DE60032255D1 - Polymer-stabilisierte neuropeptide - Google Patents

Polymer-stabilisierte neuropeptide

Info

Publication number
DE60032255D1
DE60032255D1 DE60032255T DE60032255T DE60032255D1 DE 60032255 D1 DE60032255 D1 DE 60032255D1 DE 60032255 T DE60032255 T DE 60032255T DE 60032255 T DE60032255 T DE 60032255T DE 60032255 D1 DE60032255 D1 DE 60032255D1
Authority
DE
Germany
Prior art keywords
polymer
neuropeptides
stabilized
blood
passing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60032255T
Other languages
English (en)
Other versions
DE60032255T2 (de
Inventor
David Bentley
James Roberts
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nektar Therapeutics
Original Assignee
Nektar Therapeutics AL Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nektar Therapeutics AL Corp filed Critical Nektar Therapeutics AL Corp
Application granted granted Critical
Publication of DE60032255D1 publication Critical patent/DE60032255D1/de
Publication of DE60032255T2 publication Critical patent/DE60032255T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
DE60032255T 1999-10-04 2000-10-04 Polymer-stabilisierte neuropeptide Expired - Lifetime DE60032255T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US15750399P 1999-10-04 1999-10-04
US157503P 1999-10-04
US16658999P 1999-11-19 1999-11-19
US166589P 1999-11-19
PCT/US2000/041070 WO2001024831A2 (en) 1999-10-04 2000-10-04 Polymer stabilized neuropeptides

Publications (2)

Publication Number Publication Date
DE60032255D1 true DE60032255D1 (de) 2007-01-18
DE60032255T2 DE60032255T2 (de) 2007-06-28

Family

ID=26854193

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60032255T Expired - Lifetime DE60032255T2 (de) 1999-10-04 2000-10-04 Polymer-stabilisierte neuropeptide

Country Status (11)

Country Link
US (6) US20020019340A1 (de)
EP (1) EP1221975B1 (de)
JP (1) JP4027663B2 (de)
KR (1) KR100619612B1 (de)
AT (1) ATE347377T1 (de)
AU (1) AU782298B2 (de)
CA (1) CA2385533C (de)
DE (1) DE60032255T2 (de)
ES (1) ES2275561T3 (de)
MX (1) MXPA02003176A (de)
WO (1) WO2001024831A2 (de)

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EP1389130B1 (de) 2001-05-17 2012-05-02 Merck Serono SA Verwendung von osteopontin zur behandlung und/oder vorbeugung von neurologischen erkrankungen
JP4838968B2 (ja) * 2001-09-28 2011-12-14 参天製薬株式会社 薬物−ポリエチレングリコール結合体を含有する眼組織内注入剤
KR101100059B1 (ko) * 2004-06-30 2011-12-29 넥타르 테라퓨틱스 중합체­인자 ｉｘ 부분의 접합체
US8420602B2 (en) * 2004-09-14 2013-04-16 Landon C. G. Miller Endocannabinoid conjugate and a pharmaceutical composition for treatment of neuronal disorders
JP2009523129A (ja) 2006-01-05 2009-06-18 ユニバーシティ オブ ユタ リサーチ ファウンデーション 神経系を標的する薬理学的物質の性質を改善することに関連する方法および組成物
PL381925A1 (pl) * 2007-03-07 2008-09-15 Andrzej W. Lipkowski Zastosowanie peptydu i przeciwbólowy środek farmaceutyczny
US10512644B2 (en) 2007-03-12 2019-12-24 Inheris Pharmaceuticals, Inc. Oligomer-opioid agonist conjugates
US8173666B2 (en) 2007-03-12 2012-05-08 Nektar Therapeutics Oligomer-opioid agonist conjugates
US10540861B2 (en) * 2007-12-20 2020-01-21 Ncr Corporation Sustained authentication of a customer in a physical environment
CN102159249A (zh) * 2008-09-16 2011-08-17 尼克塔治疗公司 具有低滥用潜在性的聚乙二醇化阿片样物质
WO2010033239A1 (en) * 2008-09-19 2010-03-25 Nektar Therapeutics Polymer conjugates of biphalin peptides
EP2334337A1 (de) * 2008-09-19 2011-06-22 Nektar Therapeutics Polymerkonjugate von opioid-wachstumsfaktor-peptiden
EP2350118B1 (de) * 2008-09-19 2016-03-30 Nektar Therapeutics Kohlenhydratbasisierte polymere zur wirkstoffabgabe und konjugate davon
DE202009004764U1 (de) * 2009-04-30 2010-09-16 Hettich Holding Gmbh & Co. Ohg Siphon und Möbel
NZ603611A (en) 2010-05-27 2014-12-24 Janssen Biotech Inc Insulin-like growth factor 1 receptor binding peptides
US8524215B2 (en) * 2010-08-02 2013-09-03 Janssen Biotech, Inc. Absorbable PEG-based hydrogels
AU2011343822B2 (en) * 2010-12-15 2017-06-29 Neuroadjuvants, Inc. Neuropeptide analogs, compositions, and methods for treating pain
WO2012095523A1 (en) * 2011-01-13 2012-07-19 Theralpha Analgesic composition for transbuccal administration
EP2476410A1 (de) * 2011-01-13 2012-07-18 Theralpha Analgetische Peptid enthaltende Zusammensetzung zur transbuccalen Verabreichung
JP6631827B2 (ja) 2014-03-31 2020-01-15 日油株式会社 環状ベンジリデンアセタールリンカーを有する親水性ポリマー誘導体
CN111220676B (zh) * 2019-11-13 2022-11-29 上海药明生物技术有限公司 利用毛细管电泳技术检测含聚乙二醇的蛋白质样品纯度的方法

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Also Published As

Publication number Publication date
ES2275561T3 (es) 2007-06-16
MXPA02003176A (es) 2002-09-30
ATE347377T1 (de) 2006-12-15
US8440623B2 (en) 2013-05-14
KR100619612B1 (ko) 2006-09-01
WO2001024831A3 (en) 2002-03-07
AU1631201A (en) 2001-05-10
EP1221975A2 (de) 2002-07-17
US20030139346A1 (en) 2003-07-24
CA2385533C (en) 2008-03-25
US20040038899A1 (en) 2004-02-26
DE60032255T2 (de) 2007-06-28
KR20020032604A (ko) 2002-05-03
US8008435B2 (en) 2011-08-30
WO2001024831A9 (en) 2002-11-14
US20030144207A1 (en) 2003-07-31
AU782298B2 (en) 2005-07-14
CA2385533A1 (en) 2001-04-12
US20020019340A1 (en) 2002-02-14
JP4027663B2 (ja) 2007-12-26
US20110257106A1 (en) 2011-10-20
JP2003511357A (ja) 2003-03-25
WO2001024831A2 (en) 2001-04-12
US20020013266A1 (en) 2002-01-31
EP1221975B1 (de) 2006-12-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NEKTAR THERAPEUTICS (N.D.GES.D. STAATES DELAWA, US