HRP20020344B1 - Method for the preparation of citalopram - Google Patents

Method for the preparation of citalopram

Info

Publication number
HRP20020344B1
HRP20020344B1 HR20020344A HRP20020344A HRP20020344B1 HR P20020344 B1 HRP20020344 B1 HR P20020344B1 HR 20020344 A HR20020344 A HR 20020344A HR P20020344 A HRP20020344 A HR P20020344A HR P20020344 B1 HRP20020344 B1 HR P20020344B1
Authority
HR
Croatia
Prior art keywords
citalopram
preparation
dimethylamino
acyl
reacting
Prior art date
Application number
HR20020344A
Other languages
English (en)
Croatian (hr)
Inventor
Harold Rock Michael
Petersen Hans
Ellegaard Peter
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/DK1999/000581 external-priority patent/WO2000012044A2/en
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of HRP20020344A2 publication Critical patent/HRP20020344A2/hr
Publication of HRP20020344B1 publication Critical patent/HRP20020344B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton
HR20020344A 1999-10-25 2002-04-19 Method for the preparation of citalopram HRP20020344B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/DK1999/000581 WO2000012044A2 (en) 1999-10-25 1999-10-25 Method for the preparation of citalopram

Publications (2)

Publication Number Publication Date
HRP20020344A2 HRP20020344A2 (en) 2004-02-29
HRP20020344B1 true HRP20020344B1 (en) 2010-10-31

Family

ID=8157164

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020344A HRP20020344B1 (en) 1999-10-25 2002-04-19 Method for the preparation of citalopram

Country Status (25)

Country Link
US (1) US6566540B2 (ko)
EP (1) EP1298124B1 (ko)
KR (1) KR100505820B1 (ko)
AR (1) AR024518A1 (ko)
AT (2) ATE355268T1 (ko)
CA (1) CA2291133C (ko)
CY (1) CY1107635T1 (ko)
CZ (1) CZ292894B6 (ko)
DE (3) DE69920526T2 (ko)
DK (2) DK1228056T3 (ko)
EA (1) EA002801B1 (ko)
ES (1) ES2282365T3 (ko)
HK (1) HK1043129B (ko)
HR (1) HRP20020344B1 (ko)
HU (1) HUP0200169A3 (ko)
IL (3) IL143875A0 (ko)
IS (1) IS2260B (ko)
NO (1) NO20071311L (ko)
NZ (1) NZ512406A (ko)
PL (1) PL201056B1 (ko)
PT (2) PT1298124E (ko)
SI (2) SI1228056T1 (ko)
SK (1) SK287140B6 (ko)
TR (1) TR200401456T1 (ko)
UA (1) UA72238C2 (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR034612A1 (es) * 2001-06-25 2004-03-03 Lundbeck & Co As H Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram
PE20040991A1 (es) * 2002-08-12 2004-12-27 Lundbeck & Co As H Separacion de intermediarios para la preparacion de escitalopram
PT1578738E (pt) * 2002-12-23 2008-04-11 Lundbeck & Co As H Bromidrato de escitalopram e um método para a sua preparação
US20050137255A1 (en) * 2002-12-23 2005-06-23 H. Lundbeck A/S Crystalline escitalopram hydrobromide and methods for preparing the same
AU2003223105A1 (en) * 2003-03-24 2004-10-18 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
US20050196453A1 (en) * 2004-03-05 2005-09-08 H. Lundbeck A/S Crystalline composition containing escitalopram
EP1945198A4 (en) * 2005-10-14 2009-08-26 Lundbeck & Co As H STABLE PHARMACEUTICAL FORMULATIONS CONTAINING ESCITALOPRAM AND BUPROPION
JP2009511606A (ja) * 2005-10-14 2009-03-19 ハー・ルンドベック・アクチエゼルスカベット エスシタロプラムおよびブプロピオンの低用量の併用を用いる中枢神経系障害の治療方法
WO2009020897A1 (en) * 2007-08-03 2009-02-12 Forest Laboratories Holdings Limited Pharmaceutical compositions containing dopamine receptor ligands and methods of treatment using dopamine recptor ligands

