HUP0401986A2 - LHRH antagonistát tartalmazó injekciós oldat és eljárás az előállítására - Google Patents
LHRH antagonistát tartalmazó injekciós oldat és eljárás az előállításáraInfo
- Publication number
- HUP0401986A2 HUP0401986A2 HU0401986A HUP0401986A HUP0401986A2 HU P0401986 A2 HUP0401986 A2 HU P0401986A2 HU 0401986 A HU0401986 A HU 0401986A HU P0401986 A HUP0401986 A HU P0401986A HU P0401986 A2 HUP0401986 A2 HU P0401986A2
- Authority
- HU
- Hungary
- Prior art keywords
- preparation
- lhrh
- lhrh antagonist
- injection solution
- lhrh antagonists
- Prior art date
Links
- 229940124041 Luteinizing hormone releasing hormone (LHRH) antagonist Drugs 0.000 title abstract 5
- 239000000243 solution Substances 0.000 title abstract 3
- 239000002474 gonadorelin antagonist Substances 0.000 title abstract 2
- 238000002347 injection Methods 0.000 title abstract 2
- 239000007924 injection Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 239000004480 active ingredient Substances 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 230000002776 aggregation Effects 0.000 abstract 1
- 238000004220 aggregation Methods 0.000 abstract 1
- 239000004067 bulking agent Substances 0.000 abstract 1
- SBNPWPIBESPSIF-MHWMIDJBSA-N cetrorelix Chemical compound C([C@@H](C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(O)C=C1 SBNPWPIBESPSIF-MHWMIDJBSA-N 0.000 abstract 1
- 229960003230 cetrorelix Drugs 0.000 abstract 1
- 108700008462 cetrorelix Proteins 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biochemistry (AREA)
- Pregnancy & Childbirth (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A találmány LHRH antagonisták olyan, vizes injekciós oldatairavonatkozik, amelyek az LHRH antagonistán, például cetrorelixen kívülszerves, fiziológiásan elfogadható savat és adott esetben felületaktívanyagot és térfogatnövelő szert tartalmaznak. Az LHRH antagonistákoldhatósága jelentősen megnő, és így nagyobb koncentrációjú oldatokállíthatók elő a hatóanyagokból. Javul a hatóanyagokbiohasznosíthatósága; valamint szignifikáns mértékben csökken az LHRHantagonisták aggregációs hajlama. Ó
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10157628.5 | 2001-11-26 | ||
| DE10157628A DE10157628A1 (de) | 2001-11-26 | 2001-11-26 | Injektionslösung eines LHRH-Antagonisten |
| PCT/EP2002/012798 WO2003045419A1 (de) | 2001-11-26 | 2002-11-15 | Injektionslösung eines lhrh-antagonisten |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0401986A2 true HUP0401986A2 (hu) | 2005-01-28 |
| HUP0401986A3 HUP0401986A3 (en) | 2012-09-28 |
| HU230992B1 HU230992B1 (hu) | 2019-08-28 |
Family
ID=7706799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0401986A HU230992B1 (hu) | 2001-11-26 | 2002-11-15 | LHRH antagonistát tartalmazó injekciós oldat |
Country Status (33)
| Country | Link |
|---|---|
| EP (1) | EP1448221B1 (hu) |
| JP (1) | JP4343693B2 (hu) |
| KR (1) | KR100936636B1 (hu) |
| CN (1) | CN100404068C (hu) |
| AR (1) | AR037424A1 (hu) |
| AT (1) | ATE350050T1 (hu) |
