ES2169471T3 - Derivados de la tetrahidroimidazo(2,1-a)isoquinolina. - Google Patents

Derivados de la tetrahidroimidazo(2,1-a)isoquinolina.

Info

Publication number
ES2169471T3
ES2169471T3 ES98202076T ES98202076T ES2169471T3 ES 2169471 T3 ES2169471 T3 ES 2169471T3 ES 98202076 T ES98202076 T ES 98202076T ES 98202076 T ES98202076 T ES 98202076T ES 2169471 T3 ES2169471 T3 ES 2169471T3
Authority
ES
Spain
Prior art keywords
rent
tetrahydroimidazo
alcoxi
sub
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98202076T
Other languages
English (en)
Inventor
Dirk Leysen
Gerardus Stephanus Franc Ruigt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Application granted granted Critical
Publication of ES2169471T3 publication Critical patent/ES2169471T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Abstract

LA PRESENTE INVENCION SE REFIERE A CIERTOS DERIVADOS DE TETRAHIDROIMIDAZO [2, 1 - A] ISOQUINOLINA, SEGUN LA FORMULA I DONDE X ES UN GRUPO (A) O (B) R 1 , R 2 Y R 3 , QUE PUEDEN SER IGUALES O DISTINTOS, REPRESENTAN CADA UNO UNO O MAS SUSTITUYENTES SELECCIONADOS A PARTIR DE HIDROGENO, ALQUILO C SUB,1-6 , CICLOALQUILO C 3-6 , ALCOXI C 1-6 , ALQUILTIO C 16 , CICLOALQUENILO C 4-6 , ALQUENILO C 2-6 , ALQUINILO C 2-6 Y HALOGENO; R 4 , R 5 , R 6 Y R 7 , QUE PUEDEN SER IGUALES O DISTINTOS, SE SELECCIONAN CADA UNO A PARTIR DE HIDROGENO, ALCOXI C 1-6 ALQUILO C SUB ,1-6 , CICLOALQUENILO C 4-6 , ALQUENILO C 2-6 , ALQUINILO C 2-6 , CICLOALQUILO C 3-6 Y ALQUILO C 1-6 ; N ES 1 O 2; O UNA SAL O SOLVATO FARMACEUTICAMENTE ACEPTABLE DEL MISMO. LA INVENCION SE REFIERE TAMBIEN A PROCEDIMIENTOS DE PREPARACION DE DICHOS COMPUESTOS, A FORMULACIONES FARMACEUTICAS QUE LOS CONTIENEN Y A SU UTILIZACION EN TERAPIA MEDICA, ESPECIALMENTE EN EL TRATAMIENTO DE LA DEPRESION.
ES98202076T 1997-06-26 1998-06-23 Derivados de la tetrahidroimidazo(2,1-a)isoquinolina. Expired - Lifetime ES2169471T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97201950 1997-06-26

Publications (1)

Publication Number Publication Date
ES2169471T3 true ES2169471T3 (es) 2002-07-01

Family

ID=8228485

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98202076T Expired - Lifetime ES2169471T3 (es) 1997-06-26 1998-06-23 Derivados de la tetrahidroimidazo(2,1-a)isoquinolina.

Country Status (27)

Country Link
US (1) US5994366A (es)
EP (1) EP0887349B1 (es)
JP (1) JP4339939B2 (es)
KR (1) KR100540317B1 (es)
CN (1) CN1139589C (es)
AR (1) AR013132A1 (es)
AT (1) ATE209649T1 (es)
AU (1) AU737924B2 (es)
BR (1) BR9802286A (es)
CA (1) CA2241469C (es)
CZ (1) CZ293265B6 (es)
DE (1) DE69802624T2 (es)
DK (1) DK0887349T3 (es)
ES (1) ES2169471T3 (es)
HK (1) HK1018059A1 (es)
HU (1) HUP9801451A3 (es)
ID (1) ID20494A (es)
IL (1) IL124914A (es)
NO (1) NO311028B1 (es)
NZ (1) NZ330722A (es)
PL (1) PL190281B1 (es)
PT (1) PT887349E (es)
RU (1) RU2204560C2 (es)
SG (1) SG66484A1 (es)
TR (1) TR199801175A1 (es)
TW (1) TW513411B (es)
ZA (1) ZA985559B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20060653A1 (es) * 2004-08-31 2006-09-27 Glaxo Group Ltd Derivados triciclicos condensados como moduladores del receptor 5-ht1

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3624093A (en) * 1970-03-10 1971-11-30 American Home Prod 5,6-disubstituted-2,3,5,6-tetrahydroimidazo-{8 2,1-{60 {9 isoquinolin-6-ols
US4100165A (en) * 1975-06-17 1978-07-11 Sandoz, Inc. Imidazo [2,1-a]isoquinolines

Also Published As

Publication number Publication date
NO982952D0 (no) 1998-06-25
NO311028B1 (no) 2001-10-01
RU2204560C2 (ru) 2003-05-20
NO982952L (no) 1998-12-28
JPH1171373A (ja) 1999-03-16
IL124914A0 (en) 1999-01-26
CZ204898A3 (cs) 1999-08-11
HUP9801451A3 (en) 1999-03-29
HUP9801451A2 (hu) 1999-02-01
ID20494A (id) 1998-12-31
DK0887349T3 (da) 2002-03-25
NZ330722A (en) 1999-08-30
PT887349E (pt) 2002-04-29
KR100540317B1 (ko) 2006-04-17
CA2241469A1 (en) 1998-12-26
EP0887349B1 (en) 2001-11-28
CZ293265B6 (cs) 2004-03-17
CN1203916A (zh) 1999-01-06
ZA985559B (en) 1999-01-20
US5994366A (en) 1999-11-30
CN1139589C (zh) 2004-02-25
EP0887349A1 (en) 1998-12-30
CA2241469C (en) 2008-08-19
IL124914A (en) 2000-10-31
KR19990007323A (ko) 1999-01-25
DE69802624D1 (de) 2002-01-10
HK1018059A1 (en) 1999-12-10
TR199801175A1 (xx) 1999-01-18
BR9802286A (pt) 2000-02-08
TW513411B (en) 2002-12-11
HU9801451D0 (en) 1998-08-28
AU737924B2 (en) 2001-09-06
SG66484A1 (en) 1999-07-20
ATE209649T1 (de) 2001-12-15
AR013132A1 (es) 2000-12-13
AU7319698A (en) 1999-01-07
PL327053A1 (en) 1999-01-04
DE69802624T2 (de) 2002-08-01
JP4339939B2 (ja) 2009-10-07
PL190281B1 (pl) 2005-11-30

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