HRP20020517A2 - Substituted norbornylamino derivatives, method for the production thereof, use thereof as a medicament or a diagnostic reagent and medicaments containing said compounds - Google Patents
Substituted norbornylamino derivatives, method for the production thereof, use thereof as a medicament or a diagnostic reagent and medicaments containing said compounds Download PDFInfo
- Publication number
- HRP20020517A2 HRP20020517A2 HR20020517A HRP20020517A HRP20020517A2 HR P20020517 A2 HRP20020517 A2 HR P20020517A2 HR 20020517 A HR20020517 A HR 20020517A HR P20020517 A HRP20020517 A HR P20020517A HR P20020517 A2 HRP20020517 A2 HR P20020517A2
- Authority
- HR
- Croatia
- Prior art keywords
- exo
- methane
- inden
- endo
- amine
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims description 81
- 239000003814 drug Substances 0.000 title claims description 35
- 238000004519 manufacturing process Methods 0.000 title claims description 26
- 238000000034 method Methods 0.000 title claims description 14
- 239000003153 chemical reaction reagent Substances 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 48
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical class OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims description 44
- 239000000460 chlorine Substances 0.000 claims description 43
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 38
- 150000001412 amines Chemical class 0.000 claims description 31
- 229910052757 nitrogen Inorganic materials 0.000 claims description 31
- 238000011282 treatment Methods 0.000 claims description 28
- 229910052731 fluorine Inorganic materials 0.000 claims description 22
- 239000000126 substance Substances 0.000 claims description 21
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims description 19
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 17
- 229940079593 drug Drugs 0.000 claims description 17
- 230000002829 reductive effect Effects 0.000 claims description 16
- 229920006395 saturated elastomer Polymers 0.000 claims description 16
- 150000003839 salts Chemical class 0.000 claims description 15
- 229910052801 chlorine Inorganic materials 0.000 claims description 14
- 125000000217 alkyl group Chemical group 0.000 claims description 13
- 239000001257 hydrogen Substances 0.000 claims description 13
- 229910052739 hydrogen Inorganic materials 0.000 claims description 13
- 229910052794 bromium Inorganic materials 0.000 claims description 12
- 125000004432 carbon atom Chemical group C* 0.000 claims description 12
- 238000011321 prophylaxis Methods 0.000 claims description 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 11
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 11
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 10
- 201000010099 disease Diseases 0.000 claims description 10
- 239000011737 fluorine Substances 0.000 claims description 10
- 125000001153 fluoro group Chemical group F* 0.000 claims description 10
- 229910052799 carbon Inorganic materials 0.000 claims description 8
- 239000003574 free electron Substances 0.000 claims description 8
- 210000000056 organ Anatomy 0.000 claims description 8
- DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 claims description 7
- 208000035475 disorder Diseases 0.000 claims description 7
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 6
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 claims description 6
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 6
- 229930195734 saturated hydrocarbon Natural products 0.000 claims description 6
- 229930195735 unsaturated hydrocarbon Natural products 0.000 claims description 6
- -1 phenyloxy Chemical group 0.000 claims description 5
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 claims description 4
- 239000002168 alkylating agent Substances 0.000 claims description 4
- 229940100198 alkylating agent Drugs 0.000 claims description 4
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 claims description 4
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 4
