DE602004015725D1 - Stabilisierte lyophilisierte zubereitungen mit gewebefaktor-inhibitor (tfpi) oder varianten des gewebefaktor-inhibitors - Google Patents

Stabilisierte lyophilisierte zubereitungen mit gewebefaktor-inhibitor (tfpi) oder varianten des gewebefaktor-inhibitors

Info

Publication number
DE602004015725D1
DE602004015725D1 DE602004015725T DE602004015725T DE602004015725D1 DE 602004015725 D1 DE602004015725 D1 DE 602004015725D1 DE 602004015725 T DE602004015725 T DE 602004015725T DE 602004015725 T DE602004015725 T DE 602004015725T DE 602004015725 D1 DE602004015725 D1 DE 602004015725D1
Authority
DE
Germany
Prior art keywords
tissue factor
factor inhibitor
tfpi
variations
lyophilized preparations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004015725T
Other languages
English (en)
Inventor
Bao-Lu Chen
Maninder Hora
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Novartis Vaccines and Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Vaccines and Diagnostics Inc filed Critical Novartis Vaccines and Diagnostics Inc
Publication of DE602004015725D1 publication Critical patent/DE602004015725D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
DE602004015725T 2003-01-08 2004-01-08 Stabilisierte lyophilisierte zubereitungen mit gewebefaktor-inhibitor (tfpi) oder varianten des gewebefaktor-inhibitors Expired - Lifetime DE602004015725D1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US43852403P 2003-01-08 2003-01-08
US49454703P 2003-08-13 2003-08-13
US50927603P 2003-10-08 2003-10-08
US51209203P 2003-10-20 2003-10-20
PCT/US2004/000235 WO2004062646A1 (en) 2003-01-08 2004-01-08 Stabilized lyophilized compositions comprising tissue factor pathway inhibitor or tissue factor pathway inhibitor variants

Publications (1)

Publication Number Publication Date
DE602004015725D1 true DE602004015725D1 (de) 2008-09-25

Family

ID=32719507

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004015725T Expired - Lifetime DE602004015725D1 (de) 2003-01-08 2004-01-08 Stabilisierte lyophilisierte zubereitungen mit gewebefaktor-inhibitor (tfpi) oder varianten des gewebefaktor-inhibitors

Country Status (9)

Country Link
US (2) US20040180827A1 (de)
EP (1) EP1589949B1 (de)
JP (1) JP2008500942A (de)
AT (1) ATE404176T1 (de)
CA (1) CA2512680A1 (de)
DE (1) DE602004015725D1 (de)
ES (1) ES2311789T3 (de)
PT (1) PT1589949E (de)
WO (1) WO2004062646A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
EP2298278B1 (de) 2002-06-07 2015-11-11 Dyax Corp. Verhinderung und Reduzierung von Blutverlust und Entzündungsreaktion
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
SI2386310T1 (sl) 2002-08-28 2019-03-29 Dyax Corp. Metode za ohranjanje organov in tkiv
US20050032153A1 (en) * 2003-04-30 2005-02-10 Ropp Philip A. Control of cyanate in aqueous urea solutions by non-1,2-ethylene diamine like compounds for the protection of protein/peptide carbamylation
AU2005277357B2 (en) * 2004-08-17 2011-08-04 Regeneron Pharmaceuticals, Inc. IL-1 antagonist formulations
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
WO2006081320A2 (en) * 2005-01-27 2006-08-03 Human Genome Sciences, Inc. Pharmaceutical formulation
GB0517688D0 (en) * 2005-08-31 2005-10-05 Cambridge Biostability Ltd Improvements in the stabilisation of biological materials
GB2430880A (en) * 2005-10-04 2007-04-11 Cambridge Biostability Ltd Pharmaceutical compositions stabilized in glassy particles
GB0523638D0 (en) * 2005-11-21 2005-12-28 Cambridge Biostability Ltd Pharmaceutical device for the administration of substances to patients
WO2007103425A2 (en) * 2006-03-06 2007-09-13 Novartis Ag Kits and methods for preparing pharmaceutical compositions comprising tissue factor pathway inhibitor (tfpi)
EP2001500A4 (de) * 2006-03-10 2010-07-28 Dyax Corp Formulierungen für ecallantid
AU2010203712A1 (en) 2009-01-06 2010-07-15 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
LT2521568T (lt) 2010-01-06 2018-12-10 Dyax Corp. Plazmos kalikreiną surišantys baltymai
BR112013017080A8 (pt) 2011-01-06 2023-05-09 Dyax Corp Anticorpo ou fragmento funcional do mesmo que se liga a forma ativa de calicreína do plasma humano, composiçao farmacêutica e método de detecçao de calicreína do plasma em um paciente
CN102942597A (zh) * 2012-10-24 2013-02-27 江苏大学 含氯或氟的五配位咔咯钴配合物及其合成方法
US10428158B2 (en) 2014-03-27 2019-10-01 Dyax Corp. Compositions and methods for treatment of diabetic macular edema
CA2961739C (en) * 2014-08-20 2024-04-30 Portola Pharmaceuticals, Inc. Lyophilized formulations for factor xa antidote
BR112018011622A2 (pt) 2015-12-11 2018-11-27 Dyax Corp método para tratar ataque de angioedema hereditário (hae) ou reduzir a taxa de ataque de hae
CN108883160B (zh) 2016-02-24 2022-06-28 博尔托拉制药公司 因子xa解毒剂的冻干制剂
EP3710063A1 (de) * 2017-11-16 2020-09-23 Amgen Inc. Stabile zusammensetzungen von pegylierten carfilzomib-verbindungen

