ATE287705T1 - Wärmegellierende bioabbaubare wässrige polymerlösung - Google Patents

Wärmegellierende bioabbaubare wässrige polymerlösung

Info

Publication number
ATE287705T1
ATE287705T1 AT01975509T AT01975509T ATE287705T1 AT E287705 T1 ATE287705 T1 AT E287705T1 AT 01975509 T AT01975509 T AT 01975509T AT 01975509 T AT01975509 T AT 01975509T AT E287705 T1 ATE287705 T1 AT E287705T1
Authority
AT
Austria
Prior art keywords
polymer solution
aqueous polymer
block
gelelling
biodegradable
Prior art date
Application number
AT01975509T
Other languages
English (en)
Inventor
Byeong Moon Jeong
Anna Gutowska
Original Assignee
Battelle Memorial Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Battelle Memorial Institute filed Critical Battelle Memorial Institute
Application granted granted Critical
Publication of ATE287705T1 publication Critical patent/ATE287705T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66—Polyesters containing oxygen in the form of ether groups
    • C08G63/664—Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Polymerisation Methods In General (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
AT01975509T 2000-09-28 2001-09-27 Wärmegellierende bioabbaubare wässrige polymerlösung ATE287705T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23692600P 2000-09-28 2000-09-28
US09/833,460 US6841617B2 (en) 2000-09-28 2001-04-11 Thermogelling biodegradable aqueous polymer solution
PCT/US2001/030322 WO2002026215A2 (en) 2000-09-28 2001-09-27 Thermogelling biodegradable aqueous polymer solution

Publications (1)

Publication Number Publication Date
ATE287705T1 true ATE287705T1 (de) 2005-02-15

Family

ID=26930226

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01975509T ATE287705T1 (de) 2000-09-28 2001-09-27 Wärmegellierende bioabbaubare wässrige polymerlösung

Country Status (8)