- 230000004663 cell proliferation Effects 0.000 claims description 4
- 239000003638 chemical reducing agent Substances 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 230000000241 respiratory effect Effects 0.000 claims description 4
- 230000029058 respiratory gaseous exchange Effects 0.000 claims description 4
- 230000035939 shock Effects 0.000 claims description 4
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 4
- 208000009304 Acute Kidney Injury Diseases 0.000 claims description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 3
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 3
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- 125000006536 (C1-C2)alkoxy group Chemical group 0.000 claims description 2
- 208000030090 Acute Disease Diseases 0.000 claims description 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 2
- 239000002841 Lewis acid Substances 0.000 claims description 2
- 150000001408 amides Chemical class 0.000 claims description 2
- JEPPYVOSGKWVSJ-UHFFFAOYSA-N bicyclo[2.2.1]heptan-3-amine Chemical class C1CC2C(N)CC1C2 JEPPYVOSGKWVSJ-UHFFFAOYSA-N 0.000 claims description 2
- 210000000941 bile Anatomy 0.000 claims description 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 2
- 150000001735 carboxylic acids Chemical class 0.000 claims description 2
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
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- 239000013067 intermediate product Substances 0.000 claims description 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims description 2
- 150000002500 ions Chemical class 0.000 claims description 2
- 150000007517 lewis acids Chemical class 0.000 claims description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 2
- 230000000269 nucleophilic effect Effects 0.000 claims description 2
- 238000010534 nucleophilic substitution reaction Methods 0.000 claims description 2
- 125000004043 oxo group Chemical group O=* 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
- 230000008569 process Effects 0.000 claims description 2
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims description 2
- 125000001424 substituent group Chemical group 0.000 claims description 2
- 150000003512 tertiary amines Chemical class 0.000 claims description 2
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 claims description 2
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 117
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 105
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- 239000000243 solution Substances 0.000 description 71
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 69
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 57
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- 239000002904 solvent Substances 0.000 description 38
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- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 34
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- 210000004027 cell Anatomy 0.000 description 28
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- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 12
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- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 7
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Classifications
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
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- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
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- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
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- C07C2601/00—Systems containing only non-condensed rings
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- C07C2601/14—The ring being saturated
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- C07—ORGANIC CHEMISTRY
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- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/60—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