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5106833A (en) * 1987-07-23 1992-04-21 Washington University Coagulation inhibitors
US4966852A (en) * 1987-07-23 1990-10-30 Monsanto Company DNA clone of human tissue factor inhibitor
US5219994A (en) * 1988-11-08 1993-06-15 W. Alton Jones Cell Science Center, Inc. Inhibitor of tissue factor activity
DK408089D0 (da) * 1989-08-18 1989-08-18 Novo Nordisk As Proteiner
US5583107A (en) * 1990-09-04 1996-12-10 Cor Therapeutics, Inc. Agents affecting thrombosis and hemostasis
US5849704A (en) * 1991-12-20 1998-12-15 Novo Nordisk A/S Pharmaceutical formulation
US5276015A (en) * 1992-03-18 1994-01-04 Washington University Method of inhibiting microvascular thrombosis
US5358708A (en) * 1993-01-29 1994-10-25 Schering Corporation Stabilization of protein formulations
FR2719479B1 (fr) * 1994-05-04 1996-07-26 Sanofi Elf Formulation stable lyophilisée comprenant une protéine: kit de dosage.
US5580856A (en) * 1994-07-15 1996-12-03 Prestrelski; Steven J. Formulation of a reconstituted protein, and method and kit for the production thereof
JP3435946B2 (ja) * 1994-12-21 2003-08-11 王子製紙株式会社 耐熱性キシラナーゼ
DK0813525T3 (da) * 1995-03-10 2004-02-16 Berlex Lab Benzamidinderivater, deres fremstilling og anvendelse som antikoagulanter
ATE358684T1 (de) * 1995-06-07 2007-04-15 Novartis Vaccines & Diagnostic Waessrige formulierung enthaltend tfpi und lösungsvermittlers
US5721214A (en) * 1995-06-07 1998-02-24 Cor Therapeutics, Inc. Inhibitors of factor Xa
US5888968A (en) * 1995-06-07 1999-03-30 Chiron Corporation TFPI formulation
ATE239501T1 (de) * 1995-06-07 2003-05-15 Chiron Corp Regulierung der neutrophil elastase synthese und freisetzung
US5919765A (en) * 1995-06-07 1999-07-06 Cor Therapeutics, Inc. Inhibitors of factor XA
US6267958B1 (en) * 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
US5580107A (en) * 1995-09-25 1996-12-03 Dell U.S.A., L.P. Hidden latch hook for portable personal computer and the like
US5736364A (en) * 1995-12-04 1998-04-07 Genentech, Inc. Factor viia inhibitors
US5824660A (en) * 1996-06-10 1998-10-20 G. D. Searle & Co. Method of inhibiting glomerulonephritis
CA2279345A1 (en) * 1997-01-31 1998-08-06 Human Genome Sciences, Inc. Tissue factor pathway inhibitor-3
PT1491208E (pt) * 1999-10-04 2010-05-12 Novartis Vaccines & Diagnostic Composições farmacêuticas contendo polipéptido líquidas estabilizadas
PL356641A1 (en) * 1999-12-30 2004-06-28 Chiron Corporation Methods for pulmonary delivery of interleukin-2
DE10022092A1 (de) * 2000-05-08 2001-11-15 Aventis Behring Gmbh Stabilisiertes Protein-Präparat und Verfahren zu seiner Herstellung
WO2003055442A2 (en) * 2001-10-15 2003-07-10 Chiron Corporation Treatment of sepsis by low dose administration of tissue factor pathway inhibitor (tfpi)

