BR0011835A - Polimorfos de cloreto de (2-benzidril-1-azabiciclo [2,2,2] Èct-3-il)-(5-isopropil-2-metoxibenzil) amÈnio cristalino como antagonistas de receptor nk-1 - Google Patents
Polimorfos de cloreto de (2-benzidril-1-azabiciclo [2,2,2] Èct-3-il)-(5-isopropil-2-metoxibenzil) amÈnio cristalino como antagonistas de receptor nk-1Info
- Publication number
- BR0011835A BR0011835A BR0011835-4A BR0011835A BR0011835A BR 0011835 A BR0011835 A BR 0011835A BR 0011835 A BR0011835 A BR 0011835A BR 0011835 A BR0011835 A BR 0011835A
- Authority
- BR
- Brazil
- Prior art keywords
- èct
- benzhydryl
- polymorphs
- methoxybenzyl
- isopropyl
- Prior art date
Links
- 102000002002 Neurokinin-1 Receptors Human genes 0.000 title abstract 2
- 108010040718 Neurokinin-1 Receptors Proteins 0.000 title abstract 2
- 239000002464 receptor antagonist Substances 0.000 title abstract 2
- 229940044551 receptor antagonist Drugs 0.000 title abstract 2
- -1 oct-3-yl Chemical group 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 206010047700 Vomiting Diseases 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 238000002512 chemotherapy Methods 0.000 abstract 1
- 150000004683 dihydrates Chemical class 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14023399P | 1999-06-22 | 1999-06-22 | |
| PCT/IB2000/000756 WO2000078759A1 (en) | 1999-06-22 | 2000-06-06 | Polymorphs of crystalline (2-benzhydryl-1-azabicyclo[2,2,2]oct-3-yl)-(5-isopropyl-2-methoxybenzyl)-ammoniumchloride as nk-1 receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0011835A true BR0011835A (pt) | 2002-03-05 |
Family
ID=22490317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0011835-4A BR0011835A (pt) | 1999-06-22 | 2000-06-06 | Polimorfos de cloreto de (2-benzidril-1-azabiciclo [2,2,2] Èct-3-il)-(5-isopropil-2-metoxibenzil) amÈnio cristalino como antagonistas de receptor nk-1 |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US6262067B1 (cs) |
| EP (1) | EP1187834A1 (cs) |
| JP (1) | JP2003502425A (cs) |
| KR (1) | KR20020030280A (cs) |
| CN (1) | CN1390216A (cs) |
| AP (1) | AP2001002367A0 (cs) |
| AR (1) | AR024411A1 (cs) |
| AU (1) | AU767336B2 (cs) |
| BG (1) | BG106205A (cs) |
| BR (1) | BR0011835A (cs) |
| CA (1) | CA2375265A1 (cs) |
| CO (1) | CO5190663A1 (cs) |
| CZ (1) | CZ20014458A3 (cs) |
| DZ (1) | DZ3055A1 (cs) |
| EA (1) | EA004264B1 (cs) |
| EC (1) | ECSP003538A (cs) |
| EE (1) | EE200100698A (cs) |
| HR (1) | HRP20010920A2 (cs) |
| HU (1) | HUP0201694A3 (cs) |
| IL (1) | IL146410A0 (cs) |
| IS (1) | IS6161A (cs) |
| MA (1) | MA26744A1 (cs) |
| MX (1) | MXPA02000033A (cs) |
| NO (1) | NO20016187D0 (cs) |
| NZ (1) | NZ515348A (cs) |
| OA (1) | OA11952A (cs) |
| PA (1) | PA8496701A1 (cs) |
| PE (1) | PE20010322A1 (cs) |
| PL (1) | PL352899A1 (cs) |
| SK (1) | SK18672001A3 (cs) |
| TN (1) | TNSN00137A1 (cs) |
| TR (1) | TR200103688T2 (cs) |
| UY (1) | UY26211A1 (cs) |
| WO (1) | WO2000078759A1 (cs) |
| ZA (1) | ZA200110387B (cs) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6387925B1 (en) * | 1999-06-01 | 2002-05-14 | Pfizer Inc. | Polymorphs of a crystalline azo-bicyclo (2.2.2) oct-3-yl amine citrate and their pharmaceutical compositions |
| US7683071B2 (en) * | 2000-07-26 | 2010-03-23 | Taro Pharmaceuticals Industries Ltd. | Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid |
| US6756379B2 (en) | 2001-07-26 | 2004-06-29 | Taro Pharmaceutical Industries Ltd. | Non-sedating barbiturate compounds as neuroprotective agents |