- C07C2603/66—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing five-membered rings
- C07C2603/68—Dicyclopentadienes; Hydrogenated dicyclopentadienes
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19960204A DE19960204A1 (de) | 1999-12-14 | 1999-12-14 | Substituierte Norlbornylamino-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
PCT/EP2000/012107 WO2001044164A1 (de) | 1999-12-14 | 2000-12-01 | Substituierte norbornylamino-derivate, verfahren zu ihrer herstellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20020517A2 true HRP20020517A2 (en) | 2004-08-31 |
Family
ID=7932583
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20020517A HRP20020517A2 (en) | 1999-12-14 | 2002-06-13 | Substituted norbornylamino derivatives, method for the production thereof, use thereof as a medicament or a diagnostic reagent and medicaments containing said compounds |
Country Status (26)
Country | Link |
---|---|
US (1) | US6825231B2 (zh) |
EP (1) | EP1255724B1 (zh) |
JP (1) | JP2003517033A (zh) |
KR (1) | KR20030004308A (zh) |
CN (1) | CN1210251C (zh) |
AR (1) | AR032434A1 (zh) |
AT (1) | ATE338022T1 (zh) |
AU (1) | AU778888B2 (zh) |
BR (1) | BR0016360A (zh) |
CA (1) | CA2394130A1 (zh) |
CZ (1) | CZ20022006A3 (zh) |
DE (2) | DE19960204A1 (zh) |
EE (1) | EE200200292A (zh) |
HK (1) | HK1049655B (zh) |
HR (1) | HRP20020517A2 (zh) |
HU (1) | HUP0204360A3 (zh) |
IL (1) | IL150228A0 (zh) |
MX (1) | MXPA02003763A (zh) |
NO (1) | NO20022801L (zh) |
NZ (1) | NZ519511A (zh) |
PL (1) | PL356235A1 (zh) |
RU (1) | RU2260584C2 (zh) |
SK (1) | SK8202002A3 (zh) |
WO (1) | WO2001044164A1 (zh) |
YU (1) | YU30302A (zh) |
ZA (1) | ZA200204663B (zh) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10063294A1 (de) | 2000-12-19 | 2002-07-04 | Aventis Pharma Gmbh | Substituierte Heterocyclo-Norbornylamino-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE10156617A1 (de) | 2001-11-17 | 2003-05-28 | Biosphings Ag | Herstellung reiner Stereoisomere von Tricyclo[5.2.1.0··2··.··6··]-dec-9-yl-xanthogenat und Arzneimittel daraus |
US20030187045A1 (en) * | 2001-12-21 | 2003-10-02 | Uwe Heinelt | Substituted imidazolidines, process for their preparation, and their use as a medicament or diagnostic |
DE10163239A1 (de) * | 2001-12-21 | 2003-07-10 | Aventis Pharma Gmbh | Substituierte Imidazolidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie enthaltendes Medikament |
DE10224892A1 (de) * | 2002-06-04 | 2003-12-18 | Aventis Pharma Gmbh | Substituierte Thiophene, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
US7049333B2 (en) | 2002-06-04 | 2006-05-23 | Sanofi-Aventis Deutschland Gmbh | Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis |
US20050054705A1 (en) * | 2003-02-04 | 2005-03-10 | Aventis Pharma Deutschland Gmbh | N-substituted (benzoimidazol-2-yl) phenylamines, process for their preparation, their use as medicament or diagnostic aid, and medicament comprising them |
DE10304374A1 (de) * | 2003-02-04 | 2004-08-05 | Aventis Pharma Deutschland Gmbh | Neue substituierte 2-Aminoimidazole, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE102005001411A1 (de) | 2005-01-12 | 2006-07-27 | Sanofi-Aventis Deutschland Gmbh | Substituierte 4-Phenyltetrahydroisochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament |
EP2170872B1 (en) | 2007-06-28 | 2010-09-01 | Sanofi-Aventis U.S. LLC | Process for the preparation of the n-(2-chloro-4-methyl-3-thienyl)-1h- benzimidazol-2-amine hydrochloride and intermediates thereof |
KR20110050718A (ko) | 2008-09-02 | 2011-05-16 | 사노피-아벤티스 | 치환된 아미노인단 및 그의 유사체, 및 그의 제약 용도 |
DE102009030291A1 (de) * | 2009-06-24 | 2011-01-05 | Cu Chemie Uetikon Gmbh | Enantiomerenreine tricyclische Verbindung und Verfahren zur diastereomerenreinen und enantiomerenreinen Herstellung bicyclischer und tricyclischer Verbindungen |
US9556322B2 (en) | 2013-08-13 | 2017-01-31 | Colormatrix Holdings, Inc. | Liquid pigment dispersions |
WO2023249027A1 (ja) * | 2022-06-20 | 2023-12-28 | 三菱ケミカル株式会社 | 第4級アンモニウム塩、有機構造規定剤、第4級アンモニウム塩の製造方法、con型ゼオライト、con型ゼオライトの製造方法、触媒および低級オレフィンの製造方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2403138A1 (de) * | 1974-01-23 | 1975-07-31 | Hoechst Ag | Benzylaminderivate und verfahren zu ihrer herstellung |
