C2/ru unknown
- 2002-11-15 RS YUP-449/04A patent/RS51408B/sr unknown
- 2002-11-15 RU RU2004119821/15A patent/RU2322969C2/ru active
- 2002-11-15 GE GE5568A patent/GEP20063861B/en unknown
- 2002-11-15 PT PT02790384T patent/PT1448221E/pt unknown
- 2002-11-15 DE DE50209193T patent/DE50209193D1/de not_active Expired - Lifetime
- 2002-11-15 DK DK02790384T patent/DK1448221T3/da active
- 2002-11-20 TW TW091133846A patent/TWI312283B/zh not_active IP Right Cessation
- 2002-11-25 AR ARP020104523A patent/AR037424A1/es not_active Application Discontinuation
-
2004
- 2004-05-06 IS IS7251A patent/IS2725B/is unknown
- 2004-05-10 IL IL161894A patent/IL161894A/en active IP Right Grant
- 2004-05-14 CO CO04044748A patent/CO5580793A2/es not_active Application Discontinuation
- 2004-05-25 ZA ZA2004/04051A patent/ZA200404051B/en unknown
- 2004-06-11 NO NO20042449A patent/NO333364B1/no not_active IP Right Cessation
- 2004-06-24 HR HR20040587A patent/HRP20040587B1/xx not_active IP Right Cessation
-
2005
- 2005-07-11 HK HK05105809.5A patent/HK1073078A1/xx not_active IP Right Cessation
-
2007
- 2007-03-20 CY CY20071100391T patent/CY1106401T1/el unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001021194A2 (en) * | 1999-09-23 | 2001-03-29 | Zentaris Ag | Method for the therapeutic management of endometriosis and fallopian tube obstruction |
| WO2001087265A2 (de) * | 2000-05-18 | 2001-11-22 | Zentaris Ag | Pharmazeutische darreichungsform für peptide, verfahren zu deren herstellung und verwendung |
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