| US6939873B2 (en) | 2000-07-26 | 2005-09-06 | Taro Pharmaceuticals Industries Limited | Non-sedating barbituric acid derivatives |
| EP1551846A1 (en) * | 2002-10-04 | 2005-07-13 | Merck Sharp & Dohme Ltd. | Azabicyclic spiroether derivatives as receptor antagonists |
| TWI334780B (en) | 2002-12-11 | 2010-12-21 | Taro Pharmaceuticals Ireland Ltd | Method of treating movement disorders using barbituric acid derivatives |
| CA2572797A1 (en) * | 2004-07-02 | 2006-01-12 | Daniella Gutman | A process for preparing 1-methoxymethyl-5,5-diphenylbarbituric acid |
| EP2081576A4 (en) * | 2006-11-14 | 2010-06-30 | Taro Pharmaceuticals North Ame | METHOD FOR IMPROVING BIOAVAILABILITY FOR NON-EDMING BARBITURATES |
| UA102128C2 (en) * | 2008-12-05 | 2013-06-10 | Х. Луннбек А/С | Nalmefene hydrochloride dihydrate |
| AU2020288163A1 (en) * | 2019-06-03 | 2022-01-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Non-hygroscopic crystalline salts of a pyrazole compound, and pharmaceutical compositions and use thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX18467A (es) * | 1988-11-23 | 1993-07-01 | Pfizer | Agentes terapeuticos de quinuclidinas |
| WO1992021677A1 (en) * | 1991-05-31 | 1992-12-10 | Pfizer Inc. | bibNUCLIDINE DERIVATIVES |
| JP2668164B2 (ja) * | 1992-11-12 | 1997-10-27 | ファイザー・インク． | Ｐ物質拮抗薬としてのキヌクリジン誘導体 |
| US5393762A (en) * | 1993-06-04 | 1995-02-28 | Pfizer Inc. | Pharmaceutical agents for treatment of emesis |
-
2000
- 2000-05-04 US US09/564,528 patent/US6262067B1/en not_active Expired - Fee Related
- 2000-06-06 EE EEP200100698A patent/EE200100698A/xx unknown
- 2000-06-06 OA OA1200100314A patent/OA11952A/en unknown
- 2000-06-06 CN CN00809305A patent/CN1390216A/zh active Pending
- 2000-06-06 NZ NZ515348A patent/NZ515348A/en unknown
- 2000-06-06 PL PL00352899A patent/PL352899A1/xx not_active Application Discontinuation
- 2000-06-06 KR KR1020017016407A patent/KR20020030280A/ko not_active Ceased
- 2000-06-06 EA EA200101179A patent/EA004264B1/ru not_active IP Right Cessation
- 2000-06-06 AP APAP/P/2001/002367A patent/AP2001002367A0/en unknown
- 2000-06-06 CZ CZ20014458A patent/CZ20014458A3/cs unknown
- 2000-06-06 WO PCT/IB2000/000756 patent/WO2000078759A1/en not_active Ceased
- 2000-06-06 IL IL14641000A patent/IL146410A0/xx unknown
- 2000-06-06 HR HR20010920A patent/HRP20010920A2/hr not_active Application Discontinuation
- 2000-06-06 JP JP2001504925A patent/JP2003502425A/ja active Pending
- 2000-06-06 MX MXPA02000033A patent/MXPA02000033A/es unknown
- 2000-06-06 BR BR0011835-4A patent/BR0011835A/pt not_active IP Right Cessation
- 2000-06-06 TR TR2001/03688T patent/TR200103688T2/xx unknown
- 2000-06-06 SK SK1867-2001A patent/SK18672001A3/sk unknown
- 2000-06-06 HU HU0201694A patent/HUP0201694A3/hu unknown
- 2000-06-06 CA CA002375265A patent/CA2375265A1/en not_active Abandoned
- 2000-06-06 EP EP00929745A patent/EP1187834A1/en not_active Withdrawn
- 2000-06-06 AU AU47745/00A patent/AU767336B2/en not_active Ceased
- 2000-06-06 PA PA20008496701A patent/PA8496701A1/es unknown
- 2000-06-13 CO CO00043885A patent/CO5190663A1/es not_active Application Discontinuation
- 2000-06-20 UY UY26211A patent/UY26211A1/es not_active Application Discontinuation
- 2000-06-20 AR ARP000103053A patent/AR024411A1/es not_active Application Discontinuation
- 2000-06-20 PE PE2000000613A patent/PE20010322A1/es not_active Application Discontinuation
- 2000-06-21 DZ DZ000113A patent/DZ3055A1/xx active
- 2000-06-21 MA MA26007A patent/MA26744A1/fr unknown