EP0556674B1 (de) * | 1992-02-15 | 1996-06-19 | Hoechst Aktiengesellschaft | 3,5-Substituierte Benzoylguanidine, mit antiarrythmischer Wirkung und inhibierender Wirkung auf die Proliferationen von Zellen |
DE19518073A1 (de) * | 1995-05-17 | 1996-11-21 | Hoechst Ag | Substituierte Benzyloxycarbonylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
US5792635A (en) * | 1995-06-07 | 1998-08-11 | Magainin Pharmaceuticals, Inc. | Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine |
DE19633966A1 (de) * | 1996-08-22 | 1998-02-26 | Hoechst Ag | Phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
-
1999
- 1999-12-14 DE DE19960204A patent/DE19960204A1/de not_active Withdrawn
-
2000
- 2000-12-01 YU YU30302A patent/YU30302A/sh unknown
- 2000-12-01 CZ CZ20022006A patent/CZ20022006A3/cs unknown
- 2000-12-01 AU AU15254/01A patent/AU778888B2/en not_active Ceased
- 2000-12-01 EP EP00977604A patent/EP1255724B1/de not_active Expired - Lifetime
- 2000-12-01 HU HU0204360A patent/HUP0204360A3/hu unknown
- 2000-12-01 JP JP2001545253A patent/JP2003517033A/ja active Pending
- 2000-12-01 WO PCT/EP2000/012107 patent/WO2001044164A1/de active Search and Examination
- 2000-12-01 DE DE50013410T patent/DE50013410D1/de not_active Expired - Lifetime
- 2000-12-01 KR KR1020027007555A patent/KR20030004308A/ko not_active Application Discontinuation
- 2000-12-01 IL IL15022800A patent/IL150228A0/xx unknown
- 2000-12-01 MX MXPA02003763A patent/MXPA02003763A/es active IP Right Grant
- 2000-12-01 RU RU2002118700/04A patent/RU2260584C2/ru not_active IP Right Cessation
- 2000-12-01 CN CNB008144648A patent/CN1210251C/zh not_active Expired - Fee Related
- 2000-12-01 CA CA002394130A patent/CA2394130A1/en not_active Abandoned
- 2000-12-01 SK SK820-2002A patent/SK8202002A3/sk unknown
- 2000-12-01 BR BR0016360-0A patent/BR0016360A/pt not_active IP Right Cessation
- 2000-12-01 NZ NZ519511A patent/NZ519511A/en unknown
- 2000-12-01 AT AT00977604T patent/ATE338022T1/de not_active IP Right Cessation
- 2000-12-01 EE EEP200200292A patent/EE200200292A/xx unknown
- 2000-12-01 PL PL00356235A patent/PL356235A1/xx not_active Application Discontinuation
- 2000-12-12 AR ARP000106577A patent/AR032434A1/es unknown
- 2000-12-12 US US09/734,008 patent/US6825231B2/en not_active Expired - Fee Related
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2002
- 2002-06-11 ZA ZA200204663A patent/ZA200204663B/en unknown
- 2002-06-12 NO NO20022801A patent/NO20022801L/no not_active Application Discontinuation
- 2002-06-13 HR HR20020517A patent/HRP20020517A2/hr not_active Application Discontinuation
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2003
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Also Published As
Publication number | Publication date |
---|---|
JP2003517033A (ja) | 2003-05-20 |
ZA200204663B (en) | 2003-09-29 |
KR20030004308A (ko) | 2003-01-14 |
CA2394130A1 (en) | 2001-06-21 |
AU1525401A (en) | 2001-06-25 |
DE19960204A1 (de) | 2001-06-28 |
MXPA02003763A (es) | 2002-09-30 |
CN1379756A (zh) | 2002-11-13 |
ATE338022T1 (de) | 2006-09-15 |
NO20022801L (no) | 2002-08-09 |
NZ519511A (en) | 2004-08-27 |
US6825231B2 (en) | 2004-11-30 |
SK8202002A3 (en) | 2002-10-08 |
EE200200292A (et) | 2003-08-15 |
HUP0204360A2 (en) | 2003-05-28 |
RU2002118700A (ru) | 2004-01-20 |
HK1049655B (zh) | 2005-10-14 |
AU778888B2 (en) | 2004-12-23 |
CN1210251C (zh) | 2005-07-13 |
AR032434A1 (es) | 2003-11-12 |
US20010023257A1 (en) | 2001-09-20 |
EP1255724A1 (de) | 2002-11-13 |
PL356235A1 (en) | 2004-06-28 |
CZ20022006A3 (cs) | 2002-09-11 |
IL150228A0 (en) | 2002-12-01 |
BR0016360A (pt) | 2002-10-01 |
WO2001044164A1 (de) | 2001-06-21 |
NO20022801D0 (no) | 2002-06-12 |
YU30302A (sh) | 2005-06-10 |
HK1049655A1 (en) | 2003-05-23 |
EP1255724B1 (de) | 2006-08-30 |
RU2260584C2 (ru) | 2005-09-20 |
DE50013410D1 (de) | 2006-10-12 |
HUP0204360A3 (en) | 2005-04-28 |
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