HRP20040587B1 - Injection solution comprising an lhrh antagonist - Google Patents

Injection solution comprising an lhrh antagonist

Info

Publication number
HRP20040587B1
HRP20040587B1 HR20040587A HRP20040587A HRP20040587B1 HR P20040587 B1 HRP20040587 B1 HR P20040587B1 HR 20040587 A HR20040587 A HR 20040587A HR P20040587 A HRP20040587 A HR P20040587A HR P20040587 B1 HRP20040587 B1 HR P20040587B1
Authority
HR
Croatia
Prior art keywords
lhrh antagonist
gluconic acid
injection solution
adjuvant
surfactant
Prior art date
Application number
HR20040587A
Other languages
Croatian (hr)
Inventor
Sarlikiotis Werner
Bauer Horst
Rischer Matthias
G�thlein Frank
Engel J�rgen
Di Stefano Dominique
Original Assignee
Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentaris Gmbh filed Critical Zentaris Gmbh
Publication of HRP20040587A2 publication Critical patent/HRP20040587A2/en
Publication of HRP20040587B1 publication Critical patent/HRP20040587B1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • A61K38/09Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/10Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36Antigestagens

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Reproductive Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Vodena otopina za uštrcavanje LHRH antagonista koja sadrži glukonsku kiselinu, po izboru surfaktanti pomoćno sredstvo, naznačena time, da se kao LHRH antagonist koriste cetrorelix, teverelix, D-63 153 (Ac-D-Nal-pCl-D-Phe-3-D-Pal-Ser-N-Me-Tyr-D-H-Cit-Iso-Leu-Arg-Pro-D-Ala-NH2), ganirelix, abarelix,antide ili azaline B i da je glukonska kiselina nazočna u iznosu koji je veći od ekvimolarnog, temeljeno na količini LHRH antagonista, da se glukonska kiselina dodaje u obliku glukonska kiselina delta-lakton, te da se po izboru Tween 80 rabi kao surfaktant, a mannitol kao pomoćno sredstvo. Patent sadrži još 4 patentna zahtjeva.Aqueous solution for injecting LHRH antagonist containing gluconic acid, optionally a surfactant adjuvant, characterized in that cetrorelix, teverelix, D-63 153 (Ac-D-Nal-pCl-D-Phe-3-D) are used as LHRH antagonist -Pal-Ser-N-Me-Tyr-DH-Cit-Iso-Leu-Arg-Pro-D-Ala-NH2), ganirelix, abarelix, antide or azaline B and that gluconic acid is present in an amount greater than equimolar, based on the amount of LHRH antagonist, that gluconic acid is added in the form of delta-lactone gluconic acid, and optionally Tween 80 is used as a surfactant and mannitol as an adjuvant. The patent contains 4 more patent claims.

HR20040587A 2001-11-26 2004-06-24 Injection solution comprising an lhrh antagonist HRP20040587B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10157628A DE10157628A1 (en) 2001-11-26 2001-11-26 Solution for injection of an LHRH antagonist
PCT/EP2002/012798 WO2003045419A1 (en) 2001-11-26 2002-11-15 Injection solution comprising an lhrh antagonist

Publications (2)

Publication Number Publication Date
HRP20040587A2 HRP20040587A2 (en) 2004-10-31
HRP20040587B1 true HRP20040587B1 (en) 2008-01-31

Family

ID=7706799

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20040587A HRP20040587B1 (en) 2001-11-26 2004-06-24 Injection solution comprising an lhrh antagonist

Country Status (33)

Country Link
EP (1) EP1448221B1 (en)
JP (1) JP4343693B2 (en)
KR (1) KR100936636B1 (en)
CN (1) CN100404068C (en)
AR (1) AR037424A1 (en)
AT (1) ATE350050T1 (en)
AU (1) AU2002365504B2 (en)
BR (1) BRPI0214412B8 (en)
CO (1) CO5580793A2 (en)
CY (1) CY1106401T1 (en)
DE (2) DE10157628A1 (en)
DK (1) DK1448221T3 (en)
EA (1) EA010787B1 (en)
ES (1) ES2276970T3 (en)
GE (1) GEP20063861B (en)
HK (1) HK1073078A1 (en)
HR (1) HRP20040587B1 (en)
HU (1) HU230992B1 (en)
IL (2) IL161894A0 (en)
IS (1) IS2725B (en)
ME (1) ME00499B (en)
MX (1) MXPA04005018A (en)
NO (1) NO333364B1 (en)
NZ (1) NZ533712A (en)
PL (1) PL206199B1 (en)
PT (1) PT1448221E (en)
RS (1) RS51408B (en)
RU (1) RU2322969C2 (en)
SI (1) SI1448221T1 (en)
TW (1) TWI312283B (en)
UA (1) UA81612C2 (en)
WO (1) WO2003045419A1 (en)
ZA (1) ZA200404051B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7658938B2 (en) 1999-02-22 2010-02-09 Merrion Reasearch III Limited Solid oral dosage form containing an enhancer
US8119159B2 (en) 1999-02-22 2012-02-21 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
US7704977B2 (en) 2006-04-07 2010-04-27 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
JP2011519928A (en) * 2008-05-07 2011-07-14 メリオン・リサーチ・Iii・リミテッド Peptide composition and method for preparing the same
US9089484B2 (en) 2010-03-26 2015-07-28 Merrion Research Iii Limited Pharmaceutical compositions of selective factor Xa inhibitors for oral administration
AU2012204213A1 (en) 2011-01-07 2013-06-13 Merrion Research Iii Limited Pharmaceutical compositions of iron for oral administration
CN103690560B (en) * 2013-12-17 2016-08-17 辽宁海思科制药有限公司 A kind of Invert sugar electrolyte injection pharmaceutical composition and preparation method thereof
EP3250191B1 (en) 2015-01-29 2024-01-17 Novo Nordisk A/S Tablets comprising glp-1 agonist and enteric coating
RU2614234C2 (en) * 2015-03-31 2017-03-23 Федеральное государственное бюджетное учреждение науки Институт общей генетики им. Н.И. Вавилова Российской академии наук (ИОГЕН РАН) PHARMACEUTICAL COMPOSITION BASED ON 3-(4-METHYLIMIDAZOLE-1-YL)IMIDAZO[1,2-b][1,2,4,5]TETRAZINE AS ANTI-TUMOR AGENT
US20200000872A1 (en) * 2017-01-30 2020-01-02 Antev Limited A composition comprising at least one gnrh antagonist
PL3811927T3 (en) 2019-10-24 2022-02-07 Sun Pharmaceutical Industries Ltd A stable parenteral dosage form of cetrorelix acetate

