HRP20040364B1 - Carbonic acid new derivatives, the production and use thereof - Google Patents

Carbonic acid new derivatives, the production and use thereof

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Publication number
HRP20040364B1
HRP20040364B1 HR20040364A HRP20040364A HRP20040364B1 HR P20040364 B1 HRP20040364 B1 HR P20040364B1 HR 20040364 A HR20040364 A HR 20040364A HR P20040364 A HRP20040364 A HR P20040364A HR P20040364 B1 HRP20040364 B1 HR P20040364B1
Authority
HR
Croatia
Prior art keywords
alkyl
alkylthio
alkoxy
sulfur
phenyl
Prior art date
Application number
HR20040364A
Other languages
English (en)
Inventor
Reichers Hartmut
Klinge Dagmar
Amberg Wilhelm
Kling Andreas
Mueller Stefan
Baumann Ernst
Rheinheimer Joachim
Joseph Vogelbacher Uwe
Wernet Wolfgang
Unger Liliiane
Raschack Manfred
Original Assignee
Basf Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6530833&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20040364(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Publication of HRP20040364A2 publication Critical patent/HRP20040364A2/xx
Publication of HRP20040364B1 publication Critical patent/HRP20040364B1/xx

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    • C07—ORGANIC CHEMISTRY
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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D239/72—Quinazolines; Hydrogenated quinazolines
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  • Pyridine Compounds (AREA)

Abstract

Derivati karboksilne kiseline formule (I) koji sunaznačeni time da R predstavlja tetrazolil ili COOH grupu, a drugi supstituenti imaju značenja kako slijedi: R2 je C1-C4-alkil, C1-C4-alkoksiX jedušik ili CR14, gdjeR14 je vodik ili alkil, ili CR14 formira zajedno sa CR3 4- ili 5-članski alkilenski ili alkenilenski prsten kao što se spominje uprimjeru -CH2-CH2-CH2-, -CH=CH-CH2-, u kojem u svakom slučaju metilenska grupa može biti zamijenjena kisikom ili sumporom kao npr. -CH2-CH2-O-, -CH=CH-O-, -CH2-CH2-CH2-O-, -CH=CH-CH2O-, a posebice vodikom -CH2-CH2-O-, -CH(CH3)-CH(CH3)-O-, -C(CH3)=C(CH3)-O-, -CH=C(CH3)-O- ili -C(CH3)=C(CH3)-S; R3 je kao što je navedeno za R2 C1-C4-alkil, C1-C4-alkoksi ili C1-C4-alkiltio ili je pak vezan na R14 kao što je nevedeno naprijed, kada se dobije 5- ili 6-članski prsten; R4 i R5 su fenil (jednak ili različit), koji može biti supstituiran sa jednim iliviše slijedećih radikala: halogen, dušik, hidroksil, C1-C4-alkil, C1-C4-alkoksi, C1-C4-alkiltio iliR4 i R5 su fenilne grupe koje su povezane zajednou orto pozicijama preko direktne veze, preko metilena, etilena ili etenilenske grupe, atoma kisika ili sumpora, preko SO2-; NH- ili N-alkilne grupe; R6 je C1-C8-alkil, C3-C6-alkenil ili C3-C8-cikloalkil, s tim da svaki od rečenih radikala može bitisupstituiran jednom ili više puta sa: halogen, hidroksil, nitro, cijano, C1-C4-alkoksi, C3-C6-alkeniloksi, C1-C4-alkiltio; fenil ili naftil, s tima da svaki od njih može biti supstituiran s jednim ili više slijedećih radikala: halogen, nitro, cijano, hidroksil, amino, C1-C4-alkil, C1-C4-haloalkil, C1-C4-alkoksi, C1-C4-haloalkoksi, fenoksi, C1-C4-alkiltio, C1-C4-alkilamino ili C1-C4-dialkilamino; 5- ili 6-članska heteroaromatska jedinica koja sadržava jedan atom dušika i/ili jedan atom sumpora ili kisika, koji može nositi jedan do četiri atoma halogena i/ili jedan do dva slijedeća radikala: C1-C4-alkil, C1-C4-haloalkil, C1-C4-alkoksi, C1-C4-alkiltio, fenil, fenoksi ili fenilkarbonil, s time da je moguće ga fenil radikali mogu nositi jedan do pet atoma halogena i/ili jedan do tri slijedeća radikala: C1-C4-alkil, C1-C4-haloalkil, C1-C4-alkoksi i/ili C1-C4-alkiltio; Y je sumpor, kisik ili jednostruka veza; Z je sumpor, kisik, -SO-, SO2- ili jednostruka veza. Patent sadrži još 15 patentnih zahtjeva.
HR20040364A 1994-10-14 2004-04-22 Carbonic acid new derivatives, the production and use thereof HRP20040364B1 (en)

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NO971675D0 (no) 1997-04-11
NO2008015I2 (no) 2012-03-05
ATE204568T1 (de) 2001-09-15
CZ113297A3 (cs) 1998-03-18
US20060276645A1 (en) 2006-12-07
FI971529A (fi) 1997-04-11
US7601730B2 (en) 2009-10-13
LU91487I2 (fr) 2008-12-15
CA2201785A1 (en) 1996-04-25
US20060160808A1 (en) 2006-07-20
CN1923820B (zh) 2010-04-21
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ZA958642B (en) 1997-04-14
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NO971675L (no) 1997-06-10
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US5969134A (en) 1999-10-19
DE19533023A1 (de) 1996-04-18
JP2007126488A (ja) 2007-05-24
FR08C0041I1 (hr) 2008-11-28
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UA45985C2 (uk) 2002-05-15
HRP950517B1 (en) 2004-06-30
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US20060276474A1 (en) 2006-12-07
JP4512105B2 (ja) 2010-07-28
ES2162942T3 (es) 2002-01-16
US20040092742A1 (en) 2004-05-13
EP1110952A1 (de) 2001-06-27
FI971529A0 (fi) 1997-04-11
NL300361I1 (nl) 2008-12-01
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TW577880B (en) 2004-03-01
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JPH10507190A (ja) 1998-07-14
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US6197958B1 (en) 2001-03-06
EP0785926A1 (de) 1997-07-30
WO1996011914A1 (de) 1996-04-25
HRP20040364A2 (en) 2005-06-30
JP4787184B2 (ja) 2011-10-05
US5932730A (en) 1999-08-03
DE122008000049I1 (de) 2009-01-29
USRE42462E1 (en) 2011-06-14
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US20120088911A1 (en) 2012-04-12
ES2226996T3 (es) 2005-04-01
HRP950517A2 (en) 1997-10-31
AU688611B2 (en) 1998-03-12
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JP3957748B2 (ja) 2007-08-15
MX9702658A (es) 1997-06-28
EP0785926B1 (de) 2001-08-22
CN1513844A (zh) 2004-07-21
US20020052495A1 (en) 2002-05-02
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EP1110952B1 (de) 2004-09-29

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