- 2000-06-21 TN TNTNSN00137A patent/TNSN00137A1/fr unknown
- 2000-06-22 EC EC2000003538A patent/ECSP003538A/es unknown
-
2001
- 2001-11-13 IS IS6161A patent/IS6161A/is unknown
- 2001-12-10 BG BG106205A patent/BG106205A/bg unknown
- 2001-12-18 NO NO20016187A patent/NO20016187D0/no not_active Application Discontinuation
- 2001-12-19 ZA ZA200110387A patent/ZA200110387B/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| UA72881C2 (uk) | Похідні тієнопіридину, фармацевтична композиція з використанням таких сполук (варіанти), проміжна сполука | |
| MXPA05010859A (es) | Antagonistas mchr1 heterociclicos. | |
| BR0011835A (pt) | Polimorfos de cloreto de (2-benzidril-1-azabiciclo [2,2,2] Èct-3-il)-(5-isopropil-2-metoxibenzil) amÈnio cristalino como antagonistas de receptor nk-1 | |
| WO2003093250A3 (en) | Positive allosteric modulators of the nicotinic acetylcholine receptor | |
| IL115040A (en) | Substituted piperidines useful for the treatment of allergic diseases process for their preparation and pharmaceutical compositions containing them | |
| HU224496B1 (hu) | Pirrolidin-3-il-alkil-piperidin-származékok és e vegyületeket tartalmazó gyógyászati készítmények | |
| WO2003048164A3 (en) | Adenosine a2a receptor antagonists | |
| WO2001066534A3 (en) | Cyclic and bicyclic diamino histamine-3 receptor antagonists | |
| MXPA04005209A (es) | Antagonistas del receptor de adenosina a2a. | |
| IL142893A0 (en) | Fused polyclic heterocyclic compounds and pharmaceutical compositions containing the same | |
| NZ512526A (en) | 4-sulfonamido-6-sulfamidoalkoxypyrimidine derivatives, pharmaceuticals thereof, and their use for the treatment of disorders associated with a role of endothelin. | |
| PT1140031E (pt) | Preparacao farmaceutica de libertacao controlada com mesilato de tilidina como substancia activa | |
| MX9705801A (es) | Derivados de acido 5-(4-piperidinil-1-sustituido)-3-arilpentaoico como antagonistas del receptor de taquicinina. | |
| ES2032570T3 (es) | Derivados antiparkinson de ergolina. (reserva del art. 167.2 cpe). | |
| BR0011125A (pt) | Polimorfos de citrato de (2-benzidril-1-azabiciclo[2.2.2]oct-3-il)-(5-iso-propil-2-m etoxibenzil)-amina cristalino como antagonistas de receptor nk-1 | |
| Stevenson et al. | Phase I/pharmacokinetic trial of the novel thioxanthone SR233377 (WIN33377) on a 5-day schedule | |
| EA200100871A1 (ru) | Кристаллическая форма эплеренона, обладающая повышенной скоростью растворения | |
| SE8302979D0 (sv) | Piperazine derivatives, their production and pharmaceutical compositions containing them | |
| ES8501390A1 (es) | Procedimiento para la preparacion de nuevas dibenzodiazepinonas sustituidas | |
| YU81101A (sh) | Polimorfni oblici kristalnog citrata azabiciklo (2,2,2) oktan-3-amina i njihovih farmaceutskih kompozicija | |
| DE3571619D1 (en) | 4-oxo-pyrido-û2,3-d¨pyrimidine derivatives, process for their preparation and medicaments containing them | |
| ES2169471T3 (es) | Derivados de la tetrahidroimidazo(2,1-a)isoquinolina. | |
| MY140450A (en) | New crystalline forms of 2, 3 dimethyl-8-(2,6-dimethylbenzylamino)-n-hydroxyethyl-imidazo [1,2-a] pyridine-6-carboxamide mesylate salt | |
| PE20040066A1 (es) | NUEVA FORMULACION PARA LA ADMINISTRACION PARENTERAL DE UN BLOQUEANTE DEL CANAL DEL Na | |
| HK1195907A1 (zh) | 取代的2，3-二氢咪唑并[1，2-c]喹唑啉盐 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A, 7A E 8A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008. |