SI1228056T1 - Method for the preparation of citalopram - Google Patents

Method for the preparation of citalopram

Info

Publication number
SI1228056T1
SI1228056T1 SI9930703T SI9930703T SI1228056T1 SI 1228056 T1 SI1228056 T1 SI 1228056T1 SI 9930703 T SI9930703 T SI 9930703T SI 9930703 T SI9930703 T SI 9930703T SI 1228056 T1 SI1228056 T1 SI 1228056T1
Authority
SI
Slovenia
Prior art keywords
citalopram
preparation
Prior art date
Application number
SI9930703T
Other languages
English (en)
Slovenian (sl)
Inventor
Michael Harold Rock
Hans Petersen
Peter Ellegaard
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Priority claimed from EP99950511A external-priority patent/EP1228056B1/en
Publication of SI1228056T1 publication Critical patent/SI1228056T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
SI9930703T 1999-10-25 1999-10-25 Method for the preparation of citalopram SI1228056T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99950511A EP1228056B1 (en) 1999-10-25 1999-10-25 Method for the preparation of citalopram
PCT/DK1999/000581 WO2000012044A2 (en) 1999-10-25 1999-10-25 Method for the preparation of citalopram

Publications (1)

Publication Number Publication Date
SI1228056T1 true SI1228056T1 (en) 2005-02-28

Family

ID=8157164

Family Applications (2)

Application Number Title Priority Date Filing Date
SI9930703T SI1228056T1 (en) 1999-10-25 1999-10-25 Method for the preparation of citalopram
SI9930960T SI1298124T1 (sl) 1999-10-25 1999-10-25 Postopek za pripravo citaloprama

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI9930960T SI1298124T1 (sl) 1999-10-25 1999-10-25 Postopek za pripravo citaloprama

Country Status (25)

Country Link
US (1) US6566540B2 (ko)
EP (1) EP1298124B1 (ko)
KR (1) KR100505820B1 (ko)
AR (1) AR024518A1 (ko)
AT (2) ATE277032T1 (ko)
CA (1) CA2291133C (ko)
CY (1) CY1107635T1 (ko)
CZ (1) CZ292894B6 (ko)
DE (3) DE69920526T2 (ko)
DK (2) DK1228056T3 (ko)
EA (1) EA002801B1 (ko)
ES (1) ES2282365T3 (ko)
HK (1) HK1043129B (ko)
HR (1) HRP20020344B1 (ko)
HU (1) HUP0200169A3 (ko)
IL (3) IL143875A0 (ko)
IS (1) IS2260B (ko)
NO (1) NO20071311L (ko)
NZ (1) NZ512406A (ko)
PL (1) PL201056B1 (ko)
PT (2) PT1298124E (ko)
SI (2) SI1228056T1 (ko)
SK (1) SK287140B6 (ko)
TR (1) TR200401456T1 (ko)
UA (1) UA72238C2 (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR034612A1 (es) * 2001-06-25 2004-03-03 Lundbeck & Co As H Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram
TWI306846B (en) * 2002-08-12 2009-03-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
EP1578738B1 (en) * 2002-12-23 2008-03-12 H. Lundbeck A/S Escitalopram hydrobromide and a method for the preparation thereof
US20050137255A1 (en) * 2002-12-23 2005-06-23 H. Lundbeck A/S Crystalline escitalopram hydrobromide and methods for preparing the same
AU2003223105A1 (en) * 2003-03-24 2004-10-18 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
US20050196453A1 (en) * 2004-03-05 2005-09-08 H. Lundbeck A/S Crystalline composition containing escitalopram
KR20080075113A (ko) * 2005-10-14 2008-08-14 하. 룬트벡 아크티에 셀스카브 에스시탈로프람 및 부프로피온을 함유하는 안정한 약학적제형
US7569605B2 (en) * 2005-10-14 2009-08-04 Forest Laboratories Holdings Limited Methods of treating central nervous system disorders with a low dose combination of escitalopram and bupropion
EP2185155B1 (en) * 2007-08-03 2017-10-04 Richter Gedeon Nyrt. Pharmaceutical compositions containing dopamine receptor ligands and methods of treatment using dopamine recptor ligands

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143703A (ko) 1965-03-18
GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
DE3926765A1 (de) 1989-08-12 1991-02-14 Hoechst Ag Verfahren zur verminderung von primaerem und sekundaerem amin in einem tertiaeren amin
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
DE69801764T2 (de) 1997-07-08 2002-07-04 Lundbeck & Co As H Verfahren zur herstellung von citalopram
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
ES2149734T3 (es) * 1997-11-11 2003-02-16 Lundbeck & Co As H Metodo para la preparacion de citalopram.
US6365747B1 (en) 1998-10-20 2002-04-02 H. Lundbeck A/S Method for the preparation of citalopram
EP1140886B1 (en) 1998-12-23 2003-04-02 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
CA2291129C (en) 1999-04-14 2002-10-22 H. Lundbeck A/S Method for the preparation of citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
FR2805812A1 (fr) 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
CA2354877C (en) 2000-08-18 2006-05-02 H. Lundbeck A/S Method for the preparation of citalopram
DK1181272T3 (da) 2000-12-28 2002-12-30 Lundbeck & Co As H Fremgangsmåde til fremstilling af rent citalopram

Also Published As

Publication number Publication date
IL143875A0 (en) 2002-04-21
PT1298124E (pt) 2007-05-31
EP1298124A1 (en) 2003-04-02
AR024518A1 (es) 2002-10-16
TR200401456T1 (tr) 2005-04-21
IS2260B (is) 2007-06-15
CZ292894B6 (cs) 2003-12-17
HUP0200169A2 (en) 2002-06-29
DE69920526D1 (de) 2004-10-28
CA2291133C (en) 2003-06-17
US6566540B2 (en) 2003-05-20
EP1298124B1 (en) 2007-02-28
HRP20020344A2 (en) 2004-02-29
KR100505820B1 (ko) 2005-08-03
NO20071311L (no) 2001-08-24
ATE355268T1 (de) 2006-03-15
SK287140B6 (sk) 2010-01-07
NZ512406A (en) 2004-01-30
HK1043129B (zh) 2004-10-21
HUP0200169A3 (en) 2002-11-28
DE69935355D1 (de) 2007-04-12
ES2282365T3 (es) 2007-10-16
DK1228056T3 (da) 2005-01-24
PT1228056E (pt) 2005-02-28
CA2291133A1 (en) 2001-04-25
CY1107635T1 (el) 2013-04-18
US20020177722A1 (en) 2002-11-28
IS5970A (is) 2001-06-15
KR20010092799A (ko) 2001-10-27
DE69920526T2 (de) 2006-02-23
PL201056B1 (pl) 2009-03-31
PL349440A1 (en) 2002-07-29
EA002801B1 (ru) 2002-10-31
IL176943A0 (en) 2006-12-10
HK1043129A1 (en) 2002-09-06
IL143875A (en) 2008-03-20
DE69935355T2 (de) 2007-11-08
HRP20020344B1 (en) 2010-10-31
DE19983836C1 (de) 2003-10-23
SI1298124T1 (sl) 2007-08-31
EA200100593A1 (ru) 2001-10-22
DK1298124T3 (da) 2007-07-09
UA72238C2 (en) 2005-02-15
ATE277032T1 (de) 2004-10-15

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