Country Link
US (1) US6841617B2 (de)
EP (1) EP1320359B1 (de)
JP (1) JP5031974B2 (de)
AT (1) ATE287705T1 (de)
AU (2) AU2001294828B2 (de)
CA (1) CA2423488C (de)
DE (1) DE60108651T2 (de)
WO (1) WO2002026215A2 (de)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7087244B2 (en) 2000-09-28 2006-08-08 Battelle Memorial Institute Thermogelling oligopeptide polymers
US20040228794A1 (en) * 1998-04-10 2004-11-18 Battelle Memorial Institute Therapeutic agent carrier compositions
US6841617B2 (en) 2000-09-28 2005-01-11 Battelle Memorial Institute Thermogelling biodegradable aqueous polymer solution
US20060177416A1 (en) 2003-10-14 2006-08-10 Medivas, Llc Polymer particle delivery compositions and methods of use
US20040185101A1 (en) * 2001-03-27 2004-09-23 Macromed, Incorporated. Biodegradable triblock copolymers as solubilizing agents for drugs and method of use thereof
US7649023B2 (en) * 2002-06-11 2010-01-19 Novartis Ag Biodegradable block copolymeric compositions for drug delivery
TWI353854B (en) * 2002-06-25 2011-12-11 Alza Corp Short duration depot formulations
US8986737B2 (en) 2002-09-05 2015-03-24 Wm. Marsh Rice University Antibiotic microspheres for treatment and prevention of osteomyelitis and enhancement of bone regrowth
ES2388623T3 (es) * 2002-09-05 2012-10-17 Catherine G. Ambrose Microesferas de antibiótico para el tratamiento de infecciones y osteomielitis
TW200410717A (en) * 2002-12-31 2004-07-01 Ind Tech Res Inst Delivery system for control release of temperature sensitive bioactive material
GB0307011D0 (en) * 2003-03-27 2003-04-30 Regentec Ltd Porous matrix
JP5346148B2 (ja) * 2003-03-28 2013-11-20 エー・デー・ガイストリヒ・ゾーネ・アクチェンゲゼルシャフト・フュール・ヒェーミシェ・インダストリー 抗新生物性組成物および治療方法
US7051654B2 (en) 2003-05-30 2006-05-30 Clemson University Ink-jet printing of viable cells
ATE410186T1 (de) * 2003-06-26 2008-10-15 Control Delivery Sys Inc In-situ gelierendes arzneimittelabgabesystem
JP5628467B2 (ja) 2003-06-26 2014-11-19 シヴィダ・ユーエス・インコーポレイテッドPsivida Us, Inc. 生体分解性徐放性ドラッグデリバリーシステム
GB2408510B (en) * 2003-11-28 2008-05-14 Ind Tech Res Inst Thermosensitive biodegradable copolymer
US20060034889A1 (en) 2004-08-16 2006-02-16 Macromed, Inc. Biodegradable diblock copolymers having reverse thermal gelation properties and methods of use thereof
US8128952B2 (en) * 2005-01-12 2012-03-06 Clemson University Research Foundation Ligand-mediated controlled drug delivery
US8663686B2 (en) * 2005-05-09 2014-03-04 University Of Washington Biodegradable chitosan-PEG compositions and methods of use
WO2007038246A2 (en) 2005-09-22 2007-04-05 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
CA2623198C (en) 2005-09-22 2014-08-05 Medivas, Llc Bis-(a-amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use
US20070237803A1 (en) 2006-04-11 2007-10-11 Medtronic Vascular, Inc. Biodegradable Biocompatible Amphiphilic Copolymers for Coating and Manufacturing Medical Devices
US8974542B2 (en) 2006-06-27 2015-03-10 University of Pittsburgh—of the Commonwealth System of Higher Education Biodegradable elastomeric patch for treating cardiac or cardiovascular conditions
WO2008045904A2 (en) * 2006-10-10 2008-04-17 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Thermoresponsive, biodegradable, elastomeric material
US20080140106A1 (en) * 2006-12-12 2008-06-12 Kimberly-Clark Worldwide, Inc. Enhanced cuff sealing for endotracheal tubes
JP5264103B2 (ja) * 2007-05-09 2013-08-14 学校法人 関西大学 温度応答性を有する生分解性グラフト共重合体
US20090004243A1 (en) 2007-06-29 2009-01-01 Pacetti Stephen D Biodegradable triblock copolymers for implantable devices
JP5171146B2 (ja) * 2007-07-27 2013-03-27 学校法人 関西大学 温度応答性を有する生分解性ポリマー及びその製造方法
US8642062B2 (en) 2007-10-31 2014-02-04 Abbott Cardiovascular Systems Inc. Implantable device having a slow dissolving polymer