| AU (1) | AU2002365504B2 (hu) |
| BR (1) | BRPI0214412B8 (hu) |
| CO (1) | CO5580793A2 (hu) |
| CY (1) | CY1106401T1 (hu) |
| DE (2) | DE10157628A1 (hu) |
| DK (1) | DK1448221T3 (hu) |
| EA (1) | EA010787B1 (hu) |
| ES (1) | ES2276970T3 (hu) |
| GE (1) | GEP20063861B (hu) |
| HK (1) | HK1073078A1 (hu) |
| HR (1) | HRP20040587B1 (hu) |
| HU (1) | HU230992B1 (hu) |
| IL (2) | IL161894A0 (hu) |
| IS (1) | IS2725B (hu) |
| ME (1) | ME00499B (hu) |
| MX (1) | MXPA04005018A (hu) |
| NO (1) | NO333364B1 (hu) |
| NZ (1) | NZ533712A (hu) |
| PL (1) | PL206199B1 (hu) |
| PT (1) | PT1448221E (hu) |
| RS (1) | RS51408B (hu) |
| RU (1) | RU2322969C2 (hu) |
| SI (1) | SI1448221T1 (hu) |
| TW (1) | TWI312283B (hu) |
| UA (1) | UA81612C2 (hu) |
| WO (1) | WO2003045419A1 (hu) |
| ZA (1) | ZA200404051B (hu) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7658938B2 (en) | 1999-02-22 | 2010-02-09 | Merrion Reasearch III Limited | Solid oral dosage form containing an enhancer |
| US8119159B2 (en) | 1999-02-22 | 2012-02-21 | Merrion Research Iii Limited | Solid oral dosage form containing an enhancer |
| EP2007397B1 (en) | 2006-04-07 | 2013-07-24 | Merrion Research III Limited | Solid oral dosage form containing an enhancer |
| US8999383B2 (en) | 2008-05-07 | 2015-04-07 | Merrion Research Iii Limited | Compositions of GnRH related compounds and processes of preparation |
| US9089484B2 (en) | 2010-03-26 | 2015-07-28 | Merrion Research Iii Limited | Pharmaceutical compositions of selective factor Xa inhibitors for oral administration |
| KR20140026354A (ko) | 2011-01-07 | 2014-03-05 | 메리온 리서치 Ⅲ 리미티드 | 경구 투여용 철의 제약 조성물 |
| CN103690560B (zh) * | 2013-12-17 | 2016-08-17 | 辽宁海思科制药有限公司 | 一种转化糖电解质注射液药物组合物及其制备方法 |
| JP7211704B2 (ja) | 2015-01-29 | 2023-01-24 | ノヴォ ノルディスク アー／エス | Ｇｌｐ－１アゴニスト及び腸溶コーティングを含む錠剤 |
| RU2614234C2 (ru) * | 2015-03-31 | 2017-03-23 | Федеральное государственное бюджетное учреждение науки Институт общей генетики им. Н.И. Вавилова Российской академии наук (ИОГЕН РАН) | Фармацевтическая композиция на основе 3-(4-Метилимидазол-1-ил)имидазо[1,2-b][1,2,4,5]тетразина в качестве противоопухолевого средства |
| AU2018212806A1 (en) * | 2017-01-30 | 2019-07-18 | Antev Limited | A composition comprising at least one GnRH antagonist |
| MD3811927T2 (ro) | 2019-10-24 | 2022-03-31 | Sun Pharmaceutical Ind Ltd | O formă de dozaj parenterală stabilă de acetat de cetrorelix |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4800191A (en) * | 1987-07-17 | 1989-01-24 | Schally Andrew Victor | LHRH antagonists |
| US5300492A (en) * | 1988-02-10 | 1994-04-05 | Tap Pharmaceuticals | LHRH analogs |
| US5140009A (en) * | 1988-02-10 | 1992-08-18 | Tap Pharmaceuticals, Inc. | Octapeptide LHRH antagonists |
| EP1214086A2 (en) * | 1999-09-23 | 2002-06-19 | Zentaris AG | Method for the therapeutic management of endometriosis and fallopian tube obstruction |
| DE10024451A1 (de) * | 2000-05-18 | 2001-11-29 | Asta Medica Ag | Pharmazeutische Darreichungsform für Peptide, Verfahren zu deren Herstellung und Verwendung |
