HRP20010920A2 - Polymorphs of crystalline (2-benzhydryl-1-azabicyclo[2,2,2]oct-3-yl)-(5-isopropyl-2-methoxybenzyl)-ammoniumchloride as nk-1 receptor antagonists - Google Patents

Polymorphs of crystalline (2-benzhydryl-1-azabicyclo[2,2,2]oct-3-yl)-(5-isopropyl-2-methoxybenzyl)-ammoniumchloride as nk-1 receptor antagonists Download PDF

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Publication number
HRP20010920A2
HRP20010920A2 HR20010920A HRP20010920A HRP20010920A2 HR P20010920 A2 HRP20010920 A2 HR P20010920A2 HR 20010920 A HR20010920 A HR 20010920A HR P20010920 A HRP20010920 A HR P20010920A HR P20010920 A2 HRP20010920 A2 HR P20010920A2
Authority
HR
Croatia
Prior art keywords
dihydrochloride
approximately
anhydrous
polymorphic form
water
Prior art date
Application number
HR20010920A
Other languages
English (en)
Croatian (hr)
Inventor
Douglas John Meldrum Allen
Troy Anthony Appleton
Michael Jon Gumkowski
David Joseph Muehlbauer
Timothy Norris
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of HRP20010920A2 publication Critical patent/HRP20010920A2/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hospice & Palliative Care (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HR20010920A 1999-06-22 2000-06-06 Polymorphs of crystalline (2-benzhydryl-1-azabicyclo[2,2,2]oct-3-yl)-(5-isopropyl-2-methoxybenzyl)-ammoniumchloride as nk-1 receptor antagonists HRP20010920A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14023399P 1999-06-22 1999-06-22
PCT/IB2000/000756 WO2000078759A1 (en) 1999-06-22 2000-06-06 Polymorphs of crystalline (2-benzhydryl-1-azabicyclo[2,2,2]oct-3-yl)-(5-isopropyl-2-methoxybenzyl)-ammoniumchloride as nk-1 receptor antagonists

Publications (1)

Publication Number Publication Date
HRP20010920A2 true HRP20010920A2 (en) 2003-02-28

Family

ID=22490317

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20010920A HRP20010920A2 (en) 1999-06-22 2000-06-06 Polymorphs of crystalline (2-benzhydryl-1-azabicyclo[2,2,2]oct-3-yl)-(5-isopropyl-2-methoxybenzyl)-ammoniumchloride as nk-1 receptor antagonists

Country Status (35)