US20110027379A1 (en) * 2007-12-06 2011-02-03 Cornell University Oligo-Ethylene Glycol-Based Polymer Compositions and Methods of Use
US20090286907A1 (en) * 2008-01-23 2009-11-19 Beltz Mark W Fumaric Acid/Diol Polyesters and Their Manufacture and Use
TWI388591B (zh) * 2008-03-28 2013-03-11 Ind Tech Res Inst 溫度敏感性材料
US8916188B2 (en) 2008-04-18 2014-12-23 Abbott Cardiovascular Systems Inc. Block copolymer comprising at least one polyester block and a poly (ethylene glycol) block
JP5435534B2 (ja) * 2008-08-27 2014-03-05 多木化学株式会社 生体材料
US8821364B2 (en) 2008-09-02 2014-09-02 Battelle Memorial Institute Brachytherapy seed with fast dissolving matrix for optimal delivery of radionuclides to cancer tissue
TWI374903B (en) * 2008-12-31 2012-10-21 Ind Tech Res Inst Biodegradable copolymer hydrogel materials
WO2011015958A2 (en) 2009-08-06 2011-02-10 Koninklijke Philips Electronics N.V. Oncology therapies employing radioactive seeds
MX338939B (es) * 2009-09-18 2016-05-06 Protherics Medicines Dev Ltd Polimeros de gelificación térmica reversa reconstituible.
JP5643824B2 (ja) * 2009-09-18 2014-12-17 プロセリクス メディスンズ ディベロプメント リミテッド 放出特性が改善されたbabブロックポリマー
WO2011065916A1 (en) 2009-11-24 2011-06-03 Agency For Science, Technology And Research Crosslinking branched molecule through thiol-disulfide exchange to form hydrogel
US9421307B2 (en) 2010-08-17 2016-08-23 University of Pittsburgh—of the Commonwealth System of Higher Education Biohybrid composite scaffold
EP2672998B1 (de) 2011-01-31 2018-06-27 Northwestern University Injizierbare thermoresponsive polyelektrolyte
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
ES2558357T3 (es) 2011-06-23 2016-02-03 Dsm Ip Assets B.V. Micro- o nanopartículas que comprenden un copolímero de poliesteramida biodegradable para uso en el suministro de agentes bioactivos
CN103747693B (zh) 2011-07-26 2017-08-01 密苏里大学董事会 可食用工程肉
EP2596802A1 (de) * 2011-11-23 2013-05-29 PLS-Design GmbH Pharmazeutische Zusammensetzung zur Behandlung allergischer Reaktionen
WO2014179615A2 (en) * 2013-05-01 2014-11-06 Dae Won Park Biodegradable copolymers, systems including the copolymers, and methods of forming and using same
US10364451B2 (en) 2013-05-30 2019-07-30 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
US10392611B2 (en) 2013-05-30 2019-08-27 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
WO2015038988A1 (en) 2013-09-13 2015-03-19 Modern Meadow, Inc. Edible and animal-product-free microcarriers for engineered meat
EP3102043A4 (de) 2014-02-05 2017-08-09 Modern Meadow, Inc. Getrocknete lebensmittelprodukte aus kultivierten muskelzellen
MX2017007873A (es) 2014-12-15 2017-11-06 Univ Johns Hopkins Formulaciones de sunitinib y metodos para uso de las mismas en el tratamiento de trastornos oculares.
CA2969171C (en) 2014-12-18 2023-12-12 Dsm Ip Assets B.V. Drug delivery system for delivery of acid sensitive drugs
US9687526B2 (en) 2015-01-30 2017-06-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9937223B2 (en) 2015-01-30 2018-04-10 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9925233B2 (en) 2015-01-30 2018-03-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9375478B1 (en) 2015-01-30 2016-06-28 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9750785B2 (en) 2015-01-30 2017-09-05 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9744209B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
WO2016154530A1 (en) 2015-03-26 2016-09-29 Duke University Targeted therapeutic agents comprising multivalent protein-biopolymer fusions
US11458205B2 (en) 2015-08-04 2022-10-04 Duke University Genetically encoded intrinsically disordered stealth polymers for delivery and methods of using same
CN105062019B (zh) * 2015-08-18 2016-11-30 九江学院 一种具有快速凝胶能力的透明型温敏可逆可降解聚酯水凝胶及其制备方法