Also Published As

Publication number Publication date
US20060159679A1 (en) 2006-07-20
CA2512680A1 (en) 2004-07-29
EP1589949A1 (de) 2005-11-02
WO2004062646A9 (en) 2010-11-11
ES2311789T3 (es) 2009-02-16
US20040180827A1 (en) 2004-09-16
WO2004062646A1 (en) 2004-07-29
EP1589949B1 (de) 2008-08-13
PT1589949E (pt) 2008-11-06
JP2008500942A (ja) 2008-01-17
ATE404176T1 (de) 2008-08-15

Similar Documents

Publication Publication Date Title
DE602004015725D1 (de) Stabilisierte lyophilisierte zubereitungen mit gewebefaktor-inhibitor (tfpi) oder varianten des gewebefaktor-inhibitors
BR0014486A (pt) Composições farmacêuticas contendo polipeptìdeo lìquido estabilizado
BR0214343A (pt) Inibidores de 11 - beta - hidroxi esteróide desidrogenase tipo 1
PE20040972A1 (es) Intermedio de formulacion aceptablemente no higroscopico que comprende un farmaco higroscopico
WO2007019232A3 (en) Immunoconjugate formulations
UY25055A1 (es) Formulaciones farmacéuticas que contienen voriconazol
AR039688A1 (es) Preparaciones acidas de insulina con estabilidad mejorada
ES2421447T3 (es) Métodos para proteger frente a apoptosis usando lipopéptidos
RS53945B1 (en) SUPER FAST INSULIN COMPOSITIONS
AR037490A1 (es) Composiciones farmaceuticas solidas, proceso para su preparacion, kit para el tratamiento de la obesidad y uso de dichas composiciones en la elaboracion de medicamentos
IL208697A0 (en) Aqueous based pharmaceutical formulations of water-soluble prodrugs of propofol
UY28897A1 (es) Ácido 2-((2-(2-metilaminopirimidin-4-il)-1h-indol-5-carbonil)amino)-3-(fenilpiridin-2-ilamino)propiónico sustancialmente puro como inhibidor de la cinasa ikb
AR038927A1 (es) Sales de acido organico
ATE248187T1 (de) Echinocandin-kohlenhydrate-komplexe
ATE367165T1 (de) Xanthangummi enthaltende reepithelialisierende pharmazeutische zubereitungen
HUP0101899A2 (hu) Cisztein-aktivitástól függő enzimeket gátló hatású tiadiazolvegyületek, azokat tartalmazó gyógyszerkészítmények és alkalmazásuk
DE60224449D1 (de) Gebrauchsfertige paracetamol injektionslösungen enthaltend propylenglykol als einziges cosolvens
BR0302496A (pt) Composições farmacêuticas com atividade antibiótica
NO20004306L (no) Farmasøytiske sammensetninger som inneholder fosfolipaseinhibitoren natrium[[3-(2-amino-1,2-dioksoetyl-1- fenylmetyl)-1H-indol-4-yl]oksy)acetat
RU2012122793A (ru) Композиция, способ и набор для альфа-1 ингибитора протеазы
DE60236025D1 (de) Pharmazeutische zusammensetzung enthaltend l-arginin
EP1803445A3 (de) Stabilisierte lyophilisierte Zubereitungen mit Gewebefaktor-Inhibitor (TFPI) oder Varianten des Gewebefaktor-Inhibitors
MXPA04005033A (es) Composicion farmaceutica que comprende una combinacion de metformina y acido 4-oxobutanoico y el uso de la misma para el tratamiento contra diabetes.
BR0312452A (pt) Composto; processo para a preparação de um composto; composição farmacêutica; uso de um composto; e método para o tratamento e/ou profilaxia de doenças que são moduladas por agonistas de ppar(alfa) e/ou ppar(gama)
HUP0102792A2 (hu) Benzotiadiazolszármazékot és karpromamidot tartalmazó szinergetikus hatású mikrobicid készítmény és alkalmazása

Legal Events

Date Code Title Description
8364 No opposition during term of opposition