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001021194A2 (en) * 1999-09-23 2001-03-29 Zentaris Ag Method for the therapeutic management of endometriosis and fallopian tube obstruction
WO2001087265A2 (en) * 2000-05-18 2001-11-22 Zentaris Ag Pharmaceutical form of administration for peptides, methods for its production and use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4800191A (en) * 1987-07-17 1989-01-24 Schally Andrew Victor LHRH antagonists
US5140009A (en) * 1988-02-10 1992-08-18 Tap Pharmaceuticals, Inc. Octapeptide LHRH antagonists
US5300492A (en) * 1988-02-10 1994-04-05 Tap Pharmaceuticals LHRH analogs

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001021194A2 (en) * 1999-09-23 2001-03-29 Zentaris Ag Method for the therapeutic management of endometriosis and fallopian tube obstruction
WO2001087265A2 (en) * 2000-05-18 2001-11-22 Zentaris Ag Pharmaceutical form of administration for peptides, methods for its production and use

Also Published As

Publication number Publication date
NZ533712A (en) 2006-01-27
MXPA04005018A (en) 2004-08-11
SI1448221T1 (en) 2007-06-30
CY1106401T1 (en) 2011-10-12
CN1592630A (en) 2005-03-09
HU230992B1 (en) 2019-08-28
HUP0401986A2 (en) 2005-01-28
HK1073078A1 (en) 2005-09-23
RS44904A (en) 2006-10-27
HRP20040587A2 (en) 2004-10-31
ATE350050T1 (en) 2007-01-15
TWI312283B (en) 2009-07-21
RS51408B (en) 2011-02-28
ME00499B (en) 2011-10-10
IL161894A0 (en) 2005-11-20
BR0214412A (en) 2004-09-14
IL161894A (en) 2014-05-28
JP2005510544A (en) 2005-04-21
NO20042449L (en) 2004-06-11
ZA200404051B (en) 2005-05-25
IS7251A (en) 2004-05-06
JP4343693B2 (en) 2009-10-14
EP1448221A1 (en) 2004-08-25
TW200300352A (en) 2003-06-01
PL206199B1 (en) 2010-07-30
RU2322969C2 (en) 2008-04-27
DE10157628A1 (en) 2003-06-12
ES2276970T3 (en) 2007-07-01
WO2003045419A1 (en) 2003-06-05
EA010787B1 (en) 2008-10-30
KR20040058312A (en) 2004-07-03
BRPI0214412B1 (en) 2016-01-05
BRPI0214412B8 (en) 2021-05-25
DE50209193D1 (en) 2007-02-15
PT1448221E (en) 2007-03-30
CN100404068C (en) 2008-07-23
DK1448221T3 (en) 2007-03-19
HUP0401986A3 (en) 2012-09-28
GEP20063861B (en) 2006-06-26
KR100936636B1 (en) 2010-01-14
UA81612C2 (en) 2008-01-25
IS2725B (en) 2011-03-15
CO5580793A2 (en) 2005-11-30
RU2004119821A (en) 2005-04-20
EA200400742A1 (en) 2004-12-30
NO333364B1 (en) 2013-05-13
AR037424A1 (en) 2004-11-10
AU2002365504A1 (en) 2003-06-10
PL369548A1 (en) 2005-05-02
AU2002365504B2 (en) 2007-06-28
EP1448221B1 (en) 2007-01-03

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
PNAN Change of the applicant name, address/residence

Owner name: ZENTARIS GMBH, DE

B1PR Patent granted
PNAN Change of the applicant name, address/residence

Owner name: AETERNA ZENTARIS GMBH, DE

PPPP Transfer of rights

Owner name: ZENTARIS IVF GMBH, DE

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Effective date: 20221115