ES2842501T5 (es) 2015-09-21 2023-04-13 Modern Meadow Inc Materiales compuestos de tejido reforzados con fibras
US10441548B2 (en) 2015-11-12 2019-10-15 Graybug Vision, Inc. Aggregating microparticles for medical therapy
US20170136144A1 (en) 2015-11-12 2017-05-18 John C. Herr Compositions and methods for vas-occlusive contraception
US11752213B2 (en) 2015-12-21 2023-09-12 Duke University Surfaces having reduced non-specific binding and antigenicity
WO2017142887A1 (en) 2016-02-15 2017-08-24 Modern Meadow, Inc. Biofabricated material containing collagen fibrils
WO2017210476A1 (en) 2016-06-01 2017-12-07 Duke University Nonfouling biosensors
EP3512868A4 (de) 2016-09-14 2020-04-15 Duke University Triblock-polypeptid-basierte nanopartikel zur abgabe von hydrophilen arzneimitteln
KR20190064600A (ko) 2016-09-23 2019-06-10 듀크 유니버시티 Lcst 거동을 갖는 비구조화된 비-반복적 폴리펩티드
EP3565484B1 (de) 2017-01-05 2024-04-03 Contraline, Inc. Zusammensetzungen zur implantation und umkehrung von auf stimuli reagierenden implantaten
US12383421B2 (en) 2017-01-05 2025-08-12 Contraline, Inc. Contraceptive devices
US11648200B2 (en) 2017-01-12 2023-05-16 Duke University Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
MX2019011242A (es) 2017-03-23 2020-01-21 Graybug Vision Inc Farmacos y composiciones para el tratamiento de trastornos oculares.
WO2018183624A1 (en) 2017-03-29 2018-10-04 The Regents Of The University Of Colorado, A Body Corporate Reverse thermal gels and their use as vascular embolic repair agents
MX2019013363A (es) 2017-05-10 2020-01-13 Graybug Vision Inc Microparticulas de liberacion extendida y suspensiones de las mismas para terapia medica.
WO2018213320A1 (en) 2017-05-15 2018-11-22 Duke University Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents
EP3658168A4 (de) 2017-06-30 2021-07-14 Duke University Ordnung und unordnung als designprinzip für auf stimuli ansprechende biopolymernetzwerke
AU2018253595A1 (en) 2017-11-13 2019-05-30 Modern Meadow, Inc. Biofabricated leather articles having zonal properties
AU2018384096B2 (en) * 2017-12-12 2021-04-15 Cardiol Therapeutics Inc. Amphiphilic block copolymers, micelles, and methods for treating or preventing heart failure
WO2019147954A1 (en) 2018-01-26 2019-08-01 Duke University Albumin binding peptide-drug (aibiped) conjugates and methods of making and using same
WO2019213150A1 (en) 2018-04-30 2019-11-07 Duke University Stimuli-responsive peg-like polymer-based drug delivery platform
EP3829622A4 (de) 2018-08-02 2022-05-11 Duke University Doppel-agonisten-fusionsproteine
WO2020051541A1 (en) 2018-09-07 2020-03-12 Duke University Nanoparticulate drug delivery systems
AU2019380413B2 (en) 2018-11-13 2025-04-17 Contraline, Inc. Systems and methods for delivering biomaterials
EP3704202B1 (de) 2019-01-17 2026-07-29 Modern Meadow, Inc. Geschichtete kollagenmaterialien und verfahren zu ihrer herstellung
US12491269B2 (en) 2019-07-01 2025-12-09 Vivos, Inc. Radioactive yttrium phosphate suspension and method of preparing the same
US11478557B2 (en) 2019-07-01 2022-10-25 Vivos, Inc. Method of preparing a radioactive yttrium phosphate particle suspension
US12521452B2 (en) 2019-07-01 2026-01-13 Vivos, Inc. Radiotherapy gel and method of preparing the same
US11512314B2 (en) 2019-07-12 2022-11-29 Duke University Amphiphilic polynucleotides
EP4058504A1 (de) 2019-11-12 2022-09-21 DSM IP Assets B.V. Polyesteramidcopolymere mit hohen glasübergangstemperaturen
AU2021265269A1 (en) 2020-05-01 2022-10-27 Modern Meadow, Inc. Protein polyurethane alloys and layered materials including the same
EP4317285B1 (de) * 2021-03-30 2025-04-23 Kureha Corporation Glykolsäurecopolymerzusammensetzung und erstarrungs-/extrusionsgeformter artikel
CN113214462B (zh) * 2021-05-10 2022-06-10 复旦大学 含有烷基侧链的聚乙二醇/聚酯嵌段共聚物、包含其的热致水凝胶制剂及其应用