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4650884A (en) * 1984-08-06 1987-03-17 H. Lundbeck A/S Novel intermediate and method for its preparation
US4943590A (en) * 1988-06-14 1990-07-24 H. Lundbeck A/S Pharmaceutically useful (+)-1-(3-dimethylaminopropyl)-1-(4'-fluorophenyl)-1,3-dihydrosobenzofuran-5-carbonitrile and non-toxic acid addition salts thereof
WO1998019511A2 (en) * 1997-11-10 1998-05-14 H. Lundbeck A/S Method for the preparation of citalopram

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (ko) 1965-03-18
GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
DE3926765A1 (de) 1989-08-12 1991-02-14 Hoechst Ag Verfahren zur verminderung von primaerem und sekundaerem amin in einem tertiaeren amin
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
DK1015416T3 (da) * 1997-07-08 2001-11-05 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
JP3813820B2 (ja) * 1997-11-11 2006-08-23 ハー・ルンドベック・アクチエゼルスカベット シタロプラムの製造方法
EA002977B1 (ru) 1998-10-20 2002-12-26 Х.Лундбекк А/С Способ получения циталопрама
PT1140886E (pt) 1998-12-23 2003-08-29 Lundbeck & Co As H Metodo para a preparacao de 5- cianoftalida
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ES2195554T5 (es) 1999-04-14 2010-02-02 H. Lundbeck A/S Metodo para la preparacion de citalopram.
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
FR2805812A1 (fr) 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
IL144817A0 (en) 2000-08-18 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
EP1181272B1 (en) 2000-12-28 2002-08-28 H. Lundbeck A/S Process for the preparation of pure citalopram

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4650884A (en) * 1984-08-06 1987-03-17 H. Lundbeck A/S Novel intermediate and method for its preparation
US4943590A (en) * 1988-06-14 1990-07-24 H. Lundbeck A/S Pharmaceutically useful (+)-1-(3-dimethylaminopropyl)-1-(4'-fluorophenyl)-1,3-dihydrosobenzofuran-5-carbonitrile and non-toxic acid addition salts thereof
WO1998019511A2 (en) * 1997-11-10 1998-05-14 H. Lundbeck A/S Method for the preparation of citalopram

Also Published As

Publication number Publication date
HUP0200169A2 (en) 2002-06-29
SI1228056T1 (en) 2005-02-28
IS5970A (is) 2001-06-15
ATE355268T1 (de) 2006-03-15
IS2260B (is) 2007-06-15
PL349440A1 (en) 2002-07-29
DE69920526T2 (de) 2006-02-23
IL176943A0 (en) 2006-12-10
TR200401456T1 (tr) 2005-04-21
US20020177722A1 (en) 2002-11-28
KR100505820B1 (ko) 2005-08-03
CZ292894B6 (cs) 2003-12-17
CA2291133C (en) 2003-06-17
EA002801B1 (ru) 2002-10-31
CY1107635T1 (el) 2013-04-18
NZ512406A (en) 2004-01-30
AR024518A1 (es) 2002-10-16
PT1228056E (pt) 2005-02-28
EA200100593A1 (ru) 2001-10-22
DE69920526D1 (de) 2004-10-28
DK1298124T3 (da) 2007-07-09
PL201056B1 (pl) 2009-03-31
EP1298124B1 (en) 2007-02-28
DE69935355D1 (de) 2007-04-12
PT1298124E (pt) 2007-05-31
SK287140B6 (sk) 2010-01-07
DK1228056T3 (da) 2005-01-24
NO20071311L (no) 2001-08-24
DE69935355T2 (de) 2007-11-08
HK1043129A1 (en) 2002-09-06
HK1043129B (zh) 2004-10-21
IL143875A0 (en) 2002-04-21
IL143875A (en) 2008-03-20
DE19983836C1 (de) 2003-10-23
US6566540B2 (en) 2003-05-20
HUP0200169A3 (en) 2002-11-28
UA72238C2 (en) 2005-02-15
HRP20020344A2 (en) 2004-02-29
SI1298124T1 (sl) 2007-08-31
EP1298124A1 (en) 2003-04-02
KR20010092799A (ko) 2001-10-27
CA2291133A1 (en) 2001-04-25
ES2282365T3 (es) 2007-10-16
ATE277032T1 (de) 2004-10-15

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