-
2001
- 2001-11-26 DE DE10157628A patent/DE10157628A1/de not_active Withdrawn
-
2002
- 2002-11-15 AT AT02790384T patent/ATE350050T1/de active
- 2002-11-15 PL PL369548A patent/PL206199B1/pl unknown
- 2002-11-15 CN CNB028234901A patent/CN100404068C/zh not_active Expired - Lifetime
- 2002-11-15 KR KR1020047007807A patent/KR100936636B1/ko active IP Right Grant
- 2002-11-15 BR BRPI0214412A patent/BRPI0214412B8/pt not_active IP Right Cessation
- 2002-11-15 AU AU2002365504A patent/AU2002365504B2/en not_active Expired
- 2002-11-15 NZ NZ533712A patent/NZ533712A/en not_active IP Right Cessation
- 2002-11-15 ME MEP-2008-800A patent/ME00499B/me unknown
- 2002-11-15 SI SI200230505T patent/SI1448221T1/sl unknown
- 2002-11-15 HU HU0401986A patent/HU230992B1/hu unknown
- 2002-11-15 ES ES02790384T patent/ES2276970T3/es not_active Expired - Lifetime
- 2002-11-15 JP JP2003546920A patent/JP4343693B2/ja not_active Expired - Lifetime
- 2002-11-15 MX MXPA04005018A patent/MXPA04005018A/es active IP Right Grant
- 2002-11-15 EP EP02790384A patent/EP1448221B1/de not_active Expired - Lifetime
- 2002-11-15 EA EA200400742A patent/EA010787B1/ru unknown
- 2002-11-15 WO PCT/EP2002/012798 patent/WO2003045419A1/de active IP Right Grant
- 2002-11-15 IL IL16189402A patent/IL161894A0/xx unknown
- 2002-11-15 UA UA20040503816A patent/UA81612C2/ru unknown
- 2002-11-15 RS YUP-449/04A patent/RS51408B/sr unknown
- 2002-11-15 RU RU2004119821/15A patent/RU2322969C2/ru active
- 2002-11-15 GE GE5568A patent/GEP20063861B/en unknown
- 2002-11-15 PT PT02790384T patent/PT1448221E/pt unknown
- 2002-11-15 DE DE50209193T patent/DE50209193D1/de not_active Expired - Lifetime
- 2002-11-15 DK DK02790384T patent/DK1448221T3/da active
- 2002-11-20 TW TW091133846A patent/TWI312283B/zh not_active IP Right Cessation
- 2002-11-25 AR ARP020104523A patent/AR037424A1/es not_active Application Discontinuation
-
2004
- 2004-05-06 IS IS7251A patent/IS2725B/is unknown
- 2004-05-10 IL IL161894A patent/IL161894A/en active IP Right Grant
- 2004-05-14 CO CO04044748A patent/CO5580793A2/es not_active Application Discontinuation
- 2004-05-25 ZA ZA2004/04051A patent/ZA200404051B/en unknown
- 2004-06-11 NO NO20042449A patent/NO333364B1/no not_active IP Right Cessation
- 2004-06-24 HR HR20040587A patent/HRP20040587B1/xx not_active IP Right Cessation
-
2005
- 2005-07-11 HK HK05105809.5A patent/HK1073078A1/xx not_active IP Right Cessation
-
2007
- 2007-03-20 CY CY20071100391T patent/CY1106401T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HC9A | Change of name, address |
Owner name: ZENTARIS GMBH, DE Free format text: FORMER OWNER(S): ZENTARIS GMBH, DE |
|
| GB9A | Succession in title |
Owner name: ZENTARIS IVF GMBH, DE Free format text: FORMER OWNER(S): ZENTARIS GMBH, DE; AETERNA ZENTARIS GMBH, DE; ZENTARIS GMBH, DE |
|
| HC9A | Change of name, address |
Owner name: ZENTARIS IVF GMBH, DE Free format text: FORMER OWNER(S): ZENTARIS GMBH, DE; AETERNA ZENTARIS GMBH, DE; ZENTARIS GMBH, DE |