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0092918B1 (de) * 1982-04-22 1988-10-19 Imperial Chemical Industries Plc Mittel mit verzögerter Freigabe
US4438253A (en) 1982-11-12 1984-03-20 American Cyanamid Company Poly(glycolic acid)/poly(alkylene glycol) block copolymers and method of manufacturing the same
US4946686A (en) 1987-09-24 1990-08-07 Merck & Co., Inc. Solubility modulated drug delivery system
US5634946A (en) 1988-08-24 1997-06-03 Focal, Inc. Polymeric endoluminal paving process
US5843156A (en) 1988-08-24 1998-12-01 Endoluminal Therapeutics, Inc. Local polymeric gel cellular therapy
US5575815A (en) 1988-08-24 1996-11-19 Endoluminal Therapeutics, Inc. Local polymeric gel therapy
US5328471A (en) 1990-02-26 1994-07-12 Endoluminal Therapeutics, Inc. Method and apparatus for treatment of focal disease in hollow tubular organs and other tissue lumens
EP0431046B1 (de) 1988-08-24 1995-05-03 SLEPIAN, Marvin J. Endoluminale dichtung mit bisdegradierbaren polymeren
US5213580A (en) 1988-08-24 1993-05-25 Endoluminal Therapeutics, Inc. Biodegradable polymeric endoluminal sealing process
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5462990A (en) 1990-10-15 1995-10-31 Board Of Regents, The University Of Texas System Multifunctional organic polymers
WO1996003112A1 (en) 1993-05-04 1996-02-08 Syngenix Limited Compositions comprising a tissue glue and therapeutic agents
US6919067B2 (en) 1991-09-13 2005-07-19 Syngenix Limited Compositions comprising a tissue glue and therapeutic agents
DE69329594T2 (de) 1992-02-28 2001-05-31 Board Of Regents, The University Of Texas System Photopolymerinierbare, biologisch abbaubare hydrogele als gewebekontaktmaterialien und trägerstoffe für kontrollierte freisetzung
US5573934A (en) 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
KR940003548U (ko) 1992-08-14 1994-02-21 김형술 세탁물 건조기
AU7113594A (en) 1993-06-21 1995-01-17 Enzon, Inc. Site specific synthesis of conjugated peptides
US5646131A (en) 1994-02-22 1997-07-08 The Arab Company For Drug Industries And Medical Applicances (Acdima) Method for solubilizing drugs using cyclodextrins and carboxylic acids
US6007845A (en) * 1994-07-22 1999-12-28 Massachusetts Institute Of Technology Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers
US5612052A (en) * 1995-04-13 1997-03-18 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
US6413539B1 (en) * 1996-10-31 2002-07-02 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
US5702717A (en) 1995-10-25 1997-12-30 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers
AU712953B2 (en) 1996-03-11 1999-11-18 Focal, Inc. Polymeric delivery of radionuclides and radiopharmaceuticals
ZA978537B (en) 1996-09-23 1998-05-12 Focal Inc Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
JP2001508802A (ja) 1997-06-06 2001-07-03 バッテル・メモリアル・インスティチュート 可逆的ゲル化コポリマーと製造方法
US6153211A (en) * 1997-07-18 2000-11-28 Infimed, Inc. Biodegradable macromers for the controlled release of biologically active substances
WO1999007343A1 (en) 1997-08-08 1999-02-18 University Of Utah Research Foundation Injectable biodegradable block copolymer gels for use in drug delivery
US6117949A (en) 1998-10-01 2000-09-12 Macromed, Inc. Biodegradable low molecular weight triblock poly (lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US6004573A (en) * 1997-10-03 1999-12-21 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US6201072B1 (en) * 1997-10-03 2001-03-13 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
KR20010030891A (ko) * 1997-10-03 2001-04-16 마크로메드 인코퍼레이션 가역적 열 겔화 성질을 갖는 생분해성 저분자량 트리블럭폴리(락티드-코-글리콜리드) 폴리에틸렌 글리콜 공중합체
US6686446B2 (en) 1998-03-19 2004-02-03 The Regents Of The University Of California Methods and compositions for controlled polypeptide synthesis
US6841617B2 (en) 2000-09-28 2005-01-11 Battelle Memorial Institute Thermogelling biodegradable aqueous polymer solution
US6420339B1 (en) 1998-10-14 2002-07-16 Amgen Inc. Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
WO2000056774A1 (en) 1999-03-19 2000-09-28 Duke University Methods of using bioelastomers
US6482439B2 (en) * 1999-12-29 2002-11-19 Nanodelivery, Inc. Drug delivery system exhibiting permeability control
US6444254B1 (en) 2000-03-03 2002-09-03 Duke University Microstamping activated polymer surfaces
US6852834B2 (en) 2000-03-20 2005-02-08 Ashutosh Chilkoti Fusion peptides isolatable by phase transition