Country Link
US (1) US6262067B1 (cs)
EP (1) EP1187834A1 (cs)
JP (1) JP2003502425A (cs)
KR (1) KR20020030280A (cs)
CN (1) CN1390216A (cs)
AP (1) AP2001002367A0 (cs)
AR (1) AR024411A1 (cs)
AU (1) AU767336B2 (cs)
BG (1) BG106205A (cs)
BR (1) BR0011835A (cs)
CA (1) CA2375265A1 (cs)
CO (1) CO5190663A1 (cs)
CZ (1) CZ20014458A3 (cs)
DZ (1) DZ3055A1 (cs)
EA (1) EA004264B1 (cs)
EC (1) ECSP003538A (cs)
EE (1) EE200100698A (cs)
HR (1) HRP20010920A2 (cs)
HU (1) HUP0201694A3 (cs)
IL (1) IL146410A0 (cs)
IS (1) IS6161A (cs)
MA (1) MA26744A1 (cs)
MX (1) MXPA02000033A (cs)
NO (1) NO20016187D0 (cs)
NZ (1) NZ515348A (cs)
OA (1) OA11952A (cs)
PA (1) PA8496701A1 (cs)
PE (1) PE20010322A1 (cs)
PL (1) PL352899A1 (cs)
SK (1) SK18672001A3 (cs)
TN (1) TNSN00137A1 (cs)
TR (1) TR200103688T2 (cs)
UY (1) UY26211A1 (cs)
WO (1) WO2000078759A1 (cs)
ZA (1) ZA200110387B (cs)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6387925B1 (en) * 1999-06-01 2002-05-14 Pfizer Inc. Polymorphs of a crystalline azo-bicyclo (2.2.2) oct-3-yl amine citrate and their pharmaceutical compositions
US6756379B2 (en) * 2001-07-26 2004-06-29 Taro Pharmaceutical Industries Ltd. Non-sedating barbiturate compounds as neuroprotective agents
US6939873B2 (en) * 2000-07-26 2005-09-06 Taro Pharmaceuticals Industries Limited Non-sedating barbituric acid derivatives
US7683071B2 (en) * 2000-07-26 2010-03-23 Taro Pharmaceuticals Industries Ltd. Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid
WO2004031191A1 (en) * 2002-10-04 2004-04-15 Merck Sharp & Dohme Limited Azabicyclic spiroether derivatives as receptor antagonists
AU2003302897C1 (en) * 2002-12-11 2010-07-08 Taro Pharmaceutical Industries Limited Method of treating movement disorders using barbituric acid derivatives
CA2572797A1 (en) * 2004-07-02 2006-01-12 Daniella Gutman A process for preparing 1-methoxymethyl-5,5-diphenylbarbituric acid
EP2081576A4 (en) * 2006-11-14 2010-06-30 Taro Pharmaceuticals North Ame METHOD FOR IMPROVING BIOAVAILABILITY FOR NON-EDMING BARBITURATES
UA102128C2 (en) * 2008-12-05 2013-06-10 Х. Луннбек А/С Nalmefene hydrochloride dihydrate
IL288547B2 (en) * 2019-06-03 2025-10-01 Biotheryx Inc Non-hygroscopic crystalline pyrazole compound salts, pharmaceutical preparations thereof and use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990005525A1 (en) * 1988-11-23 1990-05-31 Pfizer Inc. Quinuclidine derivatives as substance p antagonists
CA2102179C (en) * 1991-05-31 1998-10-27 Fumitaka Ito Quinuclidine derivatives
CA2149242C (en) * 1992-11-12 1998-08-04 Fumitaka Ito Quinuclidine derivative for treatment of inflammatory and gastrointestinal disorders
US5393762A (en) * 1993-06-04 1995-02-28 Pfizer Inc. Pharmaceutical agents for treatment of emesis

Also Published As

Publication number Publication date
HUP0201694A3 (en) 2002-10-28
BR0011835A (pt) 2002-03-05
PA8496701A1 (es) 2002-07-30
TR200103688T2 (tr) 2002-12-23
NO20016187L (no) 2001-12-18
PL352899A1 (en) 2003-09-22
AU4774500A (en) 2001-01-09
EE200100698A (et) 2003-02-17
ECSP003538A (es) 2002-01-25
AP2001002367A0 (en) 2001-12-31
NZ515348A (en) 2003-07-25
OA11952A (en) 2006-04-13
SK18672001A3 (sk) 2002-08-06
CA2375265A1 (en) 2000-12-28
MA26744A1 (fr) 2004-12-20
DZ3055A1 (fr) 2004-03-27
CN1390216A (zh) 2003-01-08
CZ20014458A3 (cs) 2002-03-13
KR20020030280A (ko) 2002-04-24
IL146410A0 (en) 2002-07-25
EA004264B1 (ru) 2004-02-26
UY26211A1 (es) 2001-01-31
IS6161A (is) 2001-11-13
TNSN00137A1 (fr) 2002-05-30
CO5190663A1 (es) 2002-08-29
JP2003502425A (ja) 2003-01-21
ZA200110387B (en) 2002-12-19
EP1187834A1 (en) 2002-03-20
HUP0201694A2 (en) 2002-09-28
US6262067B1 (en) 2001-07-17
WO2000078759A1 (en) 2000-12-28
PE20010322A1 (es) 2001-03-14
MXPA02000033A (es) 2002-07-02
AR024411A1 (es) 2002-10-02
BG106205A (bg) 2002-07-31
EA200101179A1 (ru) 2002-06-27
AU767336B2 (en) 2003-11-06
NO20016187D0 (no) 2001-12-18

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