Also Published As

Publication number Publication date
EP1320359B1 (de) 2005-01-26
JP2004525194A (ja) 2004-08-19
AU9482801A (en) 2002-04-08
EP1320359A2 (de) 2003-06-25
AU2001294828B2 (en) 2006-02-09
US6841617B2 (en) 2005-01-11
CA2423488A1 (en) 2002-04-04
DE60108651T2 (de) 2006-03-30
DE60108651D1 (de) 2005-03-03
WO2002026215A3 (en) 2003-01-30
CA2423488C (en) 2010-07-13
JP5031974B2 (ja) 2012-09-26
WO2002026215A2 (en) 2002-04-04
US20020173586A1 (en) 2002-11-21

Similar Documents

Publication Publication Date Title
DE60108651D1 (de) Wärmegellierende bioabbaubare wässrige polymerlösung
DE69909519D1 (de) Biologisch abbaubare ph/thermosensitive hydrogele zur verzörgerten freisetzung biologisch aktiver stoffe
DK0696297T3 (da) Pyridobisimidazolbaseret stiv stavpolymer
PA8548801A1 (es) Composiciones farmaceuticas que contienen conjuntos de polimero y farmaco
BR0012588A (pt) Copolìmero em bloco, composição para suprimento de agente bioativo, e, formulação de medicamento para implantação subcutânea ou injeção intravenosa
NO995301D0 (no) Bionedbrytbare sammensetninger omfattende poly(cykloalifatisk fosfoester) forbindelser, artikler og fremgangsmÕte for anvendelse derav
AU8701501A (en) Elastomeric functional biodegradable copolyester amides and copolyester urethanes
TR200302105T4 (tr) Siklosporin, hiyalüronik asit ve polisorbat içeren göz formülasyonları.
ATE381921T1 (de) Haarpflegezusammensetzungen
DE60023841D1 (de) Verfahren zur herstellung alkylierter salicylamide
ATE428456T1 (de) Antimikrobielle medizinische artikel
AU7486798A (en) Polyhydroxyalkanoates for (in vivo) applications
TR200003070T2 (tr) Bir komonomer olarak izosorbit içeren polyesterler
MY129356A (en) Electrospun pharmaceutical compositions
GB0328168D0 (en) Biodegradable hyaluronic acid derivative and biodegradable polymeric micelle composition
DE69401204D1 (de) Gonadotropin enthaltende gefriergetrocknete troepfen
MXPA02012937A (es) Combinaciones de productos activos con propiedades insecticidas y acaricidas.
DE60036737D1 (de) Copolymere aus bioabbaubaren aliphatischen Polyestern
DE60032255D1 (de) Polymer-stabilisierte neuropeptide
CO5540368A2 (es) Composicion de liberacion sostenida y proceso para producirla
EP1633797A4 (de) Biologisch abbaubare verzweigte polylactidderivate, die zur bildung von polymermicellen befähigt sind, herstellungsverfahren dafür und verwendung davon
ATE254922T1 (de) Pharmazeutische zusammensetzungen mit antimikrobieller wirkung
CU23318A7 (es) Composiciones farmacã0/00uticas de la tizoxanida y nitazoxanida
WO2002043706A3 (en) Prolamin-based sustained-release compositions and delayed-onset compositions
ES2189472T3 (es) Agente para el tratamiento de agua.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties